Korea Food Research Institute
Korea Food Research Institute
Korea Food Research Institute and University of Minnesota | Date: 2014-07-02
The present invention provides a method for screening for an autophagy activator or inhibitor comprising the steps of: (a) making a test material to be analyzed come into contact with cells containing Beclin 1 protein; and (b) analyzing the degree of phosphorylation at the 30^(th )serine amino acid residue of the Beclin 1 protein. The test material is determined to be an autophagy activator when the phosphorylation of the Beclin 1 protein is up-regulated, and the test material is determined to be an autophagy inhibitor when the phosphorylation of the Beclin 1 protein is down-regulated. The present invention first establishes, by ULK1, the mechanism of phosphorylation at the 30^(th )serine amino acid residue of Beclin 1.
Jeon T.-I.,Korea Food Research Institute |
Osborne T.F.,Sanford Burnham Institute for Medical Research
Trends in Endocrinology and Metabolism | Year: 2012
Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver. In addition, genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity. This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism. © 2011 Elsevier Ltd.
Korea Food Research Institute and Kyonggi University | Date: 2015-09-30
A persimmon leaf-derived polysaccharide fraction consisting of 60-80 wt % of neutral sugar and 18-39 wt % of uronic acid, and 0.5-10 wt % of 3-deoxy-D-manno-2-octulosonic acid (KDO) analogs, the wt % based on the total weight of the polysaccharide fraction.
Korea Food Research Institute | Date: 2015-07-21
Disclosed is a use of rice, rice bran or rice hull extract as a histamine receptor antagonist. The rice, rice bran or rice hull extract may be used as a natural antihistamine to prevent or treat allergic rhinitis, inflammatory bowel disease, asthma, bronchitis, nausea, gastric and duodenal ulcer, gastroesophageal reflux disease, sleep disorder, anxiety and depression. It provides comparable or better effect of decreasing sleep latency, increasing sleep duration and increasing non-REM sleep as compared to diazepam, which is currently used as sleeping drug. Derived from the natural product rice, rice bran or rice hull, it has no side effect such as cognitive impairment, resistance or dependency even after long-term use.
Korea Food Research Institute | Date: 2015-10-14
The present invention provides compositions or methods for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases. According to the prevent invention, the composition of the present invention has excellent inhibitory activities for the production of Th1- and Th2-related cytokines, the degranulation of mast cells, the penetration of allergens through an intestinal epithelial cell layer, differenciation inducing activity into Treg cells, and stabilizing activity of Treg cells. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.
Korea Food Research Institute | Date: 2014-10-08
Provided is a forced evaporative humidifier using nano-vapor, which includes: a housing having an exhaust port formed in an upper surface thereof and a suction port formed at one side of a front surface thereof; a water tank located below the suction port to store water; an injection unit having an injection nozzle located above the suction port, a pump for pulling up the water in the water tank to the injection nozzle, and a transfer tube for transferring the water pulled by the pump; a blowing fan located above the injection nozzle to carry air toward the exhaust port of the housing; a humidifying unit located below the injection nozzle so that films, each having a body surface formed to allow the water injected from the injection nozzle to flow and a plurality of tube-type spacers protruding on the body surface, are stacked in a lateral direction therein; and an eliminator located between the blowing fan and the injection nozzle to prevent water drops included in a humid air humidified by the humidifying unit from being scattered.
Korea Food Research Institute | Date: 2015-01-21
An object inspection apparatus includes a terahertz wave supplying unit for generating a terahertz wave and moving a path of the terahertz wave according to time so that the terahertz wave is supplied to an object to be inspected, a focusing lens located between the terahertz wave supplying unit and the object to be inspected to focus the terahertz wave supplied by the terahertz wave supplying unit, a rotating plate having a plate shape and including a plurality of the focusing lenses with different distances from the center thereof, the rotating plate rotating in the circumferential direction so that one of the focusing lenses is located at a path of the terahertz wave according to the path movement of the terahertz wave, and a terahertz wave detecting unit for collecting and detecting a terahertz wave incident to the object to be inspected.
Korea Food Research Institute | Date: 2014-08-13
Disclosed is a system for monitoring product quality in real time by using an RFID tag and a QR code. The product quality monitoring system includes: an RFID tag which is attached to a first packing container in which a product is packed, and transmits atmospheric history information comprising at least one of temperature, humidity, and gas concentration, which has been measured, and an identifier for a product distribution history; a QR code which is attached to a second packing container, in which the product is packed and is relatively smaller than the first packing container, or the product itself, and stores the identifier and address information of a product quality predicting server; a product distribution history DB which stores the atmospheric history information and the identifier which are received from the RFID tag; a user terminal which connects with the product quality predicting server corresponding to the address information stored in the captured QR code, and requests a quality index of the product; and the product quality predicting server which calculates the quality index of the product or a time when the product has a specific quality index, from the atmospheric history information received from the product distribution history DB in response to the request of the user terminal.
Korea Food Research Institute | Date: 2016-03-09
A wrapper for a terahertz wave according to an embodiment of the present invention includes: a terahertz wave transmission layer that is made of a material that transmits a terahertz wave; and an electric field enhancement structure that enhances an electric field by reacting with a predetermined frequency band of terahertz waves passing through the terahertz wave transmission layer. An optical identification device for a terahertz wave according to an embodiment of the present invention includes m identification units composed of: a terahertz wave transmission layer that is made of a material that transmits a terahertz wave; and a waveguide grating that resonates at a natural resonant frequency when receiving the transmitted terahertz wave, in which the natural resonant frequency is any one of a first natural resonant frequency to an n-th natural resonant frequency.
Korea Food Research Institute | Date: 2016-02-22
A method for preparing a low antigenic food, the method including removing a sugar linked to a glycoprotein of an allergenic food. A low antigenic food prepared by removing a sugar linked to a glycoprotein of an allergenic food. A method for preparing a low antigenic glycoprotein, the method including removing a glucose linked to a glycoprotein selected from the group consisting of ovalbumin, ovomucoid, ovotransferrin, -conglycinin, Ara h1, and Ara h2. A low antigenic glycoprotein prepared by removing a glucose linked to a glycoprotein selected from the group consisting of ovalbumin, ovomucoid, ovotransferrin, -conglycinin, Ara h1, and Ara h2. A low antigenic food composition including the low antigenic glycoprotein. A low antigenic cosmetic composition including the low antigenic glycoprotein as an active ingredient.