Chung J.H.,Kimmel Cancer Center at Johns |
Larsen A.R.,Kimmel Cancer Center at Johns |
Chen E.,Kimmel Cancer Center at Johns |
Bunz F.,Kimmel Cancer Center at Johns
Journal of Biological Chemistry | Year: 2014
Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.