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In Special Recognition of the work of The Stand Up To Cancer-Lustgarten Foundation Pancreatic Dream Team and in honor of Pancreatic Cancer Awareness Month SEATTLE, Nov. 10, 2016 (GLOBE NEWSWIRE) -- NanoString Technologies, Inc. (NASDAQ:NSTG), a provider of life science tools for translational research and molecular diagnostic products, today announced a new myeloid gene expression collaboration to expand the company’s immuno-oncology portfolio. The Company, in conjunction with Lisa Coussens, Ph.D., Professor & Chair, Developmental & Cancer Biology Department, OHSU Knight Cancer Institute, Portland, Oregon, is developing two new myeloid focused research panels for the study of the innate immune response to cancer.  An early version of the Myeloid Innate Immunity Panel will be made available to Dr. Coussens and her collaborators, as well as the Stand Up To Cancer – Lustgarten Foundation Pancreatic Dream Team members in an exclusive, advance offering during the month of November in conjunction with Pancreatic Cancer Awareness Month, after which the panels will be available to all researchers. “I am thrilled to be partnering with NanoString to create these novel myeloid-focused panels,” said Coussens. “We anticipate that through these efforts, we will enable a more complete understanding of the local interplay between myeloid immune components and neoplastic cells in tumors.” Myeloid cells play a key role in modulating activities fundamental to cancer development and are known to have both tumor promoting and anti-tumor functions. As myeloid cells are affected by and can have an impact on many types of cancer therapy, they are broadly applicable within immuno-oncology research. A heightened awareness of the importance of the mechanisms of immunotherapy resistance has brought the myeloid immune response into focus as a key modulator of the adaptive immune response. NanoString is currently working with Coussens on her efforts in understanding recruitment of myeloid cells into neoplastic tissue, and the subsequent regulation exerted by those myeloid cells on neoplastic cells and other cells within dynamic tumor microenvironments. The Myeloid Innate Immunity panel includes approximately 700 genes representing all major categories of myeloid cells, enabling quantitative evaluation of heterogeneous myeloid cell populations based on recruitment, differentiation, maturation status, and functional activities.  The panels are optimized to work across a range of sample types including fresh frozen tissues, formalin-fixed paraffin-embedded (FFPE) samples, peripheral blood mononuclear cells and cell lysates. “It has been a pleasure to collaborate with Dr. Coussens and we are excited to share this work with the broader community of cancer researchers. The Myeloid panel is a collection of genes that encompass the many characteristics of the innate immune response that will help advance cancer research with obvious applications in infectious disease as well,” said Joseph Beecham, Ph.D., senior vice president of R&D at NanoString. “These myeloid panels are highly complementary to NanoString’s 770 gene PanCancer Immune Profiling Panel, layering a unique dimension of gene expression information that will provide insights into the modulation activities of the innate immune response.” Dr. Coussens is chair of the Department of Cell, Developmental & Cancer Biology at OHSU. Her research is focused on revealing the role that immune cells play in regulating solid tumor development. Coussens is a principal investigator on the Stand Up To Cancer – Lustgarten Foundation Pancreatic Cancer Convergence Dream Team in which her work is focused on clinical evaluation of immune-based therapies in pancreatic cancer.  She has received numerous awards, including: the V Foundation Scholar Award, the AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship, and the 2015 recipient of the 13th Rosalind E. Franklin Award from the National Cancer Institute. This is the latest in a series of research partnerships NanoString has with global leaders in immuno-oncology. NanoString and Coussens will be presenting independently at the upcoming Society for Immunotherapy of Cancer (SITC) conference taking place Wednesday, November 9 through Sunday, November 13 at the Gaylord National Hotel & Convention Center in National Harbor, Maryland. Results from NanoString’s previously announced collaborations with Merck and MD Anderson Cancer Center will also be presented this week at AMP and SITC. - Title: Beyond PD-L1 IHC:  A Gene Expression Based Test in development for anti-PD-1 response on the nCounter® Dx Analysis System - Speaker: Dr. Matthew Marton, Director of Genomics and Companion Diagnostics, Merck - Date/time: Wednesday, November 9th, 8 AM - 9 AM. - Title: The increasing clinical relevance of predictive biomarkers in cancer immunotherapy: can we afford to move forward without them? - Speakers: Alessandra Cesano, Alex Rueben (MDACC) & Jared Lunceford (Merck). - Date/time: Saturday, November 12th, 12:00 PM – 1:00 PM. About the OHSU Knight Cancer Institute: The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle – an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials. For additional information on the OHSU Knight Cancer Institute visit www.ohsu.edu/xd/health/services/cancer or follow us on Facebook and Twitter. About the Stand Up To Cancer Initiative Stand Up To Cancer (SU2C) raises funds to accelerate the pace of research to get new therapies to patients quickly and save lives now. SU2C, a program of the Entertainment Industry Foundation (EIF), a 501(c)(3) charitable organization, was established in 2008 by film and media leaders who utilize the industry’s resources to engage the public in supporting a new, collaborative model of cancer research, and to increase awareness about cancer prevention as well as progress being made in the fight against the disease. As SU2C’s scientific partner, the American Association for Cancer Research (AACR) and a Scientific Advisory Committee led by Nobel Laureate Phillip A. Sharp, PhD, conduct rigorous, competitive review processes to identify the best research proposals to recommend for funding, oversee grants administration, and provide expert review of research progress. Current members of the SU2C Council of Founders and Advisors (CFA) include Katie Couric, Sherry Lansing, Lisa Paulsen, Rusty Robertson, Sue Schwartz, Pamela Oas Williams, Ellen Ziffren, and Kathleen Lobb. The late Laura Ziskin was also a co-founder.  Sung Poblete, Ph.D., R.N., has served as SU2C’s president since 2011. For more information on Stand Up To Cancer, visit www.standup2cancer.org. About NanoString Technologies, Inc. NanoString Technologies provides life science tools for translational research and molecular diagnostic products. The company's nCounter Analysis System has been employed in life sciences research since it was first introduced in 2008 and has been cited in more than 1,300 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company's technology is also being used in diagnostics. The Prosigna® Breast Cancer Prognostic Gene Signature Assay together with the nCounter Dx Analysis System is FDA 510(k) cleared for use as a prognostic indicator for distant recurrence of breast cancer. In addition, the company is collaborating with multiple biopharmaceutical companies in the development of companion diagnostic tests for various cancer therapies, helping to realize the promise of precision oncology. For more information, please visit www.nanostring.com. The NanoString Technologies logo, NanoString, NanoString Technologies, nCounter, 3D Biology, and Prosigna are registered trademarks of NanoString Technologies, Inc.


