Al - Hassa, Saudi Arabia

King Faisal University

www.kfu.edu.sa
Al - Hassa, Saudi Arabia

King Faisal University is a public university with the main campus in the city of Hofuf in Al-Hassa, Saudi Arabia founded in 1975. KFU was initially established with four colleges: two in Dammam and the other two in Al-Ahsa. Wikipedia.

SEARCH FILTERS
Time filter
Source Type

Pharmaceutical suspension containing oral dosage forms delivering both immediate-release and sustained-release amoxicillin was developed as a new dosage form to eradicate Helicobacter pylori. Amoxicillin-loaded gelatin nanoparticles are able to bind with the mucosal membrane after delivery to the stomach and could escalate the effectiveness of a drug, providing dual release. The objective of this study was to develop amoxicillin nanoparticles using innovative new technology - the Büchi Nano Spray Dryer B-90 - and investigate such features as drug content, particle morphology, yield, in vitro release, flow properties, and stability. The nanoparticles had an average particle size of 571 nm. The drug content and percentage yield was 89.2% ± 0.5% and 93.3% ± 0.6%, respectively. Angle of repose of nanoparticle suspension was 26.3° and bulk density was 0.59 g/cm3. In vitro drug release of formulations was best fitted by first-order and Peppas models with R2 of 0.9841 and 0.9837 respectively; release profile was 15.9%, while; for the original drug, amoxicillin, under the same conditions, 90% was released in the first 30 minutes. The nanoparticles used in this study enabled sustained release of amoxicillin over an extended period of time, up to 12 hours, and were stable for 12 months under accelerated storage conditions of 25°C ± 2°C and 60% ± 5% relative humidity. © 2013 Harsha, publisher and licensee Dove Medical Press Ltd.


Idris A.M.,King Faisal University
Critical Reviews in Analytical Chemistry | Year: 2010

Since their introduction in the mid-1970s, flow injection (FI) techniques have gained a worldwide popularity. FI techniques are automated, miniaturized, versatile, and inexpensive analytical tools for handling reagents and samples and consequently for conducting procedures related to wet chemical analysis. Due to their tremendous benefits, FI techniques have proven to be significant applications to such analytical fields as pharmaceutical, environmental, biochemical, and food. Currently, more than 10,000 publications reporting various applications of FI techniques can be retrieved from the literature. However, FI techniques have not yet received an adequate attention to the field of forensic analysis; less than 30 publications were reported. The main objective of the current article is to draw attention to the potential of FI techniques to forensic analytical chemists. The article provides a comprehensive review of the applications of FI techniques to forensic chemical analysis, which covers the literature since the inception of the techniques. The article also offers a brief historical background on the developments of the generation and versions of the techniques while highlighting their advantages. In addition, future perspectives in the applications of FI techniques to forensic analysis are discussed. © Taylor and Francis Group, LLC.


Idris A.M.,King Faisal University
Critical Reviews in Analytical Chemistry | Year: 2010

The ever increasing demand for rapid, cost-effective, practically-safe, and environmentallybenign analytical methods has aroused researchers to develop automated, miniaturized, versatile, and inexpensive analytical techniques. Flow injection (FI) techniques were well-established to meet the requirements of modern chemical analysis. The family of FI techniques includes three generations, flow injection analysis (FIA), sequential injection analysis (SIA), and bead injection analysis (BIA). In addition, new versions of SIA, micro-SIA-lab-on-valve (μSIA-LOV), and sequential injection chromatography (SIC), have recently been developed for more downscaling analysis and broadening applications. In the literature, we have not found a comprehensive and updated manuscript presenting all generations and recent versions of FI techniques. Therefore, the current manuscript briefly demonstrates the principles, developments, and applications of the FI techniques along with their consequent generations and recent versions. © Taylor and Francis Group, LLC.


2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating significant cytotoxicity. Characteristic features of oxasqualenoids containing tetrahydrofuran fragments include the presence of a cis- and/or trans-2,5-disubstituted pattern in tetrahydrofuran moieties, and molecular symmetry is often noticed as well. Given their unique structural features combined with their bioactivity, two representative examples from this class of natural products, eurylene and teurilene, have been briefly reviewed. Eurylene, with reported cytotoxicity against lymphocytic leukemia, contains two non-adjacent linked cis- and trans-2,5-disubstituted tetrahydrofuran rings and a combined total of eight stereogenic centres. It is a chiral molecule due to the lack of a C2 axis of symmetry. Teurilene shows a prominent cytotoxicity on KB cells and has three adjacently linked 2,5-disubstituted tetrahydrofurans. A distinctive achiral facet is observed in teurilene, despite having eight stereocentres, due to the presence of meso symmetry (C s). The prime objective of this account is to describe a precise mechanistic insight for both cis- and trans-2,5-disubstituted tetrahydrofurans present in these natural products and to highlight the exciting challenges encountered during the installation of functionalities or structural motifs en route to their synthetic approaches. This journal is © the Partner Organisations 2014.


cis-2,5-Disubstituted tetrahydrofurans constitute the core of several natural products and synthetic analogues which exhibit a broad and interesting range of biological activities. This review highlights a personal perspective and provides a comparative note on the synthesis of cis-2,5-disubstituted tetrahydrofuran rings from 1,5-diene precursors using metal-oxo species. Also, mechanistic insights for these synthetically significant protocols are given and striking examples from the literature are reported, which draw attention towards the scope and synthetic utility of metal oxidants in the domain of cis-2,5-tetrahydrofuran containing bioactive natural product synthesis. © 2014 The Royal Society of Chemistry.


