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Seoul, South Korea

Bae J.-H.,Inje University | Bae J.-H.,Korea University | Paik N.H.,Inje University | Park G.-W.,Inje University | And 5 more authors.
Arthroscopy - Journal of Arthroscopic and Related Surgery | Year: 2013

Purpose: The purpose of this study was to determine the accuracy, sensitivity, specificity, and predictive values of a single event of painful popping in the presence of a posterior root tear of the medial meniscus in middle-aged to older Asian patients. Methods: We conducted a retrospective review of medical records of 936 patients who underwent arthroscopic surgeries for an isolated medial meniscus tear between January 2000 and December 2010. There were 332 men and 604 women with a mean age of 41 years (range, 25 to 66 years). The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of a painful popping sensation for a posterior root tear of the medial meniscus were calculated. Results: Arthroscopy confirmed the presence of posterior root tears of the medial menisci in 237 of 936 patients (25.3%). A single event of a painful popping sensation was present in 86 of these 936 patients (9.1%). Of these 86 patients with a painful popping sensation, 83 (96.5%) were categorized as having an isolated posterior root tear of the medial meniscus. The positive predictive value of a painful popping sensation in identifying a posterior root tear of the medial meniscus was 96.5%, the negative predictive value was 81.8%, the sensitivity was 35.0%, the specificity was 99.5%, and the diagnostic accuracy was 77.9%. Conclusions: A single event of painful popping can be a highly predictive clinical sign of a posterior root tear of the medial meniscus in the middle-aged to older Asian population. However, it has low sensitivity for the detection of a posterior root tear of the medial meniscus. Level of Evidence: Level IV, therapeutic case series. © 2013 by the Arthroscopy Association of North America. Source


Kim S.-B.,Kyung Hee University | Lee J.-H.,Korea Veterans Hospital | Lee J.-H.,Soonchunhyang University | Ahn J.-O.,Soonchunhyang University | Cho J.-H.,Hallym University
Journal of Magnetics | Year: 2015

The purpose of the study was to identify how isotope and magnetic resonance imaging (MRI) contrast media impact on noise to computed tomography (CT) examination. For the study, divide the phantoms to two groups: 1) saline, saline + different kinds of contrast agent without 99mTc administration; 2) 99mTc administration: saline, saline + different kinds of contrast agent with 99mTc administration. CT contrast agent was used for Iopamidol® and Dotarem. And MRI contrast agent was used for Primovist® and Gadovist®. To obtain an image, we used CT scanner. With an obtained image, we set the 1 cm2 region of interest in the middle of bottle to measure the noise and CT number. As a result, there was no difference in CT number before and after inserting 99mTc into all contrast media including Normal Saline. However, when it comes to Noise, there was a difference before and after inserting 99mTc into every contrast media except MRI contrast media such as Primovist® and Gadovist®. © The Korean Magnetics Society. All rights reserved. Source


Lee J.-H.,Korea Veterans Hospital | Lee J.-H.,Hallym University | Lee H.-K.,Soonchunhyang University | Cho J.-H.,Hallym University
Applied Magnetic Resonance | Year: 2015

The purpose of the study is to find out the changes of the signal-to-noise ratio (SNR) of magnetic resonance imaging (MRI) when performing MRI, computed tomography (CT), and isotope examination using99mTc. For the study, divide the phantoms into two groups: (1) saline, saline + different kinds of contrast agent without99mTc administration; (2)99mTc administration: saline, saline + different kinds of the contrast agent with99mTc administration. The CT contrast agent was used for Iopamidol® and Dotarem. And MRI contrast agent was used for Primovist® and Gadovist®. To obtain image, we used 3.0 T MR System, and obtained T1 and T2 images. Using obtained image, we compared an average value of SNR of T1 and T2 before and after distributing99mTc. As a result, SNR in T1 images had a significant difference before and after putting99mTc to every contrast media except normal saline. Also SNR in T2 mages had a significant difference before and after putting99mTc in every contrast media except Gadovist®. © 2015, Springer-Verlag Wien. Source


Lee J.-H.,Korea Veterans Hospital | Lee J.-H.,Hallym University | Lee H.-K.,Soonchunhyang University | Cho J.-H.,Hallym University | Cheon M.,Korea Veterans Hospital
Journal of Magnetics | Year: 2014

The purpose of the study is to investigate how uptake counts of 201Tl of radioisotopes in the human body could change, when taking computed tomography and magnetic resonance imaging right after injecting contrast media. 201Tl radioisotope substances of iodine contrast medium, which is a computed tomography contrast medium, and paramagnetic contrast medium, which is an magnetic resonance imaging contrast medium, were used as study materials. First, 201Tl was put into 4 cc of normal saline in test tube, and then a computed tomography contrast medium of Iopamidol® or Dotarem®, was put into 2 cc of normal saline in test tube. An magnetic resonance imaging contrast medium of Primovist® or Gadovist® was also put into 2 cc of normal saline in test tube. Each contrast medium was distributed to make 201Tl as 3 mCi, with a total of 4 cc. Gamma camera, low energy high resolution collimator, and pinhole collimator were used to obtain images. The uptake count of 201Tl was measured with 1000 frames of images, and obtained after 10 times of repetition. This study revealed that the use of Gadovist®, which is an magnetic resonance imaging contrast medium, showed the smallest number of uptake count, after measuring 201Tl uptake count by low energy high resolution collimator. On the other hand, the use of Iopamidol®, which is a computed tomography contrast medium, showed the biggest difference in uptake count, when measuring 99mTc uptake count by Pinhole collimator. When examining with gamma camera, using contrast medium and 201Tl, identifying the changes of uptake count is very important for improving the value of diagnosis. © The Korean Magnetics Society. All rights reserved. Source


Jin Y.-J.,University of Ulsan | Shim J.H.,University of Ulsan | Chung Y.-H.,University of Ulsan | Kim J.A.,University of Ulsan | And 7 more authors.
Journal of Clinical Gastroenterology | Year: 2012

Goals:: We intended to analyze the relationship between specific human leukocyte antigen (HLA)-DRB1 alleles and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. Study:: A database of 468 consecutive CHB patients who received lamivudine for more than 12 months between July 1996 and February 2011 was retrospectively analyzed. Sera and buffy coats samples were obtained between April 2008 and April 2010. Six-digit HLA-DRB1 genotyping was performed with sequence-based typing. Serum α fetoprotein levels and ultrasonography or computed tomography image studies were assessed every 3 to 6 months for surveillance of HCC. Results:: At baseline, median age was 43 years (range, 16 to 71) [male: 359 (76.7%); HBeAg positivity: 385 (82.3%)]. Among the 27 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent (>10%). HCC was diagnosed in 36 (7.7%) patients during the median follow-up of 69 months. The frequency of the HLA-DRB1*140101 allele was 9.0% and significantly higher in patients of the HCC group than those of the non-HCC group (19.4 vs. 8.1%, P=0.014). The 2-year, 4-year, and 6-year cumulative rates of HCC development were markedly higher in patients with HLA-DRB1*140101 than those without HLA-DRB1*140101 (2.4, 8.2, and 25.1% vs. 1.9, 4.7, and 7.4%, respectively, P=0.011). No other HLA-DRB1 alleles were associated with HCC development. Baseline clinical characteristics did not differ between patients with and without HLA-DRB1*140101. Conclusions:: The HLA-DRB1*140101 allele may be potentially associated with increased risk of HCC development in CHB patients, irrespective of the replicative activity of hepatitis B virus and antiviral responsiveness. © 2012 by Lippincott Williams & Wilkins. Source

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