SALT LAKE CITY, Oct. 27, 2016 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a leader in molecular diagnostics and personalized medicine, today announced it will present two new studies at the American Society of Dermatopathology (ASDP) annual meeting being held Oct. 27-30, 2016 in Chicago, Ill.  The research being presented validates the accuracy of Myriad myPath® Melanoma in differentiating benign skin nevi from malignant melanoma. “We are presenting landmark data from the largest outcomes-based study ever performed with a melanoma diagnostic,” said Loren Clarke, M.D., medical director, Dermatology, Myriad Genetic Laboratories.  “The myPath Melanoma test performed very well and identified patients with melanoma versus benign skin lesions with greater than 95 percent diagnostic accuracy, which is exceptional in molecular diagnostics for cancer, particularly given the extreme heterogeneity of melanoma.” “Pigmented or suspect skin lesions are difficult to diagnose in approximately 15 percent of cases,” said Sancy Leachman, M.D., Ph.D., chair of the Department of Dermatology in the Oregon Health & Science University School of Medicine and director of the Melanoma Research Program at the Knight Cancer Institute.  “A highly accurate biomarker like the myPath Melanoma test should help dermatologists augment their diagnosis of melanoma, improve patient care and lower healthcare costs.” Below are the featured presentations at ASDP (#ASDP2016). Poster Presentation Title: Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcome​. Presenter: Jennifer Ko. Date: Friday, Oct. 28, 2016: 4:15 – 5:00 p.m. and Saturday, Oct. 29, 2016 10:00 – 10:45 a.m. CT. In this study, research collaborators from the Cleveland Clinic, Stanford University and Nottingham University assessed the clinical accuracy (sensitivity and specificity) of the myPath Melanoma test against clinical outcomes in 182 patients with skin lesions (99 melanomas and 83 nevi) with more than 5 years of follow up.  The results show that the myPath Melanoma test accurately differentiated benign lesions from melanoma with a sensitivity of 93.8 percent and a specificity of 96.2 percent when compared to known clinical outcomes.   The diagnostic accuracy of the myPath Melanoma test was high even in a subset of difficult-to-diagnose cases and, in combination with two previous validation studies, the findings support its use as an adjunct method for the early and accurate diagnosis of melanoma. Podium Presentation Title: Gene Expression Signature as an Ancillary Method in the Diagnosis of Desmoplastic Melanoma​. Presenter: Loren Clarke. Date: Sunday, Oct. 30, 2016: 8:20 – 8:30 a.m. CT. The objective of this study was to assess the accuracy of the myPath Melanoma test in the differentiation of desmoplastic melanoma (DM) from benign skin lesions.  These lesions represent approximately one percent of melanomas, but are known to be very difficult to diagnose.  The analysis included samples from 20 patients with DM and 27 from patients with benign moles (nevi).  The results showed that the myPath Melanoma test was positive in 15 of the 20 known melanomas, negative in four and indeterminate in one.  The myPath score was negative in 24 of the benign nevi and indeterminate in three.  Based on these findings, the myPath Melanoma test demonstrated approximately 80 percent diagnostic accuracy in this very difficult-to-diagnose subtype. For more information about the meeting, please visit the ASDP website at https://www.asdp.org/annual-meeting/home/.  Follow Myriad on Twitter via @MyriadGenetics to stay informed about news and updates from the Company. About Melanoma Melanoma is one of the fastest growing cancers in the United States and can strike people of all ages, races and skin types. With a one-in-50 lifetime risk of developing melanoma, nearly 76,000 Americans are expected to be diagnosed with Stage I-IV melanoma and another 68,000 will be diagnosed with melanoma in situ – totaling approximately 144,000 total diagnoses.  Early and accurate diagnosis of melanoma is critical for long-term survival.  For more information visit: www.mypathmelanoma.com/ and www.myriadpro.com/melanoma. About Myriad myPath® Melanoma Myriad myPath Melanoma is a clinically validated test to be used as an adjunct to histopathology when the distinction between a benign nevus and a malignant melanoma cannot be made confidently by histopathology alone. The test measures the expression of 23 genes and accurately distinguishes melanoma from benign nevi. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, EndoPredict, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G Safe Harbor Statement This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the Company presenting two new studies at the American Society of Dermatopathology Annual Meeting being held Oct. 27-30, 2016 in Chicago, Ill.; the accuracy and effectiveness of Myriad myPath Melanoma testing in differentiating benign skin nevi from malignant melanoma; and the Company’s strategic directives under the captions “About Myriad myPath Melanoma” and “About Myriad Genetics.” These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks and uncertainties include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests, including unexpected costs and delays; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of a healthcare clinic in Germany and Sividon Diagnostic and our planned acquisition of Assurex Health; risks related to our projections about our business, results of operations and financial condition; risks related to the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


