Kikuchi K.,Yame Public General Hospital |
Kikuchi K.,Kurume University |
Takeshige N.,Kurume University |
Miura N.,Kagoshima University |
And 14 more authors.
Experimental and Therapeutic Medicine | Year: 2012
Free radicals play an important role in the pathogenesis of a variety of diseases; thus, they are an attractive target for therapeutic intervention in these diseases. Compounds capable of scavenging free radicals have been developed for this purpose and some, developed for the treatment of cerebral ischemic stroke, have progressed to clinical trials. One such scavenger, edaravone, is used to treat patients within 24 h of stroke. Edaravone, which can diffuse into many disease-affected organs, also shows protective effects in the heart, lung, intestine, liver, pancreas, kidney, bladder and testis. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic and anti-cytokine effects in various diseases. Here, we critically review the literature on its clinical efficacy and examine whether edaravone should be considered a candidate for worldwide development, focusing on its effects on diseases other than cerebral infarction. Edaravone has been safely used as a free radical scavenger for more than 10 years; we propose that edaravone may offer a novel treatment option for several diseases.
KOHJIN Life science Co. and KOHJIN Co. | Date: 2012-10-30
KOHJIN Holdings Co. and KOHJIN Co. | Date: 2011-08-23
Industrial chemicals; Industrial auxiliary fluids for use with abrasives; paper pulp. Industrial Lubricants; cutting fluids, namely, cutting oils. paper for commercial and industrial use. Plastic film for commercial and industrial use.
KOHJIN Holdings Co. and KOHJIN Co. | Date: 2012-12-25
Dietetic foods adapted for medical purposes; mineral food-supplements; vitamin preparations; yeast for pharmaceutical purposes. Seasonings; yeast; yeast extracts for food.
KOHJIN Life science Co. and KOHJIN Co. | Date: 2010-04-06
Condiments, namely, sauces; food flavorings, other than essential oils; seasonings; yeasts; and yeast extracts.