Osaka, Japan
Osaka, Japan

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Patent
Kinki University | Date: 2015-04-30

To provide a differentiation-inducing composition and a method for producing the differentiation-inducing composition, the present disclosure describes use of a degradation product containing at least a portion of the triple helical domain of collagen or atelocollagen.


Patent
Kinki University | Date: 2017-03-08

To provide a differentiation-inducing composition and a method for producing the differentiation-inducing composition, the present disclosure describes use of a degradation product containing at least a portion of the triple helical domain of collagen or atelocollagen.


Patent
Daiichi Sankyo, U3 Pharma GmbH, Kinki University and Amgen | Date: 2016-10-19

The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.


Patent
Kinki University and Fuso Pharmaceutical Industries Ltd. | Date: 2016-03-30

The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R^(1) and R^(2) independently represents H, -OH or -OR^(11), wherein R^(11) represents a C_(1-3) alkyl group; each of R^(3) and R^(4) independently represents H, -OH or -OR^(12), wherein R^(12) represents a C_(1-3) alkyl group; and each of R^(5) and R^(6) independently represents H, a halogen atom, a C_(1-10) alkyl group, a C_(2-6) alkenyl group, a C_(2-6) alkynyl group, a phenyl group (which may be substituted by a C_(1-6) alkoxy group or a halogen atom), a -C_(1-3) alkyl-phenyl group (which may be substituted by a C_(1-6) alkyloxy group or a halogen atom) or a C_(10-50) prenyl group.)


Patent
Kinki University and Otsuka Pharmaceutical Factory Inc. | Date: 2016-06-15

The present invention relates to a nanoparticle composition which is prepared by a process which is characterized by dissolving a poorly water-soluble compound or the like under a high temperature and a high pressure, and milling a suspension or the like containing a uniform crystal obtained by cooling the obtained solution.


Patent
Kinki University, Educational Corporation Mukogawa Gakuin and Nipro Corporation | Date: 2016-11-02

The present invention provides a hemiacetal ester prodrug of the pyridone carboxylic acid antibacterial drug, wherein the prodrug is characterized in that, (i) it is hydrolyzed promptly after intestinal absorption and regenerates the pyridone carboxylic acid antibacterial drug as a drug substance, (ii) a one-dose package is possible by preventing chelate-formation in intestines in an oral administration, and (iii) the normal bacterial flora of the intestinal bacterial flora is not influenced at all until the ester is absorbed, because the hemiacetal-type esterification is executed on the carboxylic acid which is a center of the antibacterial action, resulting in prevention of the pseudomembranous colitis. The prodrug is an alkoxy carbonyl hemiacetal-type ester represented by the chemical formula (I), which is useful as a prodrug for inhibiting the enteric-bacterium-shift side effect, and can be used in combination with polyvalent metal-containing medicines.


Patent
New Environmental Technology Council and Kinki University | Date: 2016-07-13

Provided are a novel cultivation method and a storage method that are suitable for storing bacteria belonging to the genus Collimonas for a long period of time. The cultivation method for bacteria belonging to the genus Collimonas is characterized in that bacteria belonging to the genus Collimonas are cultivated in a sealed state on a culture medium that includes a rice bran culture medium and/or a soy pulp culture medium. The storage method for bacteria belonging to the genus Collimonas is characterized in that the cultivated bacteria belonging to the genus Collimonas are stored at room temperature.


Ohta N.,Kinki University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

It has been suggested that the dark energy that explains the observed accelerating expansion of the universe may arise due to the contribution to the vacuum energy of the QCD ghost in a time-dependent background. The argument uses a four-dimensional simplified model. In this Letter, we put the discussion in more realistic model keeping all components of the QCD vector ghost and show that indeed QCD ghost produces dark energy proportional to the Hubble parameter HΛQCD 3 (ΛQCD is the QCD mass scale) which has the right magnitude ̃(3×10-3 eV)4. © 2010 Elsevier B.V.


Zlotnik A.,University of California at Irvine | Yoshie O.,Kinki University
Immunity | Year: 2012

The chemokine superfamily consists of a large number of ligands and receptors. At first glance, this family appears redundant and their ligand-receptor relationships promiscuous, making its study challenging. However, analyzing this family from the evolutionary perspective greatly simplifies understanding both the organization and function of this apparently complex system. In particular, the functions of a subgroup of chemokines (designated homeostatic chemokines) have played pivotal roles in advancing our understanding of the organization and function of the cellular networks that shape the immune system. Here, we update the full scope of the human and mouse chemokine superfamilies and their relationships and summarize several important roles that homeostatic chemokines play in the immune system. © 2012 Elsevier Inc.


Patent
Tamura Teco Co. and Kinki University | Date: 2016-05-04

There are provided an anticancer agent degradation method for protecting medical professionals from exposure to an anticancer agent externally scattered in, for example, a safety cabinet or prescription laboratory, during drug preparation or other circumstance, and an anticancer agent degradation apparatus for use with this anticancer agent degradation method. Anticancer agent flyoff in a safety cabinet, etc. is degraded by exploiting an action of ozone-containing air humidified by humidifying means. A relative humidity of humidified ozone-containing air is preferably greater than or equal to 80%. In controlling degradation treatment on the basis of CT values, a difference between expected humidity and measured humidity is reflected in an increment of CT value to understand the progress of anticancer agent degradation properly.

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