Kikugawa, Japan
Kikugawa, Japan

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PubMed | National Institutes of Biomedical Innovation, Shizuoka City Shizuoka Hospital, University of Shizuoka, Keio University and 3 more.
Type: Journal Article | Journal: BMJ open | Year: 2015

Dietary supplement use has increased over past decades, resulting in reports of potentially serious adverse events. The aim of this study was to develop optimised methods to evaluate the causal relationships between adverse events and dietary supplements, and to test these methods using case reports.Causal relationship assessment using prospectively collected data.4 dietary supplement experts, 4 pharmacists and 11 registered dietitians (5 men and 14 women) examined 200 case reports of suspected adverse events using the modified Naranjo scale and the modified Food and Drug Administration (FDA) algorithm.The distribution of evaluation results was analysed and inter-rater reliability was evaluated for the two modified methods employed using intraclass correlation coefficients (ICC) and Fleiss .Using these two methods, most of the 200 case reports were categorised as lack of information or possible adverse events. Inter-rater reliability among entire assessors ratings for the two modified methods, based on ICC and Fleiss , were classified as more than substantial (modified Naranjo scale: ICC (95% CI) 0.873 (0.850 to 0.895); Fleiss (95% CI) 0.615 (0.615 to 0.615). Modified FDA algorithm: Fleiss (95% CI) 0.622 (0.622 to 0.622).These methods may help to assess the causal relationships between adverse events and dietary supplements. By conducting additional studies of these methods in different populations, researchers can expand the possibilities for the application of our methods.


Satake E.,Hamamatsu University School of Medicine | Nakagawa Y.,Hamamatsu University School of Medicine | Kubota A.,Kikugawa General Hospital | Saegusa H.,Ensyu General Hospital | And 2 more authors.
Journal of Pediatric Endocrinology and Metabolism | Year: 2010

Objective: To assess fat distribution in non-obese Japanese children and adolescents. Design: 130 non-obese Japanese children (73 boys and 57 girls) from Kikugawa, Hamamatsu were included. The visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by computed tomography (CT) and calculated (in cm 2). Subjects were divided into three groups based on age: group A (6-10 years), group B (11-15 years), and group C (16-20 years). Results: Girls had more subcutaneous fat than boys in groups B and C (P<0.01). Boys had an age-dependent increase in visceral fat, but girls did not. In group C (16-20 years), boys had more visceral fat than girls (P<0.01). Conclusions: In non-obese Japanese children, there are significant differences in visceral and subcutaneous fat amounts by age and sex. VFA seems to accumulate more in boys than in girls, and SFA is more prevalent in girls than boys. © Freund Publishing House Ltd.


Takeda M.,Kikugawa General Hospital | Shoji T.,Shizuoka City Shimizu Hospital | Yamazaki M.,Shizuoka City Shimizu Hospital | Higashi Y.,Shizuoka City Shimizu Hospital | Maruo H.,Shizuoka City Shimizu Hospital
Case Reports in Gastroenterology | Year: 2011

Adenomyoma of the ileum is a rare condition. A 68-year-old Japanese man presented with nausea and distension of the abdomen. Enhanced computed tomography of his abdomen revealed wall thickening in the ileum and dilation of the proximal small intestine. Open laparotomy was performed to find the cause of the patient's small bowel obstruction, and a tumor was found in the ileum, which had resulted in intussusception. The tumor and 20 cm of the adjacent ileum were resected. The resected specimen displayed a macroscopic appearance suggestive of a submucosal tumor. Histopathological evaluation showed duct cell proliferation and bundles of smooth muscle cells from the mucosa to the serosa, leading to a diagnosis of adenomyoma. Immunohistochemical examination found that cytokeratin 7 and carbohydrate antigen 19-9 were expressed in the duct epithelia. We report a rare case of ileal adenomyoma leading to intussusception in an adult and present the immunohistochemical evaluation of the adenomyoma. Copyright © 2011 S. Karger AG.


