Kirov Academy of Military Medicine

Saint Petersburg, Russia

Kirov Academy of Military Medicine

Saint Petersburg, Russia

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Pavlyuchenko V.N.,Kirov Academy of Military Medicine | Ivanchev S.S.,RAS Boreskov Institute of Catalysis | Primachenko O.N.,RAS Boreskov Institute of Catalysis | Khaikin S.Y.,RAS Boreskov Institute of Catalysis | And 5 more authors.
Polymer Science - Series A | Year: 2011

Hydrogels with the memory effect are synthesized from crosslinked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate) via the method of template synthesis with the use of the drug cephazoline as a matrix. It is shown that the hydrogels show an increased sorption activity against the target drug and a slow rate of drug release from the hydrogel (the memory effect) under certain conditions. In combination with cephazoline, these hydrogels may be regarded as a new prolonged-drug-release system for the treatment of infectious diseases. © 2011 Pleiades Publishing, Ltd.


Ivanchev S.S.,RAS Boreskov Institute of Catalysis | Primachenko O.N.,RAS Boreskov Institute of Catalysis | Khaikin S.Ya.,RAS Boreskov Institute of Catalysis | Pavlyuchenko V.N.,Kirov Academy of Military Medicine | And 2 more authors.
Russian Journal of Applied Chemistry | Year: 2013

Hydrogels with memory effect (imprinted hydrogels) with respect to a combination of cefotaxime and diclofenac were synthesized from 2-hydroxyethyl methacrylate and functional monomers (acrylic acid and N,Ndimethylacrylamide). The hydrogels obtained show increased ability to sorb cefotaxime and especially diclofenac. Prolonged release of cefotaxime was revealed, becoming more pronounced with an increase in the cefotaxime concentration in the solution from which it is sorbed with the hydrogel. The effect of selective sorption of diclofenac with imprinted hydrogels from the diclofenac-cefotaxime drug combination was discovered. © Pleiades Publishing, Ltd., 2013.


Karpov M.I.,Kirov Academy of Military Medicine | Sokolov A.A.,Kirov Academy of Military Medicine | Bisaga G.N.,Kirov Academy of Military Medicine | Mihaltsova E.N.,Kirov Academy of Military Medicine | Odinak M.M.,Kirov Academy of Military Medicine
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Therapeutic apheresis combined with pulse therapy with small doses of corticosteroids was used in 7 patients with secondary progressing multiple sclerosis (MS) during 4 years. Before perfusions, we investigated the lymphocyte sensitivity to methylprednisolone in vitro in the reaction of leukocyte migration with myelin basic protein in each patient. The introduction of test doses of corticosteroids in each patient's blood sample before perfusion procedures showed the different rate of leukocyte migration with the myelin basic protein. On this basis, we selected an individual optimal methylprednisolone dose that was infused intravenously just after each perfusion procedure. The number of patients sensitive to low doses of methylprednisolone increased after therapeutic apheresis. These findings allow to consider the reaction of leukocyte migration with the presence of myelin basic protein as a new method of individual selection of corticosteroid doses for increase of treatment efficacy of secondary progressing multiple sclerosis.


Zhivolupov S.A.,Kirov Academy of Military Medicine | Samar Tsev I.N.,Kirov Academy of Military Medicine | Marchenko A.A.,Kirov Academy of Military Medicine | Puljatkina O.V.,Kirov Academy of Military Medicine
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Authors have studied the efficacy of adaptol and neyromidin in the combined treatment of patients with chronic cerebral circulation insufficiency and consequences of closed head injury using neurophysiological monitoring which included dynamic evaluation of central conductivity, neuropsychological tests and analysis of blood BDNF levels. Severe autonomic disorders, anxiety and low level of learning observed in all patients are correlated with neurophysiological (increased central conductivity time) and neurotrophic (decreased blood BDNF levels) profiles. These indicators may change throughout the treatment. The combination of adaptol and neyromidin enhanced greatly the efficacy of combined treatment. The received data allow recommending neurophysiological monitoring for treatment optimization of numerous neurological diseases that demand neuroplasticity stimulation.


PubMed | Kirov Academy of Military Medicine
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2013

Authors have studied the efficacy of adaptol and neyromidin in the combined treatment of patients with chronic cerebral circulation insufficiency and consequences of closed head injury using neurophysiological monitoring which included dynamic evaluation of central conductivity, neuropsychological tests and analysis of blood BDNF levels. Severe autonomic disorders, anxiety and low level of learning observed in all patients are correlated with neurophysiological (increased central conductivity time) and neurotrophic (decreased blood BDNF levels) profiles. These indicators may change throughout the treatment. The combination of adaptol and neyromidin enhanced greatly the efficacy of combined treatment. The received data allow recommending neurophysiological monitoring for treatment optimization of numerous neurological diseases that demand neuroplasticity stimulation.

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