Kitasaito Hospital

Asahikawa, Japan

Kitasaito Hospital

Asahikawa, Japan

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Nakayama M.,Fukushima Medical University | Ishida M.,Kitasaito Hospital | Ogihara M.,Nephrology | Hanaoka K.,Jikei University School of Medicine | And 4 more authors.
Nephrology | Year: 2015

Aim Patient socialization and preservation of socioeconomic status are important patient-centred outcomes for those who start dialysis, and retention of employment is a key enabler. This study examined the influence of dialysis inception and modality upon these outcomes in a contemporary Japanese cohort. Methods We conducted a survey of prevalent chronic dialysis patients from 5 dialysis centres in Japan. All patients who had been on peritoneal dialysis (PD) since dialysis inception were recruited, and matched with a sample of those on in-centre haemodialysis (ICHD). We assessed patients' current social functioning (Short Form 36 Health Survey), and evaluated changes to patient employment status, annual income, and general health condition from the pre-dialysis period to the current time. Results A total of 179 patients were studied (102 PD and 77 ICHD). There were no differences in social functioning by modality. Among them, 113 were employed in the pre-dialysis period with no difference by modality. Of these, 22% became unemployed after dialysis inception, with a corresponding decline in average working hours and annual income. The odds of unemployment after dialysis inception were 5.02 fold higher in those on ICHD compared to those on PD, after adjustment for covariates. There were no changes for those who were already unemployed in the pre-dialysis period. Conclusions Employment status is significantly hampered by dialysis inception, although PD was associated with superior retention of employment and greater income compared to ICHD. This supports a positive role for PD in preservation of socioeconomic status and potentially other patient-centred outcomes. © 2015 Asian Pacific Society of Nephrology.


PubMed | Baxter Ltd, Kitasaito Hospital, Fukushima Medical University, University of Occupational and Environmental Health Japan and 4 more.
Type: Journal Article | Journal: Nephrology (Carlton, Vic.) | Year: 2015

Patient socialization and preservation of socioeconomic status are important patient-centred outcomes for those who start dialysis, and retention of employment is a key enabler. This study examined the influence of dialysis inception and modality upon these outcomes in a contemporary Japanese cohort.We conducted a survey of prevalent chronic dialysis patients from 5 dialysis centres in Japan. All patients who had been on peritoneal dialysis (PD) since dialysis inception were recruited, and matched with a sample of those on in-centre haemodialysis (ICHD). We assessed patients current social functioning (Short Form 36 Health Survey), and evaluated changes to patient employment status, annual income, and general health condition from the pre-dialysis period to the current time.A total of 179 patients were studied (102 PD and 77 ICHD). There were no differences in social functioning by modality. Among them, 113 were employed in the pre-dialysis period with no difference by modality. Of these, 22% became unemployed after dialysis inception, with a corresponding decline in average working hours and annual income. The odds of unemployment after dialysis inception were 5.02 fold higher in those on ICHD compared to those on PD, after adjustment for covariates. There were no changes for those who were already unemployed in the pre-dialysis period.Employment status is significantly hampered by dialysis inception, although PD was associated with superior retention of employment and greater income compared to ICHD. This supports a positive role for PD in preservation of socioeconomic status and potentially other patient-centred outcomes.


Talib A.,Asahikawa University | Nakagawa N.,Asahikawa University | Saito E.,Asahikawa University | Matsuki M.,Asahikawa University | And 8 more authors.
Hypertension Research | Year: 2012

