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Khanty-Mansiysk, Russia

The article has presented the results of a survey of 54 healthcare workers of a first aid station (FAS) in Khanty-Mansiysk including psychophysiological examination, determination of stress hormones in blood and content of chemical elements in hair. It has been found that doctors and paramedic visiting teams had a low level of subjective comfort and were highly exposed to stress negative effects. Analysis of cortisone and adrenaline concentrations in blood was high in more than a third of the examined persons. In more than a half of the FAS medical field force, there has been found deficiency of different degrees in provision with vital chemical elements responsible for psychoemotional sphere, namely, magnesium and potassium.

High body mass and obesity are of interest as a medical and social problem of the XXI century. Already at school age, many children have high body mass and obesity, one can state metabolic abnormalities in the serum lipids, carbohydrates, thyroid status. In the study, there have been examined 112 schoolchildren-nonresidents living in the Khanty-Mansiysk Autonomous Okrug: 44 - with high body mass and obesity, 68 - with normal body mass. In the group of the persons with high body mass and obesity, there have been determined reliably higher indices of general cholesterol, low-density lipoproteins, triglycerides (TG), glucose, glycohemoglobin and thyreotrophin and reliably lower indices of high-density lipoproteins and T3. There has been observed a positive correlation between glucose concentration and content of glycohemoglobin in blood (r = 0.983, p = 0.000), general cholesterol (r = 0.455, p = 0.002), triglycerides (r = 0.389, p = 0.034), free thyroxin (r = 0.314, p = 0.038). The level of glycohemoglobin correlated with the content of general cholesterol (r = 0.477, p = 0.001), triglycerides (r = 0.381, p = 0.038). The schoolchildren with high body mass and obesity had higher indices of carbohydrate-lipid metabolism and the thyroid status compared to the control group, what could cause a cascade of metabolic pathological states in young adult life period in the future.

Kolpakov V.V.,Tyumen State University | Tomilova E.A.,Tyumen State University | Bespalova T.V.,Khanty Mansiysk State Medical Academy | Larkina N.Y.,Tyumen State University | And 2 more authors.
Human Physiology | Year: 2016

The concept of typological variability of physiological individuality was a methodological basis for chrono-physiological assessment of habitual physical activity (HPA) and heart rate (HR) in individuals with different functional types of constitution (FTC) (low HPA (FTC-1), medium HPA (FTC-2), and high HPA (FTC-3)) living at different latitudes of West Siberia (Tyumen, 57°09’N; Khanty–Mansi Autonomous Okrug (KhMAO)–Yugra, 61°00’N; and Yamal–Nenets Autonomous Okrug (YaNAO), 63°12’N). The typical chronostructure of the circadian rhythm of HPA and HR was established for each FTC under the conditions of both mid-latitude (Tyumen) and northern regions. The regional differences were determined too. Compared to the mid-latitude parameters, the chrono-physiological assessment of typological variability of HPA and HR in FTC-1, FTC-2 and FTC-3 subjects living under the climatic and geographical conditions of KhMAO–Yugra and YaNAO in each respective group demonstrated a decrease in the midline-estimating statistic of rhythm (MESOR) and energy intensity of the circadian rhythm, an increase in the proportion of ultradian rhythms, differences in the time of HPA and HR acrophases, a decrease in synchronization and coherence indices, as well as a higher coefficient of the number of heart beats per locomotion and a lower circadian index. All of the above parameters of northerners with each FTC, with regard for the general principles of modern approaches, are not pathologies but rather regional characteristics that should be taken into consideration in the assessment of general state of health and prenosological diagnostics; they were the basis for using chronoprevention and time correction of reduced physical activity. © 2016, Pleiades Publishing, Inc.

Korchina T.Ya.,Khanty Mansiysk State Medical Academy
Human Ecology | Year: 2013

Spectrometric analysis of hair from 207 nonnative adult population's patients, lived in Khanty-Mansiysk autonomous region was carried out with AES - ISP methods. Particular features of an nonnative adult patient's «elemental portrait» (clinically arterial hypertension syndrome prevailed and reduction of antioxidant activity) deficiency of selenium, were high levels of sodium and iron, decreasing potassium level, high values of ratios Fe/Cu, Na/Mg and Na/K. Spectrometric analysis of chemical element may be as supplementary method donozological diagnostic of the different diseases and heart disease too.

Zakharova N.,State Clinical Hospital | Duffy S.W.,Queen Mary, University of London | Mackay J.,University College London | Kotlyarov E.,Khanty Mansiysk State Medical Academy
ecancermedicalscience | Year: 2011

Background: A breast cancer screening programme (BCSP) was started in 21 districts in the Khanty-Mansiysky Autonomous Okrug - Ugra region from 7 February 2007. Methods: From the data on the numbers of subjects screened and the resulting diagnoses we calculated screening coverage rates and cancer detection rates and estimated the sensitivity of the screening tests. The State Cancer Registry was the source for the data regarding the female population by age, the number of breast cancer cases and cancer-related deaths. The data pertained to the period 2002.9, and included pathology data. Disease rates and distribution graphs of tumours by size and node status were analysed using Poisson regression. Results: The rates of breast cancer incidence and mortality indicate that the region is one in which the population is at medium risk of developing the disease. There was a significant increase in incidence overall during the period studied (p = 0.03), and a significant downward trend in breast-cancer-related mortality to a greater extent in the 50+ age group (p = 0.004), and when all ages 40+ were considered (p < 0.001). During 2007.9 92,576 women were screened in the BCSP. The screening coverage rate was ∼30%. Of the women who were screened, 9% were referred for further assessment. The average cancer detection rate was 2.5 per 1000 women screened. The sensitivity of the test was estimated to be 74%. Approximately 90% of screening-detected cases of breast cancer were at stages 1 or 2 of the disease. Conclusion: The finding that screening led to tumours being detected at earlier stages of the disease suggests that, in the long term, the programme will be successful in achieving a further reduction in mortality from the disease. Copyright: © the authors; licensee ecancermedicalscience.

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