Park M.,University of Shizuoka | Yamada H.,University of Shizuoka | Matsushita K.,Kikugawa General Hospital | Kaji S.,University of Shizuoka | And 4 more authors.
Journal of Nutrition | Year: 2011

Green tea is known to contain antiviral components that prevent influenza infection. A limited number of adult clinical studies have been undertaken, but there is a paucity of clinical evidence concerning children. We conducted an observational study to determine the association between green tea consumption and the incidence of influenza infection among schoolchildren. Anonymous questionnaire surveys were undertaken twice during the influenza season from November 2008 to February 2009 (endemic seasonal type A influenza infection); each survey was conducted for 2663 pupils across all elementary schools in Kikugawa City (a tea plantation area), Japan. Each questionnaire was completed and submitted by 2050 pupils (response rate, 77.0%; age range, 6-13 y). The adjusted OR associated with the consumption of green tea for $6 d/wk compared with,3 d/wk was 0.60 [(95% CI = 0.39-0.92); P = 0.02] in cases of influenza confirmed by the antigen test. Meanwhile, the adjusted OR inversely associated with the consumption of 1 cup/d to,3cups/d(1cup= 200 mL) and 3-5 cups/d compared with,1 cup/d were 0.62 [(95% CI = 0.41-0.95); P = 0.03] and 0.54 [(95% CI = 0.30- 0.94); P = 0.03], respectively. However, there was no significant association with the consumption of .5 cups/d. Our findings thus suggest that the consumption of 1-5 cups/d of green tea may prevent influenza infection in children. © 2011 American Society for Nutrition.


Ide K.,University of Shizuoka | Yamada H.,University of Shizuoka | Matsushita K.,Kikugawa General Hospital | Ito M.,University of Shizuoka | And 4 more authors.
PLoS ONE | Year: 2014

Background: The anti-influenza virus activity of green tea catechins has been demonstrated in experimental studies, but clinical evidence has been inconclusive. School-aged children play an important role in the infection and spread of influenza in the form of school-based outbreaks. Preventing influenza infection among students is essential for reducing the frequency of epidemics and pandemics. As a non-pharmaceutical intervention against infection, gargling is also commonly performed in Asian countries but has not yet been extensively studied. Methods and Findings: A randomized, open label, 2-group parallel study of 757 high school students (15 to 17 years of age) was conducted for 90 days during the influenza epidemic season from December 1st, 2011 to February 28th, 2012, in 6 high schools in Shizuoka Prefecture, Japan. The green tea gargling group gargled 3 times a day with bottled green tea, and the water gargling group did the same with tap water. The water group was restricted from gargling with green tea. The primary outcome measure was the incidence of laboratory-confirmed influenza using immunochromatographic assay for antigen detection. 757 participants were enrolled and 747 participants completed the study (384 in the green tea group and 363 in the water group). Multivariate logistic regression indicated no significant difference in the incidence of laboratory-confirmed influenza between the green tea group (19 participants; 4.9%) and the water group (25 participants; 6.9%) (adjusted OR, 0.69; 95%CI, 0.37 to 1.28; P = 0.24). The main limitation of the study is the adherence rate among high school students was lower than expected. Conclusions: Among high school students, gargling with green tea three times a day was not significantly more efficacious than gargling with water for the prevention of influenza infection. In order to adequately assess the effectiveness of such gargling, additional large-scale randomized studies are needed. Trial Registration: ClinicalTrials.gov NCT01225770. © 2014 Ide et al.


PubMed | Omaezaki Municipal Hospital, University of Shizuoka and Kikugawa General Hospital
Type: Journal Article | Journal: PloS one | Year: 2014

The anti-influenza virus activity of green tea catechins has been demonstrated in experimental studies, but clinical evidence has been inconclusive. School-aged children play an important role in the infection and spread of influenza in the form of school-based outbreaks. Preventing influenza infection among students is essential for reducing the frequency of epidemics and pandemics. As a non-pharmaceutical intervention against infection, gargling is also commonly performed in Asian countries but has not yet been extensively studied.A randomized, open label, 2-group parallel study of 757 high school students (15 to 17 years of age) was conducted for 90 days during the influenza epidemic season from December 1st, 2011 to February 28th, 2012, in 6 high schools in Shizuoka Prefecture, Japan. The green tea gargling group gargled 3 times a day with bottled green tea, and the water gargling group did the same with tap water. The water group was restricted from gargling with green tea. The primary outcome measure was the incidence of laboratory-confirmed influenza using immunochromatographic assay for antigen detection. 757 participants were enrolled and 747 participants completed the study (384 in the green tea group and 363 in the water group). Multivariate logistic regression indicated no significant difference in the incidence of laboratory-confirmed influenza between the green tea group (19 participants; 4.9%) and the water group (25 participants; 6.9%) (adjusted OR, 0.69; 95%CI, 0.37 to 1.28; P=0.24). The main limitation of the study is the adherence rate among high school students was lower than expected.Among high school students, gargling with green tea three times a day was not significantly more efficacious than gargling with water for the prevention of influenza infection. In order to adequately assess the effectiveness of such gargling, additional large-scale randomized studies are needed.ClinicalTrials.gov NCT01225770.


