Menlo Park, CA, United States
Menlo Park, CA, United States

Kleiner Perkins Caufield & Byers is a venture capital firm located on Sand Hill Road in Menlo Park in Silicon Valley. The Wall Street Journal and other media have called it one of the "largest and most established" venture capital firms and by Dealbook as "one of Silicon Valley’s top venture capital providers Wikipedia.


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News Article | February 15, 2017
Site: www.businesswire.com

PALO ALTO, Calif.--(BUSINESS WIRE)--Instart Logic, a next generation technology company making the digital world faster, more reliable and more secure, today announced accelerated momentum across major aspects of its business. In FY17, concluded on January 31st, 2017, the company’s bookings more than tripled for the third year in a row. Additionally, the company added a record 10+ deals worth over one million dollars each, and added 60 new enterprise customers, including Walgreens, Edmunds, AirAsia, and TechStyle (JustFab). New products launched in 2016 included AppShield Ad Integrity, a breakthrough solution that circumvents ad blockers so web publishers and e-commerce companies can recover billions of dollars of ad revenue currently being lost to ad blocking technology. Ad Integrity was introduced quietly to the market nine months ago and is already unblocking over three billion ad impressions per month. Over 70 website properties -- one in the comScore Top 5, three in the comScore Top 15 and 20 in the comScore Top 100 -- have signed on for Ad Integrity, and web publishers have recovered over $30 million in ad revenue. Ad Integrity has the powerful and unique ability to unblock every type of advertising, including display, native, sponsored content and pre-roll/mid-roll video -- no other ad unblocking solution can do this. Instart Logic’s Q4 and FY17 results underscore the continued and rapid rise in demand for its cloud-based endpoint-aware application delivery solution. In other news today, Instart Logic announced its “Application Services Platform” with enhanced machine learning and automation capabilities, and a revolutionary new business model designed to accelerate the company’s disruption of the $10 billion content and application delivery market. Manav Mital, CEO and founder of Instart Logic, said, “ We had an absolute breakout fiscal year and I couldn’t be more thrilled with our business momentum. Market acceptance for Instart Logic’s modern cloud-based Application Services Platform continues to grow exponentially. We have reached an inflection point in the maturity of the solution. This fact, combined with the legacy content delivery network market -- one ripe for disruption, as competitors have failed to innovate or keep pace with the move to the cloud -- is allowing us to significantly accelerate our growth rate. We are now in a position where we regularly beat Akamai in competitive sales situations. In FY17 we closed 5X more enterprise deals over the prior year.” Mital continued, “ We also announced today that going forward we will be charging only for value delivered, and providing our CDN solution at cost. It’s a strong testament to the fact that pure transport and delivery has become commoditized. We believe customers shouldn’t pay for this commodity - instead they should only pay for value created through improved performance. We are so confident in our technology that we will guarantee to improve a customer's page load speed by at least 20 percent over any incumbent CDN vendor, including Akamai. Instart Logic’s unique architecture provides a robust platform upon which many value-added services can be built and delivered, without requiring customers to make any changes to their applications, or to download any software to end user devices. We call this the ‘power of the platform’ -- deploy once and leverage for a variety of use cases to generate a variety of new revenue.” Additional product and feature innovations launched in FY17, in addition to Ad Integrity, included: Instart Logic continued to execute on its strategy to build out a select ecosystem of high-value partners. Revenue driven through valuable existing strategic partnerships such as Dyn, Verisign and ChinaCache continued to grow at 3X a year, and the company onboarded many new enterprise customers through these and other partners. Adding to the momentum and providing strong external validation of the company’s leadership position, recently Business Insider, the No. 1 business publication in the United States based on traffic, included the company on its list of the “ 51 enterprise startups to bet your career on in 2017.” The introduction to the story said, “ All of these companies are ‘enterprise’ startups, meaning they specialize in making tech for work and business use, which is a $3.4 trillion worldwide market. All of them had a spectacular 2016, launching new technology, getting a boatload of funding or landing big partnerships, and generally setting themselves up for a successful 2017 and beyond.” Instart Logic’s Application Services Platform is the world’s first endpoint-aware application delivery solution. It’s a disruptive way to accelerate and secure web and mobile applications, delivering an unprecedented degree of performance, security and control. The core technology innovations, driven by 80+ patents, include machine learning, application awareness and client control via a thin JavaScript virtualization layer called the Nanovisor. Instart Logic is the world’s first endpoint-aware application delivery solution making applications lightning fast, secure, and easy to operate. Instart Logic’s platform combines machine learning, virtualization, and open APIs with a content delivery network (CDN) for global delivery. Using Instart Logic, enterprises can provide ultra-fast, visually immersive and secure experiences on any device to maximize revenue, deliver superior customer experiences and gain competitive advantage. Instart Logic is funded by Andreessen Horowitz, Four Rivers Group, Geodesic Capital, Greylock Partners, Hermes Growth Partners, Kleiner Perkins Caufield & Byers, Sutter Hill Ventures, Telstra Ventures, Tenaya Capital, Wing Venture Capital and several notable Silicon Valley angel investors. Learn more at https://www.instartlogic.com or follow us on Twitter at @InstartLogic.


