Hradec Králové, Czech Republic
Hradec Králové, Czech Republic

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Salavec M.,Klinika nemoci koznich a pohlavnich | Bostikova V.,University of Hradec Kralove | Smetana J.,University of Hradec Kralove | Chlibek R.,University of Hradec Kralove | And 2 more authors.
Epidemiologie, Mikrobiologie, Imunologie | Year: 2014

Epidemiological data on sexually transmitted infections in the Czech Republic has been carefully reported for many years. Here we present an analysis of regional data on syphilis spanning more than 30 years in eastern Bohemia. The epidemiological data were derived from the mandatory reporting of sexually transmitted diseases covering the period 1981-2011. The data showed a minimal incidence of cases in 1990 and an increasing trend thereafter. Two peaks in the incidence are apparent - within years 1995-1999 and 2003-2007. Interestingly, while before 1990 the numbers of positive men always exceeded those of women, their numbers equalized or even reversed within the two peaks. The results may also reflect trends in social change in the country after 1989. The analysis showed that the regional prevalence of syphilis in eastern Bohemia still remains low compared to some other regions of the Czech Republic. © 2001, Czech Medical Association J.E. Purkyne. all right reserved.


Bostikova V.,Katedra epidemiologie | Salavec M.,Klinika nemoci koznich a pohlavnich | Smetana J.,Katedra epidemiologie | Sleha R.,Katedra epidemiologie | And 3 more authors.
Epidemiologie, Mikrobiologie, Imunologie | Year: 2014

Varicella-zoster virus (VZV), herpes simplex virus one (HSV-1) and herpes simplex virus two (HSV-2) represent three out of the eight known human herpesviruses and belong to the subfamily of α-herpesviruses. These viruses are present worldwide and humans are their sole host and reservoir. After the primary infection, these viruses persist in the body throughout life. The period of latency may be interrupted by reactivation of infection due to various factors. Each virus can induce a wide spectrum of diseases. The primary infection is typical for children and otherwise healthy individuals are often asymptomatic. It is mainly immunocompromised patients who are at risk of developing severe disease or complications when infected by these viruses. However, even in otherwise healthy individuals an infection by a-herpesviruses can run a severe course and lead to death.


Markova L.,Klinika nemoci koznich a pohlavnich | Ettler K.,Klinika nemoci koznich a pohlavnich
Cesko-Slovenska Dermatologie | Year: 2013

Hand foot and mouth disease is an viral exanthematic disease typical for children, often ocurring in adults as well. Authors report three cases observed in the same period in the region of Hradec Králové. They describe clinical picture, laboratory diagnostic methods, differential diagnosis, complications and possible epidemiologic relations of the disease.


Celakovska J.,Klinika nemoci koznich a pohlavnich | Ettlerova K.,Ambulance klinicke imunologie a alergologie | Ettler K.,Klinika nemoci koznich a pohlavnich | Vaneckova J.,Klinika nemoci koznich a pohlavnich | Bukac J.,Ustav lekarske biofyziky
Cesko-Slovenska Dermatologie | Year: 2011

Aim: To evaluate the effect of the diagnostic hypoallergenic diet on the severity of atopic eczema in patients over 14 years of age. The diet is an important step in the diagnostic workup of the food allergy in this group of patients. Methods: The diagnostic hypoallergenic diet for the period of 3 weeks was recommended to patients suffering from atopic eczema. The severity of atopic eczema was evaluated at the beginning and at the end of the diet (SCOrAD I, SCORAD II), the difference of SCORAD was evaluated statistically. Results: 149 patients completed the diet: 108 females and 41 males with the average age of 26.03 (SD 9.6 years), min. 14, max. 63 years; with the median SCORAD 132.9 points, SD 14.11 at the beginning of the study and with the median ScORAD II 25.2 points, SD 9.99 at the end of the diet. The difference between SCORAD I and SCORAD II was evaluated with Wilcoxon signed-rank test. The average decrease of SCORAD was 7.7 points and was calculated as substantial (p-value = 0.0001). Conclusion: On the basis of our results we recommend to introduce the diagnostic hypoallergenic diet as a temporary medical arrangement in patients suffering from moderate or severe form of atopic eczema. The diet shall serve as the important diagnostic test in the diagnostic workup of food allergy especially in those with the severe form of eczema.


Article reviews some skin and mucosal lesions associated with diabetes mellitus with focus on skin fungal infections and necrobiosis lipoidica.


