KMCT Medical College
KMCT Medical College
Kumar P.N.S.,KMCT Medical College |
Mohemmedali S.P.,Government Medical College |
Anish P.K.,Institute of Mental Health and Neurosciences |
Andrade C.,National Institute of Mental Health and Neuro Sciences
Indian Journal of Psychiatry | Year: 2017
Objective: An important challenge in schizophrenia therapeutics is to develop an efficacious treatment for cognitive impairment. Acetylcholinesterase inhibitors, such as rivastigmine, have been studied for improving cognitive performance in these patients. Materials and Methods: Rivastigmine (uptitrated to 6 mg/day) was given as an add-on therapy to risperidone-treated stable schizophrenia patients in a randomized, double-blind, placebo-controlled design. Of 67 patients who met eligibility criteria, 55 were recruited into the study. Twenty-eight were assigned to rivastigmine and 27 to placebo. These patients completed tests of attention, executive functioning, verbal skills, verbal and visuospatial working memory, and psychomotor speed on five occasions: at baseline, and at the end of the 1st, 3rd, 6th, and 12th months. Results: The groups were similar in terms of sociodemographic profile and baseline clinical characteristics (Positive and Negative Syndrome Scale and Clinical Global Impression-Severity). Contrary to expectations, rivastigmine patients showed poorer outcomes on several cognitive measures. Rivastigmine patients experienced also more psychological as well as neurological side effects. Core psychopathology ratings, however, did not differ between rivastigmine and placebo groups. Conclusions: Our study does not support the long-term use of rivastigmine as an augmentation agent in schizophrenia. Rivastigmine may be associated with higher incidence of psychological and neurological side effects in patients with schizophrenia. © 2017 Indian Journal of Psychiatry | Published by Wolters Kluwer - Medknow.
Paul B.J.,KMCT Medical College |
James R.,KMCT Medical College
International Journal of Rheumatic Diseases | Year: 2017
Even though, Hippocrates recognized gout as an affection of older men and a product of high living long back in 5th century BC, this painful condition promises to accompany humanity to the 21st century. The incidence is progressively rising and females are also affected in the modern era. There are also regional and ethnic variations in the incidence, the genetics of which is being studied. The recommended best therapy for the acute attacks and long term prophylaxis has improved remarkably in the recent years. However, patients are often treated inadequately and risk factors for their disease are not well explored in daily practice. Although well designed long term studies of current and newer treatment are welcomed, educating doctors especially the primary care physicians who manage majority of gout cases, in optimizing the currently available management options would improve the present care. © 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
Gayathri R.,KMCT Medical College |
Chandni R.,Medical College |
Udayabhaskaran V.,Medical College
Journal of Association of Physicians of India | Year: 2012
The present study was carried out to study the correlation between carotid artery intima media thickness (CIMT) with risk factors for atherosclerosis and atherosclerotic events in Type 2 Diabetes mellitus patients. The predictive value of CIMT as an indicator of early atherosclerosis was determined and the various atherosclerotic risk factors in type 2 diabetes mellitus were studied. Our study showed that CIMT was significantly higher in those type 2 diabetic patients who had atherosclerotic events than in those patients who had no atherosclerotic events. It was also found that waist hip ratio showed a significant positive correlation and independent association with CIMT emphasizing the emerging concept of central obesity. Duration of diabetes, urinary albumin excretion rate, hypertension and glycated hemoglobin had positive correlation with CIMT, but could not assume statistical significance. Age, smoking and dyslipidemia did not show any association with CIMT. © JAPI.
Jeeyar,KMCT Medical College |
Hemalatha,Drbr Ambedkar Medical College |
Wilma D.S.C.R.,Sapthagiri Institute of Medical science and Research Center
Asian Pacific Journal of Tropical Disease | Year: 2011
Objective: To determine the effect of smoking, hypertension individually on lipid profile and lipid peroxidation and the cumulative influence of smoking and hypertension on oxidative stress and lipid profile. Methods: Serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides and malondialdehyde (MDA) were estimated in sixty cases including twenty smokers, twenty hypertensives, and twenty smokers with hypertension and compared with those in twenty age and sex matched healthy controls. Results: Statistically significant increase in MDA, total cholesterol, LDL, VLDL and triglycerides and decrease in HDL in cases were observed in smokers, hypertensives and smokers with hypertension when compared to healthy controls. Smokers had significantly elevated levels of lipid profile and MDA except for HDL when compared to hypertensive group. Statistically significant increase in the levels of study parameters of smoking and hypertensive group was noticed when compared to group with hypertensives (P<0.05) and there was a statistically significant decrease in HDL levels in smoking and hypertensive group when compared to healthy controls. All the biochemical study parameters had larger effects (0.80
Pradeep P.V.,KMCT Medical College
Journal International Medical Sciences Academy | Year: 2015
Diagnosis of papillary microcarcinoma (PMTC) of the thyroid is increasing. The aim of the study was to look at the incidence of PMTC in our institute and compare with the macro carcinoma (PTC) and also discuss the management and prognostic factors.
