King Saud bin Abdulaziz University for Health Sciences

www.ksau-hs.edu.sa
Riyadh, Saudi Arabia

King Saud bin Abdulaziz University for Health science is the first public university in the Kingdom of Saudi Arabia and the Middle East region specialized in health science. Its headquarters is in the main campus in Riyadh, the capital of Saudi Arabia. It has two other campuses both in Jeddah and Al-Ahsa. All of the campuses are located inside the parameters of King Abdulaziz Medical cities, and are overseen by the Saudi National Guard Health Affairs. Wikipedia.

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Patent
National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center | Date: 2016-01-29

An artificial hypothalamus system for regulating body temperature for a human can include monitoring data from a plurality of sensors. The sensor data can be used in a control system to optimize temperature regulation in real time through a feedback loop. The feedback loop can include monitoring the sensor data, evaluating a predetermined set of fuzzy rules using the data, and combining the output of the fuzzy rules to produce a precise value. The precise value can correspond to an output level for various temperature regulation devices, and a signal can be transmitted based on the precise value to activate the temperature regulation devices to a corresponding level of output.


Patent
National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center | Date: 2015-10-19

Size-controlled ultra-small iron-based metal oxide nanoparticles, nanocolloids comprising the nanoparticles, and methods of making the nanoparticles. The method for making the iron-based nanoparticles include sequential mixing of an iron(III) salt, a metal (II) salt, a carboxylic acid, an amine, and an inorganic base in water at temperatures ranging from 25-80 C. Nanoparticles in the size ranging from 2 nm to 10 nm with a narrow size distribution are obtained with the method. The nanoparticles have an iron-based core surrounded by molecules such as a panel of different carboxylates, polycarboxylates, and amines. Depending on the hydrophilicity of the carboxylates used, the functional nanoparticulate colloid can be dispersed in either organic or aqueous solvents. The nanocolloids comprise the nanoparticles in a concentration ranging from 1-10 mg/ml, and are stable for at least several months.


Shams T.,King Saud bin Abdulaziz University for Health Sciences
Journal of general internal medicine | Year: 2014

Hot flashes are the most commonly reported vasomotor symptom during the peri- and early post-menopausal period. To systematically review, appraise and summarize the evidence of the impact of different SSRIs on peri-menopausal hot flashes in healthy women in randomized, controlled trials. A comprehensive literature search was conducted of MEDLINE™, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus through March 2013. Two independent reviewers selected studies and extracted data. Random effects meta-analysis was used to pool outcomes across studies, and Bayesian mixed treatment methods were used to rank SSRIs in terms of effectiveness. We included a total of 11 randomized controlled trials with good methodological quality enrolling 2,069 menopausal and post-menopausal women (follow-up 1-9 months, mean age 36-76 years, mean time since menopause 2.3-6.6 years). Compared with placebo, SSRIs were associated with a statistically significant decrease in hot flash frequency (difference in means -0.93; 95 % CI -1.46 to -0.37; I(2) = 21 %) and severity assessed by various scales (standardized difference in means -0.34; 95 % CI -0.59 to -0.10; I(2) = 47 %). Adverse events did not differ from placebo. Mixed treatment comparison analysis demonstrated the superiority of escitalopram compared to other SSRIs in terms of efficacy. SSRI use is associated with modest improvement in the severity and frequency of hot flashes but can also be associated with the typical profile of SSRI adverse effects.


Patent
King Abdullah International Medical Research Center and King Saud bin Abdulaziz University for Health Sciences | Date: 2014-03-18

A medical material delivery device includes a shaft having a lumen that receives a therapeutic agent, and can include a guide having a channel for receiving a medical instrument adapted for positioning in conjunction with a bodily part. An expandable member positioned in conjunction with the guide is adapted for communication with the bodily part and is arranged to burst open when the expandable member is disrupted by a disrupting mechanism to deliver the therapeutic agent to the bodily part. Further embodiments include a medical instrument and an expandable member in conjunction with the medical instrument to burst or leak to deliver a therapeutic agent. The medical material delivery device can include a bodily fluid locator attached with the device, as well as can include a second expandable member to inflate and deflate to localize a bodily part, with a first expandable member bursting to deliver a therapeutic agent.


