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Kobe-shi, Japan

Kobe International University is a private university in Kobe, Hyōgo, Japan. The predecessor of the school was founded in 1963, and it was chartered as a university in 1968. In 1995 the school relocated from its original building in Kobe and moved to a newer building on the man-made island, Rokko Island. Wikipedia.

Imamura A.,Moriya Keiyu Hospital | Kusunoki M.,Kobe International University | Ueda S.,Astrazeneca | Hayashi N.,Astrazeneca | Imai Y.,Bristol Myers K.K.
Diabetes Therapy | Year: 2013

Introduction: Dapagliflozin is an orally administered selective sodium-glucose cotransporter 2 (SGLT2) inhibitor under development for the treatment of type 2 diabetes mellitus (T2DM). Dapagliflozin lowers blood glucose through a reduction in renal glucose reabsorption. This study was performed to assess the effect of the oral antidiabetic agent voglibose [0.2 mg thrice daily (t.i.d.)] at steadystate, on the pharmacokinetics, safety and tolerability of dapagliflozin administered as a single oral dose (10 mg) to Japanese patients with T2DM. Methods: This was an open-label, multi-center, drug-drug interaction study. A single oral dose of dapagliflozin (10 mg) was administered to 22 Japanese patients with T2DM in the presence and absence of voglibose (0.2 mg t.i.d.). Serial blood samples were collected before and at regular prespecified intervals after each dapagliflozin dose to determine dapagliflozin plasma concentrations and to evaluate pharmacokinetic parameters. Based on a mixed effect analysis of variance model, including the dosing condition as a fixed effect and patients as a random effect, the ratios of geometric means of area under curve from time 0 to infinity (AUC0-inf) and maximum observed plasma concentration (Cmax) with and without voglibose were estimated along with two-sided 90% confidence intervals (CIs). Results: In Japanese patients with T2DM, the exposure to dapagliflozin following a single oral dose of dapagliflozin 10 mg was not influenced by the concomitant administration of voglibose (0.2 mg t.i.d.). The geometric ratio (90% CI) for dapagliflozin AUC0-inf with/without voglibose was 1.009 (0.954, 1.067), and for Cmax 1.040 (0.899, 1.204). The median time to Cmax (tmax) and plasma clearance of dapagliflozin were also similar between treatments. The mean half-life (t) for dapagliflozin was slightly higher when administered in combination with voglibose. Dapagliflozin 10 mg was well tolerated when administered alone and in combination with voglibose in Japanese patients with T2DM. Conclusion: The results presented here support the co-administration of dapagliflozin and voglibose without dose adjustment of either agent. © The Author(s) 2013.

Kamishiro Y.,Kobe International University | Serrano R.,Brown University | Serrano R.,IMDEA Madrid Institute for Advanced Studies
Mathematics of Operations Research | Year: 2011

We study information transmission in large interim quasilinear economies using the theory of the core. We concentrate on the core with respect to equilibrium blocking, a core notion in which information is transmitted endogenously within coalitions, because blocking can be understood as an equilibrium of a communication mechanism used by players in coalitions. We focus on independent replicas of the basic economy. We offer both negative and positive convergence results as a function of the complexity of the mechanisms used by coalitions. Furthermore, all of the results are robust to the relaxation of the incentive constraints. Results for ex post and signal-based replica processes are also obtained. © 2011 INFORMS.

Kokado A.,Kobe International University | Saito T.,Kwansei Gakuin University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

In the left-right symmetric model neutral gauge fields are characterized by three mixing angles θ12,θ23,θ13 between three gauge fields Bμ,WLμ3,WRμ3, which produce mass eigenstates Aμ,Zμ,Zμ′, when G=SU(2)L×SU(2)R×U(1)B-L×D is spontaneously broken down until U(1)em. We find a new mixing angle θ′, which corresponds to the Weinberg angle θW in the standard model with the SU(2)L×U(1)Y gauge symmetry, from these mixing angles. It is then shown that any mixing angle θij can be expressed by ∈ and θ′, where ∈=gL/gR is a ratio of running left-right gauge coupling strengths. We observe that light gauge bosons are described by θ′ only, whereas heavy gauge bosons are described by two parameters ∈ and θ′. © 2015 American Physical Society.

Hiramatsu R.,Kobe International University
Journal of the Japan Research Association for Textile End-Uses | Year: 2012

Cosmetics are used for face and body directly. Therefore using of cosmetics may cause allergies to people. The consumers have been attacked by lead poisoning and melanodermia (dark skin damage caused by increased deposits of melatonin) historically by using of cosmetics. Economic activities of a company were given priority over the communications with consumers. Information on reporting and close attention to consumers has been very poor. How should a company communicate with consumers and society, and perform its economic activities? In addition, how should consumers accept the products and information that a company provides? In this study, the author introduces lead poisoning caused by cosmetics and considers the melanodermia as an example. © 2012 Jpn.Res. Assn.Text.End-Uses.

Tsuji Y.,Kobe International University
Journal of the Japan Research Association for Textile End-Uses | Year: 2012

Recently, the word, "Corporate Social Responsibility" (henceforth referred to as "CSR"), has become a common phrase in newspapers and on TV. Therefore, the author has surveyed the image of CSR considered by students. Consequently, only 6.6% of university students could explain the word, "CSR". When asked abut what their image of CSR was, examples such as "not doing injustice", "giving support during times of disaster," or "protecting the environment" etc. were often given. The following results were obtained: 5.0% of the students had both heard and knew the contents of the word; 12.5% had heard the word and knew the meaning but did not know the contents; 33.0% had heard the word but did not know the meaning! 49.5% had not heard the word before. In addition, it was found that university students, particularly in regards to the medical and cosmetic industries, desire products of value or service offers and social action; however, according to the results there were few desires in regards to trading companies. In the future, CSR needs to be taught at educational institutions. On top of understanding the meaning of CSR, we must aim to increase the number of youth who can propose what to do about it. As the results of these surveys, we must teach CSR to students in educational facilities. Also, they should learn many concrete examples from companies in order to practice CSR in their immediate circle. The young need to consider CSR because they are consumers and they will be members of companies. © 2012 Jpn.Res.Assn.Text.End-Uses.

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