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Nonsan, South Korea

Konyang University , located in Nonsan, South Korea, was founded in 1991.Konyang University has campuses in Nonsan and Daejeon. The Nonsan campus is the main campus with over 10,000 undergraduate students, eight colleges with more than forty majors, mostly in applied fields About 230 of the students are foreign students. The Daejeon campus has programs in Western medicine, medical technology, and nursing. The university has about 700 graduate students. It is accredited by the Korean Council for University Education .In 2011, Konyang was one of four private ROK universities that began offering military science as a major.The university president is Dr. Kim Hi-soo, recipient of the 2006 South Korean Mugunghwa Order of Civil Merit Medal prize for outstanding citizen, for his work in fostering education.In 2013, as part of a major reorientation of the nation's tertiary educational system and in part in response to the significantly changing demographics, the country's government announced a change in financial support to both public and private universities. Schools that have not been performing well would have their support drastically cut. At the same time, institutions could apply or grants to support specific projects. The winning schools were announced in mid-2014. Konyang had submitted seven different projects. All of them were funded in full, for a total of 49 billion won in support. Wikipedia.

Hwang Y.H.,Konyang University
Investigative ophthalmology & visual science | Year: 2012

The aim of this study was to investigate the glaucoma diagnostic ability of quadrant and clock-hour neuroretinal rim assessment by Cirrus HD spectral-domain optical coherence tomography (OCT). Eighty eyes of 80 glaucoma patients and 80 eyes of 80 healthy subjects were enrolled. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Cirrus HD-OCT. Quadrant and clock-hour rim areas and thicknesses were obtained from optic nerve head images and 360° circumferential rim thickness curve of Cirrus HD-OCT, respectively. Area under receiver operating characteristic curves (AUCs) and sensitivities of RNFL thicknesses, rim areas, and rim thicknesses at a 90% specificity level were calculated. Quadrant and clock-hour rim area and thickness showed good diagnostic ability for glaucoma in all areas (AUCs, 0.877-0.969; sensitivities, 67.5%-96.3%). When the AUCs of RNFL thicknesses, rim areas, and rim thicknesses were compared, no significant difference was found in global area and superior and inferior quadrants (P > 0.05). However, in nasal and temporal quadrants, rim area and thickness had greater AUCs (AUCs, 0.919-0.945; sensitivities, 82.5%-86.3%) than RNFL thickness (AUCs, 0.749-0.776; sensitivities, 12.5%-33.8%; P < 0.001). Eyes with moderate to advanced glaucoma (mean deviation < -6 dB) had thinner RNFL than mild glaucoma (mean deviation ≥ -6 dB) in global area, superior, inferior, and temporal quadrants (P < 0.003); rim area and thickness showed no significant difference in all areas (P > 0.003). Neuroretinal rim assessment in nasal and temporal areas by Cirrus HD-OCT may enhance glaucoma diagnostic ability. RNFL and rim changes measured by Cirrus HD-OCT may be different according to the stages of glaucomatous damage. Source

To compare the effectiveness of intravitreal injections of bevacizumab and ranibizumab in patients with treatment-naive polypoidal choroidal vasculopathy (PCV). Records from 106 consecutive patients who received intraviteral bevacizumab (n = 58, 1.25 mg) or ranibizumab (n = 52, 0.5 mg) for treatment of PCV were retrospectively reviewed. After three initial monthly loading injections, injection was performed as needed. The main outcome measures included best-corrected visual acuity (BCVA), foveal central thickness (FCT) as assessed by spectral domain optical coherence tomography, and the changes in polypoidal lesions based on an indocyanine green angiography. The average number of injections was 3.31 ± 1.25 in the bevacizumab group and 3.44 ± 0.92 in the ranibizumab group. Mean logarithm of the minimum angle of resolution of BCVA from baseline to 6 months after injection improved by 0.17 in the bevacizumab group (p = 0.03) and by 0.19 in the ranibizumab group (p = 0.01). Average FCT decreased from 322 ± 62.48 μm to 274 ± 40.77 μm in the bevacizumab group (p = 0.02) and from 338 ± 50.79 μm to 286 ± 36.93 μm in the ranibizumab group (p = 0.02). Polyp regression rate was 20.7% (12 of 58 eyes) in the bevacizumab group and 21.2% (11 of 52 eyes) in the ranibizumab group. There was no statistically significant difference between groups in BCVA improvement achieved, FCT improvement achieved, and polyp regression rate between groups. Intravitreal injections of bevacizumab and ranibizumab have similar effects in stabilizing of visual acuity, macular edema, and regression of polypoidal complex in PCV eyes over the short term. Source

