Aithal S.,Ss Institute Of Medical Science And Research Center |
Hooli T.V.,ESIC Medical College |
Patil R.,KIMS Hubli |
Varun H.V.,Ss Institute Of Medical Science And Research Center |
Swetha E.S.,Ss Institute Of Medical Science And Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014
Objective: To study the antidepressant activity of topiramate in experimental models Methods: Topiramate (15mg/kg), amitriptyline (10mg/kg) and combination of both topiramate (7.5mg/kg) and amitriptyline (5mg/kg) were administered to different groups of albino mice daily for fourteen days. The immobility period was recorded on day one and day fourteen in both forced swim test and tail suspension test. The P value less than 0.05 was considered as statistically significant Results: There was a statistically significant reduction in the immobility period in animals treated with topiramate compared to control group in both experiments on day one and day fourteen (P<0.05). There was also statistically significant difference in immobility period in the group treated with both topiramate and amitriptyline compared to group of animals treated with topiramate alone. There was no statistically significant difference in the immobility period between groups of animals treated with topiramate (15mg/kg) and amitriptyline (10mg/kg) alone. Conclusion: Topiramate at a dose of 15 mg/kg has demonstrated antidepressant activity which was comparable to amitriptyline. There was synergism in antidepressant activity of topiramate and amitriptyline.
Panchami,Father Muller Medical College |
Shenoy J.P.,Father Muller Medical College |
Shivakumar J.,KIMS Hubli |
Kole S.B.,Father Muller Medical College
Journal of Clinical and Diagnostic Research | Year: 2013
Background: Normal Intraocular pressure (IOP) is an essential prerequisite for the eye to serve its function as a light gathering and transducer organ. Various physiological factors which include age, gender and hormonal variations may influence IOP in normal subjects and these effects sometimes may be marked and relatively sustained. The present study was an attempt which was made to observe the effect of menopause on IOP and the contribution of altered Body Mass Index (BMI). Methodology: A total of 120 females who were in the age group of 40 - 55 years, who were recruited for the study, were divided into two groups of 60 each: premenopausal and postmenopausal, based on their menstrual history. The BMI of the subjects was then calculated. IOP was recorded in all individuals and it was compared between the two groups by using Student's 't' test. The IOP was also correlated with BMI. A p value of < 0.05 was considered as statistically significant. Results: The results of the present study showed that there was a significant increase in the IOP in the postmenopausal group as compared to that in premenopausal women. Moreover, it showed a significant positive correlation with BMI in post menopausal women. Conclusion: The higher IOP in postmenopausal women could be ascribed to dwindling levels of oestrogen and progesterone after menopause, which could act by altering any/several components of the IOP regulating mechanisms. A large body size, as was indicated by BMI, was associated with additional increases in IOP. The present study, therefore, provides further insights into the interactions between BMI and paucity of sex hormones in influencing the IOP.
Divakar H.,Consultant Obgyn |
Vajpyee J.,PSI population services International |
Kabadi Y.M.,KIMS Hubli |
Kittur S.,KIMS Hubli
Journal of Health Management | Year: 2013
More than 100 million women in developing countries would prefer to avoid a pregnancy; but they may not be using any form of contraception. Objective: The study was conducted to assess the safety incidence of perforation/pain/bleeding/foul discharge and expulsion rates at 6 week follow-up and willingness to continue when Copper T 380A (Cu T 380A) inserted within 10 minutes of placental expulsion both in vaginal and C-section deliveries. Methods: This was an open label, prospective, and multicentric longitudinal study. The study was approved by the Ethics Committee of FOGSI. Results: The insertion of Intrauterine Contraceptive Devices (IUCD) was easy in 98.76 per cent of subjects after normal delivery, and 100 per cent in all subjects after assisted vaginal and c-section deliveries. The position of the Cu T was in situ in 97.61 per cent of subjects, ultra sonogram was used in 1 per cent to confirm location of IUCD and in 1 per cent of subjects the IUCD was in the cervix. There was no case of perforation in this series and no other major complications. Conclusion: Inserting Cu T 380A at 10 minutes after placental delivery is safe leading to the expanding of the usage of IUCD meeting the unmet needs. The expulsion rates would be minimal if it was inserted by a trained provider and placed at the fundus. © 2013 Indian Institute of Health Management Research.
Shirol S.S.,KIMS Hubli |
Choukimath S.M.,KIMS Hubli |
Yenni V.V.,Jeevan Diagnostic Laboratory
European Journal of Plastic Surgery | Year: 2013
Hemangioma is a benign proliferation of endothelial cells within the superficial dermis, the deep dermis, internal organs and subcutis, or in both locations. It is classified as "capillary", "cavernous", or "lobular" hemangiomas. It is commonly seen in children during birth. It is very rare that hemangioma is seen in post-burn hypertrophic scar. A 42-year-old female who was treated 1 year back for 40 % of second degree superficial to deep burns had come with a history of swelling over the scar in the chin area since 1 month. There was history of occasional bleeding from the lesion. There was no history of trauma or pain. On examination, a 6 × 4 cm compressible, nontender swelling consistent with hemangioma was seen over the chin scar. The patient was taken up for excision of the lesion, and the defect was covered by a split-thickness skin graft. The histopathological examination showed that all features are suggestive of lobular hemangioma. Level of evidence: Level V, diagnostic study. © 2012 Springer-Verlag Berlin Heidelberg.
Sandhyalakshmi B.N.,ESIC and PGIMSR |
Kulkarni M.H.,KIMS Hubli
Indian Journal of Public Health Research and Development | Year: 2015
Carcinoma breast is the most common malignancy in females next to carcinoma cervix. Fine needle aspiration cytology of the lumps is the primary method in establishing the diagnosis of carcinoma. The nuclear grade of the tumor is an important prognostic factor that determines the outcome in breast cancer. The material obtained from the aspirate smears can be used to assess the cytological grade using Robinson criteria. This was correlated with well established histological grading of Scarff Bloom Richardson. Total of 70 cases were studied for which the histopathological correlation was available. The accuracy was 76.8%. © 2015, Indian Journal of Public Health Research and Development. All rights reserved.