Patent
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences and National Guard Health Affairs | Date: 2014-10-13

The nano-liposomal aminoglycoside-thymoquinone formulations are suitable for administration to a mammal and include an aminoglycoside antibiotic (amikacin, gentamicin, or tobramycin) and thymoquinone (TQ) encapsulated within a liposome. The liposome-encapsulated aminoglycoside-thymoquinone (TQ) formulations can be administered to a subject in need thereof. The liposome-encapsulated aminoglycoside-thymoquinone formulations are prepared by a method, which comprises forming a lipid film from a mixture of phospholipids and cholesterol; mixing the lipid film with methanol containing thymoquinone in molar ratio; evaporating off the methanol from the mixture; adding polysaccharides and/or polyethylene glycol (PEG) in PBS (phosphate-buffered saline) buffer in volume ratio to form a liposomal mixture; sonicating the liposomal mixture for at least five minutes; adding an aminoglycoside antibiotic in molar ratio with the thymoquinone; sonicating the mixture for at least five minutes; lyophilizing the liposomal aminoglycoside-thymoquinone formulation; and storing it at 80 C. until use.


Patent
National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center | Date: 2015-12-29

A method for detecting cancer by determining ratios of alternatively spliced Lamin A/C gene mRNAs in tissue samples, especially an increased ratio of Lamin C to Lamin A mRNAs. Therapeutic for subjects having a tumor or cancer characterized by an elevated ratio of Lamin C to Lamin A mRNA or protein.


Patent
King Abdullah International Medical Research Center, National Guard Health Affairs and King Saud bin Abdulaziz University for Health Sciences | Date: 2014-01-02

The thermometer using differential temperature measurements utilizes a pair of adjacent temperature sensors in order to measure the temperature of a common surface over a pre-selected period of time. The thermometer includes a housing and first and second thermistors mounted adjacent one another on the housing. The first and second thermistors are positioned against the surface, which can be a body part (for oral, rectal or axial body temperature measurements) or can be any other desired surface for which a spot check temperature reading is desired. A programmable current source pre-heats the second thermistor to a pre-selected temperature, while the first thermistor is initially at room temperature. A controller inside the housing causes both the first and second thermistors to take instantaneous temperature measurements of the surface at two successive times. The controller linearizes the measurements to predict the temperature of the surface, which is then displayed to the user.


Patent
National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center | Date: 2016-01-29

A conjugate comprising a dendritic polymer or other scaffold, a metalloproteinase-cleavable linker and alpha-amanitin. Methods of using this conjugate for safe targeted treatment of cancer cells expressing metalloproteinases.


Patent
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences and National Guard Health Affairs | Date: 2014-07-10

The releasable torque device obviates the need for removal of the wire introducer in order to torque or manipulate a vascular or other guide wire and/or catheter in a medical procedure, and further obviates the need to remove the torque device for wire and/or catheter introduction. The device may include a base cylinder and an inflation cylinder defining a variable fluid volume therebetween. As the inflation cylinder is pushed toward the base cylinder, the fluid is forced through a port in the inner wall of the inflation cylinder and between a tubular inner cylinder and an inflatable guide wire grip within the inner cylinder to squeeze the grip onto the guide wire passing axially therethrough. Alternatively, the device only has a central tube and an inflatable guide wire grip therein, using a remotely disposed fluid pump and reservoir supplying fluid to the tube and guide wire grip.


Patent
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences and National Guard Health Affairs | Date: 2014-10-22

The composition for management of periodontal diseases includes a gel matrix having a polymer system and a plurality of microspheres dispersed in the polymer system. The polymer system contains about one-half a dose of medicament, while the microspheres contain the remainder. Upon administration of the composition into the periodontal cavity, the medicament in the polymer system provides an initial therapeutic benefit, while the remainder of the medication is released over time via degradation of the microspheres. This biphasic pattern of medicament delivery provides increased efficacy of the medicament through sustained delivery of the same.

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