Khulna, Bangladesh
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Siddiqi U.R.,Tohoku University | Siddiqi U.R.,Khulna Medical College | Punpunich W.,Rangsit University | Chuchottaworn C.,Chest Disease Institute | And 6 more authors.
International Journal of Tuberculosis and Lung Disease | Year: 2012

OBJECTIVE: To evaluate immunoglobulin G (IgG) and immunoglobulin A (IgA) responses to tuberculousg lycolipid antigen (TBGL-IgG and -IgA) in pulmonary tuberculosis (TB) patients and healthy controls in Thailand. DESIGN: Anti-TBGL antibody titres and other TB related markers were measured in the serum samples of 24 adults with pulmonary TB (PTB), 28 healthy adults (HA), 23 children with TB and 24 healthy children. RESULT: Both TBGL-IgG and -IgA titres were significantly higher only in adult PTB cases compared to controls (P < 0.001 for all). TBGL-IgG was highly sensitive (92%) in PTB patients, but frequent positive proportions of TBGL-IgG (46%) and -IgA (36%) in HAs were the cause of low specificities of TBGL-IgG (54%) and -IgA (64%); that of TBGL-IgG+IgA (75%) was the highest. Antibody titres were positively correlated in TBGL-IgG+IgA double-positive HAs (HA+, 7/28, P < 0.01), but not in HA- (P > 0.05). Serum IgG and IgA levels were not correlated with TBGL-IgG or -IgA levels (P > 0.05). KL-6 and leptin levels were normal and were not different between HA+ and HA-, indicating absence of active TB in HAs. CONCLUSION: Enhanced TBGL-IgG+IgA responses in HAs could indicate latent TB infection. Careful follow-up studies in HAs could clarify the significance of elevated TBGL antibodies as early disease markers. © 2012 The Union.


Roshed M.M.,Khulna Medical College | Ahsan S.M.,Khulna Medical College | Rashed K.A.,General Hospital
Journal of Medicine (Bangladesh) | Year: 2013

A rare case of primary non-Hodgkin's Lymphoma in a 52-year-old female presented with a large mass in the right lobe of thyroid. The diagnosis was established by fine needle aspiration cytology (FNAC) followed by surgery and finally confirmed by histopathology.


Alim A.,Khulna Medical College | Nurunnabi A.S.M.,Dhaka Medical College | Mahbub S.,Shahabuddin Medical College | Ara S.,Dhaka Medical College
Bangladesh Journal of Medical Science | Year: 2012

Context: The spleen is the largest single mass of lymphoid tissue in all vertebrates. Histological changes are evident in advancing age along with functional capability of the human spleen. A cross-sectional, descriptive type of study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from January to December 2008, to see the age related microscopic changes in the human spleen. Methods: 30 human spleens were collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine of Dhaka Medical College, Dhaka. The samples were divided into three age-groups including group A (15-29 years), group B (30-49 years) & group C (50-69 years). Then 5 best prepared histological slides from each group were taken and examined under the light compound microscope to determine the thickness of capsule, diameter, number and percent amount of white pulp in the human spleen. Results: The thickness of the splenic capsule were found 84.60±7.97?m, 117.92±4.16?m, and 132.17±6.37?m in group A, B and C respectively. The diameter of the white pulp were found 0.32±0.01 mm, 0.32±0.01 mm and 0.31±0.01 mm, while the number of white pulp per sq. mm were 2.28±1.04, 2.38±0.93 and 2.04±0.76 in group A, B and C respectively. Moreover, the amounts of the white pulp were determined 23.09±1.38, 24.45±1.84 and 22.54±1.08 in group A, B and C respectively. The difference in thickness of the splenic capsule was statistically significant among the study groups (p<0.001). However, no difference was found in diameter, number and percentage of the white pulp of the spleen among those age groups. Conclusion: The thickness of the capsule of the spleen was found to increase with advancing age in humans. However, no age change was evident in diameter, number or amount of the white pulp.


Akhter N.,Khulna Medical College | Begum B.N.,Khulna Medical College | Newaz M.,Khulna Medical College
Mymensingh medical journal : MMJ | Year: 2015

We report on a 22 years old lady with aplasia of uterus and most of the vagina with normal secondary sexual characteristics, unilateral renal hypoplasia and anomalies of cervico throacic somites (MURCS Association), growth retardation, cardiac defect and congenital urethrovaginal fistula. Although there is a broad spectrum of anomalies described with MURCS association genitourinary fistula is not yet reported and reviewed in published articles. The relevance of this paper is to show the importance of further investigation in cases of primary amenorrhoea with mullerian agenesis to establish that the patient has MURCS association and not simply MRKH (Mayer Rokitansky-Kusterhauser Syndrome) syndrome. Consequently we should provide guidance to the patients and their families about the best way to conduct the case including genetic counseling and family screening.


