Stauch B.,Structural and Computational Biology Unit |
Simon B.,Structural and Computational Biology Unit |
Basile T.,Structural and Computational Biology Unit |
Schneider G.,ETH Zurich |
And 4 more authors.
Angewandte Chemie - International Edition
chemical equation presentation Complex considerations: The proteasome plays a key role in diseases and is thus an appealing drug target. A structural model (see picture) of the proteasome as a complex with argyrin, a cyclic heptapeptide with antitumoral activity, provides a rationale for the high biological activity of this natural product. The structure-activity-relationship data available for the drug are discussed on the basis of this model. © 2010 Wiley-VCH Verlag GmbH & Co. KCaA, Weinheim. Source