News Article | February 20, 2017
Site: www.eurekalert.org

PORTLAND, OR - Nine years ago, SWOG researchers confirmed a new standard of care for patients with incurable gastrointestinal stromal tumors (GIST), who could survive by being treated with imatinib mesylate, the breakthrough drug marketed as Gleevec. SWOG researchers are back with long-term findings from that study, which estimate that nearly one in four patients treated with Gleevec will survive 10 years. Results are published in JAMA Oncology. "This is a really exciting finding," said Dr. Michael Heinrich, a SWOG investigator and a professor of medicine and cell and developmental biology at Oregon Health & Science University, where SWOG is based. "Until Gleevec arrived on the scene 15 years ago, patients with advanced GISTs faced a life expectancy of 18 months. Now we've learned that some might live a decade or longer. And we've come to understand which class of patients benefit the most from Gleevec." In new study results published in JAMA Oncology, researchers from SWOG, the international cancer research community supported by the National Cancer Institute, report a follow-up of patients originally enrolled in S0033, a SWOG-led trial supported by other groups in the NCI's National Clinical Trials Network (NCTN). This was a Phase III study that began in 2000. Initial results published in 2008 confirmed Gleevec as an effective treatment for advanced GIST patients, and recommended that therapy start with a 400 mg daily dose. The SWOG team decided to collect post-study data on S0033 patients, and from 2011 to 2015 gathered information. As part of their research, the team used next-generation DNA sequencing on some tumor tissue samples taken for S0033, which had been deposited in a biospecimen bank. The team reanalyzed tissue from 20 patients originally classified as having a wild-type tumor - one without any mutations of KIT, a gene implicated in 85 to 88 percent of all GISTs. Analysis showed that of the 695 eligible patients originally enrolled in S0033, 189 survived eight years or longer, with a 10-year estimate of overall survival of 23 percent, or nearly one in four patients. DNA sequencing also showed that survival rates were significantly higher for patients with a KIT exon-11 mutant GIST, when compared with patients whose tumor had a KIT exon-9 mutation or with no KIT mutations or mutations in the platelet-derived growth factor receptor gene, or PDGFRA. "Our findings show two things," Heinrich said. "One is that Gleevec has revolutionized treatment for patients with advanced GISTs. Our findings also highlight the importance of banked biospecimens to drive new scientific findings, and how tumor mutation testing can optimize treatment for cancer patients." GISTs are different from more common types of gastrointestinal tumors because of the type of tissue in which they start. GISTs belong to a group of cancers called soft-tissue sarcomas. Soft-tissue sarcomas develop in the tissues that support and connect the body, including muscles, nerves, tendons, and joints. GIST is a rare cancer, with about 6,000 new cases diagnosed in the United States each year. Researchers at Oregon Health & Science University have pioneered the treatment of GISTs. Dr. Brian Druker, director of the OHSU Knight Cancer Institute, conducted the most influential work in the development of Gleevec, and OHSU researchers have been part of major discoveries in the use of the drug to treat GISTs, as well as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Along with Heinrich, lead author of the JAMA Oncology article, the SWOG study team includes: Cathryn Rankin, MS, of Fred Hutchinson Cancer Research Center; Dr. Charles D. Blanke of Knight Cancer Institute; Dr. George Demetri of Dana-Farber Cancer Institute; Dr. Ernest Borden of Cleveland Clinic; Dr. Christopher Ryan of Knight Cancer Institute; Dr. Margaret von Mehren of Fox Chase Cancer Center; Dr. Martin Blackstein of Mount Sinai Hospital; Dr. Dennis Priebat of MedStar Hospital Research Center; Dr. William Tap of Memorial Sloan Kettering Cancer Center; Dr. Robert Maki of Norwell Health and Cold Spring Harbor Laboratory; Dr. Christopher Corless of Knight Cancer Institute; Dr. Jonathan Fletcher of Dana-Farber Cancer Institute; Kouros Owzar, PhD, of Duke University School of Medicine; John Crowley, PhD, of Cancer Research And Biostatistics; Dr. Robert Benjamin of University of Texas MD Anderson Cancer Center; and Laurence Baker, DO, of University of Michigan. Research reported in this article was supported by the NCI of the National Institutes of Health (NIH) in part under award numbers U10CA180888 and U10CA180819. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Novartis Pharmaceuticals also supported the research. SWOG is a global cancer research community of over 12,000 members in 47 states and six foreign countries who design and conduct publicly funded clinical trials. Since 1956, SWOG trials have led to the approval of 14 cancer drugs, changed more than 100 standards of cancer care, and saved more than 2 million years of human life. The group is a proud member of the NCI's National Clinical Trials Network and the NCI Community Oncology Research Program, and is a major part of the cancer research infrastructure in the U.S. and the world. Headquartered at the Knight Cancer Institute at Oregon Health & Science University in Portland, Ore., SWOG's Statistics and Data Management Center is based at Fred Hutchinson Cancer Research Center in Seattle, Wash. and its Operations Office is located in San Antonio, Texas. Learn more at swog.org.


News Article | December 2, 2016
Site: www.eurekalert.org

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: "I sometimes compare MicroRNA to tweets -- they're short, transient and constantly changing." Because microRNA is dynamic, it makes for a compelling target for cancer research. Anand, an assistant professor of radiation medicine in the School of Medicine and member of the Knight Cancer Institute, teamed up with a group of researchers to take a closer look at microRNA in the context of the tumor microenvironment. Their findings, published in Nature Communications, provide early evidence that a panel of microRNA may be used in the future as a biomarker for several types of cancer. Using a mouse model, Anand and colleagues demonstrated how microRNAs in the tumor microenvironment play a critical role in tumor progression and response to radiation therapy. With microRNAs, the team mimicked features of the autoimmune disease lupus within cancers to provoke an immune response. This promising, early research may one day translate to human cancer radiation and treatment, and begs the question: Can we use microRNA biomarkers to influence cancer radiation? Anand and team believe it is a line of inquiry worth pursuing. "Biology is such a random process," Anand says. "Two neighboring cells won't always act the same way, just like two people don't react the same way when they see the same event. We hope we will one day be able to read microRNAs and predict if a person's cancer is going to respond to radiation." More information about this paper can be found on the OHSU Knight Cancer Institute's science blog, Cancer Translated. This research was funded by: National Heart Lung Blood Institute (NHLBI)/NIH, grant R00HL112962, and the Barbara-Ann Miller Dive for the Cure Award from the OHSU Knight Cancer Institute. The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle - an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials. For additional information on the OHSU Knight Cancer Institute visit http://www. or follow us on Facebook and Twitter.