Kamal S.M.,Khulna Medical College | Rashid A.M.,Khulna Medical College | Bakar M.A.,Khulna Medical College | Ahad M.A.,Khulna Medical College
Asian Pacific Journal of Tropical Biomedicine | Year: 2011

Anthrax is a zoonotic disease caused by Bacillus anthracis. It is potentially fatal and highly contagious disease. Herbivores are the natural host. Human acquire the disease incidentally by contact with infected animal or animal products. In the 18th century an epidemic destroyed approximately half of the sheep in Europe. In 1900 human inhalational anthrax occured sporadically in the United States. In 1979 an outbreak of human anthrax occured in Sverdlovsk of Soviet Union. Anthrax continued to represent a world wide presence. The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene. Human anthrax clinically presents in three forms, i.e. cutaneous, gastrointestinal and inhalational. About 95% of human anthrax is cutaneous and 5% is inhalational. Gastrointestinal anthrax is very rare (less than 1%). Inhalational form is used as a biological warefare agent. Penicillin, ciprofloxacin (and other quinolones), doxicyclin, ampicillin, imipenem, clindamycin, clarithromycin, vancomycin, chloramphenicol, rifampicin are effective antimicrobials. Antimicrobial therapy for 60 days is recommended. Human anthrax vaccine is available. Administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90%-100% survival. The combination of CPG-adjuvanted anthrax vaccine adsorbed (AVA) plus dalbavancin significantly improved survival. © 2011 Asian Pacific Tropical Biomedical Magazine.


Chowdhury F.R.,Sylhet MAG Osmani Medical College | Rahman A.U.,Dhaka Medical College | Mohammed F.R.,Dhaka Medical College | Chowdhury A.,Khulna Medical College | And 2 more authors.
Bangladesh Medical Research Council Bulletin | Year: 2011

This retrospective study was carried out in the Medicine Department of Khulna Medical College, the biggest tertiary hospital in the southern part of Bangladesh to observe the trends of poisoning in southern part of Bangladesh over four years including age and sex variation, mode of poisoning, type of poison used and outcome of poisoning. The hospital medical records of all patients, aged 10 years and above with history of acute poisoning from January, 2003 to December, 2006 were enrolled. Patients were categorized into four age group including Group (Gr.) I, Gr. II, Gr. III & Gr. IV having age range of 10-20, 21-30, 31-40 & >40 respectively. Underlying causes of poisoning were also observed totally and individually in different mode with male, female ratio and the percentage. Death cases according to mode of poisoning with demographic alignment were also observed. Statistical analysis were done using epi-info version 3.5.1 and measures were presented as proportion and percentage. Among 1903 cases, 1012 (53.1%) were male and 891 (46.8%) female with a ratio of 1.4: 1. The year wise total number of cases were progressively decreased from 627 (2003) to 353 (2006). Most commonly found toxic agent was Organo-Phosphate compound (526; 27.64%) with a very little sexual variation & this trend remained same in all study years. Poisoning with unknown substance was the second leading cause (16.03%) followed by Copper-sulphate (14.03%), Sedative (13.35%), Snakebite (12.93%) etc. Incidence of unknown poisoning, sedatives, snake-bite and corrosives were found to be gradually decreased over the study years. Male were found mostly affected in majority type of poisoning except Copper-sulphate, kerosene, puffer fish, paracetamol and other drugs category. Age group II (710; 37.3%) was the most vulnerable group with male (57.89%) preponderance followed by group I (643; 33.7%), III (329; 17.2%) and IV (221; 11.6%) respectively. Highest 1308 (68.7%) cases were suicidal in mode followed by 304 (15.9%) accidental and 291 (15.2%) homicidal. Out of 1903, 140 (7.3%) patients died. Death rate was highest in OPC poisoning (52.1%) followed by unknown substance (13.5%), snakebite and copper-sulphate (11.4%) etc. In an agro-based country like Bangladesh, it's very difficult to reduce the poisoning cases and mortality. Prospectively designed multi-centered studies are needed to reflect the epidemiological properties of poisonings throughout Bangladesh, and would be very valuable for the determination of preventive measures.