Talla J.A.,King Faisal University
Chemical Physics | Year: 2012

The interactions between oxygen and nitrogen atoms with single-walled carbon nanotubes were investigated for nanotubes with two different geometrical configurations using first-principle calculations within the framework of the density functional theory. We introduced a new type of toxic gas sensor that can detect the presence of H 2, Cl 2, CO, and NO molecules. We also demonstrated that the sensitivity of this device can be controlled by the concentration of the dopants on the surface of the nanotube. In addition, the transport properties of the doped nanotube were studied for different concentrations of oxygen or nitrogen atoms that were randomly distributed on the surface of the single-walled carbon nanotube. We observed that small amounts of dopants can modify the electronic and transport properties of the nanotube and can lend metallic properties to the nanotube. Band-gap narrowing occurs when the nanotube is doped with either oxygen or nitrogen atoms. © 2011 Elsevier B.V. All rights reserved.


Background and methods: A dual (immediate/sustained-release) oral amoxicillin suspension was developed as a new dosage form to eradicate Helicobacter pylori. Carbopol®-loaded amoxicillin nanospheres could bind with the mucosa after delivery to the stomach and could increase the efficiency of the drug, providing both an immediate and a sustained action. Results: The objective of this research was to develop amoxicillin nanospheres using a spray-drying technique and to investigate such features as their particle size, drug content, percentage yield, surface morphology, in vitro release, and stability. The nanospheres had a particle size range of 280-320 nm after optimizing the preparation method using a central composite design. The drug content and percentage yield was 85.3% ± 0.7% and 92.8% ± 0.9%, respectively. The in vitro release profile of the amoxicillin nanospheres was consistent with a Korsmeyer-Peppas pattern, and the release after one hour was 19%, while for the original drug, amoxicillin, under the same conditions, 90% was released in the first 30 minutes. Conclusion: The nanospheres used in this study enabled controlled release of amoxicillin over an extended period of time for up to 12 hours and the formulation was stable for 12 months. © 2012 Harsha, publisher and licensee Dove Medical Press Ltd.


Al-Mohammed H.I.,King Faisal University
Parasitology Research | Year: 2011

Giardiasis is the most worldwide parasitic disease with the major clinical impact on infant and children. Two genotypes were reported commonly among humans (assemblage A and B). In this study, genotypes of Giardia intestinalis clinical isolates obtaining from 24 gastrointestinal symptomatic Saudi primary school children and 16 asymptomatic ones were explored by real-time polymerase chain reaction using the high resolution melting curve analysis targeting intergenic spacer (IGS) region rDNA of G. intestinalis. Children having acute, intermittent, and chronic diarrhea were 14, 5, and 5, respectively. Among all the giardiasis subjects, assemblage B was 37.5% followed by both of assemblages AI and AII with 30% and 27.5%, respectively. Mixed infection with the three previous assemblages was present in 5% of cases. Among symptomatic children, the prevalence of assemblage B was 62.5% then followed by assemblage AI (16.7%) and assemblage AII with 12.5%. All of the children who harbored G. intestinalis assemblages B were symptomatic, while asymptomatic ones had only assemblage AI and AII with 50% each. The difference was statistically highly significant. In symptomatic patients having acute diarrhea, assemblage B was present in 71.5%, while assemblage AI and AII were equal with 7.1%. All of the patients (14.3%) with mixed infection had acute diarrhea. In intermittent diarrhea, assemblage AI and B were equally distributed with 40% each. In chronic diarrhea, assemblage AI and AII were equal with 20% each, while assemblage B was found in 60%. The difference was statistically not significant. In conclusion, assemblage B is the commonest, while assemblage A is a predominant in symptomatic and asymptomatic giardiasis Saudi children, respectively. So human transmission is the common risk factor among symptomatic, while zoonotic transmission is a common risk factor in asymptomatic ones. On the other hand, a strong correlation between assemblage B and symptoms and no relation between genotypes and types of diarrhea are found. Also, PCR with HRM in one-step closed-tube methods is able to genotype G. intestinalis IGS rDNA without using the sequencing methods or the electrophoresis. © 2011 Springer-Verlag.


Patent
King Faisal University | Date: 2014-11-13

A sex-determination method for a date palm plant includes obtaining a sample of a date palm plant and determining a presence or absence of the date palm SRY gene (SEQ ID NO: 1) in the sample. The presence of the date palm SRY gene (SEQ ID NO: 1) in the sample is indicative that the sample is from a male date palm plant. Using the sex determination method for a date palm plant, the sex of date palm plants may even be determined when the date palm plants are still young, i.e., prior to flowering of the plants.


Talla J.A.,King Faisal University
Physica B: Condensed Matter | Year: 2012

We investigated the interactions between two different geometrical configurations of single-walled carbon nanotubes and boron atoms using first-principle calculations within the framework of the density functional theory. With the aid of ab initio calculations, we introduced a new type of toxic gas sensor that can detect the presence of CO, NO and H 2 molecules. We proved that the dopant concentration on the surface of the nanotube plays a crucial role in the sensitivity of this device. Furthermore, we showed that small concentrations of dopants can modify the transport and electronic properties of the single-walled carbon nanotube and can lend metallic properties to the nanotube. Band-gap narrowing occurs when the nanotube is doped with boron atoms. The emerged new energy level near the Fermi level upon boron doping clearly indicates the coupling between the p orbital of the boron atom and the large p bond of the carbon nanotube. We also predicted a weak hybridization between the boron atoms and the nanotube for the valence-band edge states; this weak coupling leads to conducting states around the band gap. © 2012 Elsevier B.V. All rights reserved.

Loading King Faisal University collaborators
Loading King Faisal University collaborators