News Article | February 22, 2017
Site: www.businesswire.com

SANTA CRUZ, Calif.--(BUSINESS WIRE)--Looker today announced the expansion of its international operations with the opening of its new European Headquarters in Dublin, Ireland. Looker opened its first European office in London in 2015 and since then has helped over 100 companies across Europe build data cultures. The newly established headquarters in Dublin allows Looker to better support its ongoing growth and market opportunities across Europe. Led by John O’Keeffe, who held executive positions with Salesforce.com and Nitro in Europe, Looker’s Dublin operations will create approximately 50 positions within Sales, Marketing, Professional Services and Support over the next three years. “There are a number of reasons I came to Looker – innovative product and technology that customers love; smart, dedicated people; a very impressive growth trajectory; and, the company has a strong, long-term vision,” said O’Keeffe, VP of EMEA for Looker. “Looker fits in perfectly with Dublin’s thriving technology sector and its diverse and talented workforce. It’s an exciting time for Looker and I’m very proud to lead the team in Europe.” “Looker’s market adoption was built on, and will continue to be built on, satisfying one customer at a time,” said Frank Bien, CEO of Looker. “We opened the Dublin office because providing that level of service to our European customers and prospects required a deeper commitment to the region. Now with our London office well established and our initial team in Dublin in place, I look forward to further building out our presence in Europe.” Looker is a complete data platform that offers data analytics, exploration and insights to every function of a business and easily integrates into every departmental application to get data directly into the decision-making process. The company is powering data-driven cultures at more than 800 industry-leading and innovative companies such as Sony, Amazon, The Economist, Sears, Spotify, Kohler, Etsy, Lyft and Kickstarter. The company is headquartered in Santa Cruz, California, with offices in San Francisco, New York, and London. Investors include Kleiner Perkins Caufield & Byers, Meritech Capital Partners, Redpoint Ventures, First Round Capital, Sapphire Ventures, and PivotNorth. For more information, Connect with us on LinkedIn, Twitter, Facebook, G+ and YouTube or visit looker.com.