News Article | October 28, 2016
Site: www.prweb.com

To celebrate Breast Cancer Awareness Month, all Dutch Bros Coffee locations will donate proceeds from the sale of its specialty “Be Aware” travel mugs to the advancement of breast cancer research at Oregon Health Sciences University Knight Cancer Institute (OHSU Knight Cancer Institute). Beginning on Saturday, Oct. 1, these specialty travel mugs will be available at all locations. Dutch Bros will donate $5 from the sale of every mug to raise awareness and funds for breast cancer research and the development of new techniques for detection, treatment and prevention. "The OHSU Knight Cancer Institute is doing an amazing job in breast cancer research," said Dutch Bros Co-Founder, Travis Boersma. "I cannot be more proud to partner with an organization that has such credibility and a tremendous track record for really making a difference. It's an honor to be a part such impactful work." Dutch Bros locations will donate funds raised throughout the month to the Oregon Health and Sciences University (OHSU) Knight Cancer Institute. Funds will directly benefit this institute as they continue their research. Donated funds support top researchers at OHSU as they discover new forms of breast cancer detection, treatment and prevention. “We are grateful for the support the OHSU Knight Cancer Institute has received from Dutch Bros and the Dutch Bros community over the years,” said Brian Druker, M.D., director of the OHSU Knight Cancer Institute. “These valuable dollars will help our mission to build an early detection cancer research program, with the ultimate goal to end cancer as we know it.” To find a location near you, please visit http://www.dutchbros.com/locations About Dutch Bros Coffee Dutch Bros Coffee is the country’s largest privately held, drive-thru coffee company, with over 270 locations and over 7,000 employees in seven states. The rich, proprietary coffee blend is handcrafted from start to finish. Every ingredient is measured, every process timed, and every cup perfected. With a mission of, “Making a Difference, One Cup at a Time,” Dutch Bros donates over $2 million annually to nonprofit organizations and local causes selected by local owner-operators. Dutch Bros. Coffee is headquartered in Grants Pass, Ore., where it was founded in 1992 by Dane and Travis Boersma, brothers of Dutch descent. To learn more about Dutch Bros, visit http://www.dutchbros.com, like Dutch Bros Coffee on Facebook or follow @DutchBros on Twitter.


