Kongunadu Arts and Science College Autonomous

Coimbatore, India

Kongunadu Arts and Science College Autonomous

Coimbatore, India
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Santhosh Kumar S.,Kongunadu Arts and Science College Autonomous | Samydurai P.,Kongunadu Arts and Science College Autonomous | Ramakrishnan R.,Kongunadu Arts and Science College Autonomous | Nagarajan N.,Kongunadu Arts and Science College Autonomous
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: In this present study, to analyze Gas Chromatography and Mass Spectrometry analysis of whole plant methanol extract of Adiantum capillus-veneris. Methods: Gas chromatography and mass spectrometry analysis of whole plant extract carried out with instrument GC-MS-QP 2010 [SHIMADZU]. Results: The methanol extracts of Adiantum capillus-veneris to identified thirty seven bioactive compounds which are major compound such as 5- 7A-Isoprpenyl-4, 5-Dimethyloctahydro-1h-inden-4yl)-3-methyl-2-penta, (24.49%), n-hexadecanoic acid (18.29%) and gamma-sitosterol (10.61%), cis-vaccenic acid(9.25%), 5-7A-Isopropenyl-4,5-Dimethyl-octahydro-inden-4-yl)-3-methyl-pent-2-EL (2.63%), Tetrdecanoic acid (2.20%) and Phenanthrene, 9-dodecyltetradecahydro (2.15%). The lowest percentage of peak area 0.25% and their compound as 2-methoxy-4-propyl, among these bioactive compounds are including Vitamin E (1.58%) also present. Conclusion: In this identified compounds are having in antioxidant, antimicrobial, anti-inflammatory, diuretic and analgesic properties also these thirty seven bioactive compounds are biologically significance in many activities.


Rajeswari P.,Kongunadu Arts and Science College Autonomous | Krishnakumari S.,Kongunadu Arts and Science College Autonomous
Journal of Pharmaceutical Sciences and Research | Year: 2010

To estimate phenols and flavonoids, enzymic antioxidants in the leaves of Boerhaavia erecta (LBE). The sample was extracted with 0.1M phosphate buffer for the analysis of phenols, flavonoids and antioxidants. The total phenolic content and total flavonoids in LBE were measured using Folin-Ciocalteau and aluminium chloride colorimetric methods respectively. The activity of Superoxide Dismutase (SOD) was assessed by the formation of nitrite from hydroxylamine hydrochloride, Catalase (CAT) activity was determined by reduction of dichromate in acetic acid to chromic acetate, the peroxidase (POD) activity was assessed by the formation of oxidised pyrogallol colorimetric methods. Methanolic extraction of the sample was done for the HPTLC analysis. The presence of phenols and flavonoids was analysed using HPTLC method. The amount of total phenols and total flavonoids present in the leaves was found to be 85.90 ± 1.97 mg CEQ /100mg and 11.39 ± 0.86 mg CE/100mg respectively. The HPTLC fingerprinting has proved the presence of four phenolic and two flavonoid compounds. The activities of SOD, CAT and POD were 0.086 ± 0.009, 0.440 ± 0.350, 40.95 ± 12.60 units/mg protein respectively. This investigation demonstrates that the leaves of Boerhaavia erecta have therapeutic properties and hence could be used as source for nutraceuticals.


Samydurai P.,Kongunadu Arts and Science College Autonomous | Thangapandian V.,Kongunadu Arts and Science College Autonomous
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

The current study describes minimum inhibitory concentration and phytochemical constituents of petroleum ether, methanol and aqueous extracts of different parts of Decalepis hamiltonii. Phytochemical analysis of the crude extracts revealed the presence of tannins, Phlobatannins, saponins, flavonoids, steroids, terpenoids, cardiac glycosides and reducing sugar in this investigated plant. However phlobatannins were found to be absent in methanol extract of the root. Different solvent extracts were tested against four gastrointestinal pathogenic bacteria and a fungus, Candida albicans which causes skin disease. The bacteria include two gram positive, Staphylococcus aureus, Bacillus subtilis and two gram negative bacteria, E. coli, Klebsiella pneumoniae. 1ml of petroleum ether containing 0.098 and 0.049μg of extracts were recorded as MIC and MID respectively, which exhibited greater activity against tested pathogens.


