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Biswas G.R.,Group of Institutions Kolkata | Chakraborty S.,Group of Institutions Kolkata | Das U.,Joy Beauty Care Private Ltd | Majee S.B.,Group of Institutions Kolkata
Research Journal of Pharmaceutical, Biological and Chemical Sciences

To get successful buccal controlled release dosage form hydrophilic, swellable polymeric material alone or in optimum combination is essential. This dosage form should get stuck to the oral cavity and release the drug at a controlled rate under the conditions prevailing in the mouth. Here a natural gum (Gum karaya) has been selected to prepare buccal tablets of Amoxicillin trihydrate. The tablets were prepared by wet granulation method. After granulation the pre-compression evaluation tests were performed. The granules showed good flow ability and compressibility. Physicochemical tests of the tablets revealed satisfactory results. Buccoadhesive strength of the tablets was found to be in the range of 28-39 gm, which is good enough to hold the tablets in the buccal cavity. Percent Swelling of the tablets was 10-107.87 % in phosphate buffer pH-6.8. The release data were fitted in kinetic models of zero order, first order and Higuchi. The tablets with 10-15 % of gum karaya showed zero order kinetics whereas the other formulations (2.5-7.5% and 17.5-20 % of gum karaya) showed mixed and higuchi kinetics of drug release respectively. Optimum concentration of gum karaya (10-15%) reveals the dominance of the highly swollen layer which controls the drug release from the buccoadhesive tablets. Source

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