- GRAIL to Apply High-Intensity Sequencing on an Unprecedented Scale to Build an Atlas of Cancer Biology - MENLO PARK, Calif., Dec. 01, 2016 (GLOBE NEWSWIRE) -- GRAIL, Inc., a life sciences company whose mission is to detect cancer early when it can be cured, announced today that it has commenced its first multi-center clinical study, the Circulating Cell-free Genome Atlas (CCGA) study to facilitate the development of GRAIL’s blood test for early-stage cancer detection. The CCGA study will characterize the landscape of cell-free DNA profiles in individuals with cancer and in healthy non-cancer participants using GRAIL’s “high-intensity” (ultra-broad and ultra-deep) sequencing approach, leveraging Illumina sequencing technology. GRAIL was launched in January 2016, with initial investors including Illumina, ARCH Ventures, Jeff Bezos, Bill Gates, Sutter Hill Ventures and GV. “For too many patients and their families, a late diagnosis of incurable cancer is devastating, and the complexity of cancer has made it challenging to find biomarkers for early stage detection when the cancer could be cured,” stated Jose Baselga, M.D., Ph.D., Physician-in-Chief, Memorial Sloan Kettering Cancer Center, Chairman of GRAIL’s Scientific Advisory Board (SAB) and member of the CCGA SAB. "The CCGA study will provide a critically important library of knowledge about cell-free nucleic acid profiles in cancer patients and new insights into the biology of cancer at its earliest stages. Of equal importance, the CCGA will characterize the heterogeneity of the population of individuals without cancer, and thus enable the development of models which distinguish people with and without cancer with unprecedented accuracy." “Combining our ability to detect and characterize tumor DNA with our unparalleled computing power, we will convert vast amounts of genomic data into disease insight,” said Jeff Huber, GRAIL’s Chief Executive Officer. “Our approach will produce more than a terabyte of data per individual thereby creating datasets of a scale and complexity that are unprecedented in genomic medicine. Furthermore, we are committed to conducting large-scale studies to enable the most accurate detection of early stage disease. Initiating the CCGA study is an important first step for GRAIL and its collaborators, as we pursue our goal of reducing global cancer mortality.” The CCGA study has begun at several leading community and academic medical centers and eventually will include up to four-dozen clinical trial sites across the U.S. These medical centers will collect blood and tissue samples from patients recently diagnosed with cancer, and blood samples from healthy individuals. In its first phase, the CCGA study will enroll and analyze samples from 10,000 study participants. GRAIL and its advisors believe that studies enrolling tens of thousands of people will be needed to identify the patterns required to detect many types of cancer. To confirm clinical validity and utility of these tests, studies enrolling hundreds of thousands of people will be needed. The initial collaborators in the CCGA study include: medical centers of the Guardian Research Network, Mayo Clinic (Minnesota, Arizona and Florida) and Hartford HealthCare Cancer Institute, a member of the Memorial Sloan Kettering Cancer Alliance. More information about the CCGA study can be found at NCT02889978. “We are very pleased to be working with GRAIL and other collaborators on this landmark study and we have already begun enrolling study participants across our broad network of cancer centers and hospitals in the U.S.,” said Timothy Yeatman, M.D., President and Chief Scientific Officer of Guardian Research Network. “Detecting cancer at an earlier stage when it can be cured is an ambitious goal with the potential for immeasurable benefit to society. We are proud to support this initiative.” GRAIL has assembled leading cancer research and clinical oncology experts from the academic and medical community to serve as CCGA Scientific Advisory Board members: “Cancer is an incredibly complex and heterogeneous disease, making accurate, early stage detection extremely difficult,” said Brian Druker, M.D., Director, Knight Cancer Institute at Oregon Health & Science University; JELD-WEN Chair of Leukemia Research; Investigator, Howard Hughes Medical Institute, and a member of GRAIL’s Scientific Advisory Board. “The oncology field needs the expertise and resources to build the technology infrastructure to collect, analyze, categorize and use vast amounts of data. The CCGA study represents a critically important step in establishing