Nonsan, South Korea
Nonsan, South Korea

Konyang University , located in Nonsan, South Korea, was founded in 1991.Konyang University has campuses in Nonsan and Daejeon. The Nonsan campus is the main campus with over 10,000 undergraduate students, eight colleges with more than forty majors, mostly in applied fields About 230 of the students are foreign students. The Daejeon campus has programs in Western medicine, medical technology, and nursing. The university has about 700 graduate students. It is accredited by the Korean Council for University Education .In 2011, Konyang was one of four private ROK universities that began offering military science as a major.The university president is Dr. Kim Hi-soo, recipient of the 2006 South Korean Mugunghwa Order of Civil Merit Medal prize for outstanding citizen, for his work in fostering education.In 2013, as part of a major reorientation of the nation's tertiary educational system and in part in response to the significantly changing demographics, the country's government announced a change in financial support to both public and private universities. Schools that have not been performing well would have their support drastically cut. At the same time, institutions could apply or grants to support specific projects. The winning schools were announced in mid-2014. Konyang had submitted seven different projects. All of them were funded in full, for a total of 49 billion won in support. Wikipedia.

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Stress hormones have been implicated in both tumor initiation and progression. Human telomerase reverse transcriptase (hTERT) is overexpressed in cancer cells and associated with malignant tumor progression and poor outcome. We thus sought to determine whether the stress hormone norepinephrine (NE) could induce hTERT expression and subsequently ovarian cancer progression. Unexpectedly, NE induced hTERT transcript and protein expression, and subsequently ovarian cancer cell invasion. Pharmacologic inhibition of β2-adrenergic receptor 2 and protein kinase A, as well as silencing of hypoxia-inducible factor-1α and c-Myc expression, profoundly attenuated NE-induced hTERT expression. Strikingly, stimulation of the cells with NE or ectopic expression of hTERT induced expression of Slug, ovarian cancer cell epithelial-mesenchymal transition (EMT) and invasion. Silencing of hTERT expression abrogated NE-induced ovarian cancer cell invasion, EMT and Slug expression. In addition, silencing of Slug expression significantly inhibited NE- and hTERT-induced ovarian cancer cell EMT and invasion. Moreover, continuous exposure to NE was sufficient to enhance in vivo hTERT expression and metastasis of ovarian cancer cells to the lung. Finally, we provide evidence that hTERT links Src to Slug expression in NE-induced ovarian cancer EMT and metastasis. We thus demonstrate a novel role of hTERT in stress hormone-induced ovarian cancer aggressiveness through inducing Slug, providing novel biomarkers and potential therapeutic targets for ovarian cancer.Oncogene advance online publication, 25 August 2014; doi:10.1038/onc.2014.270.

Cho H.J.,Konyang University
American journal of ophthalmology | Year: 2013

To evaluate the therapeutic effect of intravitreal bevacizumab injection for symptomatic retinal arterial macroaneurysm. Retrospective interventional case series. The study included 23 patients (23 eyes) with symptomatic retinal arterial macroaneurysm. They were categorized according to treatment method into 2 groups: an intravitreal bevacizumab-treated group (11 eyes) and an untreated group (12 eyes). Bevacizumab was injected at the initial visit, followed by as-needed monthly reinjection. Best-corrected visual acuity (BCVA) and central macular thickness were documented and analyzed between groups. The mean follow-up period for all subjects was 10.83 ± 4.6 months. The mean number of injections for the treated group was 1.42 ± 0.69. The mean logarithm of the minimal angle of resolution (logMAR) of BCVA improved from baseline at the last follow-up by 0.26 in the bevacizumab-treated group (P = .02) and by 0.34 in the untreated group (P = .005). Average central macular thickness decreased from 384.4 ± 150.1 μm to 265 ± 112.5 μm in the bevacizumab-treated group (P = .0002) and from 413.2 ± 155.2 μm to 236.3 ± 103.5 μm in the untreated group (P = .008). The BCVA was significantly improved from baseline after 1 month in the bevacizumab-treated group (P = .02) and after 3 months in the untreated group (P = .01). However, there was no statistically significant difference in BCVA improvement or central macular thickness improvement achieved at the final visit. Intravitreal bevacizumab injection likely hastens resolution of macular edema and hemorrhage secondary to retinal arterial macroaneurysm. Intravitreal bevacizumab injection could be an effective treatment option for symptomatic retinal arterial macroaneurysm. Copyright © 2013. Published by Elsevier Inc.

Rab coupling protein (RCP)-induced tumor cell migration has been implicated in tumor pathophysiology and patient outcomes. In the present study, we demonstrate that RCP stabilizes β1 integrin leading to increased β1 integrin levels and activation of a signaling cascade culminating in Slug induction, epithelial-to-mesenchymal transition and increased invasion. Ectopic expression of RCP induced Slug expression. Silencing β1 integrin efficiently inhibited RCP-induced Slug expression and subsequent cancer cell invasion. Conversely, ectopic expression of β1 integrin was sufficient to induce Slug expression. Pharmacological inhibition of integrin linked kinase (ILK), EGFR and NF-κB, as well as transfection of a dominant-negative mutant of Ras (RasN17), significantly inhibited RCP-induced Slug expression and cancer cell invasion. Strikingly, ectopic expression of RCP was sufficient to enhance metastasis of ovarian cancer cells to the lung. Collectively, we demonstrate a mechanism by which RCP promotes cancer cell aggressiveness through sequential β1 integrin stabilization, activation of an ILK/EGFR/Ras/NF-κB signaling cascade and subsequent Slug expression.Oncogene advance online publication, 15 August 2016; doi:10.1038/onc.2016.277. © 2016 Macmillan Publishers Limited, part of Springer Nature.