Gokul B.,Kongunadu Arts and Science College Autonomous | Matheswaran P.,Kongunadu Arts and Science College Autonomous | Sathyamoorthy R.,Kongunadu Arts and Science College Autonomous
Journal of Materials Science and Technology | Year: 2013

Cadmium oxide (CdO) thin films were prepared by successive ionic layer adsorption and reaction (SILAR) method and annealed at 250-450 °C for 2 h. The prepared films were characterized by X-ray diffraction (XRD), optical spectroscopy, scanning electron microscopy (SEM) and Hall effect measurement. The XRD analysis reveals that the films were polycrystalline with cubic structure. Both crystallinity and the grain size were found to increase with increasing annealing temperature. SEM analysis shows the porous nature of the surface with spherical nanoclusters. Energy dispersive spectroscopic analysis (EDS) confirmed the presence of Cd and O elements without any additional impurities. The films exhibited maximum transmittance (82%-86%) in infra-red (IR) region. Transmittance was found to decrease with increasing annealing temperature and the estimated band gap energy (Eg) was in the range of 2.24-2.44 eV. Hall effect measurement shows an increase in carrier concentration and a decrease in resistivity with increasing annealing temperature. The carrier concentration (N) and resistivity (ρ) of about 1.26 × 1022 cm-3 and 8.71 × 10-3 Ω cm are achieved for the film annealed at 450 °C for 2 h. © 2013.


Gokul B.,Kongunadu Arts and Science College Autonomous | Matheswaran P.,Kongunadu Arts and Science College Autonomous | Abhirami K.M.,Kongunadu Arts and Science College Autonomous | Sathyamoorthy R.,Kongunadu Arts and Science College Autonomous
Journal of Non-Crystalline Solids | Year: 2013

NiO nanoparticles were prepared by wet chemical precipitation and dielectric, AC conductivity, and impedance properties were studied by complex impedance spectroscopy as a function of frequency at different temperatures. Non-stoichiometric sample (Ni40O60) shows diffraction peaks corresponding to cubic NiO and near stoichiometric sample (Ni 48O52) was found to be amorphous. Stoichiometry of NiO nanoparticles was determined using EDS analysis. The estimated dielectric constant was found to be 35 and 40 for Ni40O60 and Ni 48O52 nanoparticles. Loss peak shifts to the higher frequency which is due to long range hopping of charge carriers. Impedance analysis reveals Debye type relaxation process. The presence of two semicircular arcs in Nyquist plot explains that the grain and grain boundary conduction prevails in the sample. Nyquist plot shows that NiO nanoparticles possess negative temperature coefficient of resistance (NTCR). The variation of AC conductivity as function of temperature indicates that the conduction is due to thermally activated charge carriers. © 2012 Elsevier B.V.


Mageshwari K.,Kongunadu Arts and Science College Autonomous | Sathyamoorthy R.,Kongunadu Arts and Science College Autonomous | Sudhagar P.,Hanyang University | Kang Y.S.,Hanyang University
Applied Surface Science | Year: 2011

Nanostructured bismuth sulfide thin films were prepared onto glass substrates with particle size of 21 nm by thermal evaporation using readily prepared bismuth sulfide nanocrystallite powder. The X-ray diffraction pattern revealed that bismuth sulfide thin films exhibit orthorhombic structure. The existence of quantum confinement effect was confirmed from the observed band gap energy of 1.86 eV. AC and DC electrical conductivity of Al/BiSnc/Al structures was investigated in the frequency range 0.5-100 kHz at different temperatures (303-463 K) under vacuum. The AC conductivity (σac) is found to be proportional to angular frequency (ωs). The obtained experimental result of the AC conductivity showed that the correlated barrier hopping model is the appropriate mechanism for the electron transport in the nanostructured bismuth sulfide thin films. DC conduction mechanism in these films was studied and possible conduction mechanism in the bismuth sulfide thin films was discussed. © 2011 Elsevier B.V.