News Article | February 15, 2017
Site: www.prweb.com

Red Trident Incorporated today announced that it is a Managed Security Service Provider (MSSP) for AlienVault® and has added its Unified Security ManagementTM (USMTM) platform to its Cyber Security Operations Center (CSOC) services. Red Trident is the first industrial control system (ICS) cyber security company in Houston, the Energy Capital of the World, to join AlienVault as an MSSP. The cyber threat to energy and critical infrastructure organizations is increasing globally at alarming rates. The AlienVault USM platform coupled with Red Trident’s expertise in automation and ICS cyber security architecture, program implementation and continuous monitoring enables increased operational efficiencies and significant risk deduction associated with advanced persistent threats and downtime. AlienVault USM provides a reliable, highly flexible and scalable deployment model that helps service providers quickly implement and start monitoring customer environments from day one. With robust asset discovery, vulnerability assessment, behavioral monitoring, threat detection and security intelligence, AlienVault USM offers a unified, all-in-one approach to security management and threat detection. "We are excited about our new offering,” said Tony Gore, CEO of Red Trident. “Working with AlienVault will enable us to leverage advanced technologies and provide timely and critical cyber security services to customers. We partner with our customers to help build and implement cyber security programs for ICS and IT environments. Our solutions are purpose built and customized to meet Corporate level and plant (or site) level security programs that meet customer business requirements and risk appetites. By developing policies and procedures that support the cyber security maturity level of organizations, we develop compliance and technology roadmaps that mature manual operations to automated workflows for maximizing the return on security investment available to mitigate top threats.” “Our technology combined with Red Trident’s expertise provides companies of all sizes challenged by limited cyber security staff and budgets with a complete security solution at a competitive price point,” said Mike LaPeters, VP of Global Channels at AlienVault. “Red Trident can now leverage AlienVault’s proven security and threat intelligence platform to help reduce the time needed to detect and respond to today’s advanced threats in their customer’s environments.” About Red Trident Red Trident’s mission is to provide cyber security solutions for protecting and securing our Nation’s critical infrastructure. We employ a systems-of-systems engineering approach that combines resources, tools and processes to create an optimized solution that offers increased functionality and performance. By building solutions that leverage existing infrastructure and inter-operate with solutions that we develop, we are able to provide our clients a maximized return on their security investment. Our ICS cyber security assessments, architecture and Cyber Security Operations Center services provide continuous monitoring of critical assets providing operational efficiencies and significantly increased uptimes for production facilities. About AlienVault AlienVault has simplified the way organizations detect and respond to today’s ever evolving threat landscape. Our unique and award-winning approach, trusted by thousands of customers, combines the essential security controls of our all-in-one platform, AlienVault Unified Security Management, with the power of AlienVault’s Open Threat Exchange, the world’s largest crowd-sourced threat intelligence community, making effective and affordable threat detection attainable for resource-constrained IT teams. AlienVault is a privately held company headquartered in Silicon Valley and backed by Trident Capital, Kleiner Perkins Caufield & Byers, Institutional Venture Partners, GGV Capital, Intel Capital, Jackson Square Ventures, Adara Venture Partners, Top Tier Capital and Correlation Ventures. AlienVault, Open Threat Exchange, OTX, Unified Security Management, and USM are trademarks of AlienVault and/or its affiliates. Other names may be trademarks of their respective owners.


PadMapper (http://www.padmapper.com), a leading home and apartment rental search platform today introduced Post a Pad, enabling users to post rooms and apartments for rent directly from their iOS or Android device. The launch opens a broad new set of listings for those searching for roommates and sublets on PadMapper. Over 25 million users every year will have the ability to post, leading to a significant amount of new inventory for rooms, apartments, and other shared accommodations. Unlike other platforms specializing in this space, PadMapper has created a proprietary security algorithm to combat against spammy listings and scams from entering the platform, which will launch alongside Post a Pad. The algorithm uses a combination of machine learning and community moderation to ensure only high-quality, legitimate listings are posted. “Post a Pad aligns perfectly with our mission to provide the highest quality, most diverse rental listings in every market across the U.S. and Canada”, said Russell Middleton, President of PadMapper. “We’re excited to further enhance our platform for renters searching for rooms, while also providing those looking to fill vacancies with a streamlined way to market to millions at no cost .” Using Post a Pad takes less than a minute, and is completed entirely through the PadMapper mobile app. The feature adds to the robust PadMapper rental marketplace, which has millions of renters in the U.S. and Canada searching through over a million active rental listings at any time. ● Post a Pad lets anyone post a private or shared room, entire apartment, or rental home to the PadMapper and Zumper rental marketplaces free of charge. ● Download the PadMapper application on an iOS or Android device and tap the “Post” tab. ● Drag the map pin or enter an address to select the location. The app provides the ability to hide the exact street address. ● Add images to the listing by snapping photos using the built-in camera on your device. ● Include relevant listing information and a description, and select whether the post is an entire residence, private room, or shared room. ● Once verified via Facebook login and PadMapper’s security algorithm, the listing will go live to millions of renters on both PadMapper and Zumper. Posters will also have the ability to make the listing visible to only those with a direct link. Zumper (https://www.zumper.com) is the largest startup in home and apartment rentals, helping over 25 million renters find a new home every year. In addition to its consumer search and lease products, Zumper offers rental professionals industry-leading tools to market listings and screen prospective tenants. PadMapper joined the Zumper family of sites in February of 2016. With a team of 40, Zumper has raised $39.2 million in venture capital funding from investors including Kleiner Perkins Caufield & Byers, Goodwater Capital, Breyer Capital, Foxhaven Asset Management, Andreessen Horowitz, Greylock, NEA, CrunchFund, xfund, Dawn Capital, Marcus & Millichap, Scott Cook, and the DeWilde Family Trust. For more information or to Post a Pad, please download the PadMapper application on your iOS or Android device.


