Kocaeli Derince Education and Research Hospital

İzmit, Turkey

Kocaeli Derince Education and Research Hospital

İzmit, Turkey
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Terzi H.,Kocaeli Derince Education and Research Hospital | Terzi R.,Kocaeli Derince Education and Research Hospital | Kale A.,Kocaeli Derince Education and Research Hospital
Pain Research and Management | Year: 2015

Objective: To evaluate the number of tender points, pressure pain threshold and presence of fibromyalgia among women with or without dyspareunia. Methods: The present cross-sectional study included 40 patients with dyspareunia and 30 healthy controls. The participants were asked if they had engaged in sexual intercourse during the previous four weeks, and dyspareunia was rated from 0 to 3 based on the Marinoff Dyspareunia Scale. A pressure algometer (dolorimeter) was used to measure the pressure pain threshold. Fibromyalgia was diagnosed based on the 1990 American College of Rheumatology criteria. The depression status of the participants was assessed using the Beck Depression Inventory. Results: No statistically significant difference was found with regard to age, body mass index, habits (alcohol use and smoking), educational status and occupational status between the two groups. Total myalgic score, total control score and tender point mean pain threshold were significantly lower in the group with dyspareunia. The number of tender points was significantly higher in patients with dyspareunia. The mean Beck Depression Inventory score was 14.7±8.4 in the dyspareunia group compared with 11.2±7.1 in the control group. Five (12.5%) of the patients with dyspareunia were diagnosed with fibromyalgia, whereas no patients in the control group were diagnosed with fibromyalgia. There was no significant difference between the two groups with regard to the presence of fibromyalgia. Conclusion: The finding of lower pressure pain thresholds and a higher number of tender points among patients with dyspareunia suggests that these patients may have increased generalized pain thresholds. Additional studies involving a larger number of patients are required to investigate the presence of central mechanisms in the pathogenesis of dyspareunia. © 2015, Pulsus Group Inc. All rights reserved.


Kale A.,Kocaeli Derince Education and Research Hospital | Terzi H.,Kocaeli Derince Education and Research Hospital | Kale E.,Kocaeli Derince Education and Research Hospital
Clinical and Experimental Obstetrics and Gynecology | Year: 2014

Background: The aim of the present study was to evaluate the efficacy of misoprostol administered sublingually, vaginally or rectally on cervical ripening before hysterescopic surgery in post-menopausal women. Materials and Methods: Post-menopausal women were randomised to receive either 400 ug of misoprostol, administered sublingually, vaginally or rectally six hours and 12 hours prior to operative hysterescopy. Results: Patients were randomized to receive receive sublingual (n = 30), rectal (n = 30) or vaginal (n = 30) misoprostol. The control group did not receive misoprostol (n = 30). The four groups were comparable in terms of preoperative cervical width after misoprostol administration. The mean cervical widths for control group was 9.0 ± 1.1 mm and the mean post-treatment cervical widths for the sublingual, vaginal, and rectal groups were 7.1 ± 1.1 mm, 8.9 ± 1.3mm, and 8.6 ± 1.5 mm, respectively. The cervical widths of sublingual group were significantly different from control, vaginal, and rectal groups (p < 0.001). Conclusion: Four hundred micrograms of sublingual misoprostol, 12 and six hours prior to operative hysteroscopy has a significant cervical ripening effect compared with vaginal, rectal, and control groups in post-menopausal women.


Dindar S.,Duzce University | Cinemre H.,Duzce University | Sengul E.,Kocaeli Derince Education and Research Hospital | Annakkaya A.N.,Duzce University
The West Indian medical journal | Year: 2013

To investigate the relationship between mean platelet volume (MPV) and glycometabolic indices, to compare MPV according to HbA1c levels, and to analyse the difference in MPV between patients with and without microvascular complications. This retrospective study was conducted on 60 Type 2 diabetic patients and 50 age- and sex-matched non-diabetic controls. We obtained demographic, clinical and laboratory data including MPV, platelet count, fasting and postprandial blood glucose (FBG and PBG), haemoglobin A1c (HbA1c), lipid profile, creatinine, systolic and diastolic blood pressure (BP) in patient and control groups, and diabetic microvascular complications including nephropathy, neuropathy, and retinopathy in the patient group. All analyses were performed using SPSS version 15.0 for Windows. Mean platelet volume in the diabetic group was higher than in the control group (p = 0.001). Mean platelet volume was positively correlated with FBG and HbA1c levels (p = 0.03 and p < 0.001, respectively). It was also negatively related to platelet count (p < 0.001). Mean platelet volume in patients with HbA1c > 7% was significantly higher than those with HbA1c ≤ 7% (p < 0.001). Mean platelet volume was significantly increased in patients with retinopathy compared to those without retinopathy (p = 0.04). This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.


