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Tenan, South Korea

Korea Nazarene University is a Christian based on university located in Cheonan, Republic of Korea. Wikipedia.

Kang J.U.,Korea Nazarene University | Koo S.H.,Chungnam National University
International Journal of Molecular Medicine | Year: 2012

The lymph node metastatic (LNM) spread of tumor cells is a frequent event in the initial process of cancer dissemination and is a powerful independent prognostic indicator in gastric adenocarcinoma (GAC). High density genomic arrays were conducted to identify molecular markers associated with lymph node metastasis in GAC. In the genome-wide profile, large copy number gains involving chromosomes 1p, 3q, 8q, 9q, 11q, 16p, 19p, and 20q (log2 ratio >0.25) (>40% of patients) were more prevalent than copy number losses. The most notable finding was copy number gains at the long arm of chromosome 11, which occurred in 75.0% of lymphatic metastasis GAC cases, and the delineated minimal common region was 11q24.2-q12.1. More specifically, 2 amplified (>1 log2 ratio) loci on the 11q13.3 region were detected in 12.5% of the cases. The first locus, covers a region of ∼7.7 Mbp, and comprises the representative oncogene of cyclin D1 (CCNDI). This finding occurred in 12.5% of the cases. Additionally, an oral cancer overexpressed 1 (ORAOV1) gene was identified as a probable target within the 11q13 amplicon, which previously was not assumed to play a pathogenic role in GACs (12.5%). A second locus spanning 7.8 Mbp on 11q13.3 without associated genes also showed high-level amplifications in 12.5% of the GACs. This study indicates that the long arm of chromosome 11 harbors protooncogenes that are associated with lymphatic metastasis formation and the ORAOV1 gene at the 11q13.3 region could be a potential target and serve as an indicator for the presence of occult metastases in GAC. Source

Kang J.U.,Korea Nazarene University | Koo S.H.,Chungnam National University
International Journal of Molecular Medicine | Year: 2012

Microarray-based cytogenetics is revealing the tremendous fluidity and complexity of the human genome, and is starting to illustrate the implications of genomic variability with respect to human health and disease. In the last few years, the robustness of array-based technologies has provided accurate diagnosis and appropriate clinical management in a timely and efficient manner for identifying genomic defects of congenital and developmental abnormalities including developmental delay (DD), intellectual disability (ID), autism spectrum disorders (ASD) and/or multiple congenital anomalies (MCA). The implementation of this technology in these categories of disorders has been thoroughly evaluated and is now recommended as a first-line diagnostic approach for clinically suspected genetic disorders. However, clinical application of array-CGH in postnatal evaluation raises the debate of whether array-CGH will replace traditional cytogenetics in the near future and whether there is still a role for karyotyping and FISH. In this article, we therefore review the current status of array-based technology use for postnatal diagnosis and predict that it will replace standard cytogenetics as a first-line test for clinical evaluation in these population groups. Source

Kang J.U.,Korea Nazarene University
Oncology Letters | Year: 2014

Early gastric carcinoma (GC) is considered to be a curable cancer, as it progresses to the advanced stage following varying durations. Understanding the early stage of GC may provide an insight into its pathogenesis and contribute to reducing the mortality rate of this disease. To investigate the genomic aberrations associated with 22 cases of early GC, high-density microarray comparative genomic hybridization was performed in the present study. The most notable finding was copy number gains (log2 ratio >0.25) on the long arm of chromosome 8, which occurred in 77.3% (17/22) of GC cases, and the delineated minimal common region was 8q22.1-q24.3. More specifically, two amplified (log2 ratio >1) loci in the 8q22.1-q24.3 region were detected in 18.2% (4/22) of GC cases. The first loci covered a region of 102.4-107.9 kb, mapping on 8q22.3-q23.1, and comprised the transcription factor CP2-like 3 gene. The second loci, spanning 128.7-145.7 kb on 8q24.21-q24.3, comprised the representative oncogene of myelocytomatosis. Furthermore, the following possible target genes that were not previously considered to play a pathogenic role in GC were identified: Plasmacytoma variant translocation 1, cysteine/histidine rich 1, kinesin family member C2, forkhead box H1, protein phosphatase 1 regulatory subunit 16A, glutamic-pyruvate transaminase, LOC113655 and RecQ protein-like 4. In the present study, previous findings showing that 8q mutations accumulate early during the multistage pathogenesis of GC were confirmed and expanded upon. The confirmation of previously reported 8q gains and the identification of novel target genes at 8q22.1-q24.3 amplified chromosomal sites should aid in improving our understanding of the molecular mechanisms underlying the tumorigenesis of early GC. Source

Kim K.,Korea Nazarene University
International Journal of Multimedia and Ubiquitous Engineering | Year: 2014

In this paper, we proposed the sound scene control (SSC) of the multi-channel audio signals in MPEG Surround to enhance the MPEG Surround with respect to the functionality. To add a new functionality to the MPEG Surround, we proposed the multi-channel sound scene control by modification of the spatial parameters such as the channel level difference and the inter-channel correlation. Even though the panning law is directly applied to the spatial parameters, the output channel signals are successfully panned by given panning angle. The quality and the localization ability of the proposed SSC are confirmed by the subjective listening test. © 2014 SERSC. Source

Nam Y.,Korea Nazarene University
Contemporary Engineering Sciences | Year: 2016

Recently, Korea house market is experiencing a dramatic structural change. House sales and Chonsei (lease on a deposit basis without monthly rent) that dominated the market are rapidly giving way to monthly rent with security deposit. As the Chonsei prices are soaring due to the low interest rate, a portion of the increase is changing to monthly rent. Therefore, calculating the proper conversion rate from Chonsei to monthly rent is important for the housing stability of the general people. The current Housing Lease Protection Act, however, not only applies the same conversion rate regardless of the deposit amount or the region, but also is not strict. A way to provide proper conversion rates depending on the region and the deposit amount to the market on time was suggested in this study to improve the current situation. The proper conversion rate proved to be different depending on the region and the deposit amount according to the analysis. Also, the proper conversion rate for the monthly rent with low deposit and the half monthly rent proved to be lower than the 6% that the law specifies. As such, the construction of the system that can provide proper conversion rate on time is highly required. A way to build an information database and a calculation system to calculate the proper conversion rates was suggested in this study. © 2015 Dongjun Suh and Sungil Ham. Source

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