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Chabiniok R.,Kings College London St Thomas Hospital | Chabiniok R.,French Institute for Research in Computer Science and Automation | Wang V.Y.,Auckland Bioengineering Institute | Hadjicharalambous M.,Kings College London St Thomas Hospital | And 10 more authors.
Interface Focus | Year: 2016

With heart and cardiovascular diseases continually challenging healthcare systems worldwide, translating basic research on cardiac (patho)physiology into clinical care is essential. Exacerbating this already extensive challenge is the complexity of the heart, relying on its hierarchical structure and function to maintain cardiovascular flow. Computational modelling has been proposed and actively pursued as a tool for accelerating research and translation. Allowing exploration of the relationships between physics, multiscale mechanisms and function, computational modelling provides a platform for improving our understanding of the heart. Further integration of experimental and clinical data through data assimilation and parameter estimation techniques is bringing computational models closer to use in routine clinical practice. This article reviews developments in computational cardiac modelling and how their integration with medical imaging data is providing new pathways for translational cardiac modelling. © 2016 The Authors.

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