Terzi R.,Kocaeli Derince Education and Research Hospital | Ozer T.,Kocaeli Derince Education and Research Hospital
Osteoporosis International | Year: 2015

Calcaneus fractures constitute 1.2 % of all fractures. Tuber calcanei avulsion fractures constitute 1.3–2.7 % of calcaneus fractures. Osteoporosis, osteomalacia, and diabetes mellitus have been reported to increase the risk of development of these fractures. It has been reported that tuber calcanei avulsion fractures in elderly females might develop due to osteoporosis. As far as we know, no tuber calcanei avulsion fracture developing on the basis of osteoporosis without presence of a trauma has been reported in young males in the literature. In the current case report, a 41-year-old male patient who was admitted with complaints of pain in the left heel and diagnosed with calcaneal avulsion fracture that developed on the basis of idiopathic osteoporosis and who was treated with conservative methods was presented. © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation.


Terzi R.,Kocaeli Derince Education and Research Hospital | Yilmaz Z.,Kocaeli Derince Education and Research Hospital
Sleep and Biological Rhythms | Year: 2015

The aim of this study was to assess the presence of Restless Leg Syndrome (RLS) in patients with poliomyelitis, and associated factors. Forty-six patients with paralytic poliomyelitis who were followed-up in 2014 were included in the study. The RLS diagnosis was made according to the survey forms by International Restless Legs Syndrome Study Group. The RLS rating scale was used to rate the disease severity. The Pittsburgh sleep quality index (PSQI) was used to assess sleep quality. The Beck depression inventory was used in order to evaluate depression. Forty-six patients (30 males, 16 females) were included in the study. The mean age was 54.1 ± 5.8 years. Eighteen patients (39.1%) were diagnosed with RLS. For patients with RLS, the mean age at poliomyelitis onset was 2.4 ± 1.1 years; on the other hand, the mean age at poliomyelitis onset was 6.8 ± 3.8 years for patients without RLS (P = 0.03). Bilateral extremity involvement was detected in four patients with RLS, and one patient without RLS (P = 0.01). We did not find a significant difference in depression scores between the groups (P = 0.541). The PSQI score was significantly higher in RLS patients (P = 0.01). RLS is more common in patients with poliomyelitis, compared to the general population. Patients, especially those who have bilateral lower extremity involvement and low age at poliomyelitis onset, might be at risk for RLS development. Further studies are required to evaluate the mechanisms that could explain RLS development and disease-associated factors. © 2015 Japanese Society of Sleep Research.


Aksu T.,Kocaeli Derince Education and Research Hospital | Tufekcioglu O.,Yuksek Ihtisas Heart Education and Research Hospital
Rheumatology International | Year: 2015

Behçet’s disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus formation (ICTF) is an uncommon but important complication of BD. To highlight recent insights into this disease, we aimed to review ICTF and other systemic involvements associated with ICTF in BD. We conducted a comprehensive review of the relevant literature in MEDLINE and EMBASE from 1966 to 2014 to analyze cumulated data about ICTF in BD. We aimed to evaluate 93 cases of BD with ICT (group 1), four of which have been recently identified and have not been discussed in the relevant literature yet, and to compare the frequency of pulmonary, venous and arterial involvements in group 1 and general Behçet population (group 2). The right heart was the most common site of ICTF in group 1. Pulmonary involvement, venous involvement (especially venous thrombosis) and arterial involvement were more frequent in group 1 than in group 2 (56 vs. 0.7 %, 42 vs. 10 % and 38 vs. 0.8 %, respectively, p < 0.0001). The diagnosis of BD should be considered if a patient presents with a mass in the right-sided cardiac chambers, even in the absence of the characteristic clinical manifestations of the illness. This approach is particularly applicable if the patient is a young man from the Mediterranean basin or the Middle East. All Behçet patients with ICTF must be investigated with thoracic computed tomography for pulmonary and arterial involvements and lower extremity venous Doppler ultrasonography for venous thrombosis, regardless of whether they are symptomatic for these systems. © 2014, Springer-Verlag Berlin Heidelberg.