Chladek J.,Ustav farmakologie | Simkova M.,Klinika nemoci koznich a pohlavnich | Vaneckova J.,Klinika nemoci koznich a pohlavnich | Hroch M.,Ustav farmakologie | And 3 more authors.
Cesko-Slovenska Dermatologie | Year: 2012

Methotrexate (MTX) is an effective immunosuppressive drug formoderate-to-severe psoriasis. In an open prospective study patients with chronic plaque psoriasis (n = 25, aged 28-79 yr) were treated with oral methotrexate using an individualized dose guided by plasma concentrations and with folic acid in case the concentration of blood folates dropped below the lower limit of normal range. The aimwas to study the relationship between changes in PASI (the Psoriasis Area and Severity Index) and concentrations of MTX polyglutamates (MTXPG) in erythrocytes and blood folates. After 26 weeks, PASI improved fromthemedian of 13.5 (range 2.2-33) by 91% on the average and the frequency of PASI75 (improvement ≥ 75 %) was 76%. There was a correlation between PASI improvement and the ratio of concentrations MTXPG/folates (rs = 0. 51, P < 0.01). In patients experiencing PASI75, the ratio achieved 0.61 as compared to 0.26 in those with less improvement (P < 0.05). In conclusion, individual-tailored therapy with MTX and folic acid can improve the results in the remission-induction phase of psoriasis treatment. Its efficacy should be compared with other established drug regimens in controlled studies.


Celakovska J.,Klinika nemoci koznich a pohlavnich | Ettlerova K.,Ambulance klinicke imunologie a alergologie | Ettler K.,Klinika nemoci koznich a pohlavnich | Vaneckova J.,Ustav lekarske biofyziky | Bukac J.,Ustav lekarske biofyziky
Cesko-Slovenska Dermatologie | Year: 2015

A few reports demonstrate the relationship between IgE sensitization to aeroallergens in atopic dermatitis and other allergic diseases and parameters. The objective of this study is to evaluate, if there is a significant relationship between the sensitization to common aeroallergens in atopic dermatitis patients and the occurrence of asthma bronchiale, rhinitis, and other atopic parameters. Sensitization to dust, mites, animal dander, and bird feather was examined byskin prick test and specific IgE. The relationship of sensitization to these allergens and the occurrence of asthma bronchiale, rhinitis, duration of atopic dermatitis, family history, and onset of atopic dermatitis was evaluated. We examined 288 patients, 90 men and 198 women. According to our results, IgE sensitisation to animal dander, dust and mites may increase the risk of developing asthma or rhinitis. In patients with sensitization on the feathers of birds occurs significantly more frequently the onset of atopic eczema after the 5th year of life and in these patients no relationship to the positive family history of atopy has been found. © 2015, Czech Medical Association J.E. Purkyne. All rights reserved.


Ettler K.,Klinika nemoci koznich a pohlavnich
Pediatrie pro Praxi | Year: 2011

Vitamin D is involved in bone tissue metabolism. Recently it has been suggested to prevent cancer and to have any other positive health effects. UV radiation photosynthesis of vitamin D in the epidermis is its natural source. It could be controversial for some adverse events of UV radiation on the skin. Sunbathing and photoprotection regarding vitamin D serum level and use of mineral sunscreens with nanoparticules in kids are discussed here. Sun beds do not be a suitable source for vitamin D supply. The vitamin D supplementation is possible by diet and drug delivery.


Drlik L.,Dermatovenerologicke oddeleni | Ettler K.,Klinika nemoci koznich a pohlavnich
Cesko-Slovenska Dermatologie | Year: 2011

The authors describe two cases of intensively itching lichenoid dermatitis developed after an injury caused by a sea coral while diving in the Red Sea. The rash reacted to topical steroid and antihistamine treatment. In the first case a partial improvement occurred within two weeks, in the other patient dermatological lesions persisted for more than a month. The article gives an overview of skin lesions caused by the sea corals and their therapy.


Ettler J.,Dermatovenerologicka klinika | Ettler K.,Klinika nemoci koznich a pohlavnich
Pediatrie pro Praxi | Year: 2014

Photosensitivity in pediatric population is much less prevalent then in adults. Every unexpected reaction to sun exposure should be thoroughly investigated for it can be manifestation of serious systemic disease. Early diagnosis can lower risks of future complications, comorbidities and decreased quality of life or life expectancy. Mainstay of management is careful fotoprotection and specific treatment, if available.

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