Takeda M.,Hamamatsu University School of Medicine | Ohnuki Y.,Kikugawa General Hospital | Uchiyama T.,Kikugawa General Hospital | Kubota O.,Kikugawa General Hospital | Ohishi K.,Kikugawa General Hospital
International Surgery | Year: 2013

Internalhernias inwhich the gate is locatedin theparacolicgutter are rare.A75-year-oldman was admitted to our hospital with severe epigastric pain without past history of laparotomy and/or trauma. He was diagnosed with strangulation of the ileum by the findings of computed tomography, and the operation was performed. During laparotomy, the small intestine was found to be strangulated and to enter the retroperitoneum from the right paracolic gutter near the hepatic flexure. The patient was diagnosed with an internal hernia, which differed froma pericecal hernia in that the hernia gate was located along the paracolic gutternear thehepaticflexure far fromthececum.Hence, itwas consideredtobe a rare type of internal hernia.We report the clinical presentation and imaging findings of this rare internal hernia.


Kubota O.,Kikugawa General Hospital | Onuki Y.,Kikugawa General Hospital | Uchiyama T.,Kikugawa General Hospital | Oishi K.,Kikugawa General Hospital | Takeda M.,Kikugawa General Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2012

Background: Aromatase inhibitors (Als) are frequently employed for advanced or metastatic postmenopausal breast cancer as first-line hormone therapy. However, it is unknown which hormonal agent is the most appropriate after Al has failed. Patients and Methods: Five hormone-responsive postmenopausal women who used Al as a first-line hormone therapy for advanced or metastatic breast cancer, but Al failed, received high-dose toremifene therapy (HD-TOR: 120mg/day) in our hospital. Efficacy and safety were evaluated. Results: Patients were all-hormone sensitive, and only one case had HER2 overexpression. All patients had received anastrozole (ANA) as first-line hormone therapy. Of a total of 5 cases, 3 were evaluated as partial responses (PR), 1 was a long stable disease (L-SD), and 1 was a progressive disease (PD). The overall response rate (RR) was 60. 0% (3/5 cases) and the clinical benefit rate (CB) was 80.0% (4/5 cases). Grade 1 dry mouth was observed in one case as an adverse event. Conclusions: HD-TOR as a second-line therapy is optimal for advanced or metastatic Al resistance postmenopausal breast cancer.


PubMed | Kikugawa General Hospital
Type: Journal Article | Journal: Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2012

Aromatase inhibitors(AIs)are frequently employed for advanced or metastatic postmenopausal breast cancer as first-line hormone therapy. However, it is unknown which hormonal agent is the most appropriate after AI has failed.Five hormone-responsive postmenopausal women who used AI as a first-line hormone therapy for advanced or metastatic breast cancer, but AI failed, received high-dose toremifene therapy(HD-TOR: 120mg/day)in our hospital. Efficacy and safety were evaluated.Patients were all-hormone sensitive, and only one case had HER2 overexpression. All patients had received anastrozole(ANA)as first-line hormone therapy. Of a total of 5 cases, 3 were evaluated as partial responses(PR), 1 was a long stable disease(L-SD), and 1 was a progressive disease(PD). The overall response rate (RR)was 60. 0%(3/5 cases)and the clinical benefit rate(CB)was 80. 0%(4/5 cases). Grade 1 dry mouth was observed in one case as an adverse event.HD-TOR as a second-line therapy is optimal for advanced or metastatic AI resistance postmenopausal breast cancer.


PubMed | Kikugawa General Hospital
Type: Journal Article | Journal: Case reports in gastroenterology | Year: 2011

Adenomyoma of the ileum is a rare condition. A 68-year-old Japanese man presented with nausea and distension of the abdomen. Enhanced computed tomography of his abdomen revealed wall thickening in the ileum and dilation of the proximal small intestine. Open laparotomy was performed to find the cause of the patients small bowel obstruction, and a tumor was found in the ileum, which had resulted in intussusception. The tumor and 20 cm of the adjacent ileum were resected. The resected specimen displayed a macroscopic appearance suggestive of a submucosal tumor. Histopathological evaluation showed duct cell proliferation and bundles of smooth muscle cells from the mucosa to the serosa, leading to a diagnosis of adenomyoma. Immunohistochemical examination found that cytokeratin 7 and carbohydrate antigen 19-9 were expressed in the duct epithelia. We report a rare case of ileal adenomyoma leading to intussusception in an adult and present the immunohistochemical evaluation of the adenomyoma.

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