Lim J.W.,Konyang University
Korean Journal of Pediatrics | Year: 2011

Although Korean population has been growing steadily during the past four decades, the nation is rapidly becoming an aging society because of its declining birth rate combined with an increasing life expectancy. In addition, Korea has one of the lowest fertility rates in the world due to fewer married couples, advanced maternal age, and falling birth rate. The prevalence of low birth weight infants and multiple births has been increased compared with the decrease in the birth rate. Moreover, the number of congenital anomalies is expected to increase due to the advanced maternal age. In addition, the number of interracial children is expected to increase due to the rise in the number of international marriages. However, the maternal education level is high, single-mother birth rate is low, and the gender imbalance has lessened. The number of overweight babies has been decreased, as more pregnant women are receiving adequate prenatal care. Compared to the Asian average birth weight, the average birth weight is the highest in Asia. Moreover, the rate of low birth weight infants is low, and infant mortality is similarly low across Asia. Using birth data from Statistics Korea and studies of birth outcomes in Korea and abroad, this study aimed to assess the changes in maternal and infant characteristics associated with birth outcomes during the past four decades and identify necessary information infrastructures to study countermeasures the decrease in birth rate and increase in low birth weight infants in Korea. © 2011 by The Korean Pediatric Society. Source

Cho H.J.,Konyang University
American journal of ophthalmology | Year: 2013

To evaluate the therapeutic effect of intravitreal bevacizumab injection for symptomatic retinal arterial macroaneurysm. Retrospective interventional case series. The study included 23 patients (23 eyes) with symptomatic retinal arterial macroaneurysm. They were categorized according to treatment method into 2 groups: an intravitreal bevacizumab-treated group (11 eyes) and an untreated group (12 eyes). Bevacizumab was injected at the initial visit, followed by as-needed monthly reinjection. Best-corrected visual acuity (BCVA) and central macular thickness were documented and analyzed between groups. The mean follow-up period for all subjects was 10.83 ± 4.6 months. The mean number of injections for the treated group was 1.42 ± 0.69. The mean logarithm of the minimal angle of resolution (logMAR) of BCVA improved from baseline at the last follow-up by 0.26 in the bevacizumab-treated group (P = .02) and by 0.34 in the untreated group (P = .005). Average central macular thickness decreased from 384.4 ± 150.1 μm to 265 ± 112.5 μm in the bevacizumab-treated group (P = .0002) and from 413.2 ± 155.2 μm to 236.3 ± 103.5 μm in the untreated group (P = .008). The BCVA was significantly improved from baseline after 1 month in the bevacizumab-treated group (P = .02) and after 3 months in the untreated group (P = .01). However, there was no statistically significant difference in BCVA improvement or central macular thickness improvement achieved at the final visit. Intravitreal bevacizumab injection likely hastens resolution of macular edema and hemorrhage secondary to retinal arterial macroaneurysm. Intravitreal bevacizumab injection could be an effective treatment option for symptomatic retinal arterial macroaneurysm. Copyright © 2013. Published by Elsevier Inc. Source

Stress hormones have been implicated in both tumor initiation and progression. Human telomerase reverse transcriptase (hTERT) is overexpressed in cancer cells and associated with malignant tumor progression and poor outcome. We thus sought to determine whether the stress hormone norepinephrine (NE) could induce hTERT expression and subsequently ovarian cancer progression. Unexpectedly, NE induced hTERT transcript and protein expression, and subsequently ovarian cancer cell invasion. Pharmacologic inhibition of β2-adrenergic receptor 2 and protein kinase A, as well as silencing of hypoxia-inducible factor-1α and c-Myc expression, profoundly attenuated NE-induced hTERT expression. Strikingly, stimulation of the cells with NE or ectopic expression of hTERT induced expression of Slug, ovarian cancer cell epithelial-mesenchymal transition (EMT) and invasion. Silencing of hTERT expression abrogated NE-induced ovarian cancer cell invasion, EMT and Slug expression. In addition, silencing of Slug expression significantly inhibited NE- and hTERT-induced ovarian cancer cell EMT and invasion. Moreover, continuous exposure to NE was sufficient to enhance in vivo hTERT expression and metastasis of ovarian cancer cells to the lung. Finally, we provide evidence that hTERT links Src to Slug expression in NE-induced ovarian cancer EMT and metastasis. We thus demonstrate a novel role of hTERT in stress hormone-induced ovarian cancer aggressiveness through inducing Slug, providing novel biomarkers and potential therapeutic targets for ovarian cancer.Oncogene advance online publication, 25 August 2014; doi:10.1038/onc.2014.270. Source

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