Rajeswari P.,Kongunadu Arts and Science College Autonomous | Krishnakumari S.,Kongunadu Arts and Science College Autonomous
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objectives: As vegetables, fruits and medicinal plants, mushrooms have become attractive as a functional food and as a source for the development of drugs and nutraceuticals. The present study was carried to find the antihyperglycemic effect of the milky mushroom, Calocybe indica. Materials and methods: Female swiss albino rats weighing 200-250g were used for the study. Streptozotocin was used to induce diabetes mellitus. Hot and cold water decoctions of the milky mushroom, Calocybe indica (20ml/kg body weight) was orally administered to the diabetic rats for 45 days. The blood glucose, serum insulin, hemoglobin, glycosylated hemoglobin and total blood count and the survival and mortality rate were studied. Results: The blood glucose level was significantly decreased in the decoction treated diabetic rats. Serum insulin level was increased and the glycosylated hemoglobin level was significantly altered back to the near normal level. The treatment has effect also in hematological parameters. The survival rate was significantly increased in the decoction treated rats. Conclusion: The results suggests that both hot and cold water decoction of the mushroom possess antidiabetic activity but when compared, the cold water decoction showed more significant activity than the hot water decoction.


Sindhu S.,Kongunadu Arts and Science College Autonomous | Manorama S.,Kongunadu Arts and Science College Autonomous
Journal of Chemical and Pharmaceutical Research | Year: 2012

Polycarpaea corymbosa are widely used traditional medicinal plant to treat various ailments. The antimicrobial potential of Polycarpaea corymbosa against human pathogenic microorganisms (fifteen bacteria and six fungus) ware investigated. Antimicrobial activity of various plants extracts was compared with commercially available antibiotics. The antimicrobial potential of the above plant extracts was seen against the test organism using disc diffusion method. The phytochemical prospection of the dried aerial and root extracts showed the presence of different classes of secondary metabolites, as phenols, flavonoid, alkaloids and tannins that have demonstrated antimicrobial action. Acetone and methanolic extracts showed considerably good antibacterial activity against all bacteria and fungi. This study shed the light on the ability of extracts from the plant to combat pathogens which will help as natural antimicrobial agents as well as can be used in pharmaceutical and food preservation systems.


Sindhu S.,Kongunadu Arts and Science College Autonomous | Manorama S.,Kongunadu Arts and Science College Autonomous
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The methanolic extracts of Polycarpaea corymbosa Lam. root and aerial parts were evaluated for their in vitro antioxidant potential. The crude methanolic extracts exerted significant (P<0.005) antioxidant activity as evidenced by its Total Phenol content, Total Flavanoid content, 1,1-diphenyl-2- picrylhydrazyl radical (DPPH•), reducing power assay, ABTS•+ and metal chelating activities. The methanolic root extract was found to have significant radical scavenging activity as compared to the synthetic antioxidant BHT. From the results of the present investigation, it could be concluded that Polycarpaea corymbosa extracts can be explored as a potential source for the isolation of natural antioxidant agents. However, an appropriate solvent extraction system should be used to recover potent antioxidant components from Polycarpaea corymbosa.


Nisha M.C.,Kongunadu Arts and Science College Autonomous
Indian Journal of Natural Products and Resources | Year: 2010

In order to prepare a list of the raw drugs sold in Coimbatore city, a market survey was conducted. There are 72 species spreading over 41 families and according to their life forms, 29 are herbs, 13 shrubs, 23 trees and 7 climbers and 88% of these belong to the dicotyledons. It was also noticed that various plant parts were used as crude drugs. The species like Acacia nilotica (Linn.) Willd. ex Del. subsp. indica (Benth.) Brenan, Andrographis paniculata (Burm. f.) Wall. ex Nees, Eclipta prostrata (Linn.) Linn., Adhatoda zeylanica Medic., Zingiber officinale Rosc., Acorus calamus Linn., Centella asiatica (Linn.) Urban, Phyllanthus amarus Schum. & Thonn., Solanum nigrum Linn. and Gymnema sylvestre (Retz) Schult. have higher market potential. Most of the crude drugs are already commercially cultivated in India but a few endangered plants like Dysoxylum malabaricum Bedd., Rauvolfia serpentina Benth. ex Kurz are also sold in the market. If the same trend continues, we may have to lose our valuable plant heritage by way of over exploitation of the wild and endangered species. There is an urgent need of documentation of this irreplaceable knowledge to meet the ever growing demand of medicinal plants in the market.

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