Kirin Brewery Co.

Yokohama-shi, Japan

Kirin Brewery Co.

Yokohama-shi, Japan
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Watanabe S.,Kirin Brewery Co. | Seki H.,Osaka Institute of Technology | Ishii H.,Kwansei Gakuin University
IEEE International Conference on Industrial Informatics (INDIN) | Year: 2010

The single input rule modules connected fuzzy inference method (SIRMs method) can decrease the number of fuzzy rules drastically in comparison with the conventional fuzzy inference methods. Moreover, Seki et al. have proposed a functional type single input rule modules connected fuzzy inference method which generalizes the consequent part of the SIRMs method to function. However, these SIRMs methods can not realize XOR (Exclusive OR). Therefore, Seki et al. have proposed a "neural network-type SIRMs method" which unites the neural network and SIRMs method, and shown that this method can realize XOR. In this paper, neural network-type SIRMs method is shown to be superior to the conventional SIRMs method and neural network by applying to a medical data and Iris data. © 2010 IEEE.


Omasa T.,Osaka University | Furuichi K.,Osaka University | Furuichi K.,Meiji Dairies Corporation | Iemura T.,Osaka University | And 4 more authors.
Bioprocess and Biosystems Engineering | Year: 2010

Generally, mammalian cells utilize glucose and glutamine as primary energy sources. To investigate the effect of energy sources on metabolic fluxes and antibody production, glucose- or glutamine-limited serum-free continuous culture of hybridoma 3A21 cells, which produce anti-ribonuclease A antibody, was carried out. The cell volume and dry cell weight were evaluated under various steady-state conditions. The specific consumption and production rates were evaluated on the basis of dry cell weight. On the basis of these results, the fluxes of the metabolic pathway were calculated. It was found that increasing the specific growth rate causes the specific ATP and antibody production rates to decrease. The fluxes between malate and pyruvate also decreased with the increase in specific growth rate. To increase the ATP production rate under steady-state conditions by the enhancement of fluxes between malate and pyruvate, the reduced metabolic fluxes were increased by an intermediate (pyruvate, malate, and citrate) addition. As a result, higher specific ATP and antibody production rates were achieved following the intermediate addition at a constant dilution rate. © 2009 Springer-Verlag.


Kage T.,Kage Consulting Office | Kage T.,Kirin Brewery Company
Journal of the Vacuum Society of Japan | Year: 2015

The unique properties of diamond like carbon (DLC) film, including its chemical inertness and impermeability, make it possible for new applications in food and beverage. In this paper, I summarize and review the recent progress of gas barrier enhancement of polyethylene terephthalate (PET) bottles for beverage from the view point of the application of DLC coating. A unique technique of plasma CVD method has been developed to deposit DLC layer on the inside surface of PET bottles. The DLCcoated PET bottle exhibits extremely high gas barrier properties against oxygen, carbon dioxide and flavors compared to conventional bottles. For the practical use of PET bottles as a commodity, high speed and low cost coating are essential; accordingly several high speed coating machines with a capacity of up to 18000 bottles per hour have been developed, and successfully operated so far for a large production of soft drink. Low speed machines have also been introduced for wine, Japanese sake, edible oil, seasonings and others.


PubMed | Japan National Institute of Agrobiological Science, Institute of Biosciences &Applications, Indian Institute of Science, DNA Diagnostics Center and 3 more.
Type: | Journal: Scientific reports | Year: 2015

Despite more than 40 years of intense study, essential features of the silkmoth chorion (eggshell) are still not fully understood. To determine the precise structure of the chorion locus, we performed extensive EST analysis, constructed a bacterial artificial chromosome (BAC) contig, and obtained a continuous genomic sequence of 871,711 base pairs. We annotated 127 chorion genes in two segments interrupted by a 164kb region with 5 non-chorion genes, orthologs of which were on chorion bearing scaffolds in 4 ditrysian families. Detailed transcriptome analysis revealed expression throughout choriogenesis of most chorion genes originally categorized as middle, and evidence for diverse regulatory mechanisms including cis-elements, alternative splicing and promoter utilization, and antisense RNA. Phylogenetic analysis revealed multigene family associations and faster evolution of early chorion genes and transcriptionally active pseudogenes. Proteomics analysis identified 99 chorion proteins in the eggshell and micropyle localization of 1 early and 6Hc chorion proteins.


Takahashi J.,Keio University | Nakaya M.,Kirin Brewery Co. | Matsui E.,Kirin Brewery Co. | Hotta A.,Keio University
Journal of Applied Polymer Science | Year: 2013

The gas barrier properties of isotactic polypropylene (iPP) and high-density polyethylene (HDPE) are both significantly improved by diamond-like carbon (DLC) deposition and photografting polymerization using acrylic acid (AA) monomers. In fact, the gas barrier properties can be highly improved just by DLC or by AA-photografting polymerization. The improvement observed by AA-photografting polymerization is more pronounced than that by DLC deposition in our general experimental condition. In more detail, the oxygen barrier property of DLC-deposited and AA-grafted iPP is considerably improved by ∼10 times when compared with that of neat iPP. As for HDPE, the oxygen barrier property is enhanced by nearly six times through DLC deposition and photografting polymerization. By observing the surfaces, 30 nm layer of DLC and 1.0 μm of AA-grafted layer are firmly constructed on the polyolefins, which should contribute to the enhancement of the oxygen barrier property. Copyright © 2013 Wiley Periodicals, Inc.