Babu K.V.Y.,Institute of Medical science and Research Center |
Visweswaraiah D.S.,KMCT Medical College |
Kumar A.,Institute of Medical science and Research Center
Journal of Natural Science, Biology and Medicine | Year: 2014
Metallo-beta-lactamase (MBL) mediated resistance to carbapenems is an emerging threat in Pseudomonas aeruginosa (PA) nosocomial infections. Limited data on role of Imipenem resistant MBL positive PA (IR-MBLP-PA) and IR-MBL negative-PA (IR-MBLN-PA) infections on mortality and morbidity initiated the present study. Objectives: The aim of this study is to determine the role of IR-MBLP-PA and IR-MBLN-PA infections on mortality and morbidity. Materials and Methods: Prospective observational study of 1 year with 110 PA nosocomial infections was conducted with Imipenem + ethylene-diamine-tetra-acetic acid combined disc test for MBL detection. Role of IR-MBLP-PA and IR-MBLNPA infections on the outcome and morbidity were assessed in terms of crude mortality rate, Charlson's comorbidity score and mean duration of stay in intensive care unit (ICU) until cure and until death, number of episodes of complications and underlying disease. Results were analyzed by z test for proportions and Student t-test. Results: Relatively high crude mortality was observed among IR-MBLP-PA infections than IR-MBLN-PA (42.86% [6/14] vs. 20% [2/10], Z = 0.69, P = 0.49 NS). Ventilator-associated pneumonia was the underlying disease and a confounding factor in all deaths due to IR-MBLP-PA infections. IR-MBLP-PA infections resulted in rapid downhill course to death with short mean duration of stay in ICU until death than IR-MBLN-PA infections (3.167 ± 0.98 days vs. 16 ± 2.82, P < 0.001 highly significant [HS]) with more number of complications (5.85 ± 1.65 vs. 3.7 ± 1.31, P < 0.001 HS). With the exception of previous Imipenem therapy, association of higher Charlson's comorbidity score, severe underlying diseases, multidrug and pandrug resistance and pre-disposing risk factors with IR-MBLP-PA infections was not statistically significant. Conclusions: Higher mortality in IR-MBLP-PA than in IR-MBLN-PA was not significant indicating IR as an important predictor of mortality than MBL production. Higher morbidity and increased virulence was observed with certainty in IR-MBLP-PA infections. © Journal of Natural Science, Biology and Medicine.
Subash P.,KMCT Medical College
Indian Journal of Clinical Biochemistry | Year: 2015
The objective of the present study was to investigate the antioxidant status and the extent of oxidative DNA damage in lymphocytes and their relation with essential hypertension (EHT). A total of 100 South Indian subjects aged 30–65 were included for the study. Of these 50 were normotensive controls (group-1) with blood pressure ≥120/80 mm Hg, 50 were newly diagnosed (group-2) and were not on any antihypertensive drugs, but had systolic blood pressure ranging between 140 and 160 mmHg and diastolic blood pressure 95–100 mmHg and 50 newly diagnosed essential hypertensive patients underwent drug therapy for 1 year was considered as group-3. Enzymatic and non-enzymatic antioxidants significantly decreased and lymphocyte DNA damage was significantly increased in newly diagnosed hypertensive patients compared with control group. The major decrease in DNA damage and significant improvement in enzymatic and non-enzymatic antioxidants were observed after 1 year of antihypertensive therapy in treated group compared with newly diagnosed hypertensive patients. Total antioxidant status and lymphocyte DNA damage showed a strong negative correlation in all the three groups. Essential hypertension associated with oxidative stress which in turn causes genotoxic susceptibility to variety of disease including cancer. In the absence of DNA repair process and DNA checkpoint mechanisms, the genomic integrity is susceptible to extensive damage. In our study, increased oxidative DNA damage and decreased antioxidant levels were frequently observed in the newly diagnosed essential hypertensive patients, suggesting that oxidative stress is important in the pathogenesis of EHT. Therefore, the present study has additional clinical implication. Further investigations with large number of patients along with antioxidant supplement are highly warranted. © 2015 Association of Clinical Biochemists of India
Suresh Kumar P.N.,KMCT Medical College |
Rajmohan V.,KMCT Medical College
Indian Journal of Psychiatry | Year: 2012
Trichotillomania is a disorder characterized by chronic hair pulling that often results in alopecia. Eating the part of hair pulled out is a common practice and trichorhizophagia is a new term to denote the habit of eating the root of hairs pulled out, associated with trichotillomania. Many psychiatric disorders are prevalent among patients with trichotillomania. Here we report a case of trichotillomania with trichorhizophagia in a 58-year-old man with schizophrenia. The various treatment options are also discussed.
Venugopal V.,KMCT Medical College
Journal of Extra-Corporeal Technology | Year: 2012
Proper positioning of the intra-aortic balloon catheter is very important as an improperly placed balloon can causeproblems. A balloon placed too high can block off the arch vessels, whereas one placed too low can block the renal and splanchnic vessels. We propose a simple and reliable technique to properly position the intra-aortic balloon pump (IABP) catheter without the use of any sophisticated or expensive equipment in the intensive care unit if the catheter has migrated from the previously placed desired position. In this technique, we rely on the left radial arterial trace obliteration as the IABP catheter is pushed in along a guidewire as a marker for tip positioning.
PubMed | KMCT Medical College
Type: Journal Article | Journal: Indian journal of psychiatry | Year: 2017
The safety and efficacy profile of risperidone and olanzapine were compared in a double-blind trial that used doses widely accepted in clinical practice.Subjects (The two study groups were similar at baseline in all aspects. Seventy-four percent of the participants completed the trial, with no between-differences in the proportion of dropouts. Olanzapine group showed significantly greater improvement in negative symptoms in assessments at 3Both treatments were well-tolerated and efficacious. Greater reductions in severity of the illness and negative symptoms were seen with olanzapine consistently through 1 year. The frequency and severity of extrapyramidal symptoms were negligible and similar in the two treatment groups. Weight gain, hyperlipidemia, and hyperglycemia were comparable in both groups. Risperidone produced significant hyperprolactinemia.