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Ishii S.,Kindai University | Tsujiuchi T.,Kindai University | Fukushima N.,Kindai University
Biochemical and Biophysical Research Communications | Year: 2017

Lysophosphatidic acid (LPA), an extracellular lipid mediator, exerts various cellular effects through activation of LPA receptors, LPA1–LPA6, in many types of cells including cancer cells. We recently found several missense mutations of Lpar1 in rat cancer tissues. One of these mutations is located at the extracellular tip of the seventh transmembrane domain of LPA1, and another three mutations are found within the NPXXY motif in the seventh transmembrane domain. These mutants are designated F295S LPA1 and P308S, I310T, and Y311H LPA1, respectively. Here, we examined the functions of these LPA1 mutants. Compared with wild-type (WT) LPA1, F295S, P308S, and I310T LPA1 showed decreased maximal responses in inhibition of cAMP formation, Ca2+ mobilization, and cytoskeletal changes. Y311H LPA1 failed to show LPA-induced cellular responses. However, these LPA1 mutants were internalized in response to LPA exposure. Finally, while WT and F295S LPA1 showed a similar, broad distribution throughout the cell, P308S, I310T, and Y311H LPA1 displayed a restricted cellular distribution and co-localized with the endoplasmic reticulum. These data suggest that the LPA1 mutants perturb LPA signaling in cancer tissues. © 2017 Elsevier Inc.

Kawamura Y.,Kindai University
Computational and Cognitive Approaches to Narratology | Year: 2016

This chapter describes the concepts behind a Commercial Film Production Support System (CFPSS) in terms of related studies in the areas of advertising, image techniques and rhetoric, cognitive science, and information engineering. The chapter then analyzes the structure of commercial films to establish and describe an information system that is tested with a viewing experiment. The proposed system reflects the environment by implementing basic image techniques to create commercial films through an interaction between the users and the system. The experiment uses commercial films for beer with 55 participants. The results show that evaluations for image types related to the advertising story generate the most interest and high evaluations for the provider type of rhetoric stimulates willingness to buy. In terms of technique, mise-en-scène and editing attracts interest, and the advertising story associated with the product function and the supporting production and distribution stimulates willingness to buy. © 2016 by IGI Global. All rights reserved.

Taniguchi Y.,Kindai University | Nishii K.,Kindai University | Hisamatsu H.,Osaka Electro-Communication University
Proceedings - 7th International Conference on Computational Intelligence, Communication Systems and Networks, CICSyN 2015 | Year: 2015

In the case of cycling at a blind road, at night or cycling by elderly people, it is helpful to prevent accidents if information on bad road surface condition, such as break, potholes, obstacles, bumps, is preliminary obtained. In this paper, we consider to use a low-cost ultrasonic distance sensor attached on a bicycle for monitoring the road surface conditions in the front area. We design and implement a road surface condition monitoring system using an off-the-shelf node Arduino, an ultrasonic distance sensor, and a typical bicycle. In the implemented system, to limit the sensing region, the ultrasonic distance sensor is covered by a plastic shield plate. Through experimental evaluations, we show that the monitoring system can detect the 223 cm away obstacle on road in the front area of moving bicycle. © 2015 IEEE.

Kometani T.,Kindai University | Takemori K.,Kindai University
Nippon Shokuhin Kagaku Kogaku Kaishi | Year: 2016

Persimmon is well known to be a polyphenol-rich fruit. The polyphenol fraction (PPfr) was obtained from persimmon fruits using a novel method, and its effect on postprandial blood glucose levels in rats and humans was examined. PPfr contained 20% carbohydrate and 70% polyphenol which consisted of epicatechin: epicatechin gallate: epigallocatechin: epigallocatechin gallate at a ratio of 1:1:3:2. In vitro studies revealed that lowering effect of PPfr on blood glucose after carbohydrate ingestion was attributable to the inhibition of digestive enzymes, such as alpha-amylase and maltase, as well as the inhibition of glucose absorption through the digestive tract. Following the administration of 3g PPfr to 10 healthy human volunteers with 150 kcal maltose, postprandial blood glucose was significantly lowered compared with placebo. These results suggest that PPfr from persimmon fruits was useful for blood glucose control and the primary preventionofdiabetes. Copyright © 2016, Japanese Society for Food Science and Technology.