PLEASANTON, Calif.--(BUSINESS WIRE)--IronPlanet®, a leading online marketplace for selling and buying used equipment and other durable assets, today debuted its new Marketplace Direct platform that offers advanced, self-listing functionality for larger-scale equipment sellers. Unique to the industry, Marketplace Direct provides an innovative listing and reporting solution that enables sellers to better manage their assets and directly control their listing management process. With Marketplace Direct, sellers have an enhanced cloud-based platform to increase sell-thru of inventory, improve price performance and reach the most buyers through the channels of their choice. “On the heels of relaunching allEquip® with Buy Now and Make Offer functionality, and the launch of Truck Locator, which meets the needs of multi-unit and fleet truck buyers, IronPlanet is proud to announce another industry innovation that provides customers with unique, value-added services and a cutting-edge, technology-driven platform designed to improve return on investment,” said Matt Ackley, IronPlanet Chief Marketing Officer. “Marketplace Direct enables sellers to market equipment to their current client base in a private setting or publicly to IronPlanet’s 1.7 million registered users worldwide. Through the process, we provide sellers with more control and choice over timing, price, and formats than they would receive in a typical live auctions-only setting.” With IronPlanet’s new Marketplace Direct, sellers can now: More information on IronPlanet’s Marketplace Direct seller platform can be found at www.ironplanet.com. IronPlanet is a leading online marketplace for selling and buying used equipment and other durable assets and an innovative participant in the multi-billion dollar used equipment market. Founded in 1999 to transform the global used equipment market, IronPlanet has built a database of more than 1.7 million registered users worldwide. IronPlanet connects buyers and sellers of used equipment with its exclusive IronClad Assurance® equipment condition certification and family of brands, including IronPlanet®, GovPlanet®, TruckPlanet®, Cat Auction Services, Kruse Energy & Equipment AuctioneersSM, allEquip® and Asset Appraisal ServicesSM. IronPlanet is backed by Accel Partners, Kleiner Perkins Caufield & Byers, Caterpillar and Volvo. For more information, visit www.ironplanet.com.


News Article | February 21, 2017
Site: www.prweb.com

Egnyte, the leading cloud provider of smart content collaboration and governance for the enterprise, today announced BuzzFeed has deployed Egnyte Connect as their company-wide collaboration solution. Egnyte Connect provides BuzzFeed with a fast, reliable way to access, manage, and collaborate on content internally and externally, while maintaining a high level of security that is required when dealing with their most sensitive content. BuzzFeed, headquartered in New York City, is a globally distributed digital media powerhouse with more than 1,300 employees in offices across 18 cities all over the globe. BuzzFeed’s digital content is consumed by more than 500 million people a month via 30 plus platforms worldwide, touting an astounding 7 billion content views per month. “At BuzzFeed we want our content to make an impact on people’s lives, which means our staff needs to be able to work quickly to deliver unique news and entertainment content to our readers and viewers in a timely fashion,” said Jason Reich, Director of Global Security at BuzzFeed. “Egnyte Connect helps our staff do both, giving them a smart content collaboration solution that lets them work seamlessly across departments with the productivity tools they are used to, while our IT team maintains visibility and control on the backend. The Egnyte Connect solution makes us smarter about our content, which makes us smarter about our business.” BuzzFeed chose to deploy Egnyte company-wide for the following benefits and features: Collaboration Without Limits: BuzzFeed employees are able to collaborate on content with their favorite apps, on their preferred devices, completing projects in less time, without IT requiring complicated security precautions. With Egnyte Connect employees can stay productive while IT ensures the security of company content behind the scenes. Advanced Visibility and Control: Egnyte Connect provides IT at BuzzFeed complete visibility and granular control over all of their company content. Operations have also simplified, as file hierarchies are now in place for new hires, creating a centralized folder for the documents they will need at the start of employment. This solution is scalable and also allows administrators to lock down folders within folders to individuals as necessary. Salesforce Application Integration: Salesforce integration was key for BuzzFeed since it is a key platform for the business team. Salesforce for Egnyte allows all client folders to be automatically managed by Egnyte Connect, enabling users to access files and create content through the Salesforce interface. After the deployment, employees have raved that Egnyte Connect is even easier to use with Salesforce. “As one of the fastest growing brands in media and entertainment BuzzFeed has to maintain a high level of productivity and efficiency amongst their staff, making collaboration an essential piece of the puzzle,” said Rajesh Ram, co-founder and chief customer officer at Egnyte. “Egnyte Connect delivers a secure solution that not only makes collaboration faster and more efficient, but makes them smarter about their content and how they can get better for the future.” WATCH: See how BuzzFeed is getting smarter about their content a video testimonial here. To learn more of the details about how BuzzFeed chose Egnyte and what their deployment looked like, check out an in-depth case study here. About Egnyte Egnyte transforms business through smarter content allowing organizations to connect, protect, and unlock value from all their content. Our Content Intelligence platform delivers smart content collaboration and governance in the cloud or on-premises to thousands of businesses around the world even the most regulated industries. Founded in 2007, Egnyte is privately held and headquartered in Mountain View, CA. Investors include venture capital firms, such as Google Ventures and Kleiner Perkins Caufield & Byers, as well as technology partners, such as CenturyLink and Seagate Technology. Please visit http://www.egnyte.com or call 1-877-7EGNYTE for more information. About BuzzFeed BuzzFeed is a global media company that produces and distributes original news, entertainment and video. BuzzFeed is redefining online advertising with its social, content-driven publishing technology and reaches a global audience of over 7B content views.


