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Chandwani P.,Heart and General Hospital | Prajapati J.,Apollo Hospitals International Ltd | Porwal S.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Khambhati B.,Sahajanand Medical Technologies Pvt. Ltd | Thakkar A.,Sahajanand Medical Technologies Pvt. Ltd
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: Coronary artery disease is the most common catastrophic disease in India. The safety and effectiveness of dual vessel sirolimus-eluting stent (SES) implantation (used as an intervention in CAD) is currently unknown in Indian population. The purpose of this study was to investigate one year clinical outcomes of patients with dual vessel coronary artery disease after implantation of the Supralimus-Core SES, in a "real-world" setting. Materials and Methods: We evaluated 60 patients between April-2011 and August-2012, who underwent dual vessel percutaneous coronary intervention (PCI) with the Supralimus-Core SES implantation at the same index procedure. Dual vessels were defined as involvement of two major epicardial vessels (right, left anterior descending, circumflex, or left main coronary arteries) or one major epicardial vessel and a branch (≥2.5 mm in diameter) originating from another major epicardial vessel. The primary endpoint was target lesion failure (TLF) defined as the composite of cardiac death, myocardial infarction (MI), and clinically-driven target lesion revascularization (TLR) at one year. Secondary endpoint included combined (definite, probable and possible) stent thrombosis (ST). Results: A total of 120 lesions were treated in 60 enrolled patients (mean age 56.0±9.2 y; 80.0% male) with average stent length of 23.1±8.5 mm. Among 60 patients, diabetes, hypertension and hypercholesterolemia were present in 15 (25.0%), 22 (36.7%) and 25 (41.7%) patients respectively. Indications for PCI were unstable angina in 30 (50.0%) patients and stable angina in 11 (18.3%) patients. Overall, 40 (33.3%) lesions were classified as complex (American College of Cardiology/American Heart Association type B2/C). The cumulative TLF rate was 5.0% (n=3) at one year. Cardiac death, MI and clinically-driven TLR occurred in 1 (1.7%), 0 (0%) and 2 (3.3%) patients, respectively at one year follow-up. The Kaplan-Meier curve of the freedom from overall events at one year was 95.0%. According to the Academic Research Consortium definition, there were no events of stent thrombosis during one year. Conclusion: Our study shows that, dual vessel Supralimus-Core SES implantation allows safe and effective treatment with low rates of TLF at one year follow-up in Indian population. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


PubMed | Circle Technology, Kles Dr Prabhakar Kore Hospital And Medical Research Center and Jawaharlal Nehru Medical College
Type: Journal Article | Journal: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion | Year: 2014

Acute leukemia, secondary myelodysplasia and paroxysmal nocturnal hemoglobinuria evolving from severe aplastic anemia (AA) following immunosuppressive therapy are well recognized. However, severe AA occurring after complete remission of acute promyelocytic leukemia (APL) has been documented only once in 2009. We report a case of 30-year-old male diagnosed with APL who achieved complete cytogenetic remission with all-trans retinoic acid based induction regimen and developed severe AA few months later during maintenance therapy.


PubMed | Karnatak University and Kles Dr Prabhakar Kore Hospital And Medical Research Center
Type: | Journal: Cytotechnology | Year: 2016

Allophylus cobbe (L.) Raeusch. belonging to the family Sapindaceae, is a commonly distributed small shrub in Western Ghats of India previously reported for its traditional medicinal properties. It is used for the treatment of various ailments. The present study is aimed at investigating preliminary phytochemicals, inducing the determination of the total phenolic contents, antioxidant assays and anticancer activity of A. cobbeleaf extracts on (DU-145) and (PC-3) cell lines. Preliminary phytochemical screening showed a broad spectrum of secondary metabolites. Highest amount of phenolic content was present in aqueous extract (91.960.61mg/gGAE) and it also proved to have the most potent antioxidant activity at a concentration of 100mg/ml (64.710.15%).IC


PubMed | KLE University, Karnatak University and Kles Dr Prabhakar Kore Hospital And Medical Research Center
Type: | Journal: Advanced biomedical research | Year: 2015

Fibrocalculous pancreatic diabetes has distinctive features like younger age at onset, presence of large intraductal calculi, aggressive course of the disease, and proneness for pancreatic cancer. Pancreatic calculi are the hallmark for the diagnosis. We report a 32-year-old male patient, a known case of diabetes since 2 years, presented with recurrent pain abdomen, malabsorption, and neuropathic symptoms. The diagnosis was established on the basis of clinical examination, biochemical and radiological investigations. He was prescribed two doses of premix insulin and pancreatic enzyme supplements for relief of abdominal pain and steatorrhea.


