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Onbasilar E.E.,Ankara University | Unal N.,Ankara University | Erdem E.,Klrlkkale University | Kocakaya A.,Ankara University | Yaranoglu B.,Ankara University
Poultry Science | Year: 2014

The aim of this study was to investigate the differences in production performance, use of nest box, and external appearance of 2 strains of laying hens kept in conventional and enriched cages. Lohmann Brown Classic (LB, n = 532) and Lohmann LSL Classic (LW, n = 532) hens were housed from 16 to 73 wk in either conventional cages or enriched cages. Enriched cages had a nesting area, scratch pad, perch, and nail shortener. Body weight (BW), hen-day egg production, egg weight, feed intake, feed conversion ratio (FCR), cracked and dirty eggs, use of nest box for lay, and external appearance were determined. Laying period influenced the hen-day egg production, egg weight, feed intake, and feed conversion ratio. Cage type affected the hen-day egg production and feed conversion ratio, while strain affected the egg weight, feed intake, and feed conversion ratio. Laying period × cage type and laying period × strain interactions affected egg production, egg weight, and feed conversion ratio. Both strains preferred to lay in the nest box. Percentages of cracked and dirty eggs of LW hens in enriched cages were higher than that in conventional cages. Most of the dirty eggs laid by both strains were found outside of the nest box. The LW hens laid more dirty eggs than the LB hens. Cage type and cage type × strain interaction were important for total feather score. Final claw length was affected by cage type, strain, and cage type × strain interaction. This study suggests that cage type, strain, and also cage type × strain and period × strain interactions should be considered when alternative housing systems are used. © 2015 Poultry Science Association Inc.

Kocael A.,Istanbul University | Inal B.B.,Istanbul Education and Research Hospital | Guntas G.,Istanbul Education and Research Hospital | Kelten C.,Istanbul Education and Research Hospital | And 7 more authors.
Human and Experimental Toxicology | Year: 2016

Background: In this study, we investigated the alterations of matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMPs), acute inflammation, and oxidative damage in the circulatory system and the intestine in response to mesenteric ischemia/reperfusion (I/R). Methods: Twenty-one rats were divided randomly into the following three groups (n = 7 in each group): a sham group (CG), an ischemic group (IG), and an I/R group (I/RG). MMP-9, TIMP-1, and myeloperoxidase (MPO) were measured using the enzyme-linked immunosorbent assay method, and lipid peroxidation (quantified as thiobarbituric acid reactive substances (TBARS) content), ischemia-modified albumin, the prooxidant-antioxidant balance (PAB), and ferric-reducing antioxidant power (FRAP) were measured spectrophotometrically. The degree of intestinal injury was evaluated according to the Chiu scoring system. Results: A significant difference between the mean serum TIMP-1 and MMP-9 levels and the alanine transaminase activity was found among the groups. Compared with the I/RG group a significant difference in the mean tissue MMP-9, MPO, and TBARS levels in addition to the PAB and FRAP was found between the CG and IG groups. The level of MMP-9 also demonstrated a strong, positive, and valid correlation with the TBA-RS levels. A significant morphological change was observed in both the IG and the I/RG groups. The degree of intestinal injury was more severe in the I/R group and was characterized by either villous denudation or villous loss. Conclusions: These results suggest that MMP-9, TIMP-1, MPO, and oxidative stress may be important in the intestinal injury development that is induced by acute mesenteric I/R in a rat model. MMP-9 overexpression may increase the extent of intestinal villous loss, particularly when MMP-9 is upregulated by the TBARS present in the intestinal injury. © The Author(s) 2015.

