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Baltimore Highlands, MD, United States

Chung J.H.,Kimmel Cancer Center at Johns | Larsen A.R.,Kimmel Cancer Center at Johns | Chen E.,Kimmel Cancer Center at Johns | Bunz F.,Kimmel Cancer Center at Johns
Journal of Biological Chemistry | Year: 2014

Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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