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Caglar I.M.,Bakirkoy Dr Sadi Konuk Research | Demir B.,Bakirkoy Dr Sadi Konuk Research | Caglar F.N.T.,Istanbul Research and Education Hospital | Vural A.,Bakirkoy Dr Sadi Konuk Research | And 6 more authors.
Angiology | Year: 2015

Patients with angiographically normal coronary arteries sometimes exhibit delayed clearance of contrast medium. This contrast layering (CL) was tested with intravascular ultrasound (IVUS) and markers of endothelial dysfunction and oxidative stress. The study group (n = 26) consisted of patients with CL and the control group (n = 32) comprised patients with normal coronary arteries despite angina symptoms. The CL was observed in 36 coronary arteries of 26 patients in the study group. Total antioxidant status and nitric oxide levels were significantly lower; total oxidant status, malondialdehyde plasma levels, and oxidative stress index were significantly higher in patients with CL than in controls. The IVUS studies revealed that atherosclerotic plaque burden, fibrous tissue, dense calcific tissue, and necrotic core ratios were significantly higher in the coronary segments with CL compared with adjacent normal segments. These results support the concept of CL as a new angiographic appearance of early atherosclerosis. © The Author(s) 2014. Source


Ozel H.E.,Iskenderun Government Hospital | Kahraman E.,Eskisehir Military Hospital | Genc S.,Kocaeli Derince Research and Education Hospital | Cingi C.,Eskiehir Osmangazi University
B-ENT | Year: 2012

Objectives: Sensorineural hearing loss is caused by problems in the inner ear, vestibulocochlear nerve, or brain central processing centers. This study aimed to analyze the patient-reported etiology, clinical aspects, and hearing evolution of patients with profound sensorineural hearing loss (PSNHL). Study design: Retrospective. Methods: A total of 310 adult patients diagnosed with PSNHL in one or both ears between January 2002 and January 2008 were studied at a secondary center. Most subjects were military-aged males who were diagnosed with PSNHL during routine examinations prior to recruitment. A pure-tone audiometry test was performed in all patients. Auditory brainstem response was recorded in 142 (45.8%) patients. Results: A total of 310 adult patients (276 males [89%] and 34 females [11%]) with a mean age of 23.1 (range 20-81) years comprising 486 ears consisting of 176 (56.8%) bilateral and 134 (43.2%) unilateral PSNHL cases were evaluated. Etiology was based on patient self reporting. The disease was congenital in 93 (30%) patients and acquired in 217 (70%). Etiology was unknown in 35 (11.3%) patients. Acquired hearing losses were rapid in 188 (86.6%) and progressive in 29 (13.4%) patients. Articulation was impaired (no understandable speech) in a total of 146 patients (47.1%), including all patients with congenital PSNHL. Conclusion: The cause of hearing loss is often understood from medical history. Taking measures for the most common causes (congenital hearing loss and childhood infectious diseases) may reduce occurrences of PSNHL cases. Auditory screening and beginning hearing rehabilitation as soon as possible in newborns is vital. Source


Yalin K.,Bayrampasa Kolan Hospital | Golcuk E.,Koc University | Aksu T.,Kocaeli Derince Research and Education Hospital | Tiryakioglu S.K.,Cardiology Clinic | And 2 more authors.
American Journal of the Medical Sciences | Year: 2015

Background: The 2 predominant etiologies of right ventricular tachycardia (VT) are arrhythmogenic right ventricular cardiomyopathy (ARVC) and idiopathic VT arising from the right ventricular outflow tract. Discrimination between these 2 entities is critical, as their prognoses and therapeutic options differ. The microvolt T-wave alternans (TWA) is widely used to predict lethal ventricular arrhythmias in various diseases. However, the clinical significance of TWA in patients with VT originating from the right ventricle has been unknown. This study aims to investigate the possible role of TWA to discriminate ARVC from idiopathic right ventricular outflow tract tachycardia (RVOT-VT). Methods: This study enrolled 38 patients (23 male, 43 ± 16 years) with VT originating from the right ventricle. TWA was measured during exercise testing using the modified moving average method. TWA results were compared among patients with ARVC and RVOT-VT. Results: Twenty-five patients (16 male, 42 ± 16 years) met the Task Force criteria for the diagnosis of ARVC, and 13 patients (7 male, 45 ± 14 years) had idiopathic RVOT-VT. Twenty patients with ARVC had positive TWA test, whereas only 1 patient with RVOT-VT had (80% versus 8%, P< 0.001). Conclusions: In patients with VT of right ventricle origin, positive TWA test supports the diagnosis of ARVC. © Copyright by the Southern Society for Clinical Investigation. Source