this foundational knowledge.” About the Circulating Cell-free Genome Atlas (CCGA) Study The purpose of the CCGA study is to characterize the landscape of cell-free DNA profiles in individuals with and without cancer. The observational CCGA study will enroll at least 7,000 cancer patients and 3,000 healthy individuals, interrogating the biology of both tumor biopsy tissue samples and the circulating, tumor-derived nucleic acids in blood. Circulating tumor nucleic acids (ctNAs) in the blood are an emerging biomarker for earlier cancer detection. GRAIL and its collaborators will collect clinical outcomes on the enrolled participants for at least 5 years. The result will be a detailed atlas of cancer genetics that GRAIL will use to support its product development goals. The database, upon analysis, may be expanded to additional enrollment in specific cancers or healthy individuals. More information about the CCGA study can be found at NCT02889978. About GRAIL’s High-intensity Sequencing Approach GRAIL’s approach is to sequence circulating nucleic acids at unprecedented breadth and depth to optimize the detection of early-stage cancer. Combined with one of the largest clinical trial programs ever pursued in genomic medicine, GRAIL will be creating datasets of unprecedented scale to enable the deepest and most comprehensive understanding of cancer biology. GRAIL’s technology infrastructure teams are at the forefront of modern practice in developing and deploying scalable, cloud-based databases and analysis engines. Further, GRAIL is utilizing, at scale, the latest tools of data science, including powerful approaches from machine learning such as hierarchical neural networks. GRAIL will apply such methods to all steps of the Company’s data-generating pipeline including the ultimate challenge of classifying patients according to the presence, type, and severity of cancer. From the laboratory to the clinic, GRAIL’s goal is to produce the highest quality data and transform them into clinically actionable insights to save lives. About GRAIL GRAIL is a life sciences company whose mission is to detect cancer early when it can be cured. GRAIL combines the power of high-intensity sequencing (ultra-broad and ultra-deep sequencing), leading-edge computer science, and large population-scale clinical studies to enhance the scientific understanding of cancer biology and develop a blood test for early-stage cancer detection. The company has secured over $100 million in Series A financing from Illumina, Inc. and ARCH Venture Partners, with participating investors including Bezos Expeditions, Bill Gates, Sutter Hill Ventures, and GV (formerly Google Ventures). For more information, please visit www.grailbio.com About Guardian Research Network Guardian Research Network (GRN) is a nationwide consortium of high-performing community health systems that created a 21st century breakthrough platform for accelerating cures for cancer. GRN harnesses the power of big data to aggregate hundreds of thousands of patient clinical and molecular profiles into a dynamic knowledge architecture focused on the rapid identification of populations to deliver targeted and novel clinical therapies. GRN’s goals are to expand patient access to leading therapies without leaving home; enhance precision medicine in local communities; democratize clinical trial access, with special benefit to underserved populations; and radically reduce the drug approval process. GRN founding members include: Gibbs Cancer Center & Research Institute, Spartanburg Regional Healthcare System, Spartanburg, SC; Baptist Health, Louisville, KY; Mercy, Saint Louis, MO; and the Bon Secours Health System, Marriottsville, MD. Join our efforts and learn more by visiting www.guardianresearch.org. About Hartford HealthCare Cancer Institute The Hartford HealthCare Cancer Institute is the charter member of the Memorial Sloan Kettering Cancer Alliance (MSK), a pioneering initiative to bring the latest advances in cancer research and therapies to patients in a community-based setting. The Hartford HealthCare Cancer Institute is made up of five comprehensive cancer centers at acute care hospitals across Connecticut, providing multidisciplinary, innovative and coordinated care within a model that emphasizes leading-edge clinical research and a team-based clinical philosophy. For more information on the Hartford HealthCare Cancer Institute, go to www.hartfordhealthcare.org. To learn more about the Hartford HealthCare Cancer Institute’s participation in the Memorial Sloan Kettering Cancer Alliance, go to www.togetherahead.org.


