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Saint Petersburg, Russia

Elizarov A.Yu.,RAS Ioffe Physical - Technical Institute | Faizov I.I.,Kirov Military Medical Academy | Kozlovskii A.V.,ZAO Mettek | Levshankov A.I.,RAS Ioffe Physical - Technical Institute
Instruments and Experimental Techniques | Year: 2013

The use of a medical mass spectrometer for measuring the concentration of the gas mixture components in the breathing circuit of an inhalational anesthesia machine in the real-time mode is described. The resolution of the mass spectrometer is M/ΔM = 200, and the detection threshold in terms of the partial pressure of the analyzed gases is 2 × 10-12 mbar. The mass spectrometer is capable of measuring the volumetric content of CO 2, O2, and inhalational anesthetic sevoflurane. The respiratory coefficient (CO2/O2) was measured during anesthesia to estimate the patient's stress reaction to a surgical injury. © 2013 Pleiades Publishing, Inc. Source


Elizarov A.Y.,RAS Ioffe Physical - Technical Institute | Levshankov A.I.,Kirov Military Medical Academy
Technical Physics | Year: 2011

Interaction between inhalational anesthetic sevoflurane and an absorber of CO2 (soda lime) in the breathing circuit of an anesthesia machine during low-flow anesthesia (0.5 l of a fresh gaseous mixture per minute) is studied with the mass-spectrometric method. Monitoring data for the concentration of sevoflurane and three toxic products of sevoflurane decompositions (substances A, B, and C) during anesthesia in the inspiration-expiration regime are presented. The highest concentration of substance A is found to be 65 ppm. The biochemical blood analysis before and after anesthesia shows that nephropathy is related to the function of liver toxicity. It is found that inhalational anesthetic sevoflurane influences the concentration of intravenous hypnotic propofol in blood. © 2011 Pleiades Publishing, Ltd. Source


Elizarov A.Y.,RAS Ioffe Physical - Technical Institute | Ershov T.D.,RAS Ioffe Physical - Technical Institute | Levshankov A.I.,Kirov Military Medical Academy
Technical Physics | Year: 2011

Intravenous hypnotic propofol and its metabolite are detected in real time during total intravenous anesthesia by an electron ionization mass spectrometer. The mass spectrometer is connected directly to the breathing circuit of an apparatus for inhalational anesthesia. Ratios between the propofol concentrations in expired air and blood serum are measured. It is concluded that real-time noninvasive monitoring of the propofol concentration in blood using electron ionization mass spectrometry is feasible. © 2011 Pleiades Publishing, Ltd. Source


Elizarov A.Y.,RAS Ioffe Physical - Technical Institute | Levshankov A.I.,Kirov Military Medical Academy
Technical Physics | Year: 2012

Mass-spectrometric monitoring of metabolism (CO 2/O 2) in the inspiration-expiration regime is used to estimate the anesthetic protection of the patient against surgical stimulation during combined anesthesia. A correlation between the anesthetic protection of the patient and the metabolic rate is demonstrated, and the periodic variation of the metabolic rate with time is found. The sevoflurane metabolism products and intravenous analgesic fentanyl are found in the blowing air of the patient during anesthesia. © 2012 Pleiades Publishing, Ltd. Source


Andreev V.P.,Herzen State Pedagogical University | Maslov Y.I.,Saint Petersburg State University | Sorokoletova E.F.,Kirov Military Medical Academy
Russian Journal of Plant Physiology | Year: 2012

Three species of Fucus inhabiting different zones at the littoral and sublittoral of the White Sea (F. vesiculosus L., F. serratus L., and F. distichus L.) were compared with regard to performance of the photosynthetic apparatus (PSA) and PSA changes upon prolonged desiccation of algae. The content of chlorophyll a and the total content of carotenoids were significantly higher in F. serratus than in F. vesiculosus. The potential quantum yield (F v/F m) of photosystem II (PSII) was 0.69-0.74 in all species. The highest effective quantum yield of PSII (Y II) was observed in F. vesiculosus plants inhabiting zones with the most intense insolation. The ratio of non-photochemical quenching to photochemical quenching (qN/qP) increased with the depth of algal habitats in the row from F. vesiculosus to F. serratus. The fluorescence parameters F. serratus deviated during desiccation from their normal values and did not recover upon the subsequent return to water. By contrast, the fluorescence parameters of F. vesiculosus and F. distichus recovered gradually after the return of algae from air to sea water. It is supposed that F. serratus plants, unlike other species, are characterized by comparatively low physiological plasticity. © 2012 Pleiades Publishing, Ltd. Source

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