Belgaum, India
Belgaum, India

Karnatak Lingayat Education Society was founded in 1916 by seven educated youth with the objective of bringing education to the Kannada-speaking region of the erstwhile Bombay Presidency and what is today the North Karnataka region. The founder life members of the KLE Society are: Shri S.S. Basavanal Shri B.B. Mamadapur Shri M.R. Sakhare Shri H.F. Kattimani Shri B.S. Hanchinal Shri P.R. Chikodi Shri V.V. Patil Headquartered at Belgaum, KLE Society runs over 238 educational institutions in North Karnataka, South Maharashtra, Bangalore and New Delhi. On 13 November 1916, KLE Society started an Anglo Vernacular School in Belgaum. Lingaraj College came into existence in June 1933. In 1947, B.V. Bhoomaraddi College of Engineering and Technology was started in Hubli. Jawaharlal Nehru Medical College at Belgaum and Gudleppa Hallikeri College at Haveri were started in 1963. KLE also runs the world famous KLE engineering college in Belgaum, established in 1979. From 1984 onwards, KLE Society started dental, education, nursing, information technology, computer applications, hotel management, business management, tourism, fashion design, and agriculture colleges, as well as polytechnics across India. Its health care institutions include the super-specialty KLE Society's Prabhakar Kore Hospital and Medical Research Centre at Belgaum. Today under the leadership of Mr. Prabhakar Kore, the KLE Society runs 207 institutions. Wikipedia.

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Salahuddin Md.,KLE University | Jalalpure S.S.,KLE University
Journal of Ethnopharmacology | Year: 2010

Ethnopharmacological relevance: Cucumis trigonus Roxb. (Cucurbitaceae) fruit is used in the Indian traditional medicine for the treatment of diabetes. Based on a number of reports on the blood glucose level reduction and the other complications of diabetes associated with some Cucurbitaceae plants, the antidiabetic effect of Cucumis trigonus fruit was investigated. Aim of the study: To investigate the antidiabetic action of the aqueous extract of Cucumis trigonus fruits in the different models of rats. Materials and methods: The antidiabetic activity of aqueous extract of Cucumis trigonus fruit was evaluated by using normal and streptozotocin-induced-diabetic rats. The acute effect of aqueous extract was evaluated by administering 500 mg/kg p.o. to normoglycemic rats. In the chronic model, the aqueous extract was administered to normal and STZ-induced-diabetic rats at dose of 500 mg/kg p.o. per day for 21 days. Blood glucose levels and body weights were monitored at specific intervals and different biochemical parameters were also carried out. Results: The statistical data indicated the significant increase in the body weight, liver glycogen and serum insulin level and decrease in the blood glucose, glycosylated hemoglobin levels, total cholesterol and serum triglycerides. HDL cholesterol level was significantly increased when treated with the extract. Conclusion: The aqueous fruit extract of Cucumis trigonus has had beneficial effects in reducing the elevated blood glucose level and lipid profile of STZ-induced-diabetic rats. © 2009 Elsevier Ireland Ltd. All rights reserved.

Nagmoti J.M.,KLE University
Indian Journal of Medical Microbiology | Year: 2017

Purpose: PowerPoint (PPT™) presentation has become an integral part of day-to-day teaching in medicine. Most often, PPT™ is used in its default mode which in fact, is known to cause boredom and ineffective learning. Research has shown improved short-term memory by applying multimedia principles for designing and delivering lectures. However, such evidence in medical education is scarce. Therefore, we attempted to evaluate the effect of multimedia principles on enhanced learning of parasitology. Methodology: Second-year medical students received a series of lectures, half of the lectures used traditionally designed PPT™ and the rest used slides designed by Mayer's multimedia principles. Students answered pre and post-tests at the end of each lecture (test-I) and an essay test after six months (test-II) which assessed their short and long term knowledge retention respectively. Students' feedback on quality and content of lectures were collected. Results: Statistically significant difference was found between post test scores of traditional and modified lectures (P = 0.019) indicating, improved short-term memory after modified lectures. Similarly, students scored better in test II on the contents learnt through modified lectures indicating, enhanced comprehension and improved long-term memory (P < 0.001). Many students appreciated learning through multimedia designed PPT™ and suggested for their continued use. Conclusions: It is time to depart from default PPT™ and adopt multimedia principles to enhance comprehension and improve short and long term knowledge retention. Further, medical educators may be trained and encouraged to apply multimedia principles for designing and delivering effective lectures. © 2017 Indian Journal of Medical Microbiology Published by Wolters Kluwer -Medknow.