Akbas H.,Gaziosmanpasa University | Okumus A.,Ankara University | Karada A.,Gaziosmanpasa University | Klllc Z.,Ankara University | And 5 more authors.
Journal of Thermal Analysis and Calorimetry | Year: 2016

The salicylic acid salts of fully substituted mono(4-fluorobenzyl)spirocyclotriphosphazenes (10-15) were prepared. The structures of these phosphazenium salts (10a-15a) were determined by elemental analyses, FTIR and 1H, 13C{1H}, 31P{1H} NMR techniques. The crystal structure of 14a was verified by X-ray diffraction analysis. The thermal properties of the salts were investigated using TG/DTA and DSC instruments. The results obtained from DSC indicated that the melting temperatures and latent heats of the compounds were in the ranges of 107.76-143.04 °C and 41.64-69.73 J g-1, respectively. The thermal stabilities of the phosphazenium salts (10a-15a) are found to be different, but they have a similar decomposition mechanism. The compounds 14a and 15a exhibit noticeable cytotoxic activity against DLD-1 cancer cells, and they seem to be good candidates for being anticancer agents. All of the compounds have an antimicrobial effect on bacterial and yeast strains within the ranges of 312-625 μM (bacterial strains) and 19.5-312 μM (yeast strains). It is found that compounds 13a-15a were most effective against yeast strains. Moreover, interactions between the salts and pBR322 plasmid DNA show that 14a and 15a cleave the DNA and decrease the intensity of form I. BamHI and HindIII digestion results demonstrate that the compounds are not bound with G/G and A/A nucleotides, respectively. © 2015 Akadémiai Kiadó, Budapest, Hungary.

Yildiz E.,Klrlkkale University | Aydin A.,Klrlkkale University | Sarpun !.H.,Afyon Kocatepe University | Tel E.,Osmaniye Korkut Ata University
EPJ Web of Conferences | Year: 2015

The cross sections and astrophysical S-factors of the 63Cu(α,γ) and 63Cu(α,n) reactions have been calculated. The radiative alpha capture reaction cross sections was calculated in the incident energy range of 3 to 10 MeV and the (α,n) reaction cross sections was calculated in the incident energy range of 7 and 16 MeV. In these theoretical calculations, the TALYS 1.6 and NON-SMOKER codes were used. Also for these reactions, it was calculated the astrophysical S-factors which describe the possibility of reaction in low energies. Obtained results were compared to the experimental data taken from EXFOR database. © 2015 Owned by the authors, published by EDP Sciences.

Yumusak E.,Klrlkkale University | Yumusak E.,Kirikkale University | Dikel N.H.,Klrlkkale University | Ornek K.,Klrlkkale University
BMC Ophthalmology | Year: 2015

Background: The aim of this study was to investigate the potential significance of the central macular thickness (foveal thickness-FT) and choroidal thickness (CT) in the eyes of patients with iron-deficiency anemia, the most common form of the anemia, via enhanced-depth imaging optical coherence tomography (EDI-OCT). We also investigated whether such changes might serve as an early indicator of underlying hematological disease. Methods: This prospective clinical study compared 96 female patients with iron-deficiency anemia and 60 healthy female control subjects. The macular and choroidal thicknesses in the temporal and nasal subfoveal areas were measured using enhanced-depth imaging optical coherence tomography (EDI-OCT) at 500 and 1500 microns and in five different regions (FCT, T1500, T500, N500, and N1500). Results: The mean ages of the patients and healthy controls were 34.08 ± 10.39 years and 32.29 ± 8.28 years, respectively (P =0.232). There were no significant changes in macular thickness between the groups (225.58 ± 19.76 vs. 222.45 ± 13.51, P =0.2). The choroidal thickness was significantly reduced in the patient group relative to the controls at all measured points (foveal choroidal thickness, P = 0.042; nasal-500 microns, P = 0.033; temporal-500 microns, P = 0.033; and temporal-1500 microns, P = 0.019). At some points, the choroidal thickness findings correlated with the hemoglobin values (temporal-500 microns, r = -0.287, P = 0.001; nasal-500 microns, r = -0.287, P = 0.005; nasal-1500 microns, r = -0.245, P = 0.016; and temporal-1500 microns, r = -0.280, P = 0.06). Conclusions: Patients with iron-deficiency anemia had a significantly reduced choroidal thickness. © 2015 Yumusak et al.

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