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Ymittos Athens, Greece

Papaspiliopoulos A.,Asklep eion General Hospital | Papaparaskeva K.,Konstantopouleio General Hospital | Papadopoulou E.,National Technical University of Athens | Feroussis J.,Asklepeion General Hospital | And 2 more authors.
Journal of Investigative Surgery | Year: 2010

Objective: There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair. Methods: Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation. Results: Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids. Conclusions: The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor. © 2010 Informa Healthcare USA, Inc. Source


Manes K.,Konstantopouleio Agia Olga General Hospital | Delis S.,Konstantopouleio Agia Olga General Hospital | Papaspyrou N.,Konstantopouleio Agia Olga General Hospital | Ghiconti I.,Konstantopouleio General Hospital | Dervenis C.,Konstantopouleio Agia Olga General Hospital
International Journal of Surgery Case Reports | Year: 2014

INTRODUCTION Primary neuroendocrine breast carcinoma (NEBC) is a rare entity of breast cancer. PRESENTATION OF CASE We herein report a case of right hepatectomy for a NEBC liver metastasis. DISCUSSION Little is known about its evolution, bilologic behavior and optimal treatment. Its malignant potential has been addressed in few reports, with cases of metachronous metastases in diverse sites, even years following treatment of the breast primarily. CONCLUSION Treating this kind of cancer implies both breast and hepatic surgery. Primary neuroendocrine breast carcinoma (NEBC) is a rare entity of breast cancer. Little is known about its evolution, biologic behavior and optimal treatment. Its malignant potential has been addressed in few reports, with cases of metachronous metastases in diverse sites, even years following treatment of the breast primarily. We herein report a case of right hepatectomy for a NEBC liver metastasis. © 2014 The Authors. Published by Elsevier Ltd. Source


Nikolaou N.I.,Konstantopouleio General Hospital | Koutouzis M.J.,Sahlgrenska University Hospital | Christou A.,Konstantopouleio General Hospital | Fournarakis G.M.,Konstantopouleio General Hospital | And 3 more authors.
Acute Cardiac Care | Year: 2011

Background: We hypothesized that measurement of B-type natriuretic peptide could identify patients with non-ST elevation acute coronary syndromes at high risk for complications during beta-blocker (esmolol) infusion. Methods: We reviewed the records of 340 consecutive patients admitted with a non-ST elevation acute coronary syndrome. Seventy three (47 males, aged 62 ± 14 years) received esmolol up to a maximum dose of 300 μg/ kg/min until the symptoms were relieved or an adverse event occurred. Results: The median infusion rate at steady state was 175 μg/kg/min (median infusion time 18 h). Infusion was halted in 14 patients. The frequency of drug discontinuation increased across admission BNP quartiles. BNP > 141 pg/ml at admission had a 95% predictive value for subsequent withdrawal of esmolol. The presence of BNP > 141 pg/ml in combination with systolic blood pressure < 130 mmHg and left ventricular ejection fraction < 50% identified a group of patients at high risk for drug interruption (interruption frequency = 83%, 95% CI: 5595%). Conclusions: In conclusion, BNP measurement in combination with systolic blood pressure and 2D echocardiography may identify patients with non-ST elevation acute coronary syndromes at high risk for adverse events during esmolol infusion. © 2011 Informa UK, Ltd. Source


Triantopoulou C.,Konstantopouleio General Hospital | Dervenis C.,Konstantopouleio General Hospital
Imaging in Medicine | Year: 2013

Cystic lesions of the pancreas represent a heterogenous group of diseases that vary from benign to premalignant or true malignant neoplasms. The vast use of imaging modalities has led to the discovery of such incidental lesions in asymptomatic patients. Despite the advances in modern imaging, accurate differential diagnosis is not always feasible as much overlap exists. Ultrasound and specifically endoscopic ultrasound, CT and MRI are used for the evaluation of cystic pancreatic lesions, while analysis of the aspirated fluid through endoscopic ultrasound-guided fine-needle aspiration is also a valuable adjunct in the diagnostic procedure. Many societies have published recommendations or guidelines on the management of incidentally discovered pancreatic 'cysts®. The decision on the selected treatment and the follow-up should be based on the probability of malignancy and the possible surgery risk. © 2013 Future Medicine Ltd. Source


Antoniadis P.N.,Konstantopouleio General Hospital | Kyriakidis K.D.,Konstantopouleio General Hospital | Paraskevas K.I.,Red Cross
Angiology | Year: 2012

Endovascular abdominal aortic aneurysm (AAA) repair (EVAR) procedures require lifelong patient surveillance for the detection of complications (eg, endoleaks or graft migration). This follow-up may be suboptimal. Between November 2010 and November 2011, a follow-up booklet was provided at hospital discharge to 42 consecutive patients undergoing EVAR for an infrarenal AAA. Each patient was given specific instructions for completion of the booklet at each follow-up examination whether this took place at our hospital or elsewhere. After a mean follow-up of 7 ± 3 months, all patients had fully complied with the instructions. This booklet may be useful for patients who find it difficult to attend follow-up appointments. Additionally, this booklet is useful for patients who move to another town/country or in cases of emergency when patients are admitted to another hospital. © The Author(s) 2012. Source

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