Fetuin-A and osteoprotegerin (OPG) are arterial calcification regulators, which are related to cardiovascular survival in hemodialysis patients. We hypothesized that a balance of these calcification regulators might mediate the progression of left ventricular (LV) diastolic dysfunction in hemodialysis patients. We recruited 63 hemodialysis patients and measured their serum fetuin-A, OPG, arterial stiffness, aortic calcification and echocardiographic parameters, including the transmitral early diastolic velocity/tissue Doppler mitral annular early diastolic velocity ratio (E/E′), and analyzed the relationships between these variables. Fetuin-A levels were significantly and negatively correlated with the ankle-brachial pulse wave velocity (baPWV), aortic calcification score (AOCS), left atrial volume index (LAVI), LV mass index (LVMI) and E/E′. OPG levels and the ratio of OPG to fetuin-A levels were significantly and positively correlated with the baPWV, AOCS, LAVI and E/E′. A stepwise multiple regression analysis revealed that E/E′ was independently correlated with fetuin-A levels (β=-0.334, P=0.02), OPG levels (β0.367, P=0.01) and the ratio of OPG to fetuin-A (β0.295, P=0.04). Categorizing the patients according to their serum fetuin-A and OPG levels revealed that patients with low fetuin-A and high OPG levels had the highest LAVI, LVMI and E/E′ values after adjusting for potential confounders. Serum fetuin-A levels negatively reflected, whereas OPG levels and the ratio of OPG to fetuin-A positively reflected an increase in vascular and ventricular stiffness, leading to the aggravation of diastolic dysfunction. Therefore, based on our results, the balance of the tissue calcification regulators fetuin-A and OPG could mediate the progression of LV diastolic dysfunction in hemodialysis patients. © 2012 The Japanese Society of Hypertension All rights reserved.


Nakagawa N.,Asahikawa University | Yao N.,Kitasaito Hospital | Hirayama T.,Kitasaito Hospital | Ishida M.,Kitasaito Hospital | And 6 more authors.
Hypertension Research | Year: 2011

Although metabolic syndrome confers an increased risk of cardiovascular disease in the general population, little is known about the alteration of abdominal adiposity and its association with adipocytokines in hemodialysis patients. We investigated the plasma high-molecular-weight (HMW) adiponectin level and its relationship to visceral fat area (VFA) and various markers of atherosclerosis in hemodialysis patients. In a cross-sectional study, conventional cardiovascular risk factors, plasma total and HMW adiponectin, the number of components of the metabolic syndrome and, using computed tomography, the distribution of abdominal adiposity were assessed in 144 hemodialysis patients (90 men and 54 women; mean age, 60.7 years) and 30 age- and sex-matched patients with chronic kidney disease (CKD). Plasma HMW adiponectin levels in hemodialysis patients were significantly higher than those in patients with CKD, negatively associated with VFA and serum triglycerides and positively associated with plasma total adiponectin, as well as the HMW-to-total adiponectin ratio in men and women (all P0.05) in a simple regression analysis. In a multiple regression analysis, VFA was a significant determinant of HMW adiponectin in hemodialysis patients. Furthermore, after adjustment for classical risk factors, HMW adiponectin levels were significantly higher in patients undergoing treatment with renin-angiotensin system inhibitors or calcium channel blockers compared with patients not undergoing such treatment. This study shows that plasma HMW adiponectin levels were negatively associated with VFA and positively associated with treatment with blockade of the renin-angiotensin system and of the calcium channel. Therefore, these drugs might be effective for improving adipocytokine-related metabolic abnormalities in hemodialysis patients. © 2011 The Japanese Society of Hypertension All rights reserved.


Nakagawa N.,Asahikawa University | Matsuki M.,Asahikawa University | Matsuki M.,Kitasaito Hospital | Yao N.,Kitasaito Hospital | And 6 more authors.
Therapeutic Apheresis and Dialysis | Year: 2015

