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Hannover, Germany

Koch R.,Anatomisches Institute | Hennig-Pauka I.,Klinik fur Kleine Klauentiere | Gasse H.,Anatomisches Institute
Pneumologie | Year: 2010

The histological composition of the Lamina propria in pigs especially in the cranial fold of the glottis gives reason to expect other phoniatric properties than in man. Age-related changes must be considered. © 2010 Georg Thieme Verlag KG Stuttgart New York.

Ganter M.,Klinik fur Kleine Klauentiere
Tierarztliche Praxis Ausgabe G: Grosstiere - Nutztiere | Year: 2013

The epidemic occurrence of the Schmallenberg virus has induced numerous congenital malformations in small ruminants. Because of this high incidence of malformed lambs, an overview of the different causes of congenital malformations is provided. The most frequent infectious and physical causes as well as mineral and vitamin deficiencies and toxic agents which can induce congenital malformations are indicated. This list is supplemented by advice on sampling and laboratory diagnosis for an etiological diagnosis of the malformations. © 2013 Schattauer.

Strobel H.,Tierarztpraxis Dr. Strobel | Moors E.,University of Gottingen | Ganter M.,Klinik fur Kleine Klauentiere | Spengler D.,Tierseuchenkasse Baden Wurttemberg | Voigt K.,Ludwig Maximilians University of Munich
Tierarztliche Praxis Ausgabe G: Grosstiere - Nutztiere | Year: 2012

Lameness in sheep induced by infectious agents can cause problems regarding animal welfare, diagnosis and treatment. Individual lame animals and lameness caused by systemic disease, but especially flock problems due to infectious causes of lameness, such as foot rot, can for various reasons pose a problem for veterinary treatment. The causes of lameness in sheep are described with a special focus on infectious flock problems, and the different treatment options such as foot trimming, foot baths and local and systemic antibiotic therapy as well as vaccination are discussed based on a review of recent international research. The limited choice of drugs licensed for use in sheep in Germany is highlighted. Treatment, therefore, often requires off-label use or the import of footbathing agents licensed in other European countries. The legal consequences of this lack of nationally licensed veterinary products in dealing with a "minor species" are discussed, with a final call for political solutions that will help improve this unsatisfactory situation. © Schattauer 2012.

Ulrich R.,Institute For Pathologie | Buck B.,Klinik fur Kleine Klauentiere | Distl O.,Institute For Tierzucht Und Vererbungsforschung | Wohlsein P.,Institute For Pathologie
Tierarztliche Praxis Ausgabe G: Grosstiere - Nutztiere | Year: 2014

Tumours with skeletal-muscle differentiation are rare in companion animals. They are differentiated into benign rhabdomyomas and malignant rhabdomyosarcomas. A female German Holstein calf displayed a congenital, spherical, subcutaneous mass at the lateral side of the head. Histology revealed an encapsulated, expansile, highly cellular mass consisting of a reticular meshwork of moderately pleomorphic, small spindle-shaped to round cells within a fibrovascular to myxoid stroma as well as multifocal, large, blunt, multinucleated myotube-like cells (strap cells). Electron microscopy demonstrated characteristic cytoplasmic bundles of myofilaments and Z-stripes within the strap cells. Immunoreactivity for vimentin was observed in the small spindleshaped cells and for desmin in the strap cells. The results are consis -tent with the spectrum of findings characteristic for a bovine con -genital embryonal rhabdomyosarcoma. © Schattauer 2014.

Forsbach-Birk V.,University of Ulm | Foddis C.,University of Ulm | Simnacher U.,University of Ulm | Wilkat M.,University of Ulm | And 5 more authors.
PLoS ONE | Year: 2013

Enzootic abortion of ewes (EAE) due to infection with the obligate intracellular pathogen Chlamydia (C.) abortus is an important zoonosis leading to considerable economic loss to agriculture worldwide. The pathogen can be transmitted to humans and may lead to serious infection in pregnant women. Knowledge about epidemiology, clinical course and transmission to humans is hampered by the lack of reliable diagnostic tools. Immunoreactive proteins, which are expressed in infected animals and humans, may serve as novel candidates for diagnostic marker proteins and represent putative virulence factors. In order to broaden the spectrum of immunogenic C. abortus proteins we applied 2D immunoblot analysis and screening of an expression library using human and animal sera. We have identified 48 immunoreactive proteins representing potential diagnostic markers and also putative virulence factors, such as CAB080 (homologue of the "macrophage infectivity potentiator", MIP), CAB167 (homologue of the "translocated actin recruitment protein", TARP), CAB712 (homologue of the "chlamydial protease-like activity factor", CPAF), CAB776 (homologue of the "Polymorphic membrane protein D", PmpD), and the "hypothetical proteins" CAB063, CAB408 and CAB821, which are predicted to be type III secreted. We selected two putative virulence factors for further characterization, i.e. CAB080 (cMIP) and CAB063, and studied their expression profiles at transcript and protein levels. Analysis of the subcellular localization of both proteins throughout the developmental cycle revealed CAB063 being the first C. abortus protein shown to be translocated to the host cell nucleus. © 2013 Forsbach-Birk et al.

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