PubMed | KLE University and Kles Dr Prabhakar Kore Hospital And Medical Research Center
Type: | Journal: Diabetes & metabolic syndrome | Year: 2017

To determine the prevalence of Thyroid dysfunction among Type 2 Diabetes mellitus.A cross-sectional hospital-based study is conducted to find out the prevalence of thyroid dysfunction. 713 type 2 diabetes mellitus (T2DM) subjects were enrolled in the survey. These subjects were investigated for fasting blood sugar (FBS), glycosylated haemoglobin (HbA1c), total triiodothyronine (T3), total thyroxine (T4), and thyroid-stimulating hormone (TSH).Prevalence of thyroid dysfunction in T2DM was found in 16.2%. Gender-specific prevalence found higher in females (25%) compared to males (10.1%) (P<0.001). Age-specific prevalence found higher in the age group 50 yrs. (19%) Compared to other age groups (P=0.036). Subjects with poor glycaemic control demonstrated higher prevalence (27.9%) (P=0.012). Subjects with long-standing T2DM had an increased risk for thyroid dysfunction (19.8%) though findings were not statistically significant. (P=0.42).The prevalence of thyroid dysfunction with T2DM (16.2%) was high in females compared to males and especially hypothyroidism being more typical. Failure to recognise the presence of thyroid dysfunction among T2DM patients may be a primary cause of poor management of diabetes. We recommend universal screening and regular monitoring of thyroid dysfunction in T2DM patients.


Vyas N.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Ghatanatti R.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Nerlikar A.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Gan M.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Dixit M.,Kles Dr Prabhakar Kore Hospital And Medical Research Center
Journal of Clinical and Diagnostic Research | Year: 2016

Myxomas are the most common and potentially dangerous benign tumours of the heart. They may have either smooth or papillary surfaces and may have thrombus adherent. As both the papillary excrescences and the surface thrombi are friable in nature hence may undergo embolization. We report a case of left atrial myxoma, which underwent excision of the tumour for mitral valve obstructive features. In the immediate postoperative period patient developed ST elevation in lead II, III and aVF. Coronary angiogram revealed normal coronary pattern. Patient was treated with aspirin, heparin and IABP for 48 hours and recovered well. We conclude that there is a tendency for spontaneous recanalization of the obstructed coronary vessels by tumour emboli, hence patient can be managed conservatively. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.


Porwal S.C.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Halkati P.C.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Patted S.V.,Kles Dr Prabhakar Kore Hospital And Medical Research Center | Joshi A.,Kles Dr Prabhakar Kore Hospital And Medical Research Center
Journal of Cardiology Cases | Year: 2013

Stent dislodgement is a rare but recognized and potentially serious complication of percutaneous coronary intervention. Stent dislodgement was more frequent in the past when stents were manually crimped onto the balloon. Newer and improved balloon-mounted stents with better radio-opacity have reduced the incidence of stent dislodgement but do not completely eliminate it. We report a case of stent dislodgement which was successfully deployed with small-balloon technique. This patient however was successfully treated with small balloon technique at the desired site.<. Learning objective: Newer and improved balloon-mounted stents with better radio-opacity have reduced the incidence of stent dislodgement but do not completely eliminate it.>. © 2013 Japanese College of Cardiology.


PubMed | Kles Dr Prabhakar Kore Hospital And Medical Research Center
Type: Case Reports | Journal: The Annals of thoracic surgery | Year: 2012

Cleft sternum is a rare congenital anomaly due to failure of fusion of the sternal bone. The etiology of this defect is not well understood. The anomaly is more common in females and may be associated with Cantrells pentalogy. It can be partial or complete. An 8-year-old female child presented with complete defect in the sternum which was confirmed with a chest radiograph and computed tomography. Only 24 cases of isolated complete cleft sternum have been reported so far. The treatment ranges from primary closure of the defect to the use of various autologous and prosthetic grafts. Our patient was treated with primary closure of the defect.


PubMed | Kles Dr Prabhakar Kore Hospital And Medical Research Center
Type: Case Reports | Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases | Year: 2010

Kikuchi-Fujimoto disease (KFD; also called Kikuchi disease) is a rare disorder clinically characterized by lymphadenopathy along with constitutional symptoms and several systemic features which may closely mimic infections, malignancies, and autoimmune diseases. Systemic lupus erythematosus (SLE) is an autoimmune disorder which may have several clinical manifestations similar to KFD. Association of KFD with SLE is only rarely described, and whether this is a chance incidence or Kikuchi disease is a localized manifestation of SLE per se remains a matter of debate. We report here coexistence of these two diseases in 1 patient.


PubMed | Kles Dr Prabhakar Kore Hospital And Medical Research Center
Type: Case Reports | Journal: Indian journal of ophthalmology | Year: 2011

Wegeners granulomatosis (WG) is a multisystem vasculitic disorder which can commonly afflict various components of the eye. Here we describe some unusual ocular manifestations of the disease in one patient. A young male with history of upper respiratory tract symptoms including epistaxis, nasal stuffiness and maxillary sinus pain presented with bilateral lacrimal gland abscess and ptosis. Lacrimal gland biopsy revealed granulomatous vasculitis. Lung cavities, positive cytoplasmic-antineutrophil cytoplasmic antibodies and high titers of serine proteinase-3 antibodies confirmed the diagnosis of WG. The patient developed dry eyes after a month of first presentation. There was no dryness of mouth, suggesting the absence of salivary gland involvement, and antinuclear antibodies as well as antibodies against Ro and La antigens classical of primary Sjogrens syndrome were absent. Granulomatous vasculitis of lacrimal gland leading to abscess formation and dryness of eyes has not been described in WG and reflects the aggressive nature of inflammatory process in this disease.

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