Metabolic syndrome confers an increased risk of cardiovascular disease (CVD) in the general population. The relationship between adiponectins, and clinical outcomes in patients undergoing hemodialysis remains controversial. We investigated whether adiponectins, biomarkers of inflammation, nutrition status and clinical features predict the mortality of patients undergoing hemodialysis for 6 years. We measured baseline plasma total and high-molecular-weight (HMW) adiponectins, tumor necrosis factor (TNF)-α, serum high sensitivity C-reactive protein (hsCRP), and clinical characteristics including visceral fat area (VFA) and the Geriatric Nutritional Risk Index (GNRI) in 133 patients undergoing chronic hemodialysis. Forty-one of the 133 patients died during follow-up. The deceased patients were significantly older, had more prior CVD and diabetes, higher TNF-α and hsCRP levels but lower GNRI. VFA, and total and HMW adiponectin did not significantly differ between the two groups. TNF-α and hsCRP levels and GNRI score were significant for predicting all-cause and cardiovascular mortality in receiver operating curve analyses. When stratified by a GNRI score of 96, Cox proportional hazards analyses identified TNF-α as a significant predictor of all-cause mortality (hazard ratio [HR] 1.23; P=0.038) and hsCRP as a significant predictor of all-cause and cardiovascular mortality (HR, 2.32, P=0.003; HR 2.30, P=0.012, respectively) after adjusting for age, sex, diabetes mellitus, and prior CVD, only in malnourished patients. These results demonstrate that malnutrition and the inflammatory markers TNF-α and hsCRP, but not metabolic markers, including VFA and adiponectins have a significant impact on 6-year all-cause and cardiovascular mortality in Japanese patients undergoing hemodialysis. Therapeutic Apheresis and Dialysis. © 2014 International Society for Apheresis.


Motoya T.,Asahikawa University | Motoya T.,Furano Hospital | Matsumoto S.,Asahikawa University | Yamaguchi S.,Furano Hospital | And 5 more authors.
International Urology and Nephrology | Year: 2014

Objectives: To investigate the impact of abdominal aortic calcification and visceral fat area (VFA) on lower urinary tract symptoms (LUTS) and clinical parameters in patients with benign prostatic hyperplasia (BPH). Methods: We retrospectively studied 250 patients with LUTS associated with BPH. Each participant was examined with routine examination including measurement of various data; (1) voided volume (VV), maximum urinary flow rate on free uroflowmetry, (2) postvoid residual urine volume and prostate volume using transabdominal ultrasound, (3) International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS), and (4) aortic calcification index (ACI) and VFA were measured by abdominal CT. Results: Mean age of the patients was 72.4 ± 9.6 years. ACI significantly correlated with VV (P = 0.0392) and tended to correlate with maximum urinary flow rate, while ACI did not correlate with subjective symptoms. VFA significantly correlated with nocturia score of IPSS (P = 0.0177) and frequency score of OABSS (P = 0.0166) and tended to correlate with urgency score of IPSS and maximum urinary flow rate. Conclusions: Aortic calcification index (ACI) correlated with only objective parameters, while VFA correlated with only storage symptoms. This study suggested that abdominal aortic calcification and VFA have certain influence on LUTS and clinical parameters in patients with BPH. © 2014 Springer Science+Business Media Dordrecht.


Ishida M.,Kitasaito Hospital
Contributions to Nephrology | Year: 2012

In Japan, peritoneal dialysis (PD) remains the principal modality of home dialysis for the elderly although PD patients accounted for only 3.3% (n = 9,728) of the overall dialysis patient population. One of the preventing factors for introduction of PD in elderly patients is the Japanese public nursing care system. Besides, difficulties in the continuation of dialysis therapy will arise because of the progression of dementia as well as the decline in muscular strength, vigor, and physical strength of patients. In spite of these difficulties, some local dialysis centers tried to maintain and manage elderly dialysis patients at home by utilizing diverse social resources, in addition to obtaining the cooperation of care givers such as family members. In our hospital, approximately 40% of patients who started dialysis therapy have selected PD. To support patients on PD, several special forms of care are prepared: utilization of visiting nurse care or home-visit nursing care services, supply of information on renal failure and education to home-care support providers and welfare service facility staff members. In addition, modulation of PD therapy such as automated PD and hemodialysis and PD in combination is also properly prepared. Lastly, the organization of a team, including physicians, nurses, social workers and dietitians, and the construction of a centralized patient information management system are important for elderly patients who need dialysis therapy. Copyright © 2012 S. Karger AG, Basel.