Taniguchi Y.,Kindai University
Proceedings - 2014 4th International Conference on Artificial Intelligence with Applications in Engineering and Technology, ICAIET 2014 | Year: 2014

In time division multiple access (TDMA) based wireless networks, graph coloring based link scheduling mechanisms are often considered to assign time slots to links. A graph coloring based link scheduling mechanism requires a radio interference estimation method to make a conflict graph from a wireless network topology, and the protocol method is usually used among radio interference estimation methods. In this paper, we propose a radio interference estimation method for wireless relay networks, where the network topology is a tree. Through simulation experiments, we show that the accuracy of radio interference estimation with our proposed method is improved compared to that with the protocol method. © 2014 IEEE.

Azumi Y.,Nihon System Sekkei Inc. | Murakami M.,Kindai University
Journal of Structural and Construction Engineering | Year: 2016

Most formulae to calculate the shear stiffness of a sheathed shear wall are derived under the assumption of rigid frames connected with pins. But the flexural and axial deformation of vertical studs affects the shear stiffness of a shear wall. A few other conventional formulae to calculate the shear stiffness of a sheathed shear wall consider only the effect of the flexural deformation of vertical studs. Since there is no calculation method of the shear stiffness considering the effect of the flexural and the axial deformation of vertical studs, numerical analyses are conducted. In this paper, we derive simplified formulae based on the principle of minimum potential energy. The formulae are verified by numerical static elasticity analyses.

Asano K.,Kindai University
Materials Transactions | Year: 2016

Turning machinability of aluminum alloy composites reinforced with carbon fibers was examined using a carbide tool. Pitch-based short carbon fiber was used as the reinforcement. The composites were fabricated by squeeze casting. Optical microscopy revealed that the fibers were randomly arranged in the alloy matrix. The fiber reinforcement decreased the hardness of the alloy. The fiber reinforcement also decreased the cutting resistance of the aluminum alloy, and the resistance values of the composite was lower than that of a composite reinforced with short alumina fibers. The roughness of the machined surface was significantly decreased by the fiber reinforcement under every cutting condition. No carbide tool wear was observed even if the composite underwent a machining of 2 km, whereas the tool wear was clearly observed for the alumina fiber-reinforced composite. These results indicated that the carbon fibers in the alloy act as a solid lubricant. Chips formed by machining the composite were powdery, whereas the chips formed by machining the unreinforced aluminum alloy was long. ©2016 The Japan Institute of Metals and Materials.

Handa H.,Kindai University
International Journal of Advancements in Computing Technology | Year: 2012

In this paper, we constitute 1-ply Othello agents by using Evolutionary Algorithms. By using Temporal learning method, firstly, we introduce Memetic Algorithm, i.e., hybridization of EA with local search method. Secondly, we examine Evolutionary Multi-Objective Optimization to improve the performance of EAs. In addition, we propose two kinds of modified Temporal Difference Learning methods for EMO. Experimental results show the effectiveness of the proposed method.

Sakai H.,Kindai University
The Dynamics of Vehicles on Roads and Tracks - Proceedings of the 24th Symposium of the International Association for Vehicle System Dynamics, IAVSD 2015 | Year: 2016

When drivers are drowsy, sleeping, or the like, steering maneuvers stop momentarily. Focusing on this phenomenon, this paper describes a system to detect this momentary reduction in driving ability. First, the proposed system identifies some regular driver model parameters. Utilizing this model, the system estimates the driver-vehicle system behavior. As soon as a difference between the estimated and actual behavior is detected, the system judges that driving ability has decreased. This system was then verified empirically. © 2016 Taylor & Francis Group, London.

Sakai H.,Kindai University
The Dynamics of Vehicles on Roads and Tracks - Proceedings of the 24th Symposium of the International Association for Vehicle System Dynamics, IAVSD 2015 | Year: 2016

This paper first analyzes the influence of pitching motion caused by rolling motion based on the driver’s feeling in actual vehicle testing. Itwas concluded that pitching motion enhances the cornering feeling of the driver, and this result was then utilized to develop a control law for an automotive semi-active suspension that synchronizes the rolling angle with the pitching angle. The law was further applied to an automotive damping force control system. Finally, this research validated that the control law enhances the cornering feeling of the driver through tests of actual vehicles installed with the system. © 2016 Taylor & Francis Group, London.

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