Ohnuki S.,University of Tokyo | Enomoto K.,Kirin Brewery Company | Yoshimoto H.,Kirin Brewery Company | Ohya Y.,University of Tokyo
Journal of Bioscience and Bioengineering | Year: 2014

The vitality of brewing yeasts has been used to monitor their physiological state during fermentation. To investigate the fermentation process, we used the image processing software, CalMorph, which generates morphological data on yeast mother cells and bud shape, nuclear shape and location, and actin distribution. We found that 248 parameters changed significantly during fermentation. Successive use of principal component analysis (PCA) revealed several important features of yeast, providing insight into the dynamic changes in the yeast population. First, PCA indicated that much of the observed variability in the experiment was summarized in just two components: a change with a peak and a change over time. Second, PCA indicated the independent and important morphological features responsible for dynamic changes: budding ratio, nucleus position, neck position, and actin organization. Thus, the large amount of data provided by imaging analysis can be used to monitor the fermentation processes involved in beer and bioethanol production. © 2013 The Society for Biotechnology, Japan.


Nakaya M.,Kirin Brewery Co. | Shimizu M.,Kirin Brewery Co. | Uedono A.,University of Tsukuba
Thin Solid Films | Year: 2014

With a type of capacitatively coupled plasma enhanced chemical vapor deposition (PECVD) technique, where two specially designed electrodes face to each other, the inner surface of hollow 3-dimensional objects such as poly(ethylene terephthalate) (PET) bottles can be coated with diamond-like carbon (DLC) thin film. DLC-coated PET bottles obtained with this technique have an enhanced gas barrier property, and therefore are applicable to industrial use such as for the extension of the shelf-life of contents sensitive to gas permeation. In this paper, the impact of power frequency ranging from 2.5 to 13.56 MHz was studied in order to research the behavior of plasma inside PET bottles and resultant properties. Different power frequency turned out to be influential on gas barrier property, the overall and distribution of tint, and adhesion between DLC and PET substrate. In addition, positron annihilation turned out to be powerful tool for the comparison of different coating conditions because it clarifies the homogeneity of DLC thin films through providing information on overall structure and thickness of them. These findings can be used for the optimization not only in the beverage PET bottle application, but also in other capacitatively coupled PECVD devices. © 2014 Elsevier B.V.


Ishibashi T.,Kirin Brewery Co.
Nihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence | Year: 2010

It is generally assumed that subjects with ALDH2*1/1 do not exhibit flushing symptoms after alcohol intake, but recent studies have revealed discordance in ALDH2 genotypes with self-reported facial flushing and the ethanol patch test. We evaluated the reliability of a facial flushing questionnaire and the ethanol patch test in 495 Japanese volunteers. Genomic DNA was extracted from peripheral blood samples and amplified by polymerase chain reaction (PCR) to detect ALDH2 polymorphisms as reported previously. The subjects were classified by the presence or absence of facial flushing using a questionnaire. Ethanol patch tests were performed using the previously described method. Each subject's alcohol consumption was established through a questionnaire. In each gender, there was a high frequency of facial flushing and positive ethanol patch tests in ALDH2*1/1 subjects. Alcohol consumption was not significantly different between ALDH2*1/1 subjects with positive and negative results. However, alcohol consumption in the positive ALDH2*1/1 group was significantly higher than that of ALDH2*1/2 subjects in both tests, indicating that the positive results may lead to variance with ALDH2*1/1. Most of the ALDH2*1/2 subjects exhibited facial flushing and a positive patch test. Meanwhile, 100% in the ALDH2*2/2 group exhibited positive results. There was no significant gender difference in either facial flushing or ethanol patch test reactions. In addition, the frequency of both male and female ALDH2*1/1 subjects with positive flushing and ethanol patch test reactions increased roughly in proportion to drinking frequency, but no significant differences were observed between them. Consequently, the general use of self-reported facial flushing or ethanol patch tests instead of ALDH2 genotyping should be carefully handled for genetic association studies of drinking behavior and alcohol-related diseases.


A practical total synthesis of (2S,3S,4R)-l-O-(-d-galactopyranosyl)-N-hexacosanoyl-2-amino-l,3,4-octadecanetriol (KRN7000), an antitumorial and immunostimulatory glycosphingolipid derived from agelasphins, was achieved in 14 steps starting from d-lyxose in a 16% overall yield.


PubMed | Kirin Brewery Co.
Type: Journal Article | Journal: Bioscience, biotechnology, and biochemistry | Year: 2016

Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14,17)-14-hydroxy- and (14, 17)-2,14-dihydroxyestradiols (2 and 3) were synthesized as models for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.

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