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Patent
Kinki University | Date: 2017-03-08

To provide a differentiation-inducing composition and a method for producing the differentiation-inducing composition, the present disclosure describes use of a degradation product containing at least a portion of the triple helical domain of collagen or atelocollagen.


Patent
Kinki University | Date: 2015-04-30

To provide a differentiation-inducing composition and a method for producing the differentiation-inducing composition, the present disclosure describes use of a degradation product containing at least a portion of the triple helical domain of collagen or atelocollagen.


Patent
Daiichi Sankyo, U3 Pharma GmbH, Kinki University and Amgen | Date: 2016-10-19

The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.


Patent
Lintec Corporation, Lintec of America Inc. and Kinki University | Date: 2017-09-27

The present invention provides a method for producing a carbon nanotube sheet that is excellent in light transmittance and conductivity, and the carbon nanotube sheet. The method includes firstly modifying of modifying a free-standing unmodified carbon nanotube sheet in which a plurality of carbon nanotubes are aligned in a predetermined direction. The firstly modifying includes performing a densification process of bringing the unmodified carbon nanotube sheet into contact with either one of or both of vapor and liquid particles of a liquid substance to produce a modified carbon nanotube sheet that contains the carbon nanotubes which are mainly aligned in a predetermined direction, and that includes a high density portion where the carbon nanotubes are assembled together and a low density portion where density of the carbon nanotubes is relatively lower than density in the high density portion.


Kawabata A.,Kinki University
Biological and Pharmaceutical Bulletin | Year: 2011

Prostaglandin E 2 (PGE2), a cyclooxygenase (COX) product, is the best known lipid mediator that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing generation of prostanoids, mainly PGE2, while they exhibit gastrointestinal, renal and cardiovascular toxicities. Selective inhibitors of microsomal PGE synthase-1 and subtype-selective antagonists of PGE2 receptors, particularly EP1 and EP4, may be useful as analgesics with minimized side-effects. Protein kinase C (PKC) and PKA downstream of EP1 and EP4, respectively, sensitize/activate multiple molecules including transient receptor potential vanilloid-1 (TRPV1) channels, purinergic P2X3 receptors, and voltage-gated calcium or sodium channels in nociceptors, leading to hyperalgesia. PGE2 is also implicated in neuropathic and visceral pain and in migraine. Thus, PGE2 has a great impact on pain signals, and pharmacological intervention in upstream and downstream signals of PGE 2 may serve as novel therapeutic strategies for the treatment of intractable pain. © 2011 Pharmaceutical Society of Japan.


Patent
Kinki University and Fuso Pharmaceutical Industries Ltd. | Date: 2016-03-30

The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R^(1) and R^(2) independently represents H, -OH or -OR^(11), wherein R^(11) represents a C_(1-3) alkyl group; each of R^(3) and R^(4) independently represents H, -OH or -OR^(12), wherein R^(12) represents a C_(1-3) alkyl group; and each of R^(5) and R^(6) independently represents H, a halogen atom, a C_(1-10) alkyl group, a C_(2-6) alkenyl group, a C_(2-6) alkynyl group, a phenyl group (which may be substituted by a C_(1-6) alkoxy group or a halogen atom), a -C_(1-3) alkyl-phenyl group (which may be substituted by a C_(1-6) alkyloxy group or a halogen atom) or a C_(10-50) prenyl group.)


Patent
Kinki University, Educational Corporation Mukogawa Gakuin and Nipro Corporation | Date: 2016-11-02

The present invention provides a hemiacetal ester prodrug of the pyridone carboxylic acid antibacterial drug, wherein the prodrug is characterized in that, (i) it is hydrolyzed promptly after intestinal absorption and regenerates the pyridone carboxylic acid antibacterial drug as a drug substance, (ii) a one-dose package is possible by preventing chelate-formation in intestines in an oral administration, and (iii) the normal bacterial flora of the intestinal bacterial flora is not influenced at all until the ester is absorbed, because the hemiacetal-type esterification is executed on the carboxylic acid which is a center of the antibacterial action, resulting in prevention of the pseudomembranous colitis. The prodrug is an alkoxy carbonyl hemiacetal-type ester represented by the chemical formula (I), which is useful as a prodrug for inhibiting the enteric-bacterium-shift side effect, and can be used in combination with polyvalent metal-containing medicines.


Patent
New Environmental Technology Council and Kinki University | Date: 2016-07-13

Provided are a novel cultivation method and a storage method that are suitable for storing bacteria belonging to the genus Collimonas for a long period of time. The cultivation method for bacteria belonging to the genus Collimonas is characterized in that bacteria belonging to the genus Collimonas are cultivated in a sealed state on a culture medium that includes a rice bran culture medium and/or a soy pulp culture medium. The storage method for bacteria belonging to the genus Collimonas is characterized in that the cultivated bacteria belonging to the genus Collimonas are stored at room temperature.


Ohta N.,Kinki University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

It has been suggested that the dark energy that explains the observed accelerating expansion of the universe may arise due to the contribution to the vacuum energy of the QCD ghost in a time-dependent background. The argument uses a four-dimensional simplified model. In this Letter, we put the discussion in more realistic model keeping all components of the QCD vector ghost and show that indeed QCD ghost produces dark energy proportional to the Hubble parameter HΛQCD 3 (ΛQCD is the QCD mass scale) which has the right magnitude ̃(3×10-3 eV)4. © 2010 Elsevier B.V.


Zlotnik A.,University of California at Irvine | Yoshie O.,Kinki University
Immunity | Year: 2012

The chemokine superfamily consists of a large number of ligands and receptors. At first glance, this family appears redundant and their ligand-receptor relationships promiscuous, making its study challenging. However, analyzing this family from the evolutionary perspective greatly simplifies understanding both the organization and function of this apparently complex system. In particular, the functions of a subgroup of chemokines (designated homeostatic chemokines) have played pivotal roles in advancing our understanding of the organization and function of the cellular networks that shape the immune system. Here, we update the full scope of the human and mouse chemokine superfamilies and their relationships and summarize several important roles that homeostatic chemokines play in the immune system. © 2012 Elsevier Inc.

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