Kolkata Group of Institutions

Kolkata, India

Kolkata Group of Institutions

Kolkata, India
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Giri T.K.,Kolkata Group of Institutions | Verma D.,Kolkata Group of Institutions
Current Chemical Biology | Year: 2017

Objective: In this study, an attempt has been made to modify k-Carrageenan properties by grafting acrylamide chain and use to develop a pH sensitive hydrogel beads composed of grafted kcarrageenan and sodium alginate for the controlled delivery of diltiazem hydrochloride. Material: The hydrogel beads were prepared by the ionotropic gelation method using aluminium chloride (AlCl₃) as a cross-linking agent. The characterization of diltiazem HCl loaded beads was done by scanning electron microscopic, Fourier transform infrared spectroscopic, differential scanning calorimetry and X-ray powder diffraction analysis. Result: The surface morphology revealed that the prepared beads were spherical, having rough with microscopic cracks in the surface. The X-ray diffraction study indicates that the drug was dispersed molecularly in the polymer matrix and amorphous in nature in the bead. The beads were evaluated for bead size, drug entrapment efficiency, swelling ratio and in-vitro drug release study. The size of beads was in decreasing trend with increasing the AlCl3 concentration. The drug entrapment efficiency of the beads was decreased with the increase in AlCl3 concentration. The swelling of the beads decreased in both acidic and basic medium with increasing AlCl3 concentration. The drug release rate of beads was decreased when AlCl3 concentration increased. Conclusion: The preliminary investigation of the beads developed in this study showed a promising sustained release profile of the drug. Therefore, the cross-linked hydrogel beads are promising carriers for oral controlled release of water soluble drug diltiazem HCl. © 2017 Bentham Science Publishers.


Giri T.K.,Kolkata Group of Institutions | Chakrabarty S.,Kolkata Group of Institutions | Ghosh B.,Kolkata Group of Institutions
Journal of Controlled Release | Year: 2017

Application of transdermal reverse iontophoresis for diagnostic purpose is a relatively new concept but its short span of research is full of ups and downs. In early nineties, when the idea was floated, it received a dubious welcome by the scientific community. Yet to the disbelief of many, 2001 saw the launching of GlucoWatch® G2 Biographer, the first device that could measure the blood sugar level noninvasively. Unfortunately, the device failed to match the expectation and was withdrawn in 2007. However, the concept stayed on. Research on reverse iontophoresis has diversified in many fields. Numerous in vitro and in vivo experiments confirmed the prospect of reverse iontophoresis as a noninvasive tool in therapeutic drug monitoring and clinical chemistry. This review provides an overview about the recent developments in reverse iontophoresis in the field of therapeutic drug monitoring. © 2016 Elsevier B.V.


Giri T.K.,Kolkata Group of Institutions | Bhowmick S.,Kolkata Group of Institutions | Maity S.,Kolkata Group of Institutions
Journal of Drug Delivery Science and Technology | Year: 2017

Liposomes loaded with capsaicin were encapsulated in alginate hydrogel beads followed by coating with Eudragit S-100 for efficient oral colonic delivery. Liposomes were prepared by thin film hydration method using soyalecithin and cholesterol. Hydrogel beads encapsulating liposome were prepared by iontropic gelation methods which were Eudragit coated. The liposomes and hydrogel beads were characterized for size, entrapment efficiency and in vitro drug release. Coated hydrogel bead has shown better drug release after 5 h and has shown 99.3% drug release till 24 h in a controlled manner in comparison to plain hydrogel beads, which released more than 65% of the drug before entering into the colonic region. We can conclude that coated alginate hydrogel beads containing liposome can be used as a potential carrier for colonic drug delivery. © 2017 Elsevier B.V.


Giri T.K.,Kolkata Group of Institutions
Advanced Composite Materials | Year: 2015

In the presence of catalytic amount of ammonium persulfate as initiator, the grafting of polyacrylamide (PAAm) onto gellan gum (GG) was carried out using microwave irradiation. The grafting condition was optimized by varying the microwave power, exposure time, and concentrations of initiator, monomer, and GG. Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy analysis were employed to confirm that PAAm has been grafted onto the GG backbone. The intrinsic viscosity of pure and grafted samples has been measured by using Oswald viscometer. Swelling behavior of graft copolymer has been investigated and pH sensitivity of the graft copolymer was obtained. The flocculation characteristics of grafted and ungrafted polysaccharides have been evaluated in coal (coking and non-coking) suspensions. Graft copolymer shows better flocculation efficacy compared to the base polysaccharides. © 2014 Japan Society for Composite Materials, Korean Society for Composite Materials and Taylor & Francis.


PubMed | Kolkata Group of Institutions
Type: Journal Article | Journal: Indian journal of pharmacology | Year: 2016

Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs) are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats.The study was conducted on 30 Wistar albino rats of either sex; divided into five groups. Four groups were subjected to chronic mild stress induced by using various stressors randomly scheduled in a week and continued for a period of 3 weeks. The stressed rodents were subjected to sertraline treatment for 9 weeks in different human therapeutic doses extrapolated to animal doses. Behavioral changes were monitored, assessed, and evaluated throughout the treatment phase with the help of tests such as locomotor activity test, forced swim test, tail suspension test, antianxiety test, and sucrose preference test (SPT).All tests except SPT, demonstrated significant (P < 0.05) reduction in depressive-like activity in the stressed rodents by the mid-treatment phase, followed by an abrupt onset of the depressive state by the end of the treatment phase. SPT showed a significant (P < 0.05) increase in sucrose consumption throughout the treatment phase.Behavioral changes following chronic sertraline administration conferred gradual remission of depression state on initial treatment phase, followed by a reversal of effect on chronic use.


