Daejeon, South Korea
Daejeon, South Korea

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Patent
Korea Basic Science Institute | Date: 2016-10-31

The present invention relates to a beef-specific age determination marker containing the p21 protein, to an antibody specifically bound to bovine p21 protein, to a beef-specific age determination kit containing the antibody which is specifically bound to the bovine p21 protein, and to a method which involves detecting the bovine p21 protein through an antigen-antibody binding reaction using the antibody which is specifically bound to the bovine p21 protein serving as a beef-specific age determination marker in the muscle tissue of beef, so as to determine the age of the beef. According to the present invention, the p21 protein is significantly greatly expressed in the muscle tissue of beef, the age of which is lower than 30 months, and is hardly expressed in the muscle tissue of beef, the age of which is greater than 30 months, and thus can be valuably used as a beef-specific age determination marker.


Patent
Korea Basic Science Institute | Date: 2017-03-29

Provided is a time-of-flight mass spectrometer including: an ionization part receiving electron beams to thereby emit ions; a cold electron supply part injecting the electron beams to the ionization part; an ion detection part detecting the ions emitted from the ionization part; and an ion separation part connecting the ionization part and the ion detection part, wherein the cold electron supply part includes a microchannel plate receiving ultraviolet rays to thereby emit the electron beams, the ions emitted from the ionization part pass through the ion separation part to thereby reach the ion detection part, and the ion separation part has a straight tube shape.


Kim S.H.,Korea Basic Science Institute
Nature Materials | Year: 2017

Nanoscale distance-dependent phenomena, such as Förster resonance energy transfer, are important interactions for use in sensing and imaging, but their versatility for bioimaging can be limited by undesirable photon interactions with the surrounding biological matrix, especially in in vivo systems. Here, we report a new type of magnetism-based nanoscale distance-dependent phenomenon that can quantitatively and reversibly sense and image intra-/intermolecular interactions of biologically important targets. We introduce distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic ‘enhancer’ and a superparamagnetic ‘quencher’, where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the principle of an MRI-based ruler for nanometre-scale distance measurement and the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro and in vivo systems. MRET can serve as a novel sensing principle to augment the exploration of a wide range of biological systems. © 2017 Nature Publishing Group


Patent
Korea Basic Science Institute | Date: 2015-03-19

There is provided a microwave plasma torch system comprising: a plasma generator; a microwave generator; and at least one plasma source gas injector, wherein the microwave generator includes a waveguide, wherein the plasma generator includes a discharge tube, wherein the discharge tube passes through a waveguide in a perpendicular to the waveguide, wherein the waveguide has a width na, where n is an integer equal to or larger than 2, wherein a is defined as a width of a waveguide having a dominant mode for propagating a microwave, wherein the discharge tube is positioned relative to the waveguide such that a diameter center of the tube encounters a longitudinal null line of an electric field distribution, wherein the discharge tube is further positioned relative to the waveguide such that a diameter center of the tube encounters a transverse null line of an electric field distribution, wherein the transverse null line is perpendicular to the longitudinal null line.


Kim H.,Hanyang University | Kim J.-S.,Korea Basic Science Institute | Kim J.-S.,Seoul National University
Nature Reviews Genetics | Year: 2014

Programmable nucleases-including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and RNA-guided engineered nucleases (RGENs) derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system-enable targeted genetic modifications in cultured cells, as well as in whole animals and plants. The value of these enzymes in research, medicine and biotechnology arises from their ability to induce site-specific DNA cleavage in the genome, the repair (through endogenous mechanisms) of which allows high-precision genome editing. However, these nucleases differ in several respects, including their composition, targetable sites, specificities and mutation signatures, among other characteristics. Knowledge of nuclease-specific features, as well as of their pros and cons, is essential for researchers to choose the most appropriate tool for a range of applications. © 2014 Macmillan Publishers Limited. All rights reserved.


Ha M.,Korea Basic Science Institute | Ha M.,Seoul National University | Kim V.N.,Korea Basic Science Institute | Kim V.N.,Seoul National University
Nature Reviews Molecular Cell Biology | Year: 2014

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ∼22 nucleotides in length, and they are produced by two RNase III proteins-Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging. © 2014 Macmillan Publishers Limited.


Patent
Samsung and Korea Basic Science Institute | Date: 2016-02-02

A magnetic resonance imaging (MRI) apparatus and a magnetic resonance spectroscopic method are provided. The MRI apparatus includes a data collector configured to obtain reference data of reference substances, and obtain measurement data of a target region of a subject. The MRI apparatus further includes a processor configured to determine a reference substance of the target region, among the reference substances, and a concentration of the reference substance, using the reference data, the measurement data, and an external factor compensation value compensating an external factor affecting the measurement data.


Patent
Korea Advanced Institute of Science, Technology, Korea Basic Science Institute, Korea Institute of Science and Technology | Date: 2016-06-22

The present invention relates to a spintronic wireless communication system for simultaneously modulating multiband frequencies and amplitudes, the system comprising: a plurality of spin-torque transfer devices which have different frequency characteristics from each other, and OOK modulate or multi-level ASK modulate input data to thereby output a multiband OOK modulation signal or a multiband, multi-level ASK modulation signal; a plurality of matching networks which match individual impedances of the plurality of spin-torque transfer devices; and a broadband antenna which receives the multiband OOK modulation signal or the multiband, multi-level ASK modulation signal from ends of the plurality of matching networks and simultaneously transmits the signals to the outside.


Patent
Korea Basic Science Institute | Date: 2016-03-24

A method for synthesizing lithium-titanium oxide using a solid state method includes: mixing lithium oxide (Li_(2)O) and titanium oxide (TiO_(2)) in a solvent; separating a solid material which includes lithium oxide and titanium oxide from the solvent; drying the solid material separated from the solvent; and performing a heat treatment on the solid material.


The present invention is about a neutral particle beam source for producing a high density plasma in high vacuum and a thin film deposition system employing said neutral particle beam source, According to the present invention, the plasma is generated by using microwave through the microwave irradiating equipment and a magnetic field by more than one pair of belt type magnets and the high density plasma can be accomplished by maximizing the plasma confinement effect inducing an electron returning trajectory in accordance with the above continuous structure of the belt type magnet in combination with the microwave irradiating equipment.

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