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Saitama, Japan

Arashima Y.,Nihon University | Yakubo S.,Nihon University | Ueda Y.,Nihon University | Nagaoka H.,Japan Institute for Environmental Sciences | And 3 more authors.
International Medical Journal | Year: 2013

Introduction: It has been claimed that 1-2% of children are infected with Coxiella. burnetii (C. burnetii) but reports of such children are few. In addition, hitherto there have been no reports of otalgia arising from C. burnetii infection. Case: The present case concerns a boy of 11 years with severe otalgia who approximately 6 months previously had begun complaining of a sense of constriction in the throat and bronchi and had come to be suspected of feigning illness. After serologic testing revealed C. burnetii infection, we treated him with Minocycline for six weeks, which led to improvement in his symptoms. It appears that this is the first reported case of otalgia due to C. burnetii infection. Conclusion: In otorhinology, when there are difficulties in pinning down the cause of symptoms and no signs of systemic inflammation, when severe otalgia is present despite the absence of obvious physical signs, it may be appropriate to consider C. burnetii as a possible cause. © 2013 Japan International Cultural Exchange Foundation and Japan Health Sciences University. Source

Yakubo S.,Nihon University | Ueda Y.,Nihon University | Tanekura N.,Nihon University | Arashima Y.,Nihon University | And 3 more authors.
International Medical Journal | Year: 2012

Introduction: Marmion et al. recently reported a new condition, post-Q fever fatigue syndrome (QFS), in which nonspecific symptoms such as a slight fever, general malaise, headache, arthralgia, and myalgia continue indefinitely after a Q fever infection with Coxiella burnetii (C. burnetii). Case: We report the case of a 53-year-old male infected with C. burnetii, who complained of nausea, stomach pain, an abnormal sensation in the mouth, sore throat, general fatigue, and trouble sleeping, symptoms which suggested QFS. An evaluation with the self-rating depression scale led to the conclusion that the patient was in a depressive state, which can sometimes lead to suicide. In this case, the patient did indeed attempt suicide in spite of treatment with an antidepressant as well as an antibiotic against the C. burnetti infection. Conclusion: This report is the first case of a patient led to attempt suicide due to depression arising from QFS. © 2012 Japan International Cultural Exchange Foundation and Japan Health Sciences University. Source

Arashima Y.,Nihon University | Yakubo S.,Nihon University | Nagaoka H.,Japan Institute for Environmental Sciences | Komiya T.,Kitasato Institute | And 3 more authors.
International Medical Journal | Year: 2012

We report a 46-year-old male infected with Coxiella burnetii, complaining of slight fever, general fatigue, and trouble sleeping. Minocycline therapy for 3 months relieved his symptoms, including a depressive state, resulting in thoughts of death. This case is the first report on post-Q fever fatigue syndrome associated with depression. © 2012 Japan International Cultural Exchange Foundation & Japan Health Sciences University. Source

Komatsu E.,Kitasato Institute | Yamaguchi F.,Kitasato Institute | Abe A.,Kitasato University | Weiss A.A.,University of Cincinnati | Watanabe M.,Kitasato University
Clinical and Vaccine Immunology | Year: 2010

The Bordetella pertussis pertussis toxin and pertactin (Prn) are protective antigens and are contained in acellular pertussis vaccines. Polymorphisms in the A subunit of pertussis toxin (PtxA) and pertactin have been proposed to mediate vaccine resistance and contribute to pertussis reemergence. To test this hypothesis, previous studies compared clinical isolates expressing different alleles for the proteins. However, other virulence factors or virulence factor expression levels also may vary, confounding the analysis. To overcome these limitations, we constructed isogenic mutants of B. pertussis Tohama expressing the alleles ptxA1 or ptxA2 and prn1 or prn2 and compared the efficacies of an acellular pertussis vaccine against the mutants in a mouse model. While the vaccine was effective against all of the B. pertussis strains regardless of the allele expression pattern, the strain expressing ptxA1 and prn2 displayed a survival advantage over the other strains. These results suggest that an allele shift to the ptxA1 prn2 genotype may play a role in the emergence of pertussis in vaccinated populations. Copyright © 2010, American Society for Microbiology. All Rights Reserved. Source

Matsumoto T.,Kitasato University | Matsumoto T.,Kitasato Institute | Noguchi M.,Kitasato University | Hayashi O.,Kagawa Nutrition University | And 3 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2010

The effect of oral administration of Hochuekkito (HET; Bu-Zhong-Yi-Qi-Tang in Chinese), a traditional Japanese herbal medicine, on mucosal IgA immune response was investigated. To induce the antigen-specific antibodies in mucosal site, ovalbumin (OVA)-entrapped biodegradable microparticles (OVA-microparticles) were used as an antigen. Mice were orally immunized with OVA-microparticles for 3 successive days with intragastric gavage. From 7 days after the onset of immunization, the mice were boosted twice a week with the same antigen for 2 weeks. HET or water alone was orally administered to the mice via the intragastric route from 7 days before to 27 days after the onset of immunization. Although no significant change in total secretory IgA antibody level was observed in intestinal and nasal washes, OVA-specific IgA titers in intestinal washes were significantly enhanced by oral administration of HET. When lymphocytes from spleen, peripheral blood and Payers patches were investigated for cytokines production, it was found that the IFN-γ secretion from the lymphocytes was increased by the administration of HET. Microarray analysis of Peyers patch cells revealed enhanced expression of L-selectin gene. The increase of L-selectin positive cells in B lymphocytes fraction was observed in Peyers patch cells and peripheral blood mononuclear cells by flow cytometry. These results suggest that the enhanced IFN-γ secretion and increased population of L-selectin positive B lymphocytes by orally administered HET may partly contribute to enhancement of IgA immune response against intestinal antigens, and orally administered HET may strengthen defensive systems against various pathogens and food antigens in intestine. Source

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