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Krawczuk-Rybak M.,Klinika Onkologii i Hematologii Dzieciecej | Panasiuk A.,Klinika Onkologii i Hematologii Dzieciecej | Muszynska-Roslan K.,Klinika Onkologii i Hematologii Dzieciecej | Stachowicz-Stencel T.,Klinika Pediatrii | And 24 more authors.
Onkologia Polska | Year: 2012

Introduction: Anticancer treatment provokes the development of the late complications in different organs in survivors, decreased quality of life and increased risk of premature death. The aim of the study: the first Polish multicenter analysis of health status in children and adolescents >2 years after anticancer treatment. Material and methods: The data received from 1021 survivors observed in between 2008--2012 in Polish pediatric oncology institutions. Results: In analyzed group of survivors 420 (41.14%) presented normal health status; impaired growth was found in 19.2%, with the influence of cranial irradiation on height <3 centile (p<0.018), overweight/obesity - in 9.5%. The signs of thyroid dysfunction were reported in 17.2%, abnormal gonadal function - in 19.55% males and 14.48% females. Pulmonary toxicity was observed in 14.6% and cardiovascular disorders - in 20.87% cases. The different signs of renal dysfunction were presented in 18.94%, gastrointestinal - in 18.7%, liver - in 9.27%, immunological abnormalities - in 19.52%, ototoxicity - in 9.5% of survivors. Six cases of second cancer has been identified (acute myeloblastic leukemia - 3 cases, soft tissue sarcoma - 1, T cell non-Hodgkin lymphoma - 1, myelodysplastic syndrome - 1). Conclusions: Our first analysis has indicated that near 60% of cancer survivors present at least one organ late effect. It suggests the need and importance for regular, continuous and long-time monitoring for early diagnosis, prophylaxis, and treatment of different organ complications. Copyright © 2012 Cornetis. Source

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