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Kharkiv, Ukraine

Kharkov National Medical University , formerly known as Kharkov Medical Institute and Kharkov State Medical University, is a medical university in Kharkiv, Ukraine. It was first known as Kharkov state medical university.Post addresse: Prospekt Lenina, 4, Kharkiv, 61022, Ukraine.At present, over 700 teachers work at the departments of the university. Staff capacity is 5 corresponding members NAMN Ukraine, 17 Honoured Scientist of Ukraine, 2 Honored high school Ukraine, 13 distinguished doctors of Ukraine, 8 winners of the State Prize of Ukraine in Science and Engineering, 28 academicians of the public academies of Ukraine, 28 employees - Member of International Medical Associations;. Since 1951, the University has been training medical personnel for countries of the Eastern Europe, China and Mongolia, and since 1961 it has been training students from other countries of Asia, Africa and Latin America. At present, there are about 2000 foreign students in the Kharkiv National Medical University who study at the Preparatory Department, Medical, Nursing and Dental Faculties, undergo postgraduate and clinical post-graduate courses as well as professional probation at departments of the University in Dental, therapy, orthopedics, surgery, oncology, urology, psychiatry, ophthalmology, obstetrics and gynecology, as well as other medical specialties. The University has trained over 5000 specialists for 86 states of Europe, Asia, Latin America, Middle East countries. Among them there are 3 Doctors and 70 Candidates of Medical Science, about 200 clinical post-graduates . Wikipedia.

Cardio-vascular disease is an important public health problem in all developed countries.The challenge isto learn thepathogenic mechanisms of this disease.Attention of scientists of the world are drown to the role of hormones in the development of adipose tissue metabolic disorders. Adipose tissue is composed of adipocytes embedded in a loose connective tissue meshwork containing adipocyte precursors, fibroblasts, immune cells, and various other cell types. Adipose tissue was traditionally considered an energy storage depot with few interesting attributes. Due to the dramatic rise in obesity and its metabolic sequelae during the past decades, adipose tissue gained tremendous scientific interest. It is now regarded as an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. The aim of our study was to examine the metabolic disorders in patients with cardiovascular disease. Based on identifying the nature of changes of insulin antagonists and of insulin sensitizers. We were investigated 68 patients with hypertension, which included 35 women and 33 men.Estimated distance of carbohydrate and lipid metabolism and adipose tissue hormone imbalance. Our results suggest that the mechanisms underlying the progression of diabetes and obesity in patients with hypertension against metabolic disorders that manifest dysfunction of carbohydrate and lipid metabolism are associated with insulinorezistense and hypervisfatinemia and hyperrezistinemia against hypoadiponektinemia occur in hypertensive patients by having diabetes mellitus type 2. Source

Gorbenko G.P.,Kharkiv National Medical University
Journal of Fluorescence

Fluorescence spectroscopy is one of the most powerful tools for characterization of a multitude of biological processes. Of these, the phenomenon of protein oligomerization attracts especial interest due to its crucial role in the formation of fibrillar protein aggregates (amyloid fibrils) involved in ethiology of so-called protein misfolding diseases. It is becoming increasingly substantiated that protein fibrillization in vivo can be initiated and modulated at membrane-water interface. All steps of membrane-assisted fibrillogenesis, viz., protein adsorption onto lipid bilayer, structural transition of polypeptide chain into a highly aggregation-prone partially folded conformation, assembly of oligomeric nucleus from membrane-bound monomeric species and fiber elongation can be monitored with a mighty family of fluorescence-based techniques. Furthermore, the mechanisms behind cytotoxicity of prefibrillar protein oligomers are highly amenable to fluorescence analysis. The applications of fluorescence spectroscopy to monitoring protein oligomerization in a membrane environment are exemplified and some problems encountered in such kinds of studies are highlighted. © Springer Science+Business Media, LLC 2011. Source

Chaychenko T.,Kharkiv National Medical University
Polish Annals of Medicine

Introduction: Pediatric obesity reflects a real crisis for public health as associated with cardiovascular risk in subjects with developed metabolic syndrome. Simultaneously the information concerning risk related cardiovascular changes in metabolically healthy obese adolescents is pretty insufficient. Aim: This study is designed to determine the risk related cardiovascular changes in metabolically healthy obese adolescents. Material and methods: 208 obese adolescents were grouped as metabolically healthy and metabolically unhealthy by International Diabetes Federation (IDF) criteria for pediatric metabolic syndrome. We analyzed the basic metabolic parameters, left ventricular geometry and function, 24-hours blood pressure monitoring and carotid intima-media thickness. Control group consisted of 23 lean healthy subjects. Results and discussion: 69% of obese adolescents could be considered as metabolically healthy by pediatric IDF criteria. BMI in metabolically unhealthy was greater vs. metabolically healthy (P = 0.019) as well as dyslipidemia and dysglicemia. Cardiovascular parameters were deteriorated in all obese vs. lean healthy (myocardial hypertrophy and dysfunction, thickening of carotid vessels and systolic hypertension). It established low sensitivity (0.28) and low negative predictive value (0.29) of metabolic syndrome criteria to screen obesity associated cardiovascular problems. Conclusions: Prognostic capability of pediatric metabolic syndrome criteria is pretty low due to its sensitivity. Therefore obese adolescents not met diagnostic level for metabolic syndrome by IDF criteria could be falsely excluded from the cardiovascular risk group. Thus, it is not possible to assert an existence of absolutely healthy metabolic profile in obese and more sensitive markers are necessary for the metabolically healthy obesity identification. © 2016 Warmińsko-Mazurska Izba Lekarska w Olsztynie. Source

Trusova V.M.,Kharkiv National Medical University
Biophysical Reviews and Letters

Amyloid fibrils represent a generic class of mechanically strong and stable biomaterials with extremely advantageous properties. Although amyloids were initially associated only with severe neurological disorders, the role of these structures nowadays is shifting from health debilitating to highly beneficial both in biomedical and technological aspects. Intensive involvement of fibrillar assemblies into the wide range of pathogenic and functional processes strongly necessitate the molecular level characterization of the structural, physical and elastic features of protein nanofibrils. In the present contribution, we made an attempt to highlight the up-to-date progress in the understanding of amyloid properties from the polymer physics standpoint. The fundamental insights into protein fibril behavior are essential not only for development of therapeutic strategies to combat the protein misfolding disorders but also for rational and precise design of novel biodegradable protein-based nanopolymers. © 2015 World Scientific Publishing Company. Source

Kon K.V.,Kharkiv National Medical University | Rai M.K.,Sant Gadge Baba Amravati University
Expert Review of Anti-Infective Therapy

Antibiotic resistance is documented to be a serious problem that affects the choice of appropriate antibiotic therapy and increases the probability of unfavorable infection outcome. One of the proposed methods to cope with multidrug-resistant (MDR) bacteria is the use of alternative antibacterial treatments, which include natural antimicrobial substances such as plant essential oils (EOs). The aim of the present article is to review published studies on the activity of EOs and their constituents against MDR bacteria and to formulate perspectives for the future. In general, published studies indicate that EOs can be used as effective antiseptics against many species, including MDR bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, resistant isolates of Pseudomonas aeruginosa, Klebsiella pneumoniae and others; certain EOs may potentiate the effectiveness of antibiotics against MDR bacteria; EOs can be synergistic with bacteriophages; and polymeric nanoparticles can be used for delivery of EOs and enhancement of their activity at the site of infection. © 2012 2012 Expert Reviews Ltd. Source

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