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Schweiger B.,KIST Europe Forschungsgesellschaft mbH | Kim J.,KIST Europe Forschungsgesellschaft mbH | Kim Y.J.,KIST Europe Forschungsgesellschaft mbH | Ulbricht M.,University of Duisburg - Essen
Sensors (Switzerland) | Year: 2015

Piezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight estimations revealed a decrease of the polymerization rate with increasing clofibric acid concentration. XPS measurements indicated that clofibric acid could be removed after imprinting with an aqueous ethanol solution, which was further optimized by using PAD. Zeta potential and contact angle measurements revealed differences between molecularly imprinted (MIP) and non-imprinted polymer (NIP) layers. Binding experiments with clofibric acid and other substances showed a pronounced selectivity of the MIP for clofibric acid vs. carbamazepine, but the response of MIP and NIP to 2,4-dichlorophenoxyacetic acid was higher than that for clofibric acid. A smooth surface, revealed by AFM measurements, with roughness of 6–8 nm for imprinted and non-imprinted layers, might be a reason for an excessively low density of specific binding sites for clofibric acid. Furthermore, the decreased polymerization rate in the presence of clofibric acid might not result in well-defined polymer structures, which could be the reason for the lower sensitivity. © 2015 by the authors; licensee MDPI, Basel, Switzerland.


PubMed | KIST Europe Forschungsgesellschaft mbH and University of Duisburg - Essen
Type: Journal Article | Journal: Sensors (Basel, Switzerland) | Year: 2015

Piezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight estimations revealed a decrease of the polymerization rate with increasing clofibric acid concentration. XPS measurements indicated that clofibric acid could be removed after imprinting with an aqueous ethanol solution, which was further optimized by using PAD. Zeta potential and contact angle measurements revealed differences between molecularly imprinted (MIP) and non-imprinted polymer (NIP) layers. Binding experiments with clofibric acid and other substances showed a pronounced selectivity of the MIP for clofibric acid vs. carbamazepine, but the response of MIP and NIP to 2,4-dichlorophenoxyacetic acid was higher than that for clofibric acid. A smooth surface, revealed by AFM measurements, with roughness of 6-8 nm for imprinted and non-imprinted layers, might be a reason for an excessively low density of specific binding sites for clofibric acid. Furthermore, the decreased polymerization rate in the presence of clofibric acid might not result in well-defined polymer structures, which could be the reason for the lower sensitivity.


Neuzil P.,KIST Europe Forschungsgesellschaft MbH | Neuzil P.,Brno University of Technology | Neuzil P.,Institute of Microelectronics, Singapore | Campos C.D.M.,KIST Europe Forschungsgesellschaft MbH | And 6 more authors.
Lab on a Chip - Miniaturisation for Chemistry and Biology | Year: 2014

We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing system. We demonstrate different configurations to perform most detection schemes currently in use in LOC systems, including some of the most advanced such as nanowire-based biosensing, surface plasmon resonance sensing, electrochemical detection and real-time PCR. The complete system is controlled by a single chip and the collected information is stored in situ, with the option of transferring the data to an external display by using a USB interface. In addition to providing a framework for truly portable real-life developments of LOC systems, we envisage that this system will have a significant impact on education, especially since it can easily demonstrate the benefits of integrated microanalytical systems. © the Partner Organisations 2014.


The invention relates to an appliance for performing anaesthesia or analgosedation, comprising a dosing device (5) for the intravenous administration of an adjustable dose of at least one anaesthetic to a patient (1), a measuring device (2) for determining the concentration of the at least one anaesthetic in the exhaled air of the patient (1), means (4) for determining the effect of the at least one anaesthetic on the patient (1), preferably in the form of a depth of anaesthesia or depth of analgosedation, and a data processing device (7), which communicates via interfaces with the dosing device (5), the measuring device (2) and the means (4) for determining the effect and which, on the basis of the determined values of the parameters dosage, concentration and effect of the at least one anaesthetic, establishes a pharmacological model individualized to the patient (1) and, using the individualized pharmacological model that is established, calculates an individual dosage, optimized to the patient (1), of the at least one anaesthetic.


Patent
Kist Europe Forschungsgesellschaft Mbh | Date: 2011-06-09

The invention relates to a device for metering cells and also to a method for metering cells. Furthermore, the invention relates to the use of the device for metering cells.


Patent
Kist Europe Forschungsgesellschaft Mbh | Date: 2010-09-09

The present invention relates to a metering device for metered output of liquid preparations in the medicinal, pharmaceutical or cosmetic field or in the foodstuffs sphere, the use of preservatives being able to be dispensed with. Furthermore, the invention relates to a method for filling and also the use of a metering device according to the invention.


Patent
Kist Europe Forschungsgesellschaft Mbh and F. Holzer GmbH | Date: 2010-05-12

An embodiment of the present invention relates to a storage container for liquids or for viscous or atomisable products, which can be connected to a metering device, the storage container having a cylindrical configuration and a base with a pressure equalisation device and also an oppositely situated open side, the open side including a connection region, and in that an inner bag which is collapsible by suction force is disposed in the storage container.


Krause H.,KIST Europe Forschungsgesellschaft mbH | Schweiger B.,KIST Europe Forschungsgesellschaft mbH | Prinz E.,Softal Corona und Plasma GmbH | Kim J.,KIST Europe Forschungsgesellschaft mbH | Steinfeld U.,KIST Europe Forschungsgesellschaft mbH
Journal of Electrostatics | Year: 2011

The degradation of the pharmaceuticals carbamazepine, clofibric acid, and iopromide in aqueous and landfill leachate containing solutions by corona discharge over a liquid surface was investigated. Two barrier electrodes, which provided an atmospheric pressure corona, were mounted above a transport roll, which moved a thin water film of test solution from the sample reservoir. Numerous tests were performed on single, mixed, and landfill leachate containing solutions with various combinations of powers, rotational speeds, air gaps, and exhaust restrictions. Best results were obtained with the highest rotational speed, a reduced exhaust, and an electrode air gap of 1.5 mm. © 2011 Elsevier B.V.

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