Shin E.-S.,Pohang University of Science and Technology |
Nguyen K.-H.,Pohang University of Science and Technology |
Kim J.,Pohang University of Science and Technology |
Kim C.-I.,Korea Health Industry Development Institute KHIDI |
Chang Y.-S.,Pohang University of Science and Technology
Environmental Pollution | Year: 2015
Human exposure to polychlorinated biphenyls (PCBs) from foods was investigated through a Total Diet Study (TDS) for the first time in Korea. A representative food list was developed from food intake data. Non-selected foods were also included in the TDS through the mapping process to anticipate practical risk assessment. For better representativeness, data (2008-2011) from the Korea National Health and Nutrition Examination Survey (KNHANES) were combined with the TDS data set. And also, we estimated the dietary exposure to PCBs from various food items using a 'best-fit' mapping process and assessed the differences in PCB exposures by sex and age. In this study, we examined total PCBs (62 congeners) including dioxin-like PCBs (DL-PCBs) and indicator PCBs, which are congeners that are mainly detected in various environmental matrices. The average dietary exposure (3.94 ng/kg body weight/day) that was estimated through food intake was 19.7% of the World Health Organization (WHO) recommendation. © 2015 Elsevier Ltd.
PubMed | Chungbuk National University, Korea Health Industry Development Institute KHIDI and Food Republic
Type: | Journal: BioMed research international | Year: 2015
The purpose of this study was to evaluate the anticancer efficacy of cetuximab combined with cisplatin (combination treatment) on colon cancer growth, as well as its underlying action mechanism. Combination treatment synergistically potentiated the effect of cetuximab on cell growth inhibition and apoptosis induction in HCT116 and SW480 cells. Combination treatment further suppressed the expression of the activated form of epidermal growth factor receptor (EGFR) and MAP kinase (p-ERK and p-p38) and also significantly inhibited the activity of activator protein-1 (AP-1) and nuclear factor kappa B (NF-B). Additionally, the expression of cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) mRNA was significantly reduced by the combination treatment as compared to the expression seen for treatment with cetuximab or cisplatin alone. We found that the synergistic inhibitory effects of cetuximab and cisplatin on AP-1 and NF-B activation, as well as on cell viability, were reversed by pretreatment with an ERK inhibitor. Results demonstrate that combined treatment with cetuximab and cisplatin exerts synergistic anticancer effects on colon cancer cells and also suggest that the ERK pathway plays a critical role in these effects via the suppression of the EGFR signaling pathway, along with the inhibition of COX-2, IL-8, and AP-1 and NF-B.
Lee H.-J.,Harvard University |
Lee H.-J.,Korea Health Industry Development Institute KHIDI |
Park S.,Texas A&M University |
Kim C.-I.,Korea Health Industry Development Institute KHIDI |
And 7 more authors.
PLoS ONE | Year: 2013
Background: A limited amount of research, primarily conducted in Western countries, has suggested that higher socioeconomic status (SES) is associated with higher risk of eating disorders (EDs). However, little is known about this association in Asian countries. We examined the association of SES with disturbed eating behavior (DEB) and related factors in Korean adolescents. Subjects: A nationwide online panel survey was conducted in a sample of adolescents (n = 6,943, 49.9% girls). DEB was measured with the 26-item Eating Attitudes Test (EAT-26). Participants who scored ≥20 on the EAT-26 were considered to have DEB. Participants' SES was determined based on self-reported household economic status. Results: The prevalence of DEB was 12.7%: 10.5% among boys and 14.8% among girls. Both boys and girls with DEB were more likely to perceive themselves as obese, experience higher levels of stress, and have lower academic achievement. The risk for DEB was significantly higher in boys of higher SES than in those of middle SES (OR = 1.45, 95%CI = 1.05-1.99 for high SES; OR = 5.16, 95%CI: 3.50-7.61 for highest SES). Among girls, higher risk of DEB was associated with the highest and lowest SES (OR = 1.52, 95%CI: 1.13-2.06 for lowest SES; OR = 2.22, 95%CI: 1.34-3.68 for highest SES). Conclusions: Despite the lower prevalence of obesity in Korea compared with Western countries, the prevalence of DEB in Korean adolescents was high, especially among girls. Moreover, the association between SES and DEB followed a U-shaped curve for girls and a J-shaped curve for boys. © 2013 Lee et al.
