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Pan C.-J.,Huaiyin Institute of Technology | Liu H.-Q.,Kinhely Bio Technology Co. | Wang Y.-N.,Huaiyin Institute of Technology | Ding H.-Y.,Huaiyin Institute of Technology
Materials Research Bulletin | Year: 2014

In our previous study, a copper-titanium (Cu/Ti) coating was developed to enhance the blood compatibility and anti-endothelialization of NiTi vena cava filter. In the present study, the phase transformation and mechanical behaviors of the Cu/Ti-coated NiTi vena cava filters were further investigated. The filters were shaped to final dimensions by a three-step shape-setting process using different dimension moulds for each step. After each step of shape-setting process, the phase transformation and mechanical properties were examined by differential scanning calorimeter (DSC) method and tensile experiment, respectively. It was found that the austenite transformation finish temperature (Af) of Cu/Ti-coated filter increased first and then slightly decreased with the increase of aging time. The Af value of Cu/Ti-coated filter was higher than that of the pristine filter when the same shape-setting process was applied. Two phase transformation peaks could be observed on the heating curves of Cu/Ti coated samples when the aging time increased. Although on the stress-strain cycle curves there were no obvious differences between Cu/Ti-coated and the pristine filters when the same shape-setting process was applied, the values of upper yield plateau and lower yield plateau of both of the filters tended to decrease gradually with the increase of aging time. The results of the present study indicated that the fabrication of Cu/Ti coating on NiTi vena cava filter can improve the A f value and did not change its super-elasticity. It may be helpful for the development of novel biomedical devices, such as vena cava filter and vascular stent, where control of self-expansion and shape memory of implants would be preferable. © 2014 Elsevier Ltd. Source

Min Z.,Xihua University | Huang N.,Southwest Jiaotong University | Liu H.,Xihua University | Liu H.,Kinhely Bio Technology Co. | Zhang Q.,Xihua University
Asian Journal of Chemistry | Year: 2014

Vascular vessel stents were coated with titanium oxide (Ti-O) by a physical vapor deposition method. The composition, coating thickness and mechanical behaviour of the coating were investigated during stent compression and dilatation. The surface area and thickness of the Ti-O coating were calculated using known parameters. The composition of the coating was characterized via energy dispersive X-ray spectroscopy. The mechanical behaviour of the coating was investigated during stent deformation, particularly in regions experiencing high stress during compression or expansion. Results show that the Ti-O coating is smooth and uniform. There were no cracks or delaminations on the stent surface after dilation by angioplasty, indicating sufficient adhesion of the Ti-O coating to the stent. Source

Liu H.,Kinhely Bio Technology Co. | Zhang D.,Lifetech Scientific Shenzhen Co. | Min Z.,Xihua University | Pan C.,Huaiyin Institute of Technology
Journal of Biomaterials and Tissue Engineering | Year: 2014

Drug eluting stent (DES) presents a higher risk than bare-metal stents due to late thrombosis. This work reported a novel inorganic coating which showed good blood compatibility and fast proliferation of ECs in vitro. Stent implantation experiments were conducted for different time in order to evaluate the degree of endothelialization and tissue response that occurred following implantation. The result indicated that copper–titanium coating showed good compatibility, and meanwhile endothelial cells proliferated more readily than smooth muscle cells. A complete endothelialization of the coppercontaining stents can be observed in two weeks which was less than that of control stents. No cytotoxicity was observed in tissue sections of the liver or kidney. The results of the present study demonstrated that the degradable copper-containing film can be used for surface modification of vascular stent to enhance its blood compatibility and endothelialization. © 2014 American Scientific Publishers. All rights reserved. Source

Liu H.,Chengdu University of Technology | Li J.,Chengdu University of Technology | Zhou S.,Chengdu University of Technology | Long J.,Chengdu University of Technology | And 2 more authors.
Bio-Medical Materials and Engineering | Year: 2015

Surface modification is one approach to enhance the biocompatibility of implanted cardiovascular devices. In this work, a copper-containing film used to blood contacted biomaterials was prepared by vacuum arc deposition. The phase composition of the films was investigated via X-ray diffraction, and the adherence strength of the films was evaluated with conventional deformation tests. Blood compatibility of the films was characterized by hemolysis ratio, clotting time and platelet adhesion etc. The surface of inferior vena cava filters were smooth and uniform, no cracks or delaminations were observed on the deformed surface. These results indicate that the mechanical behavior of the films is suitable for withstanding deformation stresses as operation in clinic. Good blood compatibility of the copper-containing films was identified through experiment in vitro, the activated partial thromboplastin times (APTTs) of Cu/Ti films were similar to that of the uncoated substrate, and Cu/Ti films were also found to inhibit platelet adhesion comparing to the nitinol substrate. However, with increasing ratio of Cu/Ti, the hemolysis ratio increased, resulting in platelet damage. These results indicate that the copper-containing film has potential application on blood contacted devices. © 2015 - IOS Press and the authors. Source

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