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Basel, Switzerland

Haas P.,Institute of Physics | Then P.,Physikalisches Institute | Wild A.,Institute of Physics | Grange W.,Institute Jacques Monod | And 6 more authors.
Analytical Chemistry | Year: 2010

The applicability of single-molecule fluorescence assays in liquids is limited by diffusion to concentrations in the low picomolar range. Here, we demonstrate quantitative single-molecule detection at attomolar concentrations within 1 min by excitation and detection of fluorescence through a single-mode optical fiber in presence of turbulent flow. The combination of high detectability and short measurement times promises applications in ultrasensitive assays, sensors, and point-of-care medical diagnostics. © 2010 American Chemical Society. Source


Givens R.S.,University of Kansas | Rubina M.,University of Kansas | Wirz J.,Klingelbergstrasse
Photochemical and Photobiological Sciences | Year: 2012

Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds and their (often commercially available) derivatives that, however, have several disadvantages. The focus of this review is on applications of the more recently developed title compounds, which are especially well suited for time-resolved biochemical and physiological investigations, because they release the caged substrates in high yield within a few nanoseconds or less. Together, these two chromophores cover the action spectrum for photorelease from >700 nm to 250 nm. © 2012 The Royal Society of Chemistry and Owner Societies. Source


Haussinger D.,St. Johanns Ring | Pfohl T.,Klingelbergstrasse
Chimia | Year: 2010

Biophysical chemistry at the Department of Chemistry, University of Basel, covers the NMR analysis of protein-protein interaction using paramagnetic tags and sophisticated microscopy techniques investigating the dynamics of biological matter. © Schweizerische Chemische Gesellschaft. Source


Glatt K.,Klingelbergstrasse | Glatt K.,University of Heidelberg | Grebel E.K.,Klingelbergstrasse | Grebel E.K.,University of Heidelberg | Koch A.,University of Leicester
Astronomy and Astrophysics | Year: 2010

Aims. In this paper we discuss the age and spatial distribution of young (age < 1 Gyr) Small Magellanic Cloud (SMC) and Large Magellanic Cloud (LMC) clusters using data from the Magellanic Cloud Photometric Surveys. Luminosities are calculated for all age-dated clusters. Methods. The ages of 324 and 1193 populous star clusters in the SMC and the LMC were determined fitting Padova and Geneva isochrone models to their resolved color-magnitude diagrams. The clusters cover an age range between 10 Myr and 1 Gyr in each galaxy. For the SMC, a constant distance modulus of $(m-M)-0$ = 18.90 and a metallicity of Z = 0.004 were adopted. For the LMC, we used a constant distance modulus of $(m-M)-0$ = 18.50 and a metallicity of Z = 0.008. For both galaxies, we used a variable color excess to derive the cluster ages. Results. We find two periods of enhanced cluster formation in both galaxies at 160 Myr and 630 Myr (SMC) and at 125 Myr and 800 Myr (LMC). We present the spatially resolved recent star formation history of both Clouds based on young star clusters. The first peak may have been triggered by a close encounter between the SMC and the LMC. In both galaxies, the youngest clusters reside in the supergiant shells, giant shells, the intershell regions, and toward regions with a high Hα content, suggesting that their formation is related to expansion and shell-shell interaction. Most of the clusters are older than the dynamical age of the supergiant shells. No evidence of cluster dissolution was found. Computed V band luminosities show a trend toward fainter magnitudes with increasing age, as well as a trend toward brighter magnitudes with increasing apparent cluster radii. © 2010 ESO. Source

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