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Kubo M.,Tokushima Bunri University | Gima M.,Tokushima Bunri University | Baba K.,Tokushima Bunri University | Nakai M.,Kochi Medical Graduate School | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

Two new curcuminoids 1 and 2, and a new phenylbutenoid dimer 3, were isolated from Bangle (Zingiber purpureum). Their structures were determined on the basis of comprehensive spectroscopic data and their biogenetic pathway. Compounds 1 and 2 are the first example of curcumin coupled with phenylbutenoid. Compounds 1 and 2 promoted neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 1 to 10 μM. In addition, compound 1 was found to accelerate the prevention of Aβ42 aggregation. © 2015 Elsevier Ltd. All rights reserved.

Abe N.,Kochi Medical School Hospital | Hirata A.,Kochi Medical School Hospital | Funato H.,Kochi Medical School Hospital | Nakai M.,Kochi Medical School Hospital | And 9 more authors.
Food Science and Technology Research | Year: 2015

Deterioration of swallowing function leads to the risk of aspiration pneumonia mortality. In elderly persons, decreased secretion of substance P (SP) from the oral and bronchial mucosae can lead to reduced swallowing function. Capsaicin has been reported to increase SP secretion and enhance swallowing function. We formulated orally disintegrating (OD) tablets consisting primarily of ginger, which contains the same vanillin derivatives as capsaicin, and performed pharmaceutical evaluation and a clinical study to assess the effect of ginger on swallowing function. OD tablets containing ginger increased the amount of SP in saliva immediately after oral ingestion, and showed a significantly higher concentration of SP in saliva between 15 and 120 min after oral ingestion as compared to placebo. Our results suggest that OD tablets containing ginger are likely to increase the amount of SP in saliva after oral ingestion and enhance swallowing function. © 2015, Japanese Society for Food Science and Technology.

Nakai M.,Kochi Medical Graduate School | Iizuka M.,Kochi Medical School Hospital | Matsui N.,Tokushima Bunri University | Hosogi K.,Kochi Medical Graduate School | And 14 more authors.
Journal of Medicinal Food | Year: 2016

Bangle (Zingiber purpureum) is a tropical ginger that is used as a spice in Southeast Asia. Phenylbutenoid dimers isolated from Bangle have exhibited neurotrophic effects in primary cultured rat cortical neurons and PC12 cells. Furthermore, chronic treatment with phenylbutenoid dimers enhances hippocampal neurogenesis in olfactory bulbectomized mice. In this study, we investigated the effects of Bangle extract on behavior and hippocampal neurogenesis in vivo. SAMP8 mice, which are an established model for accelerated aging, with age-related learning and memory impairments, were given a Bangle-containing diet for 1 month, and subsequent behavioral tests and immunohistochemistry for Ki67, a proliferating cell marker, were performed. We found that the Bangle-containing diet improved spatial learning and memory deficits in the Morris water maze and significantly increased the numbers of Ki67-positive cells in the dentate gyrus of the SAMP8 mice. In addition, the Bangle extract exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting in PC12 cells. Our results suggest that Bangle is beneficial for the prevention of age-related progression of cognitive impairment. © Copyright 2016, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2016.

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