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Manipala, India

Ibrahim S.,Louisiana Tech University | Chowriappa P.,Louisiana Tech University | Dua S.,Louisiana Tech University | Acharya U.R.,Ngee Ann Polytechnic | And 3 more authors.
Medical and Biological Engineering and Computing | Year: 2015

Prolonged diabetes retinopathy leads to diabetes maculopathy, which causes gradual and irreversible loss of vision. It is important for physicians to have a decision system that detects the early symptoms of the disease. This can be achieved by building a classification model using machine learning algorithms. Fuzzy logic classifiers group data elements with a degree of membership in multiple classes by defining membership functions for each attribute. Various methods have been proposed to determine the partitioning of membership functions in a fuzzy logic inference system. A clustering method partitions the membership functions by grouping data that have high similarity into clusters, while an equalized universe method partitions data into predefined equal clusters. The distribution of each attribute determines its partitioning as fine or coarse. A simple grid partitioning partitions each attribute equally and is therefore not effective in handling varying distribution amongst the attributes. A data-adaptive method uses a data frequency-driven approach to partition each attribute based on the distribution of data in that attribute. A data-adaptive neuro-fuzzy inference system creates corresponding rules for both finely distributed and coarsely distributed attributes. This method produced more useful rules and a more effective classification system. We obtained an overall accuracy of 98.55 %. © 2015, International Federation for Medical and Biological Engineering. Source


Thanusubramanian H.,Manipal University India | Patil N.,Manipal University India | Shenoy S.,Manipal University India | Bairy K.L.,Manipal University India | Sharma Y.,KMC Manipal
Journal of Clinical and Diagnostic Research | Year: 2014

The author reports a 55-year-old female diagnosed of chronic kidney disease grade-5 with associated co-morbidities like type 2 diabetes mellitus, diabetic retinopathy and hypothyroidism was admitted for arteriovenous fistula construction. She was started on ferric carboxymaltose for the treatment of anaemia. She was given a test dose before administering the drug intravenously and she did not develop any reaction. The drug ferric carboxymaltose was then administered over a period of one hour. About half an hour after drug administration, the patient developed breathlessness and myalgia. After half hour of the above episode of breathlessness and myalgia. She also developed vomiting (one episode). Patient was managed with oxygen therapy, IV fluids and other drugs like corticosteroids, phenaramine maleate and nalbuphine which controlled the above symptoms. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Kulkarni C.,KMC Manipal | Vivekanand U.,ASRAM Medical CollegeAndhra Pradesh
Journal of Clinical and Diagnostic Research | Year: 2014

Purpose: To determine the outcomes of extra large temporal sclero-corneal tunnel incision Cataract Surgery.Materials and Methods: This consecutive case series of eyes undergoing temporal tunnel cataract extraction with tunnel length of 8 to 10 mm was identified retrospectively. Surgical procedure details, follow up, complications, visual and astigmatic outcomes at 6wks were recorded and analysed.Results: Ninety six eyes with extra large tunnel incision were identified for analysis from a dataset of 670 manual small incision cataract surgery cases. 58% eyes had NO5 or denser cataracts. Intraoperative complications included, tunnel related problems (1 eye, 1.04%), bleeding into Anterior Chamber (10 eyes, 10.4%), Posterior Capsular Rent (2 eyes, 2.1%). Early postoperative complications included striate keratopathy (7 eyes, 7.3%). The mean Best Corrected Visual Acuity was 6/7.5 (0.1 logMAR) and 98% cases had Best Corrected Visual Acuity of 6/12 (0.3 logMAR) or better at 6wk. The aggregate Surgically Induced Astigmatism was 0.32D at 850.Conclusion: Extra Large Tunnel of length 8 to 10 mm can be self sealing with low SIA. The complication rates and visual outcomes of ETCE are comparable to those of conventional MSICS. This method can be valuable in complicated cases and during learning period. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Jayaprakash B.,Manipal University India | Karthik Rao N.,Manipal University India | Patil N.,Manipal University India | Balaji O.,Manipal University India | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

Melioidosis, a highly contagious disease, often fatal caused by Burkholderia pseudomallei, a gram negative bacteria, often lurks in water, soil and air and is widely prevalent in India. It is a nightmare to the physician to reach to a substantial diagnosis as it mimics various infections. High variability is seen in the clinical presentation and ranges from acute respiratory illness to chronic debilitating illness with pneumonia being the commonest presentation. Sputum culture remains the gold standard for diagnosing melioidosis. Antibiotics remains the choice of treatment. It often presents as community-acquired pneumonia and sepsis, but can involve almost any part of the body. In this case report, we illustrate a rare but fatal complication of this increasingly reported and important disease. A 61 year old patient, known alcoholic, smoker and a diabetic, presents with low grade fever, night sweats associated with cough and hemoptysis since 10 days to the emergency department. Vitals were stable and chest X-ray revealed right hilar prominence with opacity in upper zone and CT scan reveals right apical segment cavity with pseudoaneurysm and centrilobular nodules. Sputum samples for AFB and malignant cells were negative. Sputum culture showed burkholderia pseudomallei sensitive to ceftazidime and the patient was started on parenteral ceftazidime, continued for 10 days and then shifted to oral ceftazidime and cotrimoxazole for a period of 8 weeks. The condition of the patient gradually improved, hemoptysis stopped in two weeks. After 8 weeks on follow up visit patient was clinically normal. Further studies are necessary to determine the medical, economical impact and their outcomes in endemic population in India. © 2010 RJPBCS. Source


Rao N.K.,Manipal University India | Jayaprakash B.,Manipal University India | Patil N.,Manipal University India | Rau N.R.,Yenepoya Medical College | And 2 more authors.
Journal of Applied Pharmaceutical Science | Year: 2016

The author reports a case of a 22-year-old female, daughter of a known hypertensive patient, who happened to consume her mother's medicine. Her mother was on a fixed drug combination (FDC) of amlodipine and atenolol. The patient was brought to the emergency department with drowsiness following ingestion of 15 tablets of amlodipine-atenolol FDC (5+ 50 mg). On evaluation, she had refractory bradycardia and hypotension along with hyperkalemia. She was managed initially with gastric lavage with activated charcoal, and subsequently with supplementation of atropine, inotropes, anti-hyperkalaemic measures, pacemaker and levosimendan. © 2016 N. Karthik Rao et al. Source

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