Kummara S.,KLE University | Patil M.B.,KLE University | Uriah T.,KLE University
Biomedicine and Pharmacotherapy | Year: 2016

Silver nanoparticles (AgNPs) are superior cluster of nanomaterials that are recently recognized for their different applications in various pharmaceutical and clinical settings. The objective of this work deals with novel method for biosynthesis of AgNPs using Azadirachta indica (neem) leaf extract as reducing agent. These bio and chemical synthesized nanoparticles were characterized with the help of UV–vis Spectroscopy, Nanotarc, Dynamic light scattering (DLS), Zeta Potential (ZP), Transmission Electron Microscopy and Fourier transform infrared spectroscopy (FTIR). The obtained results from Nanotrac and TEM revealed that the synthesized AgNPs possess spherical shape with a mean diameter at 94 nm for green and 104 nm for chemical method, the zeta potential values was −12.02 mV for green AgNPs and −10.4 mV for chemical AgNPs. In addition, FT-IR measurement analysis was conceded out to identify the Ag+ ions reduced from the specific functional groups on the AgNPs, which increased the stability of the particles. Further, we compared the toxicities of green and chemical AgNPs against human skin dermal fibroblast (HDFa) and brine shrimp followed by anticancer activity in NCI-H460 cells. We observed green AgNPs cause dose-dependent decrease in cell viability and increase in reactive oxygen species (ROS) generation. Further, we proved to exhibit excellent cytotoxic effect and induction of cellular apoptosis in NCI-H460 cells. Furthermore, green AgNPs had no significant changes in cell viability, ROS production and apoptotic changes in HDFa cells. In contrary, we observed that the chemical AgNPs possess significant toxicities in HDFa cells. Hence, the green AgNPs were able to induce selective toxicity in cancer cells than the chemical AgNPs. Furthermore, green AgNPs exhibit less toxic effects against human red blood cells and brine shrimp (Artemia salina) nauplii than the chemical AgNPs. It was concluded, that apart from being superior over chemical AgNPs, the green AgNPs are effective and safer to the milieu as they show less toxic effect to normal cells and can be extensively applied in biomedical sciences particularly in cancer field. © 2016 Elsevier Masson SAS

Purpose of review: Current undergraduate medical curricula in most institutions around the globe do not nurture the skills, needed for self-directed lifelong learning in medical graduates, and it needs to be reformed in such a way that the medical graduate who is trained through this reformed curriculum, possesses all the competencies of a self-directed learner.Evidence-based medicine (EBM), a new vision of physician learning which is based on continuous development and assessment of competencies needed for creating self-directed learners is to be strongly advocated for inclusion in the undergraduate medical curriculum. Recent findings: Clinical teaching opportunities which are available while treating patients, in outpatient clinic, operating room, and by the bedside need to be utilized to teach EBM.Medical curricula, both undergraduate and postgraduate, should incorporate both EBM and quality improvement training, and these should be taught in a holistic fashion. Evidence-based practice competency was shown to increase, regardless of whether evidence-based practice is delivered to medical students at an undergraduate or postgraduate level.Early introduction of EBM in the undergraduate medical curriculum, in the form of a short course, using various modes of instruction, enhances the competence of critical thinking and also influences change in attitude towards EBM positively in medical students. Summary: Introduction of EBM in undergraduate medical curriculum helps in the development of professional competencies of self-directed learners in medical students. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Kulkarni N.,KLE University | Muddapur U.,KLE University
Journal of Nanotechnology | Year: 2014

The synthesis of nanostructured materials, especially metallic nanoparticles, has accrued utmost interest over the past decade owing to their unique properties that make them applicable in different fields of science and technology. The limitation to the use of these nanoparticles is the paucity of an effective method of synthesis that will produce homogeneous size and shape nanoparticles as well as particles with limited or no toxicity to the human health and the environment. The biological method of nanoparticle synthesis is a relatively simple, cheap, and environmentally friendly method than the conventional chemical method of synthesis and thus gains an upper hand. The biomineralization of nanoparticles in protein cages is one of such biological approaches used in the generation of nanoparticles. This method of synthesis apart from being a safer method in the production of nanoparticles is also able to control particle morphology. © 2014 Narendra Kulkarni and Uday Muddapur.

To investigate whether feeding and oral hygiene practices of preschool children are associated with the risk and prevalence of Early Childhood Caries (EC). A cross-sectional study comprising 1250 children aged 3 to 5 years from Belgaum was designed. On the first day, validated questionnaires along with parental informed consent forms were distributed to the children and were collected after a week. Validated questionnaires consisted of 20 close-ended questions pertaining to feeding and oral hygiene practices. Consent was obtained from parents of the 1116 children who were examined for EC. Data analysis included correlation coefficients and logistic regressions. Among the children studied, 97.3% were breastfed, of which 41.25% were breastfed until 2 years of age. Seventy- five percent of children who were breastfed beyond 2 years were affected by EC. Exclusive bottle feeding was practiced in 46.15%; 64.85% of them suffered from EC. Burping was not practiced in 25.18%, and 68.68% of these were affected by EC. EC was more prevalent in 89% of children who were weaned later than 12 months of age. Parental assistance for oral hygiene was not seen in 37.27% and 67.22% of these suffered from EC. Overall, 63.17% of the children were affected by EC. Prolonged breastfeeding, absence of burping the child, delay in starting oral hygiene practices and lack of parental assistance with the same were shown to be significant determining factors for EC. Health education and proper guidelines on feeding and oral hygiene practices can substantially reduce the risk and prevalence of EC.