Park J.-H.,Kyung Hee University |
Youm S.,Dongguk University |
Jeon Y.,Korea Health Industry Development Institute KHIDI |
Park S.-H.,Kyung Hee University
International Journal of Industrial Ergonomics | Year: 2015
The purpose of this research is to develop a postural balance evaluation system using center-of-pressure (COP) analysis techniques for early diagnosis of Parkinson's disease (PD). A COP sensing device was developed, and applicable test protocols were proposed. Subsequently, posturographic parameters, which reflect the characteristics of postural control, were extracted to evaluate postural balance. Decisive indicators for postural stability were selected among the posturographic parameters through statistical validation based on clinical data. A discriminant function was then suggested to predict the existence of PD in patients. This clinical study consisted of 127 participating subjects. A validation study (n = 51, 40% of the overall data) using the discriminant function concluded with 100% accuracy that 37 healthy subjects did not have PD and 14 subjects with PD were correctly diagnosed. Relevance to industry: Postural instability has become a critical issue since people with postural balance disorders are frequently exposed to the danger of falling and injuries. This paper provides a device, test protocol, and evaluation method to analyze postural balance and predict the existence of PD. We expect that our proposed system can be exploited for neurosurgery of PD patients, and other clinical medical fields such as rehabilitation, geriatrics, and orthopedics. © 2015 Elsevier B.V.
Lee H.-E.,Chonbuk National University |
Choi E.-S.,Chonbuk National University |
Shin J.-A.,Chonbuk National University |
Lee S.-O.,Texas A&M University |
And 3 more authors.
Experimental and Therapeutic Medicine | Year: 2013
Fucoidan is a sulfated polysaccharide present in brown algae that has been identified to exhibit multiple biological effects. In this study, the apoptotic effects of fucoidan in MC3 human mucoepidermoid carcinoma (MEC) cells were investigated. The apoptotic effects of fucoidan on MC3 MEC cells were evaluated by cell proliferation assay, 4′,6-diamidino-2-phenylindole staining and western blot analysis. The results showed that fucoidan decreased cell proliferation and induced caspase-dependent apoptosis in MC3 MEC cells. Fucoidan downregulated the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, whereas phospho-p38 mitogen-activated protein kinase or phospho-c-Jun NH2-terminal kinase (JNK) levels were not altered. In addition, fucoidan significantly decreased the expression levels of myeloid cell leukemia-1 (Mcl-1). These results suggest that fucoidan is able to modulate the ERK1/2 pathway and thereby regulate Mcl-1 protein expression and induce apoptosis in MC3 MEC cells. Therefore, fucoidan may be a promising agent for the treatment of human MEC.
Korea Health Industry Development Institute Khidi and Konkuk University | Date: 2012-02-16
The present invention relates to a novel compound isolated from Allium tuberosum and the use thereof as an antiviral agent. The compound isolated from Allium tuberosum shows the ability to inhibit highly pathogenic virus, and thus is a promising candidate for an antiviral agent.
PubMed | Gwangju Institute of Science and Technology, Korea Institute of Science and Technology and Korea Health Industry Development Institute KHIDI
Type: | Journal: European journal of medicinal chemistry | Year: 2015
As an optimization strategy, the flexible structure of KN-62, a known P2X7 receptor antagonist, was converted into conformationally constrained derivatives using pyrimidine-2,4-dione as the core skeleton. Various modifications at the 4-position of the piperazine moiety of the new lead compound were performed to improve P2X7 receptor antagonistic activities, which were evaluated in HEK293 cells stably expressing the human P2X7 receptor (EtBr uptake assay) and in THP-1 cells (IL-1 ELISA assay). According to the results, polycycloalkyl acyl or di-halogenated benzoyl substituents were much more favorable than the original phenyl group of KN-62. Among these compounds, the trifluoromethyl-chloro benzoyl derivative 18 m and adamantyl carbonyl derivatives 19 g-19 i and 19k showed potent antagonistic effects, with IC50 values ranging from 10 to 30 nM. In addition, the in vitro adsorption, distribution, metabolism, excretion, and toxicity (ADMET) profile of 18 m was determined to be in acceptable ranges in terms of metabolic stability and cytotoxicity. These results suggest that pyrimidine-2,4-dione derivatives may be promising novel P2X7 receptor antagonists for the development of anti-inflammatory drugs.