News Article | December 8, 2016
Site: www.eurekalert.org

Jennifer Lycette, M.D., understands the importance of treating patients with cancer at home in their in rural communities. It allows them to spend more time with their families and to focus on their treatment and recovery, not traveling. Lycette and other physicians who treat these patients are keenly aware of the numerous challenges they encounter. Consequently, they are strongly committed to ensuring rural patients have access to the latest targeted therapies and other cutting-edge treatment options. When faced with a breast cancer patient with underlying mental illness who was reluctant to try standard cancer treatments, Lycette asked herself an important question: "What good were targeted therapies when her coexisting mental illness prevented her from taking them?" Lycette outlines this and other concerns while sharing one patient's profound struggle in a New England Journal of Medicine "Perspective" paper published today titled, "Neglected -- Cancer Care and Mental Health in Rural America." An oncologist with the OHSU Knight Cancer Institute, Lycette treats patients in the coastal community of Astoria, Oregon. Astoria, like many other rural settings in the United States, has a severe shortage of psychiatric health care providers. According to the Department of Health and Human Services, approximately 4,000 Mental Health Professional Shortage Areas, defined as having less than one psychiatrist per 30,000 people, were identified in the United States in 2016. In reviewing what was available for the citizens of Clatsop County, of which the city of Astoria is a part, she found a disappointing zero psychiatrists per 100,000 people. Lycette's recounting of this patient's experience demonstrates the terrible impacts of insufficient or nonexistent psychiatric care. In her commentary, Lycette notes her inability to reach her patient with mental illness marked " ... the saddest final chapter in the devastating story of untreated mental illness, the true neglect." Lycette has served as the Columbia Memorial Hospital/OHSU Cancer Care Center's medical director for more than three years through the CMH/OHSU Knight Cancer Collaborative. In 2015, the collaborative, which has the goal to provide rural oncology care, announced the development of an 18,000 square-foot comprehensive cancer treatment center and specialty clinic in Astoria, scheduled to open in October 2017. The Knight Cancer Institute at Oregon Health & Science University is a pioneer in the field of precision cancer medicine. The institute's director, Brian Druker, M.D., helped prove it was possible to shut down just the cells that enable cancer to grow. This breakthrough has made once-fatal forms of the disease manageable and transformed how cancer is treated. The OHSU Knight Cancer Institute is the only National Cancer Institute-designated Cancer Center between Sacramento and Seattle - an honor earned only by the nation's top cancer centers. It is headquarters for one of the National Cancer Institute's largest research collaboratives, SWOG, in addition to offering the latest treatments and technologies as well as hundreds of research studies and clinical trials. For additional information on the OHSU Knight Cancer Institute visit http://www. or follow us on Facebook and Twitter.