News Article | March 1, 2017
Site: www.theguardian.com

Haana was so repulsed by what happened to her, she covered up her mirror so she wouldn’t have to look at herself. The Silicon Valley tech worker said that after drinks with startup colleagues last year, a male executive at her company put his hand up her shirt and groped her while they walked down the street. “I felt disgusted for months after that,” said Haana, who requested that the Guardian not include her full name or identify the small tech startup where she used to do marketing. “It affects me on a level that I wish it didn’t.” According to Haana, the CEO refused to fire him, and she eventually left the business. Her allegations are far from unique in Silicon Valley. On the contrary, in the male-dominated technology industry, female staffers and workers of color say sexual misconduct, discrimination and retaliation are rampant – and that men in powerful positions are routinely protected while women are often pushed out of their jobs by harassment. Following the recent viral blogpost of Susan Fowler, a former Uber engineer who chronicled claims of sexual harassment and mistreatment, the Guardian has found that similar allegations are widespread across the tech sector. According to a number of prominent attorneys, hundreds if not thousands of women and people of color in tech come forward each year with complaints of toxic work environments largely controlled by white men. Under the guise of “disruption” and “innovation”, startups and tech corporations skirt employment laws and reject HR practices while sometimes fostering a party culture where young male executives encourage socializing and drinking. Often, founders hire and promote friends and people similar to them. In these settings, women are vulnerable to all kinds of abuse, ranging from lewd comments to unwanted propositions to groping to assault. “The scale is sort of breathtaking,” said Kelly Dermody, an attorney who annually assists hundreds of women in tech and represents thousands across class-action lawsuits. “Most of the women I’ve worked with in startups have had stories where they have been physically touched, if not worse, without their consent.” In recent years, there have been public claims of sexism and discrimination at numerous high-profile technology companies, including Twitter, Apple, Oracle, Google and Tesla, where a female engineer shared her claims of “pervasive harassment” with the Guardian this week. At Uber, a top engineering executive also stepped down this week amid allegations that he was accused of sexual harassment at his previous job at Google. But some say the problem is under-reported and particularly acute in early-stage startups where there are no HR departments. There, young CEOs may choose not to fire or reprimand executives who are college friends they consider vital to the company, and when founders or CEOs commit offenses, it can be impossible for women to find justice. In a recent survey of more than 200 women in tech, 60% said they faced unwanted sexual advances, often from superiors. One in three women said they felt afraid for their personal safety, and 66% said they felt excluded because of their gender. The research was inspired by Ellen Pao, the former Reddit CEO, whose discrimination lawsuit against venture capital firm Kleiner Perkins Caufield & Byers sparked national debate about misogyny in Silicon Valley. “Most women have experienced some version of this,” Pao, who lost her landmark suit, said in an interview last week. She said she hopes the Uber case is a “watershed moment” that inspires the industry to fix a “fundamentally broken” culture. Therese Lawless, an employment attorney who represented Pao and the female engineer at Tesla, said the impact of the social scene at some of the companies can be extreme. “You have a culture which is more like a fraternity than it is a workplace … Sometimes it ends in disaster,” she said. “There’s a huge range, from sexual assault to propositions for sex to wanting sexual favors in the workplace to unwanted touching to showing of explicit pictures.” When young startups grow their businesses at very rapid rates, they fail to properly invest in HR, said Jahan Sagafi, a lawyer with Outten and Golden, the nation’s largest firm representing workers in claims against employers. “You have this insular group of like-minded and similar-looking people who are suddenly given immense privilege and opportunity and wealth. And before long, they can feel like they are above the law.” Amélie Lamont, a former employee of Squarespace, the popular website design company, said that she felt obligated to go to bars with colleagues for regular hangouts. “If you weren’t drinking, you weren’t a part of the culture. That was frustrating,” said Lamont, who last year published an account of facing racism and sexism as a