Yoon J.M.,Konyang University
Pediatric Gastroenterology, Hepatology and Nutrition | Year: 2014

Recently, the incidence and prevalence of obesity and dyslipidemia are increasing. Dyslipidemia is associated with significant comorbidities and complications, and with cardiovascular risk factors (obesity, diabetes mellitus, hypertension and smoking). The main objectives of this article are that describe the prevalence of dyslipidemia in Korean children and adolescents and review the diagnosis and management of dyslipidemia in children and adolescents. © 2014 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.

Hwang Y.H.,Konyang University
Investigative ophthalmology & visual science | Year: 2012

The aim of this study was to investigate the glaucoma diagnostic ability of quadrant and clock-hour neuroretinal rim assessment by Cirrus HD spectral-domain optical coherence tomography (OCT). Eighty eyes of 80 glaucoma patients and 80 eyes of 80 healthy subjects were enrolled. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Cirrus HD-OCT. Quadrant and clock-hour rim areas and thicknesses were obtained from optic nerve head images and 360° circumferential rim thickness curve of Cirrus HD-OCT, respectively. Area under receiver operating characteristic curves (AUCs) and sensitivities of RNFL thicknesses, rim areas, and rim thicknesses at a 90% specificity level were calculated. Quadrant and clock-hour rim area and thickness showed good diagnostic ability for glaucoma in all areas (AUCs, 0.877-0.969; sensitivities, 67.5%-96.3%). When the AUCs of RNFL thicknesses, rim areas, and rim thicknesses were compared, no significant difference was found in global area and superior and inferior quadrants (P > 0.05). However, in nasal and temporal quadrants, rim area and thickness had greater AUCs (AUCs, 0.919-0.945; sensitivities, 82.5%-86.3%) than RNFL thickness (AUCs, 0.749-0.776; sensitivities, 12.5%-33.8%; P < 0.001). Eyes with moderate to advanced glaucoma (mean deviation < -6 dB) had thinner RNFL than mild glaucoma (mean deviation ≥ -6 dB) in global area, superior, inferior, and temporal quadrants (P < 0.003); rim area and thickness showed no significant difference in all areas (P > 0.003). Neuroretinal rim assessment in nasal and temporal areas by Cirrus HD-OCT may enhance glaucoma diagnostic ability. RNFL and rim changes measured by Cirrus HD-OCT may be different according to the stages of glaucomatous damage.

Provided is a structural state evaluation system for a smart structure using multi-sensing capable of coping with and controlling vibrations in real time by reasonably and efficiently determining positions of sensors included in a constructional structure using an optimal position determining algorithm and defining a baseline structure using a finite element (FE) model improving algorithm to measure and acquire various information on the smart structure through multi-sensing and evaluate and analyze structural safety.

Konyang University | Date: 2014-06-17

A cannula for preventing spraying of liquid is disclosed. The cannula includes a support tube partially inserted into a human body to guide a surgical instrument to an inside of the human body and a handle integrally formed with the support tube to allow the surgical instrument to be in and out of the human body, wherein the handle further includes a plurality of seal plates coupled to an inside thereof to prevent spraying of liquid onto an operator by an internal pressure of the human body and an outlet formed at a side surface thereof to reduce an internal pressure of the handle to atmospheric pressure.

Konyang University | Date: 2014-01-09

A three-dimensional imaging system based on a stereo hologram is disclosed. Images composed of sub-images having the same vertical-horizontal resolutions which are generated at plural image projection modules having a two-dimensional arrangement structure are projected to a prism array plate or a transmission-type diffusion plate, and are converted into light points, i.e., image points through a microlens array unit. A diffusion plate used as an image display screen is mounted to a position at which images diffused from the light points intersect with images diffused from the adjacent light points.

Provided is a wireless measuring system based on a cochlea principle for acquiring a dynamic response of a constructional structure and capable of monitoring and controlling health of the constructional structure in real time by acquiring the dynamic response of the constructional structure in which irregular random vibrations occur, effectively compressing the acquired data, wirelessly transmitting a signal, and analyzing the transmitted signal.

News Article | November 28, 2016

PARIS--(BUSINESS WIRE)--Regulatory News: EOS imaging (Paris:EOSI) (Euronext, FR0011191766 – EOSI), the pioneer in 2D/3D orthopedic medical imaging, announced today the official opening of the first EOS site in South Korea, the third largest market in Asia, at the Konyang University Hospital. The University Hospital serves an adult and pediatric population of 7 million outpatients and 25 million inpatients on average per year. The University Hospital has a strong orthopedics department for surgi

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