Sanikop S.,KLE University
Journal of oral science | Year: 2011

Dental pain, anxiety and fear are important factors that prevent patients from seeking dental care. In this study, we aimed to evaluate the pain perception of patients during scaling and its relationship with dental anxiety. One hundred dental patients participated in the study. Pain levels after scaling were assessed with a Visual Analog Scale (VAS) and an Anxiety Questionnaire consisting of seven questions. The mean VAS score for the entire study group was 17.3 ± 13.8 with no statistically significant differences between gender and different age groups. The mean anxiety score was 11.66 ± 4.17. This was significantly higher in women (P = 0.005), but there were no statistically significant differences between different age groups. There was a statistically significant correlation between VAS and total anxiety score (P < 0.001) as well as each question, except for questions number 3 and 4 in men. Patients were found to experience only limited pain during scaling. They were anxious because they expected pain, women being more anxious than men. Hence, dentists should seek to alleviate or reduce pain and anxiety related to treatment not only to successfully complete the treatment, but also to sustain and carry the patients into successful maintenance and patient recall.

Kumar S.,KLE University | Alagawadi K.R.,KLE University
Pharmaceutical Biology | Year: 2013

Context: Alpinia galanga Willd (Zingiberaceae) (AG) is a rhizomatous herb widely cultivated in shady regions of Malaysia, India, Indochina and Indonesia. It is used in southern India as a domestic remedy for the treatment of rheumatoid arthritis, cough, asthma, obesity, diabetes, etc. It was reported to have anti-obesity, hypoglycemic, hypolipidemic and antioxidant properties. Objective: A flavonol glycoside, galangin, was isolated from AG rhizomes. Based on its in vitro pancreatic lipase inhibitory effect, the study was further aimed to clarify whether galangin prevented obesity induced in female rats by feeding cafeteria diet (CD) for 6 weeks. Materials and methods: The in vitro pancreatic lipase inhibitory effect of galangin was determined by measuring the release of oleic acid from triolein. For in vivo experiments, female albino rats were fed CD with or without 50mg/kg galangin for 6 weeks. Body weight and food intake was measured at weekly intervals. On day 42, serum lipids levels were estimated and then the weight of liver and parametrial adipose tissue (PAT) was determined. The liver lipid peroxidation and triglyceride (TG) content was also estimated. Results: The IC50 value of galangin for pancreatic lipase was 48.20mg/mL. Galangin produced inhibition of increased body weight, energy intake and PAT weight induced by CD. In addition, galangin produced a significant decrease in serum lipids, liver weight, lipid peroxidation and accumulation of hepatic TGs. Conclusion: Galangin present in AG rhizomes produces anti-obesity effects in CD-fed rats; this may be mediated through its pancreatic lipase inhibitory, hypolipidemic and antioxidant activities. © 2013 Informa Healthcare USA, Inc.

Mane D.R.,KLE University
Journal of oral science | Year: 2010

Trichilemmal carcinoma is a rare malignant skin adnexal tumor derived from the outer root sheath epithelium of the hair follicle. We describe a rare case of trichilemmal carcinoma of the upper lip associated with xeroderma pigmentosa in a young patient. We demonstrate that this tumor, as well as the more frequently reported squamous cell carcinoma and basal cell carcinoma can occur in association with xeroderma pigmentosa. Making this diagnosis is imperative as the biological behavior of Trichilemmal carcinoma is less aggressive than that of other epithelial malignancies, requiring a different approach to treatment planning.

To determine the efficacy of mini-implants as intraoral anchorage during en masse intrusion of the six maxillary anterior teeth. Ten patients from the Department of Orthodontics, KLE University, Belgaum, India, who required intrusion of their anterior teeth were selected for this study. After initial alignment and leveling, the maxillary arch was divided into one anterior segment and two posterior segments. A 0.021 3 0.025-inch stainless steel wire was placed in all three segments. In all patients, one mini-implant was placed bilaterally between the lateral incisor and canine. An elastic chain was used to deliver an intrusive force of 45 cN; it was supplemented by a distal force of about 20 cN per side. Patient records were taken at the beginning and end of intrusion. The amount of intrusion was statistically and clinically significant. The canines were more intruded (3.5 ± 0.9 mm) than the incisors (2.9 ± 1.0 mm). The axial inclination of the incisors did not significantly change. The average duration to accomplish this intrusion was 4.0 ± 1.5 months, with a mean rate of 0.9 mm per month for the canines and 0.7 mm per month for the incisors. Mini-implants are an efficient and stable source of anchorage for the en masse intrusion of the six maxillary anterior teeth. © 2010 BY QUINTESSENCE PUBLISHING CO, INC.

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