black female supervisor at Squarespace. “That was really hard keeping up … If you skipped them, it meant you weren’t really connecting with your co-workers. You weren’t building a strong relationship.” Haana, who is in her 20s and has worked for multiple startups, said she had had a close relationship with the CEO of her previous company for years. She said the chief technology officer groped her and that he was friends with the CEO. This kind of intimate nature of an early stage startup makes it challenging to deal with these kinds of conflicts, she said. “When you’re involved in a startup, you kind of need to be involved in each other’s lives,” Haana explained. “You live, you eat, you work together.” That made it all the more painful, she said, that no one seemed to take her concerns seriously. “What can I say to make people believe it wasn’t my fault?” she said, noting that the incident had a long-term impact on her. “It’s something that’s a part of me, and I have to figure out how to deal with it. I don’t know how to get rid of that anxiety.” In phone interviews, the CEO said he didn’t think automatically terminating the CTO was an appropriate response, and the CTO denied that he groped Haana but said it was possible she “misinterpreted” a “hug”. Pao said the tight-knit nature of startups can make the experience of harassment all the more painful. “If you’re not part of that group of founding friends, you’re excluded. And that exclusion can take on many forms.” While many victims of discrimination or harassment choose not to file legal complaints or go public, the ones who do speak out face serious risks. Days after her post about Uber, Fowler tweeted that people she knows were being asked for “personal and intimate” information about her as part of what seemed to be a “smear campaign”. Uber claimed it was not behind the investigation. The company also hired former attorney general Eric Holder to investigate harassment and vowed to hold offenders accountable. After Lamont, 28, went public about the prejudice and misogyny she said she faced at Squarespace, she faced an onslaught of nasty comments and harassing messages, with some branding her a liar and others lecturing her about how black women should behave. Lamont, who now works as a product design lead at the New York Times, said she was one of a very small handful of black women at Squarespace and that she felt white managers and executives didn’t understand her experience. “I felt devalued,” she said. “Even going into other jobs, I carried all the baggage.” Squarespace did not respond to multiple requests for comment. After she published her post, Lamont said many women of color in tech reached out to share similar stories: “That was validating.” One black woman told her about a manager who said she shouldn’t wear her hair naturally in an afro or braids because she appeared “too ethnic”. Another woman told her she was repeatedly given grunt work that didn’t match her level of expertise. Jennifer Schwartz, another Outten and Golden lawyer, said she has represented a number of transgender women in tech who “face shocking and blatant discrimination and impropriety in all forms”, including jokes like, “Have you decided today whether you’re a man or a woman?” Schwartz said that for one trans female programmer she represented at a successful startup was “consistently marginalized”, with men excluding her from meetings and ignoring her successes. “They were going out of their way to try to sabotage her work, creating a sort of clubbiness where the men were patting each other on the back for denigrating her.” The woman, Schwartz said, eventually left the company.


Monath T.P.,Kleiner Perkins Caufield & Byers
American Journal of Tropical Medicine and Hygiene | Year: 2010

Two cases of yellow fever vaccine-associated viscerotropic adverse events (YEL-AVD) were identified by review of correspondence received at the Centers for Disease Control and Prevention (CDC; Ft. Collins, CO). The cases occurred in Indiana and Maryland in 1973 and 1978, respectively. One patient, a 75-year-old man with multi-organ failure died, and the other, a 31-year-old woman, was hospitalized for 14 days. Onset was 3-6 days after vaccination. The illness was characterized by fever, headache, myalgia, gastrointestinal symptoms, hepatic and renal dysfunction, and (in the fatal case), shock and coagulopathy, compatible with YEL-AVD. Liver pathology showed diffuse, spotty necrosis, acidophilic degeneration, Kupffer cell hyperplasia, and microvesicular fat. No virological confirmation was obtained, so that both cases remain classified as "suspect." The 1973 case is the earliest record of YEL-AVD; until now, the earliest known case of YEL-AVD had been in 1975 in Brazil, and most subsequent cases have been reported after 1995. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.


