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Ishikawa, Japan

Kinjo University is a private university in Hakusan, Ishikawa, Japan. The predecessor of the school was founded in 1904, and it was chartered as a university in 2000. Wikipedia.

Sasaki K.,Kinjo University | Senda M.,Okayama University of Science | Nishida K.,Okayama University of Science | Ota H.,Okayama University of Science
Acta Medica Okayama

We examined whether the preoperative time required for the Timed "Up and Go" (TUG) test could predict the risk for deep venous thrombosis (DVT) in patients with hip osteoarthritis after total hip arthroplasty (THA). Eighteen patients with DVT diagnosed by venography were selected, and 18 without DVT of the same age and sex and with the same operated side as the DVT group were selected as a control group. We evaluated the 5 preoperative factors that might affect the occurrence of DVT complications, as follows: disease duration, body mass index, serum total cholesterol, subjective pain evaluated by the visual analog scale, and TUG. The JOA hip score (pain, range of motion, walking ability, and daily life) was also evaluated before surgery. As a postoperative factor, we checked the postoperative day when weight-bearing was initiated. As a result, TUG (DVT, 18.4 ± 4.0 sec vs. control, 15.0 ± 3.2 sec; p < 0.01) was only significantly different between the 2 groups. The ROC curve revealed that the cut-off point of 15.3 sec in preoperative time for TUG was sensitive (83.3%) and specific (61.1%) for DVT after THA (odds ratio = 7.0; 95% confidence interval, 1.630.8). These results suggested that low preoperative ambulatory ability in patients with hip osteoarthritis might be associated with DVT after THA. An improvement in TUG before surgery might contribute to a decrease in the occurrence of DVT after THA. © 2010 by Okayama University Medical School. Source

Kaneko Y.S.,Fujita Health University Hospital | Ota A.,Fujita Health University Hospital | Nakashima A.,Fujita Health University Hospital | Mori K.,Fujita Health University Hospital | And 4 more authors.
Clinical and Experimental Pharmacology and Physiology

Previously, we reported that an optimal dose of lipopolysaccharide (LPS) markedly extends the life span of mouse primary-cultured microglia by suppressing apoptotic and autophagic cell death pathways. The aim of the present study was to assess how these cells protect themselves against reactive oxygen species (ROS) generated by LPS treatment. The study was conducted in microglia obtained from murine neonate brain, which are destined to die within a few days under ordinary culture conditions. The generation of ROS was maximal after 15 h LPS treatment (1 ng/mL LPS and 100 ng/mL LPS). The expression of inducible nitric oxide (NO) synthase protein was significantly increased by Day 1 of LPS treatment and was followed by the production of NO. The expression of either Cu/Zn- or Mn-superoxide dismutase protein (SOD) was also increased by 16 h and Day 1 of LPS treatment. LPS did not affect the expression of Cu/Zn- and Mn-SOD proteins, nor did it extend the life span of microglia that had mutated Toll-like receptor (TLR) 4. The findings of the present study suggest that SODs function as a potent barrier to overcome ROS generated in primary-cultured microglia following LPS treatment and that TLR4 may be significantly involved in inducing these proteins. The microglia may be able to protect themselves against oxidative stress, allowing them to live for more than 1 month. Because long-lived microglia may play a critical role in the exacerbation of neurodegeneration, bringing activated microglia back to their resting stage could be a new and promising strategy to inhibit the deterioration underlying neurodegenerative disorders. © 2012 Blackwell Publishing Asia Pty Ltd. Source

Miyai I.,Annual Survey Committee | Miyai I.,Neurorehabilitation Research Institute | Sonoda S.,Annual Survey Committee | Sonoda S.,Mie University | And 7 more authors.
Neurorehabilitation and Neural Repair