Rashid A.K.M.M.,Khulna Medical College | Kamal S.M.,Khulna Medical College | Ashrafuzzaman M.,Khulna Medical College
Current Rheumatology Reviews | Year: 2013

Background: A number of children with Juvenile Idiopathic Arthritis (JIA) got admitted in the pediatrics ward of a medical college hospital. However, burden and clinical pattern of JIA have not been studied in our country. Objectives: To estimate the burden of JIA admitted in the pediatric department of medical college hospital of Bangladesh and to observe the status of active JIA in respect to magnitude, clinical profile and hematological changes. Methods: A prospective study was carried out among the patients admitted in pediatric ward of a medical college hospital, Bangladesh from 2008 to 2010. All active JIA patients admitted during this period were included in this study. JIA was diagnosed according to the ILAR criteria. Male/Female ratio, age, Total Leukocyte Count (TLC), Differential count (D/C), Platelet count, Erythrocyte Sedimentation Rate (ESR), C Reactive Protein (CRP), Rheumatoid Factor (RF) of JIA patients were recorded. These were statistically analyzed with the help of SPSS programme using chi-square test. Results: Twenty five cases of active JIA were diagnosed during this period. Magnitude was 3.75 per 1000 admitted cases. Male/Female ratio was 1.08:1. 10 (40%) cases were between the ages of 8 to 11 years. Polyarticular seronegative JIA was found in 10 (40%) cases and oligoarticular JIA in the next order 6 (24%). High ESR, TLC, platelet count was observed in 21 (84%) [p <.001], 19 (76%) [p <.009], 3 (12%) [p <.000] cases respectively. Conclusion: Burden of JIA was similar to all the areas of the world. Polyarticular seronegative JIA was commonly observed in our study. High ESR, increased TLC and Platelet count was the reliable predictor of active JIA. © 2013 Bentham Science Publishers.


PubMed | Khulna Medical College
Type: Case Reports | Journal: Mymensingh medical journal : MMJ | Year: 2015

We report on a 22 years old lady with aplasia of uterus and most of the vagina with normal secondary sexual characteristics, unilateral renal hypoplasia and anomalies of cervico throacic somites (MURCS Association), growth retardation, cardiac defect and congenital urethrovaginal fistula. Although there is a broad spectrum of anomalies described with MURCS association genitourinary fistula is not yet reported and reviewed in published articles. The relevance of this paper is to show the importance of further investigation in cases of primary amenorrhoea with mullerian agenesis to establish that the patient has MURCS association and not simply MRKH (Mayer Rokitansky-Kusterhauser Syndrome) syndrome. Consequently we should provide guidance to the patients and their families about the best way to conduct the case including genetic counseling and family screening.


PubMed | Khulna Medical College
Type: Case Reports | Journal: Mymensingh medical journal : MMJ | Year: 2012

Hydatidosis is a parasitic zoonotic echinococcal infection that affects both humans and other mammals. These diseases are common worldwide but particularly common in sheep and cattle farming regions. Anaphylaxis mediated by IgE is a serious complication of surgery or trauma which necessitates more aware of its clinical features, diagnosis and management. It is important to make a preoperative diagnosis based on the typical image findings, so that particular precaution can be taken not to rupture the lesion. A woman presented with a right upper quadrant cutaneous abscess. USG reveals multiple cystic lesions in the liver arranged in cartwheel appearance, CT disclosed a cystic lesions having daughter cysts, marginal calcifications, marginal enhancement and contiguous abdominal wall abscess, which led to a diagnosis of complicated hepatic hydatid cysts with abdominal wall abscess formation. FNAC showed scolices surrounded by chronic inflammatory cells. Abdominal wall abscess may be a presentation of hydatid liver disease.


Islam M.N.,Khulna Medical College
Mymensingh medical journal : MMJ | Year: 2012

Hydatidosis is a parasitic zoonotic echinococcal infection that affects both humans and other mammals. These diseases are common worldwide but particularly common in sheep and cattle farming regions. Anaphylaxis mediated by IgE is a serious complication of surgery or trauma which necessitates more aware of its clinical features, diagnosis and management. It is important to make a preoperative diagnosis based on the typical image findings, so that particular precaution can be taken not to rupture the lesion. A woman presented with a right upper quadrant cutaneous abscess. USG reveals multiple cystic lesions in the liver arranged in cartwheel appearance, CT disclosed a cystic lesions having daughter cysts, marginal calcifications, marginal enhancement and contiguous abdominal wall abscess, which led to a diagnosis of complicated hepatic hydatid cysts with abdominal wall abscess formation. FNAC showed scolices surrounded by chronic inflammatory cells. Abdominal wall abscess may be a presentation of hydatid liver disease.

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