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Toropov A.L.,Vyatka State University | Tsirkin V.I.,Kirov State Medical Academy | Kostyaev A.A.,Kirov Institute of Hematology and Blood Transfusion
Bulletin of Experimental Biology and Medicine | Year: 2011

Human blood serum exhibiting β-adrenoceptor-sensitizing activity does not prevent manifestation of similar activity of histidine, tryptophan, tyrosine, mildronat, and preductal. This opens prospects for the use of analogues of endogenous β-adrenoceptor-sensitizing agent in clinical practice. © 2011 Springer Science+Business Media, Inc. Source


Skolskaya O.Yu.,Kirov Institute of Hematology and Blood Transfusion | Tarasova L.N.,Kirov Institute of Hematology and Blood Transfusion | Vladimirova S.G.,Kirov Institute of Hematology and Blood Transfusion | Cherepanova V.V.,Municipal Hospital N 33
Gematologiya i Transfusiologiya | Year: 2013

Endothelial dysfunction and hemostatic disorders in the adult patients with acute lymphoblastic leukemia de novo were studied. Hemorrhagic syndrome developed in 44% of patients, in 4% of patients developed thrombotic complications. Endothelial dysfunction and activation of intravascular blood coagulation in the presence of normal levels of natural anticoagulants were detected in patients with acute lymphoblastic leukemia de novo. This status could be characterized as unstable balance which could be disturbed by an unfavorable factor of any kind. Source


Ovsepyan V.A.,Kirov Institute of Hematology and Blood Transfusion | Gabdulkhakova A.K.,Kirov Institute of Hematology and Blood Transfusion | Shubenkiva A.A.,Kirov Institute of Hematology and Blood Transfusion | Zotina E.N.,Kirov Institute of Hematology and Blood Transfusion
Bulletin of Experimental Biology and Medicine | Year: 2015

Relationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.09-1.78 and OR=1.66, 95%CI=1.09-2.54, respectively). In addition, association of 1082AA genotype with late stages of the disease by the moment of diagnosis is detected. These data indicate that IL-10 polymorphism G-1082A may be involved in the pathogenesis of chronic lymphoid leukemia. © 2015 Springer Science+Business Media New York Source


Luchinin A.S.,Kirov Institute of Hematology and Blood Transfusion | Zagoskina T.P.,Kirov Institute of Hematology and Blood Transfusion | Kulikova M.M.,Kirov Institute of Hematology and Blood Transfusion
Gematologiya i Transfusiologiya | Year: 2010

Serum ß2-microglobulin and albumin are important prognostic factors in multiple myeloma. The International Staging System (ISS) is based on measurements of serum levels of ß2-microglobulin and albumin. We evaluated the prognostic efficiency of ISS in patients with multiple myeloma receiving combined drug therapy with bortezomib. The study was carried out in 43 patients (age 36-75). The incidence and type of response in patients with multiple myeloma did not depend on the disease stage according to ISS. Progression free survival and overall survival did not differ in different prognostic groups. Source


Ovsepyan V.A.,Kirov Institute of Hematology and Blood Transfusion | Rosin V.A.,Kirov Institute of Hematology and Blood Transfusion | Zagoskina T.P.,Kirov Institute of Hematology and Blood Transfusion | Dyakonov D.A.,Kirov Institute of Hematology and Blood Transfusion
Gematologiya i Transfusiologiya | Year: 2013

The relationship between complete blood count, degree of bone marrow lymphoid infiltration and CYP1A 1, GSTMI, GSTTI, and GSTP1 gene polymorphisms has been studied in 153 patients with chronic lymphocytic leukemia. The distribution of polymorphic variants of these genes has been evaluated in groups of patients with diffuse and non-diffuse (focal or interstitial) lymphoid Infiltration of the bone marrow and with early and late disease stages by the moment of diagnosis. The counts of lymphocytes in the peripheral blood are lower in patients with homozygotic genotype 1 O5llelle of gene GSTPI than in those with the 1 O5Val genotypes. At the time of diagnosis establishment the incidence of the homozygotic genotype 1 O5lleIle of gene GSTPJ was higher in the groups with non-diffuse lymphoid infiltration of the bone marrow and with early disease stages than that in patients with diffuse infiltration (23.4 vs. 5 1.3% in patients with focal infiltration; X2= 7.19, p = 0.007; OR 0.29, 95% Cl 0.1 2-0.73) and with late stages (24.4 vs. 46.3% in patients with the early stages; X2= 8.01; p = 0.005; OR 0.38, 95% Cl 0.19-0.75). These results indicate a probable association of GSTPI gene single nucleotide polymorphism with the clinical pattern of chronic lymphocytic leukemia and volume of the tumor substrate at the time of diagnosis establishment. This polymorphism of GSTP1 gene can be regarded as a potential marker of disease course. In contrast to GSTP 1, the polymorphic status of GSTM 1, GSTT1, and CYP1A I genes is most likely inessential for the leukemic process pattern and level of tumor cell accumulation by the moment of diagnosis. Source

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