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The updated Rome III Classification of paediatric functional gastrointestinal disorders (FGIDs) associated with abdominal pain comprises: functional dyspepsia (FD), irritable bowel syndrome (IBS), abdominal migraine, functional abdominal pain (FAP), functional abdominal pain syndrome (FAPS). To assess the value of the Rome criteria in identifying FGIDs in children with chronic abdominal pain. The study group consisted of 439 consecutive paediatric patients (192 boys and 247 girls) aged 4-18 years (mean age was 11.95 +/- 3.89 years) referred to the Paediatric Gastroenterology Department at Medical University of Lodz from January 2008 to June 2009 for evaluation of abdominal pain of at least 2 months' duration. After exclusion of organic disease children suspected of functional chronic abdominal pain were categorized with the use of Rome III criteria of FGIDs associated with abdominal pain (H2a-H2d1) and the Questionnaire on Paediatric Gastrointestinal Symptoms (with the permission of doctor L. S. Walker). The patients with known nonabdominal organic disease, chronic illness or handicap were excluded. In 161 patients (36.58%) organic etiology was confirmed. Of the 278 children (63.42%) with functional chronic abdominal pain, 228 (82.02%) met the Rome III criteria for FGIDs associated with abdominal pain (FD, 15.5%; IBS, 21.6%; abdominal migraine, 5%; FAP 24.5%; FAPS, 15.9%). Fifty cases (17.98%) did not fulfill the criteria for subtypes of abdominal pain-related FGIDs--mainly due to different as defined by Rome III criteria (at least once per week) frequency of symptom presentation. (1) In the authors'investigations FGIDs was the most frequent cause of chronic abdominal pain in children. (2) The significant number of children with nonclassified FGIDs implies the need to modify the diagnostic criteria of Rome III classification concerning the prevalence of symptoms.

Sieminska A.,Klinika Alergologii
Pneumonologia i Alergologia Polska | Year: 2010

Numerous studies indicate genetical background of susceptibility to tobacco smoking. The current review presents new achievements and perspectives in searching for genes involved in tobacco smoking and dependence, which have been described in recent years as a result of the development of molecular techniques. It has been emphasized that tobacco smoking is a complex, polygenic behavior. Presence of multiple gene-gene and gene-environment interactions makes it difficult to find a strong genetic association. The causes of inconsistency in the results of candidate gene association studies, as well as the new perspectives in searching for genetic determinants of tobacco smoking, are also widely discussed. In particular, the focus is on the genome-wide association studies which allow the complex analysis of links between thousands of single nucleotide polymorphisms with smoking phenotypes. Copyright © 2010 Via Medica.

Drozd-Werel M.,Klinika Pneumonologii | Porzezinska M.,Klinika Pneumonologii | Cynowska B.,Klinika Pneumonologii | Garbicz S.,NZOZ | And 3 more authors.
Pneumonologia i Alergologia Polska | Year: 2012

Pulmonary actinomycosis is a rare disease caused by Actinomyces sp. Its symptoms and radiological findings are not characteristic, so the diagnosis might be difficult to establish. We report a case of a 59 year old male, who developed bronchopulmonary Actinomycosis due to poor dental hygiene. The infectious process affected lung parenchyma and infiltrated chest wall causing multifocal sternal osteolisis and multiple cutaneous fistulas. The radiological findings sugested neoplasmatical process. The diagnosis was based on histopatological findings of fistular scrapes. The material contained Actinomyces colonies. Afler 6 months of antibiotic therapy the patient's state improved and the cutaneous fistulas healed. Radiological finding revealed partial resolution of the lung infiltration. © 2012 Via Medica.

Regulatory T (Treg) cells play a key role in controlling adaptive immune response and maintaining tolerance to innocuous self- and environmental proteins. There is a growing speculation that impairment in these pathways could be central in pathogenesis of many immune diseases, including allergic diseases. Although several studies suggest deficiencies in allergen-specific Treg cell numbers or function in allergic diseases, others have shown the opposite. Based on a review of recent literature, this article presents current views on naming, distribution, molecular characterization, mechanism of the action of regulatory T lymphocytes, and shows their importance in allergic diseases in both adults and children, with particular reference to food allergy. Understanding the mechanisms of immune system disorders that underly allergic diseases may help improve the treatment, prevention, and thus long-term prognosis. It seems that the development of knowledge on Treg CD4+CD25+ cells will enable the development of new therapeutic strategies, so important especially in relation to food allergy, as the first manifestation of atopy in children. © Alergia Astma Immunologia 2010.

Wasowska-Krolikowska K.,Klinika Alergologii | Kroculska A.,Klinika Alergologii
Family Medicine and Primary Care Review | Year: 2013

Food allergy (FA) is a widespread and growing disease, especially in children and adolescents. Proper diagnosis of FA plays a crucial role, especially in children. FA diagnosis is difficult and is still imperfect. The basic diagnostic tools for FA include: history, elimination diet, physical examination, assessment of specific IgE in vivo and in vitro and oral food challenges, that consistently over the years have remained the gold standard diagnostic tool. In this paper the authors present new opportunities for diagnostics using recombinant allergens, microarray test, test cell activation, atopy patch tests etc. © by Wydawnictwo Continuo.

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