Dutta S.,Kolkata Group of Institutions
International Journal of Pharmacy and Technology | Year: 2015

Improvement in treatment has led to decreased death in youth with human immunodeficiency virus (HIV) in developed countries. Despite this, youth with HIV are still at risk for increased mortality and morbidity compared with their uninfected counterparts. In developing countries, high numbers of youth die from acquired immune deficiency syndrome (AIDS)-related illnesses due to lack of access to consistent anti retroviral treatment. As a result, pediatric palliative care is a relevant topic for those providing care to youth with HIV. A systematic review was conducted to gather information regarding the status of the literature related to pediatric palliative care and medical decision-making for youth with HIV. This review article focused primarily on physical aspects of care, with less attention paid to psychological, social, ethical, and cultural aspects of care. It recommends that future research focuses on broadening the evaluation of pediatric palliative care among youth with HIV by directly evaluating the psychological, social, ethical, and cultural aspects of care and investigating the needs of all involved stakeholders. © 2015, International Journal Of Pharmacy and Technology. All rights reserved.


Biswas G.R.,Kolkata Group of Institutions | Majee S.B.,Kolkata Group of Institutions
International Journal of Pharma and Bio Sciences | Year: 2015

The aim of the current investigation is to study the kinetics of drug release pattern from buccal swellable, controlled release tablets of amoxicillin trihydrate. Buccal tablets were prepared with modified gum karaya in 5-20% concentration. Drug release from the formulated amoxicillin trihydrate loaded buccal tablets followed Zero order kinetics resulting in regulated and controlled release for a given time from all the batches. Swelling index increased with increase in concentration of modified gum karaya. The drug release mechanism was confirmed by Korsmeyer-Peppas exponential equation. It was also observed that among the four batches, the tablets with 5-15% modified gum karaya obeyed Fickian diffusion mechanism, whereas the other (20%) showed the relaxation mechanism. Further for proper clarification the data were fitted to Kopcha mathematical model. This finding is supported by evaluation of the ratios of the exponents A/B (i.e., diffusional factor A and erosional factor B) derived from the Kopcha model, which were greater than 1 in all cases. A/B were found to be much higher (35-40) in the tablets with 5-15% of modified gum karaya suggesting that drug release from the buccal tablets is primarily controlled by a Fickian diffusion process. In the buccal tablets with 20 % of modified gum karaya A/B was found to be quite less (24) than the previous batches. Due to the high water affinity of the gum there will be a greater rate of polymer swelling, which is reflected in the drug diffusion mechanism.


PubMed | Kolkata Group of Institutions
Type: | Journal: Journal of controlled release : official journal of the Controlled Release Society | Year: 2016

Application of transdermal reverse iontophoresis for diagnostic purpose is a relatively new concept but its short span of research is full of ups and downs. In early nineties, when the idea was floated, it received a dubious welcome by the scientific community. Yet to the disbelief of many, 2001 saw the launching of GlucoWatch G2 Biographer, the first device that could measure the blood sugar level noninvasively. Unfortunately, the device failed to match the expectation and was withdrawn in 2007. However, the concept stayed on. Research on reverse iontophoresis has diversified in many fields. Numerous in vitro and in vivo experiments confirmed the prospect of reverse iontophoresis as a noninvasive tool in therapeutic drug monitoring and clinical chemistry. This review provides an overview about the recent developments in reverse iontophoresis in the field of therapeutic drug monitoring.


PubMed | Kolkata Group of Institutions
Type: Journal Article | Journal: Anti-cancer agents in medicinal chemistry | Year: 2016

Nano-liposomes are the newly developed delivery systems for cancer therapy that are finding a position particularly suitable as peptide and protein carriers. These are three-layered self-assembled structures with nanoparticulate carrier systems. The overall pharmacological properties of commonly used protein and peptide in cancer therapy can be improved by the incorporation of protein and peptide into the nano-liposome. The surface modifications can be made liposomes to make compatible with targeting ligands has made these nanocarriers for targeted delivery. This review discusses the method of preparation and characterization of liposome based protein peptide delivery for the treatment of cancer. This review also explores latest work intended for targeted treatment of cancer by nano-liposomal protein and peptide delivery system. This type of delivery is targeting protein and peptide to tumor site by avoiding the reticuloendothelial system. Methods of nano-liposome delivery containing protein and peptide are also highlighted.


PubMed | Kolkata Group of Institutions
Type: | Journal: International journal of biological macromolecules | Year: 2016

The intention of the study was to evaluate the effectiveness of nanocapsulated food constituent capsaicin in protection of liver oxidative stress. We had prepared phospholipid vesicle (nanoliposome) by formation of thin lipid film followed by hydration when the mean vesicle diameter was found to be 277.7nm. Protection from sodium fluoride (NaF) induced oxidative stress by capsaicin loaded nanoliposomal formulation were tested in rats where a single dose of capsaicin in free and nanoliposome forms were administered after two hour of exposure to NaF. Membrane in hepatic cells were damaged by NaF and it was evaluated by estimating reactive oxygen species (ROS), lipid peroxidation, and catalase activity when it was observed that free capsaicin produced mild protection whereas liposomal capsaicin exerted a significant result. This can be suggested that liposome encapsulating capsaicin acts as a promising therapeutic agent in reducing liver oxidative stress produced by different stress factors.

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