News Article | November 14, 2016
Site: www.eurekalert.org

PORTLAND, Ore. - Cholesterol-lowering drugs help prevent heart attacks and strokes in adults with cardiovascular risk factors such as high cholesterol, high blood pressure, diabetes and smoking, but have not yet had a heart attack or stroke, according to a large-scale analysis of clinical trial data led by the OHSU Pacific Northwest Evidence-Based Practice Center. Drugs that lower fat levels in the blood, called statins, were effective in reducing risk of death, heart attacks and strokes, across a broad range of patient groups. The benefits were largest in people at highest risk for heart attacks and strokes. But, those at lower risk also realized some preventive benefits. In addition, the drugs did not prove to have significant harmful effects. Compared with a placebo, statins were not associated with increased risk of muscle pain or myopathy, cognitive decline or liver damage. Overall, there was no increased risk of diabetes with statins, though one trial that used a high dose of statins found an increased risk. One trial found an increased risk of cataract surgery. The analysis which was commissioned by the United States Preventive Services Task Force (USPSTF) and published on Nov. 13 in JAMA was intended to evaluate the benefits and harms of statins in preventing cardiovascular disease in adults. It reviewed results from 19 clinical trials involving 71,344 adults ages 40 to 75 with a mean age of 51 to 66 years old. The trials compared statin therapy with placebo in individuals who had not previously had a heart attack or stroke, but had known risk factors such as high cholesterol, high blood pressure, diabetes or they smoked. The trials included in the systematic data review followed study participants for six months to six years. The analysis concluded that statin therapy decreased risk of death overall by 14 percent and risk of death from cardiovascular disease by 31 percent. It reduced the risk of stroke by 29 percent and heart attack by 36 percent. "We found that all groups studied experienced a decrease in risk of suffering a heart attack, stroke, or death, and those at highest risk benefitted the most from cholesterol-lowering drugs," said the study's lead author, Roger Chou, M.D., director of the OHSU Pacific Northwest Evidence-Based Practice Center and a professor of general internal medicine, geriatrics, medical informatics and clinical epidemiology in the OHSU School of Medicine. "The majority of the trials used fixed, moderate doses of statins. The number of trials analyzed, including data from the recent HOPE 3 trial with 12,705 participants, provides much needed insight into the value of statin therapy in preventing a first heart attack or stroke, and associated deaths." Cardiovascular disease can lead to heart attacks and strokes and is a leading cause of death in the United States, accounting for 1 of every 3 deaths among adults. It is a challenging disease to treat as it can be "silent" until a heart attack or stroke occurs, potentially resulting in sudden death or serious and lasting health consequences. High cholesterol is a significant risk factor for cardiovascular disease and statin drugs help prevent the formation of cholesterol. These drugs are most effective at lowering LDL, or "bad" cholesterol, but can also help lower triglycerides (blood fats) and raise HDL, or "good," cholesterol. However, statins are also thought to reduce risk of heart attacks and strokes by stabilizing cholesterol plaques in the blood vessels, and are effective even in persons without highly elevated cholesterol levels. The USPSTF commissioned this review to inform the development of recommendations on statin therapy for the prevention of cardiovascular disease in adults ages 40 years and older who have not had a prior heart attack or stroke. Additional studies are needed to understand the effects of statins in people without risk factors for cardiovascular disease and to compare the effects of receiving a fixed dose of statins or a dose that is adjusted to reach a target cholesterol level. In addition, more research is required to definitively determine if statin use increases a patient's risk of developing diabetes or cataracts and whether higher doses of statins are associated with more benefits and/or more side effects. In addition to Chou, OHSU researchers who contributed to the study were: Tracy Dana, M.L.S.; Ian Blazina, M.P.H.; Monica Daeges, B.A.; and Thomas L. Jeanne, M.D. No conflicts of interest were reported by any of the authors. Oregon Health & Science University is a nationally prominent research university and Oregon's only public academic health center. It serves patients throughout the region with a Level 1 trauma center and nationally recognized Doernbecher Children's Hospital. OHSU operates dental, medical, nursing and pharmacy schools that rank high both in research funding and in meeting the university's social mission. OHSU's Knight Cancer Institute helped pioneer personalized medicine through a discovery that identified how to shut down cells that enable cancer to grow without harming healthy ones. OHSU Brain Institute scientists are nationally recognized for discoveries that have led to a better understanding of Alzheimer's disease and new treatments for Parkinson's disease, multiple sclerosis and stroke. OHSU's Casey Eye Institute is a global leader in ophthalmic imaging, and in clinical trials related to eye disease.


News Article | October 19, 2016
Site: www.labdesignnews.com

When Nike founder, Phil Knight, donated half a billion dollars towards further research into the early cancer detection and construction of a cutting edge research building for the Knight Cancer Institute at Oregon Health & Science University in Portland, the mandate for the designers was simple—enable “true team science” with a completely novel look at the laboratory workplace. In honor of Nike’s culture of invention, architects SRG Partnership invited B+H Advanced Strategy group to join them for an in-depth investigation into what makes a modern research center and the people that work there tick. What we were able to find should make decision-makers stop and take notice. All knowledge-driven organizations are talent-driven, and the competition for the best and brightest talent is fierce. So it follows that a competitive, attractive and well-designed work environment is a key deciding factor in the success of an organization and its research.

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