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Ram H.,University of Lucknow | Kumar M.,University of Lucknow | Bhatt M.L.B.,King Georges Medical University | Shadab M.,University of Lucknow
BMJ Case Reports | Year: 2013

Metastatic tumours of the oral cavity are uncommon, they may occur in soft tissue as well as in bone in the oropharyngeal region. Owing to its rarity, metastatic tumours of the oral regions are a challenge to diagnose. We report a case of metastasis of the oral cavity, arising from uterine cervix mimicking as mucoepidermoid carcinoma. The metastatic lesions were noticed in the soft tissue of the lower buccal and gingival side of a oral cavity, in a 40-year-old woman with history of an adenosquamous carcinoma of uterine cervix treated by panhysterectomy. Copyright 2013 BMJ Publishing Group. All rights reserved.

Dubey A.,King Georges Medical University | Singh B.P.,KGMU | Upadhyay R.,KGMU | Upadhyay S.,Dharmsinh Desai University
International Journal of Pharma and Bio Sciences | Year: 2015

Obstructive Sleep Apnoea Syndrome (OSAS) is a disorder characterized by repetitive complete or partial upper airway collapse occurring during sleep. OSAS leads to adverse medical conditions, including hypertension, cardiovascular disease, stroke, and insulin resistance. OSAS is estimated to be 7.5 per cent in males between 35-65 yr of age in the urban Indian population. Obesity is the most important risk factor for OSAS. This hospital based study was designed to study, sleep and metabolic correlates of anthropometric variables in north Indian population. Study was performed with one hundred and ninety subjects as per inclusion and exclusion criteria. Anthropometrical, overnight polysomnography, vital and biochemical data were collected and analyzed. Significant differences were found in mean values of anthropometrical, AHI, Obstructive events and Hypopnea events between OSAS and Non OSAS subjects. BMI, Neck Circumference, waist circumference and Waist Hip Ratio of subjects were observed significantly correlated with metabolic and sleep related variables.

Jain V.K.,Dr. Ram Manohar Lohia Avadh University | Kumar D.,King Georges Medical University | Arya R.K.,Dr. Ram Manohar Lohia Avadh University | Sinha S.,Dr. Ram Manohar Lohia Avadh University | Naik A.K.,Dr. Ram Manohar Lohia Avadh University
Foot | Year: 2016

The reporting of isolated metatarsal tuberculosis in the available literature is sparse, herein we report a case of 26-year-old female who presented with insidious onset pain and swelling in her forefoot. Radiograph showed osteolysis of the first metatarsal. Magnetic resonance imaging showed osseous erosion with marrow oedema. Diagnosis was ascertained by fine needle aspiration cytology of the lesion. The patient received anti-tubercular therapy and showed good clinical outcome. This case is reported because of its rarity of involving isolated metatarsal bone as a cause of forefoot pain. © 2016 Elsevier Ltd.

Nayak S.,University of Lucknow | Goel M.M.,University of Lucknow | Bhatia V.,University of Lucknow | Chandra S.,University of Lucknow | And 4 more authors.
Indian Journal of Pathology and Microbiology | Year: 2013

Background: Decorin is an extracellular matrix, multifunctional small proteoglycan molecule in tumor stroma that has been shown to be modulator of angiogenesis. No clinical data is available so far on decorin expression and survival outcome of oral cancer. Aim: The aim of the present study was to examine molecular and phenotypic expression of two angiogenesis modulators viz. decorin and vascular endothelial growth factor-A (VEGF-A) in human potentially malignant oral lesions (PMOLs) and oral squamous cell carcinomas (OSCC) in relation to clinico-pathological variables and survival outcome. Materials and Methods: Tissue biopsies were obtained from 72 PMOLs, 108 OSCC and 52 healthy controls. The PMOLs included cases of leukoplakias and oral submucous fibrosis. Immunohistochemistry was performed using antibodies against decorin, VEGF-A and CD-31. Messenger-ribonucleic acid (mRNA) expression was analyzed by using real-time polymerase chain reaction. Results: Cytoplasmic staining of decorin was observed in the basal layer of epithelium in 53 (73.61%) cases of PMOLs and in peritumoral stroma in 55 (50.92%) cases of OSCC. None of the cases showed nuclear expression of decorin. Decorin expression both at phenotypic and molecular level was found to be down-regulated from PMOLs to OSCC. Lymph node metastasis and reduced decorin expression independently correlated with overall survival in OSCC. VEGF-A expression had no significant impact on survival outcome. Conclusion: Micro vessel density and VEGF-A expression were significantly associated with reduced decorin expression in tumor stroma suggesting, decorin as angiogenic modulator in OSCC. Down-regulation of decorin expression and the presence of lymph node metastasis were adverse factor independently affecting overall survival in OSCC.

Casey S.C.,Stanford University | Amedei A.,University of Florence | Aquilano K.,University of Rome Tor Vergata | Benencia F.,Ohio University | And 24 more authors.
Seminars in Cancer Biology | Year: 2015

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adaptive immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer. © 2015 Elsevier Ltd.

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