Monath T.P.,Kleiner Perkins Caufield & Byers
Expert Review of Vaccines | Year: 2012

The live, attenuated yellow fever (YF) 17D vaccine provides highly effective and durable immunity and is widely used for travelers to and residents of endemic areas of South America and Africa. Neurotropic and viscerotropic serious adverse events associated with these vaccines occur rarely, but YF 17D vaccine-associated viscerotropic disease (YEL-AVD) is notable for its lethality. There appear to be two distinct patterns of risk for YEL-AVD: the first in younger persons, particularly women, with defects in innate immunity, in whom the case-fatality rate is higher; and the second in elderly persons, particularly men with age-related immune senescence and a lower case-fatality rate. From 1990 to the present, the number of cases (n = 31) and deaths (n = 12) from YEL-AVD in travelers has exceeded the reports of YF (n = 6) acquired by natural infection, raising the question whether the risk of vaccination exceeds the benefit in travelers. To provide some guidance on this point, the rate of vaccine-related injury is compared with the rate of naturally acquired disease in a new analysis that estimates the immunologically susceptible denominator population in YF endemic and epidemic areas. For many years, the risk of vaccine-related illness and death was similar to the risk of illness and death from natural infection with YF in South America. Africa posed a substantially higher estimated risk of wild-type YF than vaccine-related injury. Multiple factors should be considered in making decisions about YF vaccination, including specific destination, season of the year, local evidence for YF transmission, likelihood of exposure to vector mosquitoes and individual risk factors for YEL-AVD, with the goal of increasing vaccine coverage for travel to high-risk areas and reducing unnecessary vaccination. Prospects for future, safer vaccines are also described. © 2012 Expert Reviews Ltd.


News Article | February 20, 2017
Site: hosted2.ap.org

(AP) — Uber's chief executive ordered an investigation Monday into a sexual-harassment claim made by a female engineer who said her prospects at the company evaporated after she complained about advances from her boss. In a blog post about her year at Uber, Susan Fowler Rigetti said the company's human resources department ignored her complaints because her boss was a high performer. CEO Travis Kalanick responded Monday on Twitter that he had instructed the ride-hailing app company's chief human resources officer to look into Rigetti's charges. "What's described here is abhorrent & against everything we believe in," Kalanick tweeted. "Anyone who behaves this way or thinks this is OK will be fired." The engineer, who goes alternately by Fowler or Rigetti online, said she joined Uber in November 2015 as a site-reliability engineer in San Francisco. She said that on her first official day on her team at Uber, her boss propositioned her in a string of messages on the company chat. She took screen shots of the messages because they were "clearly out of line." "Upper management told me that he 'was a high performer' (i.e. had stellar performance reviews from his superiors) and they wouldn't feel comfortable punishing him for what was probably just an innocent mistake on his part," she wrote. Rigetti said she changed assignments but found her career path blocked. She said sexism was rampant at Uber, although her original boss eventually left the company. Fowler also left, joining an online-payments company. Rigetti's remarks will strike a nerve among those trying to bolster the number of women in science and engineering, who have long argued that the male-dominated atmosphere discourages talented women from seeking careers in the sector. "It sounds like (Uber) is doing the right thing in trying to investigate what went wrong here," said Deborah Rhode, a legal-ethics expert at Stanford University law school. "But in too many organizations, high achievers often have a sense that they are invulnerable and entitled." Some of the same issues were raised when Ellen Pao sued Silicon Valley venture-capital firm Kleiner Perkins Caufield & Byers, where she had been a partner, arguing that she was fired for filing a sex-discrimination complaint. A jury ruled against her after a 2015 trial. Other tech companies have been sued by employees who charged that the firms systematically deny promotions to women. The companies often say there aren't enough women going into technical and scientific work. "The answer to that is for companies to take proactive steps to increase the number of women who want to enter these fields and to make sure that they encounter a level playing field once they get there," Rhode said.

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