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Jeddah, Saudi Arabia

Taruno W.P.,Edwar Technology Co. | Baidillah M.R.,Edwar Technology Co. | Sulaiman R.I.,Edwar Technology Co. | Ihsan M.F.,Edwar Technology Co. | And 3 more authors.
International IEEE/EMBS Conference on Neural Engineering, NER | Year: 2013

In this study, for the first time, we have used the ECVT technique, developed earlier for real-time and volumetric imaging of brain activity, to detect the presence of brain tumor. The ECVT sensor system measures the capacitance of electrical signals of the brain on the cortex, and generates a volumetric map of the brain activity on the cortex and inside the brain through a tomography image reconstruction algorithm based on a Neural-Network Multi-criteria Optimization Image Reconstruction Technique (NN-MOIRT). The ECVT is able to detect brain tumors through an examination of the brain functional abnormalities, as the tumors block the propagation of neuro-signals and cause abnormalities in the brain activity image. The ECVT sensor design has been optimized for the detection of the brain tumors in different sensitivity regions of the brain. Case studies have been carried out to five volunteers suffering from different brain tumors including ependymoma, oligodendroglioma, cranio-pharyngioma, germinoma pineal, and cerebellopontine angle tumors. Comparisons with their respective CT and MRI results have also been performed. The study has shown a great feasibility of the 4D imaging technique as a complementary alternative for a high speed non-radiation technique for brain cancer detection and functional imaging. © 2013 IEEE. Source


Fleige C.,University of Munster | Steinbuchel A.,University of Munster | Steinbuchel A.,King Abdulazis University
Applied Microbiology and Biotechnology | Year: 2014

Amycolatopsis sp. ATCC 39116 is able to synthesize the important flavoring agent vanillin from cheap natural substrates. The bacterium is therefore of great interest for the industry and used for the fermentative production of vanillin. In order to improve the production of natural vanillin with Amycolatopsis sp. ATCC 39116, the strain has been genetically engineered to optimize the metabolic flux towards the desired product. Extensive metabolic engineering was hitherto hampered, due to the lack of genetic tools like functional promoters and expression vectors. In this study, we report the establishment of a plasmid-based gene expression system for Amycolatopsis sp. ATCC 39116 that allows a further manipulation of the genotype. Four new Escherichia coli-Amycolatopsis shuttle vectors harboring different promoter elements were constructed, and the functionality of these regulatory elements was proven by the expression of the reporter gene gusA, encoding a β-glucuronidase. Glucuronidase activity was detected in all plasmid-harboring strains, and remarkable differences in the expression strength of the reporter gene depending on the used promoter were observed. The new expression vectors will promote the further genetic engineering of Amycolatopsis sp. ATCC 39116 to get insight into the metabolic network and to improve the strain for a more efficient industrial use. © 2014 Springer-Verlag. Source


Taruno W.P.,Spectra - Physics | Baidillah M.R.,Spectra - Physics | Sulaiman R.I.,Spectra - Physics | Ihsan M.F.,Spectra - Physics | And 4 more authors.
Proceedings - International Symposium on Biomedical Imaging | Year: 2013

A real time, volumetric (4D) imaging for human brain activity based on Electrical Capacitance Volume Tomography (ECVT) has been proposed, for the first time, in this work. The ECVT has been used to measure electrical signals generated from human brain activity and reconstruct volumetric image of the brain signal in real time. The ECVT system comprises of a helmet shaped capacitive sensor, 32-channel data acquisition system and a computer system to control the measurement, process the image reconstruction and display the brain activities on the scalp and inside the brain. Tests with simulation as well as experimental data showed different images of charged as compared to non-charged phantoms. The charged phantoms used an electrical source of 100mV with 250Hz positive pulses to simulate the action potentials of the brain. The ECVT has also been applied to monitor activity of the brain during different stimulations. Electrical signals measured from capacitance electrodes clearly showed significant differences when the brain was in rest and in high tasks such as listening to music, moving hands and solving a mathematical problem. Preliminary results have shown that ECVT was able to detect brain activities related to human motoric and language functions. © 2013 IEEE. Source


Ewais H.A.,King Abdulaziz University | Ewais H.A.,Beni Suef University | Ismail I.M.I.,King Abdulaziz University | Ismail I.M.I.,King Abdulazis University | And 2 more authors.
Oxidation Communications | Year: 2014

The oxidation of the ternary complex, [Cr(III)(Gu)(Asp)(H 2O)2]2+ (Gu = guanosine and Asp = DL-Aspartic acid) by periodate in aqueous solution to chromium(VI) has been studied spectrophotometrically over the 25-45°C range. The reaction is first order with respect to both [IO4 -] and [Cr(III)], and increases with pH over the 2.38-3.68 range. The experimental rate law is consistent with the derived mechanism and the reaction follows the rate law: d[Cr(III)]/dt = (k1K5 + k2K6K1/[H +])[IO4 -][Cr(III)]T/{1 + K 1/[H+] + (K5 + K1K 6/[H+])[IO4 -]}, where K1, K5 and K6 are the deprotonation of [Cr(III)(Gu)(Asp) (H2O)2]2+ and preequilibrium formation constants for [Cr(III)(Gu)(Asp)(H2O)(OIO3)]+ and [Cr(III)(Gu) (Asp)(OH)OIO3] precursor complexes, respectively. The reaction may follow a 2-step inner-sphere electron transfer mechanism via coordination of IO4 - to chromium(III). Thermodynamic activation parameters have been calculated. Source


Taruno W.P.,Spectra - Physics | Ihsan M.F.,Spectra - Physics | Baidillah M.R.,Spectra - Physics | Tandian T.,Bandung Institute of Technology | And 2 more authors.
Middle East Conference on Biomedical Engineering, MECBME | Year: 2014

In this study we performed brain activity observation related to simple tasks of executed movement (EM) and imagined movement (IM) using Electrical Capacitance Volume Tomography (ECVT). ECVT has been previously applied to brain activity imaging and brain cancer detection. This study is intended to elaborate further the previous studies on the brain functional imaging. Experiment on human subjects was conducted by measuring brain signals using ECVT during five conditions: (1) relax: baseline condition, (2) actual movement with the right hands and left hands, (3) imagined movement with right and left hands. Signal normalization was used to extract the ECVT brain activity signals related to a particular condition. Qualitative and quantitative analysis was performed on the ECVT images of brain activity related to EM and IM tasks. The results indicate that lateral brain activation can be observed using ECVT in concordance with fMRI studies. © 2014 IEEE. Source

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