Okamoto T.,Hokkaido University | Tajima T.,Hokkaido University | Hirayama T.,Kitasaito Hospital | Sasaki S.,Hokkaido University
European Journal of Pediatrics | Year: 2012

Dent disease is an X-linked tubulopathy mainly caused by inactivating mutations of CLCN5. Features of Bartter syndrome such as hypokalemic metabolic alkalosis are rarely observed in patients with Dent disease. We report a Japanese male patient with Dent disease who also manifested features of Bartter syndrome. At the age of 3 years, he was diagnosed with Dent disease based on low molecular weight proteinuria and hypercalciuria. One year later, he was found to have features of Bartter syndrome, i.e., hypokalemia and metabolic alkalosis, and high levels of plasma renin activity and aldosterone with a normal blood pressure. Despite medical interventions, he developed chronic kidney disease stage 3 at the age of 21 years. To investigate the molecular basis of his disease, CLCN5, KCNJ1, SLC12A1, and CLCkb were analyzed and a novel mutation (Y567X) in CLCN5 was identified. Conclusion: Hypokalemic metabolic alkalosis is a rare manifestation in Dent disease. It is speculated that Dent patients with features of Bartter syndrome are susceptible to progression to renal failure. To study this hypothesis, additional observations and long-term follow-up of such patients are necessary. © 2011 Springer-Verlag.


Nakagawa N.,Asahikawa University | Kabara M.,Asahikawa University | Matsuki M.,Asahikawa University | Chinda J.,Asahikawa University | And 6 more authors.
Internal Medicine | Year: 2012

Objective Tonsillectomy and steroid-pulse (TSP) therapy have been proposed as a curative treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, we sometimes encounter patients who reject steroid-pulse therapy because of concerns about the side effects of corticosteroids. Here, we examined the efficacy of TSP therapy and tonsillectomy alone for IgAN with urinary abnormalities. Methods Data on 40 IgAN patients diagnosed by renal biopsies, who presented glomerular hematuria and proteinuria at baseline and underwent bilateral palatine tonsillectomy, were analyzed retrospectively. Twenty of them underwent TSP therapy (TSP group), and 20 underwent tonsillectomy alone (T group). We examined associations between therapies, changes in urinary findings and renal function, and subsequent clinical remission (CR), defined as negative proteinuria and urinary erythrocytes of less than 5/high-power field. Results TSP group showed a significant decrease in proteinuria and hematuria earlier than T group. The rates of CR were significantly higher in TSP group compared with T group on the final observation period (75% vs. 45%, p<0.05). There was a significant difference between CR group and non-CR group only in the rate of receiving TSP therapy. Conclusion TSP therapy significantly increased the probability of CR compared with tonsillectomy alone in IgAN patients with urinary abnormalities. © 2012 The Japanese Society of Internal Medicine.


PubMed | Kitasaito Hospital
Type: | Journal: Contributions to nephrology | Year: 2012

In Japan, peritoneal dialysis (PD) remains the principal modality of home dialysis for the elderly although PD patients accounted for only 3.3% (n = 9,728) of the overall dialysis patient population. One of the preventing factors for introduction of PD in elderly patients is the Japanese public nursing care system. Besides, difficulties in the continuation of dialysis therapy will arise because of the progression of dementia as well as the decline in muscular strength, vigor, and physical strength of patients. In spite of these difficulties, some local dialysis centers tried to maintain and manage elderly dialysis patients at home by utilizing diverse social resources, in addition to obtaining the cooperation of care givers such as family members. In our hospital, approximately 40% of patients who started dialysis therapy have selected PD. To support patients on PD, several special forms of care are prepared: utilization of visiting nurse care or home-visit nursing care services, supply of information on renal failure and education to home-care support providers and welfare service facility staff members. In addition, modulation of PD therapy such as automated PD and hemodialysis and PD in combination is also properly prepared. Lastly, the organization of a team, including physicians, nurses, social workers and dietitians, and the construction of a centralized patient information management system are important for elderly patients who need dialysis therapy.

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