Khanty-Mansiysk, Russia
Khanty-Mansiysk, Russia

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Kalashnikova S.P.,Khanty Mansiysk State Medical Academy | Solovyov V.G.,Khanty Mansiysk State Medical Academy
Voprosy Pitaniia | Year: 2016

In experimental studies on 448 rats treated with bear fat diet (0.08 ml/100 g body weight), the nature and mechanisms of influence of this additive on the process of blood coagulation in experimental thromboplastinemia of different origin has been studied. As a result of intravenous injection in the jugular vein of a suspension of thrombin (exogenous thrombinemia) all clothingsee tests lengthened in the control animals (p<0.05): prothrombin time by 11.1%, activated partial thromboplastin time - by 13.4%, thrombin time by 16.8%. Fibrinogen fell by 1.9 fold, that was accompanied by increase of the level of soluble fibrin monomer complexes and reduce of activity of antithrombin III by 20.2%. At the same time severe thrombocytopenia developed with a relative increase in the number of activated forms (by 73.1%). Consumption coagulopathy was also observed in rats treated with bear fat, but the potential of hemostatic cascade and anticoagulation system remained high (judging by the tests PTV, thrombin time and content of antithrombin III). Under endogenous thromboplastinemia caused by combined stress (hypothermia + physical activity) in animals of the control group on the background of the shortening of the A PIT (by 24.9%) and PTV (16.8%), RCMP concentration increased by 52% and activity of antithrombin III increased compensatory. There was an increase of platelet count, due to the activated forms. To'jh signs of hypocoagulation aggravated even more. In animals treated with bear fat, the results of clothing tests did not differ from the original figures, and by 3 h, the majority of the indicators have reached their original values. The increase in platelet count has not been observed.

Zakharova N.,State Clinical Hospital | Duffy S.W.,Queen Mary, University of London | Mackay J.,University College London | Kotlyarov E.,Khanty Mansiysk State Medical Academy
ecancermedicalscience | Year: 2011

Background: A breast cancer screening programme (BCSP) was started in 21 districts in the Khanty-Mansiysky Autonomous Okrug - Ugra region from 7 February 2007. Methods: From the data on the numbers of subjects screened and the resulting diagnoses we calculated screening coverage rates and cancer detection rates and estimated the sensitivity of the screening tests. The State Cancer Registry was the source for the data regarding the female population by age, the number of breast cancer cases and cancer-related deaths. The data pertained to the period 2002.9, and included pathology data. Disease rates and distribution graphs of tumours by size and node status were analysed using Poisson regression. Results: The rates of breast cancer incidence and mortality indicate that the region is one in which the population is at medium risk of developing the disease. There was a significant increase in incidence overall during the period studied (p = 0.03), and a significant downward trend in breast-cancer-related mortality to a greater extent in the 50+ age group (p = 0.004), and when all ages 40+ were considered (p < 0.001). During 2007.9 92,576 women were screened in the BCSP. The screening coverage rate was ∼30%. Of the women who were screened, 9% were referred for further assessment. The average cancer detection rate was 2.5 per 1000 women screened. The sensitivity of the test was estimated to be 74%. Approximately 90% of screening-detected cases of breast cancer were at stages 1 or 2 of the disease. Conclusion: The finding that screening led to tumours being detected at earlier stages of the disease suggests that, in the long term, the programme will be successful in achieving a further reduction in mortality from the disease. Copyright: © the authors; licensee ecancermedicalscience.

The article has presented the results of a survey of 54 healthcare workers of a first aid station (FAS) in Khanty-Mansiysk including psychophysiological examination, determination of stress hormones in blood and content of chemical elements in hair. It has been found that doctors and paramedic visiting teams had a low level of subjective comfort and were highly exposed to stress negative effects. Analysis of cortisone and adrenaline concentrations in blood was high in more than a third of the examined persons. In more than a half of the FAS medical field force, there has been found deficiency of different degrees in provision with vital chemical elements responsible for psychoemotional sphere, namely, magnesium and potassium.

High body mass and obesity are of interest as a medical and social problem of the XXI century. Already at school age, many children have high body mass and obesity, one can state metabolic abnormalities in the serum lipids, carbohydrates, thyroid status. In the study, there have been examined 112 schoolchildren-nonresidents living in the Khanty-Mansiysk Autonomous Okrug: 44 - with high body mass and obesity, 68 - with normal body mass. In the group of the persons with high body mass and obesity, there have been determined reliably higher indices of general cholesterol, low-density lipoproteins, triglycerides (TG), glucose, glycohemoglobin and thyreotrophin and reliably lower indices of high-density lipoproteins and T3. There has been observed a positive correlation between glucose concentration and content of glycohemoglobin in blood (r = 0.983, p = 0.000), general cholesterol (r = 0.455, p = 0.002), triglycerides (r = 0.389, p = 0.034), free thyroxin (r = 0.314, p = 0.038). The level of glycohemoglobin correlated with the content of general cholesterol (r = 0.477, p = 0.001), triglycerides (r = 0.381, p = 0.038). The schoolchildren with high body mass and obesity had higher indices of carbohydrate-lipid metabolism and the thyroid status compared to the control group, what could cause a cascade of metabolic pathological states in young adult life period in the future.