Aydin U.,Kocaeli Derince Education and Research Hospital | Kocogullari C.U.,Kocaeli Derince Education and Research Hospital
Annals of Thoracic Surgery | Year: 2013

Intraoperative detection of deeply embedded coronary arteries is difficult. This study describes an effective method to identify embedded coronary arteries by intraoperative cine angiography. Two embedded left anterior descending coronary arteries were successfully identified by intraoperative cine angiography. We believe that the intraoperative cineangiography is helpful for surgeons in this difficult situation. © 2013 The Society of Thoracic Surgeons.


Polat M.,Abant Izzet Baysal University | Kaya H.,Kocaeli Derince Education and Research Hospital | Sahin A.,Abant Izzet Baysal Education and Research Hospital
Photomedicine and Laser Surgery | Year: 2016

Keloids are scars that grow beyond the boundaries of a cutaneous injury, inflammation, surgical incision, or burn. They are the result of an overgrowth of dense fibrous tissue that usually develops after healing of a skin injury, and do not usually regress spontaneously. In addition to symptomatic relief, cosmetic concern is the primary reason patients seek medical intervention. Therapeutic options such as occlusion dressings, intralesional corticosteroids or interferon injections, silicone gel application, cryotherapy, irradiation, and ablative lasers have been used in various combinations. We present the results from two patients who underwent UVA1 laser therapy. © Copyright 2016, Mary Ann Liebert, Inc. 2016.


Mizumoto A.,Kusatsu General Hospital | Canbay E.,Kocaeli Derince Education and Research Hospital | Hirano M.,Kusatsu General Hospital | Takao N.,Kusatsu General Hospital | And 3 more authors.
Gastroenterology Research and Practice | Year: 2012

Background. Even though cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are associated with a high morbidity and mortality rates, it has been reported that CRS and HIPEC improved survival of selected patients with peritoneal carcinomatosis. We aimed to report morbidity and mortality results of CRS and HIPEC from a single institution in Japan. Methods and Results. Total of 284 procedures of CRS were performed on patients with pseudomyxoma peritonei, peritoneal carcinomatosis (PC) from colon cancer and gastric cancer between 2007 and 2011 in our institution. The morbidity rate was 49% of all procedure, and grades I/II and grades III/IV complications were 28% and 17%, respectively. Most frequent complication was surgical site infections including intraabdominal abscess. The mortality rate was 3.5%, and reoperation was needed in 11% of all procedures. Univariate and multivariate analysis showed peritoneal carcinomatosis index (PCI) greater than 20 was the only significant factor for occurrence of postoperative complications (P<0.01). In contrast, HIPEC significantly reduced postoperative complications (P<0.05). Conclusions. The morbidity and mortality rates of our institution are comparable with previous reports that are in acceptable rates. Optimal patient selection such as patients with PCI less than 20 seems to be of paramount importance to CRS and HIPEC. Copyright © 2012 Akiyoshi Mizumoto et al.


Kale E.,Kocaeli Derince Education and Research Hospital | Kale A.,Kocaeli Derince Education and Research Hospital
Clinical and Experimental Obstetrics and Gynecology | Year: 2014

The authors' objective was to measure amniotic fluid amino acid concentrations in pregnant women diagnosed as having fetuses with skeletal dysplasia in the second trimester of pregnancy. Eighteen pregnant women who had fetuses with with skeletal dysplasia detected by ultrasonography (skeletal dysplasia) in the second trimester and 35 women who had abnormal triple screenings indicating an increased risk for Down syndrome, but had healthy fetuses (control group), were enrolled in the study. Amniotic fluid was obtained by amniocentesis. The chromosomal analysis of the study and control groups was normal. Levels of free amino acids and non-essential amino acids were measured in amniotic fluid samples using GC/FID free (physiological) amino acid kit by gas chromatography. The mean levels of essential amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine) in amniotic fluid were found to be significantly lower in fetuses with skeletal dysplasia than in the control group (p < 0.05). The detection of significantly lower amino acid concentrations in the amniotic fluid of fetuses with a skeletal dysplasia compared to healthy fetuses suggests amino acid deficiency may play an etiological role in the pathogenesis of skeletal dysplasia.

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