Cetinkaya Z.A.,Kocaeli Derince Research and Education Hospital | Cetinkaya Y.,Haydarpasa Numune Research and Education Hospital | Gencer M.,Haydarpasa Numune Research and Education Hospital | Sezikli M.,Haydarpasa Numune Research and Education Hospital | And 5 more authors.
Gut and Liver | Year: 2011

Background/Aims: Inflammatory bowel disease is a chronic, recurrent disorder that involves multiple organ systems. Polyneuropathy is the most common neurological manifestation. The aim of the present study was to investigate the relationship between polyneuropathy and inflammatory bowel disease. Methods: The study included 40 patients with inflammatory bowel disease (20 with ulcerative colitis and 20 with Crohn's disease) and 24 healthy controls. The patients had no clinical signs or symptoms of polyneuropathy. Nerve conduction studies were performed using an electroneuromyography apparatus. Results: Mean distal motor latencies, conduction velocities, and F wave minimum latencies of the right median nerve were significantly abnormal in the patient group, compared to the healthy controls (p<0.05). Conclusions: Some electrophysiological alterations were observed in chronic inflammatory bowel disease patients who showed no clinical signs. While investigating extra-intestinal manifestations in inflammatory bowel disease patients, nerve conduction studies must be performed to identify electrophysiological changes and subclinical peripheral polyneuropathy, which can subsequently develop. Source


Sezikli M.,Kocaeli Derince Research and Education Hospital | Cetinkaya Z.A.,Kocaeli Derince Research and Education Hospital | Guzelbulut F.,Elazig Research and Education Hospital | Cimen B.,Haydarpasa Numune Education and Research Hospital | And 7 more authors.
Helicobacter | Year: 2012

Background and Aim: We aimed to evaluate the changes in histopathologic features, concentrations of vitamins C and E in gastric mucosa, and total antioxidant capacity of the body after ingestion of ascorbic acid and alpha tocopherol in patients with Helicobacter pylori. Material and Method: Patients with H. pylori-positive nonulcer dyspepsia were included in this study. Tissue samples were taken from the lesser and greater curvature in both prepyloric antrum and corpus for histopathologic examination and measurement of vitamins C and E concentrations. Blood samples were obtained for measurement of the total antioxidant capacity of the body. The patients were given vitamin C 500mg BID and vitamin E 200IU BID for 4weeks orally. At the end of the 4th week, the initial procedures were repeated. Histopathologic examination of the tissue samples were carried out by two pathologists. Results: The mean vitamins C and E concentrations in gastric mucosa at the 4th week were higher than those at the beginning (p=.000 and p=.006, respectively). Mean total antioxidant capacity of the body at the beginning and that at the 4th week were similar (p=.689). H. pylori intensity in the antrum at the beginning was higher than that at the 4th week for both pathologists (p=.007 and p=.039). Neutrophilic activity in the antrum at the beginning was higher than that at the 4th week for both pathologists (p=.000 and p=.025). Neutrophilic activity in the corpus at the beginning was higher than that at the 4th week for pathologist 1 (p=.033), and they were similar for pathologist 2 (p=.763). Conclusion: The findings that H. pylori intensity and neutrophilic activity decrease through increasing gastric ascorbic acid and alpha tocopherol concentrations suggest that supplementation with vitamins C and E increases the eradication rates via impairing the microenvironment created by the bacteria and facilitating the diffusion of antibiotics into gastric mucosa. © 2012 Blackwell Publishing Ltd. Source

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