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PubMed | Fukuoka University, Kitasato University, Kinder Care Veterinary Clinic, Kibun Foods Inc. and Ishikawa Natural Medicinal Products Research Center
Type: | Journal: Drug research | Year: 2016

The apoptotic effects of a novel antitumour agent (Rv-PEM01) prepared from 6 kinds of herbs, including


Suruga K.,Kibun Foods Inc | Kadokura K.,Kibun Foods Inc | Sekino Y.,Kibun Foods Inc | Nakano T.,Fukuoka University | And 6 more authors.
International Journal of Medicinal Mushrooms | Year: 2015

The goal of this study was to evaluate the antioxidant effects of and nerve growth factor (NGF) synthesis caused by Hericium ramosum mycelia. Wild mushroom fruiting bodies were collected from nature to isolate their mycelia. Pieces of H. ramosum fruiting bodies were plated onto 90-mm Petri dishes with potato dextrose agar medium to isolate their mycelia. Antioxidant activity was measured using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging activity in vitro; the ethanol extract from H. ramosum mycelia (63.11 μmol Trolox/g) was more potent than that of other mushroom mycelia extracts. There was a proportional relationship (R2 = 0.7929) between DPPH radical scavenging activity and total phenolic content in extracts of different mushroom mycelia. We investigated the ability of H. ramosum mycelia to inducing NGF synthesis in vivo. Oral administration of H. ramosum mycelia significantly increased concentrations of NGF in the hippocampus of intact mice. These results are the first concerning antioxidant activity and NGF synthesis of H. ramosum mycelia. These mushroom mycelia could be useful as food and/or nutritional supplements because of certain biological functions. © 2015 Begell House, Inc.


Kadokura K.,Kibun Foods Inc. | Suruga K.,Kibun Foods Inc. | Tomita T.,Kibun Foods Inc. | Hiruma W.,Kibun Foods Inc. | And 6 more authors.
Journal of Natural Medicines | Year: 2014

Two novel urushiols, 1 and 2, and two known urushiols, 3 and 4, were isolated from the leaves of Rhus verniciflua and were examined for their human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitory activity. The novel urushiols were found to be 1,2-dihydroxyphenyl-3-[7(E),9(Z),11(Z)-pentadecatrienyl]-14-ol (1) and 1,2-dihydroxyphenyl-3-[8(Z),10(E),12(E)-pentadecatrienyl]-14-ol (2) by spectroscopic analyses. The absolute configuration at C-14 in 1 and 2 was determined to be a racemic mixture of (R) and (S) isomers by ozonolysis. Compound 2 (IC50: 12.6 μM) showed the highest HIV-1 RT inhibitory activity among the four urushiols, being 2.5-fold more potent than the positive control, adriamycin (IC50: 31.9 μM). Although the known urushiols were isolated from the sap and leaves of R. verniciflua, 1 was exclusively present in the leaves, and higher amounts of 2 were found in the leaves than in the sap. Present findings indicate that the leaves of R. verniciflua represent a new biological resource from which novel and known urushiols may be prepared, and the possible use of novel urushiols as bioactive products. © 2014 The Japanese Society of Pharmacognosy and Springer Japan.


Patent
Kibun Foods Inc. | Date: 2013-03-13

The present invention provides a therapeutic agent for dementia comprising a pharmaceutically active substance derived from Hericium ramosum.


PubMed | Kibun Foods Inc.
Type: Journal Article | Journal: Journal of natural medicines | Year: 2014

Two novel urushiols, 1 and 2, and two known urushiols, 3 and 4, were isolated from the leaves of Rhus verniciflua and were examined for their human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitory activity. The novel urushiols were found to be 1,2-dihydroxyphenyl-3-[7(E),9(Z),11(Z)-pentadecatrienyl]-14-ol (1) and 1,2-dihydroxyphenyl-3-[8(Z),10(E),12(E)-pentadecatrienyl]-14-ol (2) by spectroscopic analyses. The absolute configuration at C-14 in 1 and 2 was determined to be a racemic mixture of (R) and (S) isomers by ozonolysis. Compound 2 (IC50: 12.6M) showed the highest HIV-1 RT inhibitory activity among the four urushiols, being 2.5-fold more potent than the positive control, adriamycin (IC50: 31.9M). Although the known urushiols were isolated from the sap and leaves of R. verniciflua, 1 was exclusively present in the leaves, and higher amounts of 2 were found in the leaves than in the sap. Present findings indicate that the leaves of R. verniciflua represent a new biological resource from which novel and known urushiols may be prepared, and the possible use of novel urushiols as bioactive products.

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