Shalamova E.Yu.,Khanty Mansiysk State Medical Academy | Safonova V.R.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2015

We have analyzed relationships between stress-coping behavior styles and subjective well-being of the first year students of the Medical Faculty of the Khanty-Mansiysk State Medical Academy, 57 girls and 22 boys. We did a statistical analysis with Statistica 8.0 for Windows in view of sign normal distribution. The boys had better results according to the sub-scales Physical Functionality (PF), Vitality (VT) and Mental Health (MH). The girls used the sub-style Diversion more often. For the girls, there was a bigger number of statistically significant correlations between the sub-scales of the SF-36 questionnaire and the stress-coping behavior. According to the scales of physical components, there have been found significant correlations in the girls according to the sub-scale General Health (GH), and in the boys - According to the sub-scale Physical Role Functioning (RP). The use of the emotionally focused stress-coping styles in both groups was combined with a decrease in the values of the individual sub-scales of the SF-36 questionnaire. On the contrary, the choice of the problem-oriented and avoidance-oriented coping styles and its sub-styles was combined with their increase.

Shalamova E.Y.,Khanty Mansiysk State Medical Academy | Safonova V.R.,Khanty Mansiysk State Medical Academy | Ragozin O.N.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2016

Parameters of central hemodynamics in young men and women - junior students of the medical faculty of Khanty-Mansiysk State Medical Academy have been studied. As a result of daily monitoring, the average daily indicators of heart rate (HR), systolic (SBP) and diastolic (DBP), mean arterial pressure (MAP), pulse (PP) blood pressure, vegetative index Kerdo (VIK) were detected. The values of HR, SBP, DBP, VIK, SBP time index, DBP time index, SBP variability, DBP variability were obtained in day and night periods. Thus the girls had significantly higher values of daily average HR, day and night HR compared to boys. The boys showed higher SBP values. According to DBP indicators vascular tone in the groups of boys and girls did not differ significantly. Thus, intersexual differences between girls and boys were observed in minute blood volume mechanisms related to heart work. As it turned out, male students had high parasympaticus tonus, especially at night, which corresponds to strengthening of parasympathetic activity. The activity of sympathetic nervous system in young women was significantly higher than in boys in all measurement periods. High pressure (SBP time index) effect on target organs was significantly higher in boys than in young women. BP variability in boys and girls was comparable to the normal values, but at night variability indices of SBP were higher in group of boys. © 2016, Springer New York LLC. All rights reserved.

Shalamova E.Y.,Khanty Mansiysk State Medical Academy | Ragozin O.N.,Khanty Mansiysk State Medical Academy | Safonova V.R.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2016

The parameters of central hemodynamics in young men and women, junior students of the medical faculty of the Khanty-Mansiysk State Medical Academy were analyzed in this study. Values of cardio hemodynamic indicators and vegetation index Kerdo are obtained by 24-hour monitoring. Arrhythmic type prevailed among boys and girls; the second largest type was evening type; the number of students with morning chronotype was limited. Significant differences in the average values of central hemodynamics parameters were found in groups of the young people of the same sex with different chronotype in the hours of morning rise, the diurnal activity and night’s repose. Differences between the representatives of different chronotypes were evident to a greater extent in the girls’ groups than in the boys’ groups. In the group of youths, joined all chronotypes representatives, desynchronosis of central hemodynamic parameters was evident as ultradian rhythms. We observed more intercalated rhythms in young men with arrhythmic chronotype than in boys with evening chronotype where pulse pressure circadian rhythm also disappeared. In the group of girls, we observed disappearance of pulse pressure circadian rhythm. Girls with arrhythmic and evening chronotypes had disorders in rhythms coherence of systolic and diastolic blood pressure and heart rate that led to the absence of circadian rhythm of pulse pressure. © Northern State Medical University, Arkhangelsk.

Safonova V.R.,Khanty Mansiysk State Medical Academy | Shalamova E.Yu.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2013

There has been studied influence of examination stress on basic parameters of the heart rate variability (HRV) of female students of a northern medical school. 35 students took part in our study. We analyzed statistic and spectral parameters of HRV. Data was analyzed by using the computer software SPSS-17.0 taking into account normalcy of characteristic distribution. A complex analysis of the heart rate basic indexes has detected different contributions in regulation of cardiac activity of the sympathetic and parasympathetic parts of the autonomic nervous system in the students of the medical school. The tone of the sympathetic nervous system was high in conditions of comparative emotional rest in the female students. During the exams the number of the students with predominance of the parasympathetic tone of the ANS which provided a favorable option of anabolic metabolism was reduced. The psycho-emotional stress caused by the examinations led to significant variations of the heart function vegetative support and increased the sympathetic influence.

Shalamova E.Y.,Khanty Mansiysk State Medical Academy | Safonova V.R.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2013

Health-related quality of life (HRQoL) was studied in 96 students of a northern medical school (71 females and 25 males) using the 36-item Short Form Health Survey questionnaire (SF36). Gender-sex differences were detected. Males had higher scores in SF36 domains according to the scales: Physical functioning (PF), Bodily pain (BP), General health (GH), Vitality (VT), Mental Health (MH). Social functioning domain scores were low in both the males and females. In contrast to the females, the male responders had a significant correlation of the BP domain score with other four domains scores (PF, GH, VT, MH). It has been suggested that despite lower BP score in the females, HRQoL can depend more on BP in the male students. © The Northern State Medical University, Arkhangelsk.

Korchina T.Ya.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2013

Spectrometric analysis of hair from 207 nonnative adult population's patients, lived in Khanty-Mansiysk autonomous region was carried out with AES - ISP methods. Particular features of an nonnative adult patient's «elemental portrait» (clinically arterial hypertension syndrome prevailed and reduction of antioxidant activity) deficiency of selenium, were high levels of sodium and iron, decreasing potassium level, high values of ratios Fe/Cu, Na/Mg and Na/K. Spectrometric analysis of chemical element may be as supplementary method donozological diagnostic of the different diseases and heart disease too.

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