Background. A new interdisciplinary postacute rehabilitation unit, the Kaifukuki (convalescent) rehabilitation ward (KRW), has been incorporated into the Japanese medical insurance system since 2000. More than 57 000 beds (45 beds per 100 000 population) are currently available nationwide. The maximal coverage for therapy sessions increased from 2 to 3 hours per day, 7 days a week, in 2006. Objective. To investigate how changes in policy affected rehabilitation outcomes of KRWs in a retrospective cohort study of 87 917 patients over 10 years. Results. The mean (standard deviation) age of the patients was 73.0 (13.8) years, and 55.4% were women. Diagnoses included stroke (47.9%); orthopedic diseases, including hip fracture (35.2%); and traumatic brain and spinal cord injury (5.4 %). Onset-admission interval (OAI) was 31.5 (18.6) days, length of stay was 75.9 (46.1) days, and 69.1% were discharged home. Daily therapy time was 79.4 (34.5) minutes. Admission/discharge scores of the Barthel Index and the Functional Independence Measure were 49.3 (31.0)/70.4 (31.9) and 75.3 (31.2)/91.7 (31.8), respectively. Year-by-year comparison revealed that older age, greater initial disability, and shorter OAI were coupled with a higher dose of rehabilitative interventions and a higher rate of home discharge. Longitudinal data from a cohort of hospitals implied a small but significant dose-dependent effect of hours of therapy on rehabilitation outcome after stroke. Conclusions. Although the organization of KRWs is in flux as the system of hospitals grows, results over the past 8 years suggest that changes in national insurance policies are affecting the quantity and organization of rehabilitation interventions and improvement in patient outcomes. © The Author(s) 2011. Source

Sako S.,Nagoya Isen School Corporation Vocational College | Sako S.,Gifu University | Sugiura H.,Nagoya Isen School Corporation Vocational College | Tanoue H.,Gifu University | And 2 more authors.
International Journal of Occupational Medicine and Environmental Health

Objectives: This study investigated the association between task-induced stress and fatigue by examining the cardiovascular responses of subjects using different mouse positions while operating a computer under time constraints. Material and Methods: The study was participated by 16 young, healthy men and examined the use of optical mouse devices affixed to laptop computers. Two mouse positions were investigated: (1) the distal position (DP), in which the subjects place their forearms on the desk accompanied by the abduction and flexion of their shoulder joints, and (2) the proximal position (PP), in which the subjects place only their wrists on the desk without using an armrest. The subjects continued each task for 16 min. We assessed differences in several characteristics according to mouse position, including expired gas values, autonomic nerve activities (based on cardiorespiratory responses), operating efficiencies (based on word counts), and fatigue levels (based on the visual analog scale - VAS). Results: Oxygen consumption (VO2), the ratio of inspiration time to respiration time (Ti/Ttotal), respiratory rate (RR), minute ventilation (VE), and the ratio of expiration to inspiration (Te/Ti) were significantly lower when the participants were performing the task in the DP than those obtained in the PP. Tidal volume (VT), carbon dioxide output rates (VCO2/VE), and oxygen extraction fractions (VO2/VE) were significantly higher for the DP than they were for the PP. No significant difference in VAS was observed between the positions; however, as the task progressed, autonomic nerve activities were lower and operating efficiencies were significantly higher for the DP than they were for the PP. Conclusions: Our results suggest that the DP has fewer effects on cardiorespiratory functions, causes lower levels of sympathetic nerve activity and mental stress, and produces a higher total workload than the PP. This suggests that the DP is preferable to the PP when operating a computer. © 2014 Versita Warsaw and Springer-Verlag Wien. Source

Gotoh M.,Kanazawa University | Seki K.,Kanazawa University | Shozu M.,Maizuru National College of Technology | Hirose H.,Kinjo University | Sasaki T.,Kanazawa University
Materials Science Forum

The fine-grained rolling steels NFG600 and the conventional usual rolling steels SM490 were processed by sand paper polishing and mechanical grinding to compare the residual stress generated after processing. The average grain size of NFG600 and SM490 is 3 μm and 15μm respectively. Therefore improvement of mechanical properties for such fine-grained steels is expected, it is important to understand the residual stress state of new fine-grained materials with processing. In this study, multi axial stresses of two kinds of specimens after polishing and grinding were measured by three kinds of analysis methods including cos-ψ method. As a result, as for σ33, the stress of NFG was compression, though that of SM490 was tension. © (2010) Trans Tech Publications. Source

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