Lee H.H.,Harvard University |
Lee H.J.,Korea Health Industry Development Institute KHIDI |
Cho J.I.,Korea Health Industry Development Institute KHIDI |
Stampfer M.J.,Harvard University |
And 3 more authors.
European Journal of Clinical Nutrition | Year: 2013
Background/Objectives: Obesity is associated with increased triglyceride levels. We examined whether overall obesity (body mass index (BMI)) and abdominal obesity (waist circumference (WC)) are independently associated with hypertriglyceridemia among the Korean population. Subjects/Methods: A national sample of 5036 Koreans aged 19-64 was examined with cross-sectional surveys, the Korea National Health and Nutrition Examination Survey, in 2007 and 2008. BMI, WC and other lifestyle information were assessed. Results: We documented 1344 cases (26.7%) of hypertriglyceridemia (fasting triglycerides of >150 mg/dl). Both BMI and WC were each independently associated with hypertriglyceridemia. Multivariate odds ratios (ORs) of increasing categories of BMI (<18.5, 18.5≤-<23, 23≤-<25, 25≤-<28, ≥28 kg/m 2), were 0.49, 1.00 (reference), 1.26, 1.63 and 1.84, respectively (P=0.0007) adjusting for WC. There was a positive association between WC and hypertriglyceridemia across increasing quintiles of WC (multivariate-adjusted ORs: 1.00 (reference), 1.54, 2.54, 2.21 and 2.36; P<0.0001), adjusting for BMI. WC was positively related to hypertriglyceridemia in both gender. However, only women's BMI was independently associated with hypertriglyceridemia after adjusting for WC. The joint relation between BMI and WC and hypertriglyceridemia showed that within each BMI category, higher WC predicted a greater prevalence of hypertriglyceridemia and vice versa. The receiver operating characteristic curves indicated that BMI (0.69) and WC (0.72) were similar in predicting hypertriglyceridemia. Conclusions: Both BMI and WC were strongly independently associated with hypertriglyceridemia among the population. Both measurements should be considered for use in assessing health risk at clinical settings and epidemiologic research among Asian population. © 2013 Macmillan Publishers Limited.
Catholic University of Korea and Korea Health Industry Development Institute Khidi | Date: 2011-12-29
A pin guide for the surgical operation of an avascular necrosis of a femoral head includes a guide body having a central pin guide hole extending along a centerline of the guide body and a plurality of side pin guide holes formed so as to make a specified angle with the central pin guide hole. The side pin guide holes are radially arranged around the central pin guide hole at a front side of the guide body and joined to the central pin guide hole at a rear side of the guide body.
PubMed | Korea Health Industry Development Institute KHIDI and Korea Advanced Institute of Science and Technology
Type: | Journal: Environmental pollution (Barking, Essex : 1987) | Year: 2015
Human exposure to polychlorinated biphenyls (PCBs) from foods was investigated through a Total Diet Study (TDS) for the first time in Korea. A representative food list was developed from food intake data. Non-selected foods were also included in the TDS through the mapping process to anticipate practical risk assessment. For better representativeness, data (2008-2011) from the Korea National Health and Nutrition Examination Survey (KNHANES) were combined with the TDS data set. And also, we estimated the dietary exposure to PCBs from various food items using a best-fit mapping process and assessed the differences in PCB exposures by sex and age. In this study, we examined total PCBs (62 congeners) including dioxin-like PCBs (DL-PCBs) and indicator PCBs, which are congeners that are mainly detected in various environmental matrices. The average dietary exposure (3.94ng/kg body weight/day) that was estimated through food intake was 19.7% of the World Health Organization (WHO) recommendation.